Erciyes University - AVESIS
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Digestion, faeces microbiome, and selected blood parameters in dogs fed extruded food containing Black soldier fly ( Hermetia illucens ) meal
Anticancer potential of benzo[b]thiophene functionalized thiosemicarbazone ligands and their organoruthenium complexes
As novel promising anticancer candidates, the piano-stool type complexes of ruthenium, [RuCl(eta 6-p-cymene)(N,S-Ln)]PF6, K1-4, were synthesized from the reaction of the substituted benzo[b]thiophene based thiosemicarbazone ligands (L1-4) with [{RuCl(eta 6-p-cymene)}2(mu-Cl)2]. All complexes were fully characterized using elemental analysis, and spectroscopic methods such as FT-IR and 1H NMR. The molecular masses of the complexes were proved by MALDI-TOF analysis. Single crystal X-ray diffraction study was employed in the structural elucidation of complex K1 which shows a distorted octahedral geometry around the Ru(II) ion. Furthermore, spectroscopic methods revealed that in all complexes the ligands are coordinated to the metal center in neutral thione form via N, S donors. In this study, the effect of all ligands, complexes and commercial drugs with a different concentration on the viability of OVCAR-3, A2780 and OSE cells were compared. In this comparison, the cytotoxicity of ruthenium (II) complexes on two ovarian cancer cell lines (human A2780 and human OVCAR-3) was evaluated. For this purpose, the resazurin assay was performed. Based on our studies, complex K2 showed the highest toxicity against OVCAR-3 and A2780 cells. The cytotoxic effect of K2 was found to be higher than that of the commercial anticancer agents Oxalpin and Carbodex, 1.8-34.7-fold for OVCAR-3 cells and 1.9-11.8-fold for A2780 cells, respectively. These results provide insight into the potential of ruthenium (II) complexes as a cytotoxic agent for the treatment of ovarian cancer, particularly for primary tumors
HTS analysis of resistance induction against PPV by four hairpin constructs in Nicotiana benthamiana
A new corrosion method (Aycan’s method)
Background: As it is known, the anatomy of the vessels is examined by removing the cast of the vessels inside the organs. Generally, liquid material (polyester, takilon, etc.) is injected into the vessels with positive pressure to remove the cast from the vessels of the organs. We built a machine to remove the cast of the vessels inside the organ. We named it corrosion machine. Materials and methods: Sheep kidneys were used in our experiment. After the kidneys were cannulated, they were placed in the vacuum chamber. With the operation of the vacuum pump, negative pressure was created in the vacuum chamber. With negative pressure, kidneys and its vessels expanded. Takilon or polyester easily entered the vessels of the kidney. The cast of the vessels of the kidney was removed. With this newly developed technique, the anatomy of the vessels whose casts were removed was examined with the naked eye, stereomicroscope or SEM. Results: The corrosion machine we built can cast the vessels of the organs very well. Takilon or polyester (which we used in our experiment) easily entered the capillaries under the effect of negative pressure. Conclusions: We think that this method can also be applied to other organs and used in vascular research
Effect of Some Post-Harvest Pre-Treatments on Vase Life and Some Quality Parameters of Cut Rose Flowers
Cut flowers are at risk of spoilage during transportation from the producer to the consumer after harvest. In cut flowers,both pre-harvest conditions and conditions during and after transportation significantly affect the post-harvest life, flowerquality, and the aesthetic appearance of flowers. This study aimed to determine the effects of some pre-treatments on thepost-harvest durability of cut rose (Rosa hybrida L.) flowers on vase life and some quality parameters. Seven differentpostharvest pretreatments [8-hydroxyquinoline 8-hydroxyquinoline+citric acid, 8-hydroxyquinoline+salicylic acid, 8hydroxyquinoline+aluminum sulfate, 8-hydroxyquinoline+glycolic acid, 8-hydroxyquinoline+succinic acid, silverthiosulfate and sodium hypochlorite (NaOCl)] were used in the study, and the results were compared with the control(distilled water). The harvested flowers were kept in pre-treatment solutions for 6 hours at room temperature and then incold storage (2-4°C) for 12 hours. After pre-treatment, the flowers were placed in glass vases containing 750 ml of distilledwater each. The vase life, daily and total water uptake, relative fresh weight and full opening time of the flowers weremeasured in the experiment. In addition, a visual quality assessment of flowers was performed on the 8th day of the vase’slife. The longest vase life among the treatments was obtained from silver thiosulfate treatment at 19.78 days, followed bycontrol (distilled water) at 14.22 days and sodium hypochlorite at 13.33 days. The vase life of flowers in other treatmentsvaried from 9.11 to 10.11 days. In conclusion, the silver thiosulfate (2 ml.L⁻¹) pretreatment was found to extend the vaselife of flowers and positively affect other quality parameters.</p
A greedy initialiser based meta-heuristic approach for planning unmanned aerial vehicles
The unpredictable benefits and low operational costs of unmanned aerial vehicles (UAVs) compared to their conventional counterparts caused a tremendous change in commercial and military concepts, and different solutions to problems regarding modern aerial vehicles were tried to further improve flight and job performances. One of the most challenging problems about the UAVs is known as the path planning problem, and a solution should satisfy some objectives related to the enemy anti-air weapons, fuel or battery consumption, and manoeuvre capability of the UAV being operated optimally. Immune plasma algorithm (IP algorithm or IPA) is a recent meta-heuristic optimiser, and its competitive performance has been validated over a set of engineering problems. In this study, a greedy initialiser that is responsible for generating a population of IPA was first introduced. Also, the treatment schema of the IPA was completely redesigned for more robust and detailed search characteristics without requiring either IPA-specific control parameters or their subtle configurations. The new IPA-based path planner, called greedy initialiser IPA (gintIPA), was tested by using three battlefields and 12 test cases belonging to them, and the obtained results were compared with the results of the well-known meta-heuristic techniques. Comparative studies showed that gintIPA is capable of planning more robust and safe UAV paths than other techniques for of all test cases. The proposed greedy initialiser gives a chance to start optimisation with qualified individuals and the newly designed treatment schema improving both exploitation and exploration routines significantly contributes to the gintIPA when outperforming other path planners
Do STEM Career Interest Levels Change Over The Years?
Educating a new generation of engineers, mathematicians, and scientists is essential for developing a competent workforce that meets the demands of the 21st century. Given that a qualified workforce trained in STEM disciplines will shape the contemporary corporate landscape, students ought to be steered toward careers associated with these domains. The study seeks to ascertain the interests of high school pupils in STEM careers. This study employs a survey, a quantitative research design. The study sample comprised 326 ninth-grade students enrolled in a high school in Kayseri province during the 2018-2019 and 2019-2020 academic years. The STEM Career Interest Survey (STEM-CIS) scale gathers research data. To ascertain the overall inclinations of the participants towards STEM careers, total STEM scores associated with the scale were computed for each individual. The investigation revealed that total scores for the 2018-2019 academic year varied from 111 to 200 points, with an average of 156.09. For the 2019-2020 academic year, total scores ranged from 113 to 200, with an average of 157.77. The maximum score achievable on this scale is 5*40=200, while the minimum value is 1*40=40. The critical value of 2.60, as recognized in the literature, indicates that findings over this threshold are deemed to exhibit significant interest in STEM careers. Consequently, we ascertained that high school pupils exhibit a favorable and progressively increasing inclination towards STEM vocations, attributable to the existing education system; their interest in mathematics is the most pronounced during both academic periods. We determined that it exhibited the lowest average for the engineering factor. The findings can be augmented by researching diverse socioeconomic and geographical regions, focusing on gender, academic performance, and familial influences, and comparing the outcomes. </p
Enhancing the Impact and Stab Resistance of Aramid Fabrics Via Boron Carbide-Reinforced Shear Thickening Suspensions
The function of single-phase and multi-phase shear thickening fluids (STFs) in body armor applications has been extensively studied. However, boron carbide (B4C), one of the toughest particles, has not been sufficiently investigated for its quasi-static role and low-speed dynamic impact with STF. In this study, multiphase STFs were formulated by incorporating B4C particles with three different size ranges (1-3 mu m, 22-59 mu m, and 125 mu m) into a silica-PEG200-based STF containing 55 wt% silica, at reinforcement concentrations of 5%, 10%, and 20% by weight. These STFs were then impregnated into p-aramid fabrics to fabricate composite samples, which were subjected to low-velocity dynamic impact tests (using a drop tower system according to ASTM D7136) and quasi-static stab tests (using a universal testing machine). The effects of B4C reinforcement content and particle size on the mechanical performance of the STF-treated fabrics were systematically investigated. Based on the test results, the research determines a critical reinforcement threshold of 10%. Beyond this level, excessive B4C disrupts the thickening mechanism of the STF and reduces impact strength. The study shows that increasing B4C particle size improves resistance, particularly in dynamic impact scenarios, but has a limited effect in quasi-static tests due to reduced contact area. The results provide important insights for optimizing STF-reinforced composites for protective applications, balancing material hardness, particle distribution, and STF rheology to maximize performance