Erciyes University - AVESIS
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Unconventional bioprinting modalities for advanced tissue biofabrication
No full textBioprinting has been widely used to fabricate three-dimensional constructs for various applications. However, conventional bioprinting modalities face challenges such as low resolution, poor repeatability, limited speed, and scalability constraints. To overcome these limitations, unconventional bioprinting modalities have been actively developed, utilizing electric fields, acoustic waves, magnetic forces, light, smart materials, and microfluidics to advance bioprinted tissues. This Review explores various unconventional bioprinting modalities, which significantly improve upon conventional counterparts to create complex, scalable heterogenous tissue constructs. In addition, emerging bioprinting methods, utilizing the principles of conventional or unconventional bioprinting modalities with new concepts integrated, such as embedded bioprinting, cryobioprinting, microgravity bioprinting and 4D bioprinting, were discussed. Key applications include functional tissue engineering, disease modeling, and organoid development, with future directions focusing on artificial intelligence-driven bioprinting, multimodal biofabrication, and intraoperative bioprinting to improve scalability and clinical translation. By integrating interdisciplinary innovations, unconventional bioprinting offers new opportunities to advance tissue biofabrication technologies
Tenha (Öykü Kitabı)
No full text“Her insan, her an, her soluk sadece kendisiyken, zihinlerimize kazınmış imgelerden arınmak gerek. İşte o zaman anlamlı ve sahici yaşarız.” Bir tenhalık var bu öykülerde... Ama insanı üşüten, yalnızlaştıran bir tenhalık değil. Issızlığın ortasında durup bakılan dünya, bildiğimiz dünya değil. Söylenen her sözde söylenmeyen, görünen her yüzde görünmeyen saklı. Ruhlar sızılı bir geçmişi anlatıyorlar; yaşayanlar ve ölüler geçmişe ve geleceğe doğru genişleyen anlarda buluşuyorlar. Kalabalık ama tenha. Keşkelerle ve umutla; gri duvarlara galebe çalan çiçeklerle; genç bir ölünün mezarına bırakılan bir demet nergisle; şiirin anlamlandırdığı sevgiyle.Tenha, Murakami’den Mişima’ya, Kenzaburo Oe’ye çevirileriyle tanıdığımız Ali Volkan Erdemir’in, üslubuyla Japon edebiyatına sıcak ve sevgi dolu bir selam gönderdiği öykü kitabı.</p
A novel PVC-membrane potentiometric sensor based on molecularly imprinted polymer for the determination of rhodamine B
No full textA rhodamine B (RH-B)-imprinted functional polymer was synthesized by free radical polymerization, utilizing RH-B as the template, methacrylic acid as the functional monomer, and ethyleneglycol dimethylacrylate as the cross-linker. The synthesized RH-B-imprinted polymer was characterized by FT-IR measurements. A novel RH-B-selective potentiometric poly(vinyl chloride) (PVC) membrane sensor was fabricated using this newly synthesized RH-B-imprinted functional polymer as the ionophore. Membrane optimization studies revealed that the most satisfactory membrane composition, yielding the best potentiometric parameters, comprised 32.0% (w/w) PVC, 64.0% (w/w) dibutyl phthalate, 3.0% (w/w) RH-B-imprinted polymer, and 1.0% (w/w) potassium tetrakis(4-chlorophenyl)borate. Further investigations into the potentiometric performance characteristics of the optimum composition demonstrated that the sensor exhibited a linear response to RH-B within the concentration range of 1.0 × 10–7 to 1.0 × 10–2 M with a detection limit of 1.0 × 10–8 M and a near Nernstian slope of 67.37 mV/decade. The sensor’s analytical proficiency was evidenced by its precise quantification of RH-B in RH-B-spiked rose-water samples, resulting in satisfactory recovery rates
Exploring the potential of minimally invasive sagittal split ramus osteotomy to transform patient outcomes: A randomized, double-blind, controlled, split-mouth study
No full textSagittal split ramus osteotomy is a widely used procedure in orthognathic surgery; however, conventional techniques are associated with notable morbidity, including bleeding, edema, and pain. Recently, minimally invasive techniques have been described to reduce surgery-related morbidities and improve patients’ outcomes. This randomized, double-blind, controlled, split-mouth trial aimed to compare the conventional approach with a minimally invasive sagittal split osteotomy (MISSRO) in terms of surgical efficiency and postoperative outcomes. In each of the thirty-six patients included in the study, a conventional sagittal split osteotomy (SSRO) was performed on one side of the mandible, and a MISSRO was performed on the contralateral side. The MISSRO technique was characterized by a short mucosal incision, minimal soft-tissue dissection, and a low and short osteotomy. Operative time and bleeding were statistically significantly lower on the minimally invasive side ( p < 0.001). Postoperative edema measurements on days 1, 7, 14, and 30 were also statistically significantly reduced ( p < 0.001). Pain scores were statistically significantly lower at the first postoperative hour ( p = 0.002) on the minimally invasive side, with no differences at later time points. The findings suggest that MISSRO is a safe and effective alternative to the conventional method, enhancing recovery by reducing tissue trauma and improving perioperative outcomes
National-scale climate forecasting in Türkiye using statistical and artificial intelligence-based machine learning models under CMIP6 scenarios
No full textClimate change represents a growing challenge to Turkey’s climatic stability, underscoring the necessity for reliable forecasting methodologies to facilitate adaptation strategies and informed policy development. The present study examines long-term trends in national-scale temperature and precipitation series between 1902 and 2022 and produces future projections for the period 2022–2040 using an integrated structure of statistical and artificial intelligence-based models. Four distinct models were utilized in the prediction process: Vector Autoregression (VAR), Extreme Learning Machine (ELM), Multilayer Perceptron (MLP), and Nonlinear Autoregressive Exogenous (NARX). These models were then compared with CMIP6-based Shared Socioeconomic Pathways (SSP1-1.9, SSP2-4.5, SSP5-8.5) scenarios. The Mann–Kendall and Pettitt tests revealed a statistically significant warming trend after 1980, as well as structural breaks in temperature in 1994 and in precipitation in 1935. The findings of quantitative assessments (R2, RMSE, NSE, KGE) demonstrate that ELM and MLP models exhibit superior accuracy (R2 ≥ 0.95, RMSE ≤ 0.25 °C) in temperature predictions. Projections indicate that the average annual temperature in Turkey will reach approximately 13.2–13.6 °C by 2040, and this trend shows a high degree of consistency with the medium emission scenario SSP2-4.5. Conversely, the performance of models in precipitation forecasts was found to be less consistent, owing to elevated temporal and spatial variability. Statistical tests (ANOVA and Kruskal–Wallis) demonstrate that there are significant differences between temperature prediction models, but no clear superiority in precipitation predictions. In conclusion, this study presents one of the first national climate projection frameworks for Turkey on a century scale, combining data-driven modelling with scenario-based projections to provide quantitative contributions to climate adaptation policies and regional planning processes
Chronic Traumatic Dental Occlusion: Its Impact on Temporomandibular Joint and Systemic Health, and Clinical Management Strategies
No full textPurpose: Traumatic dental occlusion (TDO) is a multifactorial and dynamic clinical condition that extends beyond localised tooth wear and has been reported to be associated with alterations in temporomandibular joint biomechanics, neuromuscular function and overall masticatory system performance. While acute dental trauma often receives greater clinical attention, chronic occlusal trauma may remain underrecognised in routine practice, despite its potential to influence mandibular movement patterns, modify joint loading and contribute to patient-reported functional complaints. Basic Procedures: This narrative review synthesises current concepts from the literature regarding the proposed etiologic factors, functional implications and long-term clinical consequences of traumatic dental occlusion. Particular emphasis is placed on the adaptive nature of the masticatory system and the variability of individual responses to occlusal disturbances. Contemporary digital diagnostic tools, occlusal analysis technologies and CAD/CAM-assisted restorative workflows are discussed as adjunctive modalities that may support clinical assessment and treatment planning rather than as definitive solutions. Main Findings: The review outlines commonly applied clinical approaches used in the management of TDO-related structural and occlusal changes, including tooth wear and variations in occlusal vertical dimension, with reference to provisional strategies, indirect restorations and minimally invasive interventions. Principal Conclusions: By providing an expert narrative synthesis and acknowledging ongoing controversies within occlusion and temporomandibular disorder research, this review aims to enhance clinician awareness, support cautious and patient-centred decision-making and encourage further research to clarify the clinical relevance of traumatic dental occlusion within contemporary dental practice
