Erciyes University - AVESIS
Not a member yet
96078 research outputs found
Sort by
The correlation between pro- and anti-inflammatory cytokines and anti-spike IgG antibody responses induced by the SARS-CoV-2 coronavirus vaccine
No full textInternational overview on diagnosis and treatment of nocturnal enuresis: A Survey Study by EAU YAU Paediatric Urology Working Group Perspectiva internacional sobre el diagnóstico y tratamiento de la enuresis nocturna: estudio basado en una encuesta del Grupo de Trabajo de Urología Pediátrica de la Sección de Jóvenes Urólogos Académicos (YAU) de la Asociación Europea de Urología (EAU)
No full textObjective: This study assessed global diagnostic and therapeutic approaches to nocturnal enuresis (NE), highlighting current practices and variations. Materials and methods: An 18-question survey by the European Association of Urology (EAU) Young Academic Urologist (YAU) Paediatric Urology Working Group targeted clinicians managing NE. Distributed online, it reached Urologists, Pediatric Urologists, Pediatricians, Nephrologists, and Urotherapists. The survey collected demographic data and details on diagnostic and treatment practices. Responses were analyzed using descriptive statistics. Results: Most respondents worked in university or government hospitals, with pediatric urologists forming the largest group (43.6%). A significant portion had 11-20 years of NE management experience. Initial treatment favored behavioral strategies and urotherapy (84.5%), with desmopressin as a common first-line medication (23.8%). Most clinicians initiated treatment at ages 5-6. Bladder diaries were widely used (82.0%), while airway assessments were inconsistent (52.1%). Diagnostic test usage varied, with urinary tract ultrasonography (53.65%) and urinalysis (51.5%) employed to identify underlying abnormalities. Psychological referrals were common for secondary enuresis (58.9%). Conclusion: NE management varies globally due to regional practices, clinician experience, and specialty focus. The findings emphasize the need for standardized guidelines and education on comprehensive assessments, including sleep-related factors. International collaboration and guideline development could enhance consistency and improve patient outcomes
Characterization of the midgut proteome of<i> Galleria</i><i> mellonella</i> L. (Lepidoptera: Pyralidae) larvae during development
No full textGalleria mellonella, the bigger wax moth, plagues beekeeping. It is also a good model organism in host-pathogen studies and can digest polymers, making it an attractive biotechnology contender. In 2018, the G. mellonella genome was sequenced, allowing for additional proteomics-based study on this species' complex and dynamic biochemical processes. In this study, we characterized the effects of larval development on the midgut proteome by grouping the larvae based on their body weight, which was determined to correspond to the I, II, III, and IV instar stages. Proteins were isolated from dissected midguts using the TCA-acetone method and separated by 2DPAGE (Two-Dimensional Polyacrylamide Gel Electrophoresis). The resulting gels were imaged and visually analyzed to identify stage-specific protein spots. These spots were excised, digested into peptides with trypsin enzyme, and prepared for LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) analysis. A total of 136 distinct proteins were successfully identified from these analyses. Subsequent bioinformatics analysis showed that the majority of these proteins were localized to the cytoplasm and mitochondria. This study demonstrates that the midgut proteome of G. mellonella larvae undergoes significant dynamic changes in a stagespecific manner to meet the increasing metabolic and cellular remodeling demands of growth and metamorphosis. This conclusion is supported by the ontological analysis, which emphasizes the critical functions of these proteins in structural and metabolic processes. Our findings provide proteomic information on insect developmental biology and metabolism and lay the groundwork for understanding this insect's amazing flexibility. Biotechnological applications and pest management plans benefit from these findings
Dynamical behavior of the soliton solutions of the sixth-order Benney-Luke equation using Hirota bilinear method arising in physical sciences
No full textKABUL EDİLDİIn this paper, the sixth-order Benney-Luke equation as a nonlinear partial differential equation that deter19 mines how nonlinear waves travel through analyzing wave tension in physical systems and studying the20 stress of water surface is studied. The method employs Hirota’s bilinear form to construct diverse solu21 tion models, including the multi waves, breather waves, Ma-breather, Kuznetsov-Ma-breather, periodic22 cross-kink solutions. These solutions offer critical insights into the impact of behaviours on nonlinear23 wave dynamics, particularly in the stress of water surface. Also, in this study, some standard, compat24 ible, and useful wave solutions with a high score of accuracy and applicability, designated in terms of25 hyperbolic, trigonometric, and rational functions of the stated models using the generalized tan(φ/2)-26 expansion approach are established. The model is adapted to univariate wave equations through wave27 transformation erstwhile to investigation. To enhance visualization, we use Maple software to plot three28 dimensional, two-dimensional, and density graphs, illustrating the intricate effects of solitons and other29 kinds of solutions on the obtained solutions. This work contributes to the understanding of soliton30 dynamics in higher-dimensional nonlinear systems and their relevance in practical applications. The ob31 tained solutions are compared with the exact or existing numerical results in the literature to verify the32 applicability, efficiency and accuracy of the method. The acquired results reveal the efficiency and sim33 plicity of the suggested techniques which are more conscientious to solve higher dimensional nonlinear34 ordinary as well as partial differential equations. </p
Aromatherapy Experiences of Intensive Care Nurses Regarding Sleep and Fatigue: A Phenomenological Study
No full textBackground: Critical care nurses frequently experience fatigue and sleep problems. Some nurses have used aromatherapy as a complementary approach to cope with these challenges. Aim: This study aimed to examine the personal experiences of intensive care nurses regarding the use of aromatherapy for sleep and fatigue. Study Design: A qualitative phenomenological approach was adopted, using purposive sampling. Ten intensive care nurses working in a Level 3 intensive care unit who met the inclusion criteria and agreed to participate were interviewed individually. Firsthand experiences with aromatherapy were explored in depth to obtain detailed data. Data were collected using a semi-structured interview form. With participants' consent, identifiers were anonymized and coded as ‘P1, P2, P3’. The interviews were audio-recorded, transcribed verbatim, and codes were derived directly from the participants' narratives. These codes were organised into categories and then grouped into overarching themes, which were analysed using inductive content analysis. Results: The central theme was ‘Personal Aromatherapy Experiences of Intensive Care Nurses and Their Perceptions and Impacts of Fatigue and Sleep Problems’. Within this theme, intensive care nurses shared their personal aromatherapy experiences and their perceptions of fatigue and sleep problems. Based on their personal experiences, nurses identified several factors contributing to sleep and fatigue problems, including irregular diet, 24-h shift schedules, education, alternate-day care, long working hours, family life, burnout, chronic illness, irregular sleep patterns, the debilitating nature of disease, night shifts and the intensive care environment. To address these issues, nurses reported using various aromatherapy oils, such as lavender, chamomile, orange, lemon, eucalyptus, jasmine, rose and violet. They indicated that aromatherapy increased energy, promoted relaxation, reduced pain, stress and fatigue, and facilitated falling asleep, highlighting its positive effects on their well-being and work-life balance. Conclusion: Interviewed intensive care nurses reported that aromatherapy helped them cope with fatigue and sleep difficulties and supported their well-being in high-risk work environments. Relevance to Clinical Practice: Aromatherapy may offer a supportive coping mechanism for fatigue and sleep disturbances among intensive care nurses. Randomised controlled trials with evidence-based data on this topic can be planned. Therefore, nurses in healthcare institutions can be supported with evidence-based strategies, improvements in working conditions and training in aromatherapy applications in intensive care units
Evaluation of oxadiazole-<i>N</i>-phenylacetamide conjugates as VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative assessment, molecular docking, and dynamics studies
No full textAimA novel series of oxadiazole-based derivatives was designed and synthesized as vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors.MethodThe synthesized compounds were evaluated for their cytotoxic and VEGFR-2 inhibition activities.ResultsCompound 11i was a super cytotoxic member, showing IC50 of 3.26 and 5.11 mu M, twice as active as sorafenib (IC50 = 8.83 and 6.68 mu M) against hepatocellular carcinoma (HepG2) and colon cancer (HCT-116), respectively. Also, the VEGFR-2 inhibitory assay revealed that derivative 11i was the most potent VEGFR-2 inhibitor, showing a strong IC50 value of 0.56 nM, compared to sorafenib (IC50 = 0.46 nM). Furthermore, extra mechanistic studies were conducted on the most active candidate 11i. The results indicated that such a compound arrested the cell cycle at both S and G2/M stages, triggering apoptosis in HepG2 cells. Also, compound 11i produced a significant increase in the expression levels of apoptotic suppressors, caspase-3 and BAX, and a significant reduction of apoptosis motivator, Bcl-2 protein. Moreover, docking and molecular dynamics (MD) simulation studies revealed the correct binding mode and the optimum dynamics of compound 11i inside the VEGFR-2 pocket.ConclusionThis study represents compound 11i, incorporating an oxadiazole scaffold as a promising VEGFR-2 inhibitor with potent anticancer activity
Colistin and Biofilm-Related Genes of Positive Escherichia coli O157:H7 in Cattle (Bos taurus) Carcasses Antibiotic Resistance Profiles, Biofilm and Molecular Characterisation of Isolates.
No full textFungal Biotechnology Advancements in Drug Discovery, Healthcare, and Environmental Solutions
No full textEffect of different density distributions and one-dimensional potential barrier for 15C + 12C fusion reactions at astrophysical energies
No full textThe fusion cross-sections of the 15C + 12C reaction are analyzed using the optical model at energies around the Coulomb barrier. For this objective, the present study consists of two parts. First, three different density distributions of the nucleus 15C are applied to produce the real potential of the double-folding model. Then, the fusion cross-sections are investigated using a one-dimensional potential barrier approximation at astrophysical energies with Morse-type and harmonic-oscillator potentials to make a comprehensive analysis. The theoretical results are in good agreement with the experimental data. We have concluded that the Gaussian-based density distributions are important tools for fusion cross-section calculations with neutron-rich nuclei