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Optimal Cut-Off Point for Self-Rated Successful Aging Based on the Rowe and Kahn's Model
No full textThere is no consensus on the optimal self-rated successful aging (SRSA) cut-off point for determining whether aging is successful. The present study aims to address this gap by identifying reliable SRSA cut-off points through a comparison based on Rowe and Kahn’s (1997) successful aging model. A sample of 478 older adult residents of municipal centers and nursing homes aged ?50 years (M = 72.11, SD = 10.43) were subjected to the single-item SRSA evaluation, as well as scale sets measuring Rowe and Kahn’s (1997) criteria. A receiver-operating characteristic analysis was then used to determine a range of potential SRSA cut-off points to discriminate between successful and not successful agers. The application of Rowe and Kahn’s (1997) successful aging criteria revealed an optimum cut-off point of ?7, having the best balance of sensitivity (86.7 or 74.9%) and specificity (46.9 or 55.3%). © 2025 Elsevier B.V., All rights reserved
A simple method to determine the severe-extreme intensity exercise domain boundary using the VO2 kinetic response
No full textThe boundary separating the severe intensity exercise domain, wherein the maximal O2 uptake (V.O2max) can be attained, from the extreme intensity exercise domain, wherein V.O2max cannot be attained, is not widely adopted in applied sports sciences due to the labour-intensive nature of its measurement. The aim of this study was to propose an alternative and practical approach to estimate the severe-extreme domain boundary using V.O2 kinetics. Sixteen males completed an incremental exercise test and a series of constant power output exercise tests on a cycle ergometer. The relationship between time to achieve V.O2max and time to task failure during severe-intensity exercise was calculated to estimate the highest power output at which V.O2max was momentarily attained before task failure (PUPPERBOUND). Separately, the highest power output that provided a time to task failure that was equal to or greater than four times the time constant (tau) describing the V.O2 kinetics during severe-intensity exercise (P4-tau) was calculated. The PUPPERBOUND and P4-tau occurred at similar power outputs (379 vs. 380 W; p = 0.62) and were closely related (r:0.99; bias:1 W; SEE:7 W; CV%:1.92%; LoA:-14 W to 16 W). Compared to PUPPERBOUND, the P4-tau method provides a simpler and more time efficient approach to identify the severe-extreme domain boundary.Scientific and Technological Research Council of Turkiye [TUBITAK-1002 program) [222S455]This study was financially supported by the Scientific and Technological Research Council of Turkiye [TUBITAK-1002 program; project code: 222S455]
Türkiye tarafından onaylanan milletlerarası çevre sözleşmeleri bağlamında endüstriyel tesislerle ilgili çevresel etki değerlendirmesi
No full textBu çalışmanın amacı, Türkiye’nin onayladığı çevre sözleşmeleri bağlamında, endüstriyel tesislere ilişkin ÇED tecrübelerinden yararlanarak milletlerarası çevre eğilimlerine uyum sağlamak için atılması gereken adımları belirlemektir. Çalışma kapsamında öncelikle çevre düzenlemelerinin tarihsel gelişimi değerlendirilmiş, ardından ABD, Avrupa Birliği (AB) ve BRICS ülkelerinin çevre politikaları analiz edilerek güncel milletlerarası çevre eğilimleri ortaya konmuştur. Türkiye’nin onayladığı başlıca çevre sözleşmeleri tek tek incelenmiş; bu sözleşmelere Türkiye'nin uyum düzeyi ile uygulamadaki güçlü ve zayıf yönleri belirlenmiştir. Ayrıca Avrupa İnsan Hakları Sözleşmesi’nin çevresel korumaya dolaylı etkileri değerlendirilmiş; Akbelen Ormanı davası gibi somut örnekler üzerinden endüstriyel tesislere yönelik idari ve yargısal süreçler analiz edilmiştir. Almanya ve Japonya emsal alınarak Türkiye’nin uyum stratejileri kıyaslanmış; AB Türkiye Raporları’ndan elde edilen bulgularla Türkiye’nin çevre politikasının mevcut durumu değerlendirilmiştir. Çalışmada literatür taraması, mevzuat ve yargı kararları incelemesi, örnek ÇED raporlarının analizi, istatistiksel veri kullanımı ve karşılaştırmalı analiz yöntemleri birlikte uygulanmıştır. Analizlerde somuttan soyuta ilerleyen bir yöntem izlenmiş; milletlerarası eğilimler ve Türkiye’nin mevcut uygulama ve eğilimleri, güvenilir veri kaynaklarından alınan grafik ve tablolar ile desteklenmiştir. Çalışmada ulaşılan sonuçlara göre, Türkiye’nin çevre sözleşmelerine uyumunun güçlendirilmesi için ÇED süreçlerinin muafiyetlerden arındırılması, halkın katılımı ve yargıya erişimin güçlendirilmesi, ekosistem temelli ve kümülatif etki analizlerinin yaygınlaştırılması gerekmektedir. Ayrıca Paris Anlaşması başta olmak üzere iklim değişikliğiyle ilgili taahhütlerin somutlaştırılması; mutlak ve bağlayıcı emisyon azaltım hedefleri içeren kapsamlı bir İklim Kanunu'nun yürürlüğe konulması; Emisyon Ticaret Sistemi (ETS) ve karbon fiyatlandırma gibi piyasa araçlarının etkinleştirilmesi, yerel yönetimlerin çevresel denetimde daha aktif hale getirilmesi ve biyolojik çeşitliliğin korunmasına yönelik mevzuatın güçlendirilmesi önerilmektedir. Almanya ve Japonya’nın iyi uygulama örneklerinden yararlanılarak sürdürülebilir kalkınma ilkesi doğrultusunda güçlü bir çevresel yönetim modeli geliştirilmesi büyük önem taşımaktadır.The purpose of this study is to identify the steps that need to be taken to align with international environmental trends by leveraging Environmental Impact Assessment (EIA) experiences related to industrial facilities within the context of the environmental conventions ratified by Turkey. The study initially traces the historical trajectory of environmental regulations, subsequently comparing the U.S., EU, and BRICS environmental policy frameworks to discern emerging global trends. The major environmental conventions ratified by Turkey were examined one by one, and Turkey's level of compliance with these conventions, as well as the strengths and weaknesses in their implementation, were identified. Additionally, the indirect effects of the European Convention on Human Rights on environmental protection were assessed, and administrative and judicial processes concerning industrial facilities were analyzed through concrete cases such as the Akbelen Forest Case. By taking Germany and Japan as benchmarks, Turkey's compliance strategies were compared, and the current state of Turkey's environmental policy was evaluated using findings from EU Turkey Reports. The study employed literature review, analysis of legislation and judicial decisions, examination of sample EIA reports, statistical data usage, and comparative analysis methods. The analyses followed a methodology progressing from concrete to abstract, with international trends and Turkey's current practices and tendencies supported by graphs and tables derived from reliable data sources. The findings of the study suggest that to strengthen Turkey's compliance with environmental conventions, EIA processes should be exempted from exclusions, public participation and access to justice should be enhanced, and ecosystem-based and cumulative impact analyses should be widely adopted. To advance climate action, Turkey must translate its commitments—especially under the Paris Agreement—into tangible policies. This requires passing a robust Climate Law that mandates strict, enforceable emission cuts. Market-driven mechanisms like Emissions Trading Systems (ETS) and carbon pricing schemes need operational refinement to maximize their impact. Simultaneously, empowering municipal authorities to enforce environmental regulations more rigorously would improve compliance. Finally, updating legal frameworks to prioritize biodiversity protection is critical for long-term ecological resilience. By adopting lessons from Germany and Japan’s proven environmental governance frameworks, Turkey can establish an effective sustainability-focused regulatory system. Such a model would align with global sustainable development objectives while addressing local ecological challenges
Broad-ranged, highly disjunct, locally rare and severely endangered: the challenging risk assessment and a global conservation strategy for Erica sicula Guss. sensu lato (Ericaceae)
No full textThe distribution range of Erica sicula Guss. sensu lato spans the central and eastern Mediterranean Basin, but shows a significantly fragmented pattern, and its populations are locally subject to multiple threats inducing continuous regression. The species is distributed across five countries, Italy, Libya, Cyprus,T & uuml;rkiye and Lebanon, and includestwo subspecies, subsp. sicula and subsp. bocquetii, currently represented by 31 and 8 stands, respectively. This study provides an updated overview of the distribution, ecology, and conservation status of both subspecies. New distribution data and ecological information were gathered through fieldwork, literature, and herbarium specimens. In Sicily (Italy), unmanned aerial systems and high-resolution digital elevation models were employed to perform a detailed census of the last extant stand, mapping its distribution and calculating its 3D occupation surface. Based on our analyses, Erica sicula is evaluated as Least Concern (LC) at the global level, even though each subspecies and subpopulation are nationally endangered. In fact, 19 locations of E. sicula subsp. sicula were not confirmed recently, and this subspecies should be considered as Critically Endangered (CR) in Italy and Vulnerable (VU) in Lebanon, Cyprus and T & uuml;rkiye. In Libya, E. sicula subsp. sicula is VU due to severe habitat degradation. E. sicula subsp. bocquetii, formerly known from a few locations in the mountains of SW Anatolia, T & uuml;rkiye, has been found at lower altitudes in several new locations and is also assessed as VU. Further fieldwork is recommended to better assess the demographic trends of the different subpopulations. Genetic analyses are needed to clarify the taxonomic value of infraspecific taxa previously described and to guide future conservation efforts of the most unique and genetically rich stands, both in-situ and ex-situ. Improving the conservation strategies for taxa like Erica sicula s. l. requires the collaboration of specialists from all involved countries, making it crucial to maintain networks of experts in the Mediterranean
Lamiaceae Familyasına Ait Bazı Medikal Bitkilerin Bakteriyel Balık Patojenlerine Karşı Anti-Virülans Potansiyeli
No full textBitki özleri, geleneksel tıpta yıllardır yaygın olarak kullanılmaktadır. Lamiaceae familyası, tıp, gıda, ilaç endüstrisinde kullanılan aromatik bitkileri içerir. Bu türler gıda olarak tüketilirken, aromatik özellikleriyle de geleneksel tıbbın vazgeçilmez parçası olarak değerlendirilmektedir. Sağlık ve endüstriyel ürünlerde GRAS (Güvenli) kabul edilen Lamiaceae türleri ekonomik botanik açısından da önemlidir. İzmir kekiği (Origanum onites), Anadolu adaçayı (Salvia fruticosa), Mercanköşk (Origanum majorana) gibi Lamiaceae bitkilerinin güçlü bakterisidal, antifungal özellikleri bilinirken, bu bitkilerden sağlanan yağ ve hidrosol formdaki ekstraktların anti-biyofilm, antiquorum sensing özellikleri dikkat çekmektedir. Çalışmada bu ekstraktların; kimyasal içerik analizleri, bakteriyel virülansın temelini oluşturan Quorum sensing (QS) ve biyofilm aktivitelerinin inhibisyonuna odaklanılmıştır. Sonuç olarak İzmir kekiği, Anadolu adaçayı ve Mercanköşk bitki ekstraktlarının hidrosol formlarına karşı Vibrio spp.’nin dirençli olduğu belirlenmiştir. Vibrio spp.’ye karşı en etkili formun İzmir kekiği ve mercanköşk yağ ekstraktı olduğu ortaya konmuş ve ½ MIC (Subletal) konsantrasyonunda biyofilm inhibisyonu %85 tespit edilmiştir. İzmir Kekiği ve Mercanköşk’ün çalışmadaki tüm Vibrio türleri üzerinde antimikrobiyal, anti-biyofilm etkisi gösterirken ayrıca AHL biyosensör suşu CV026’da QS mekanizmasını inhibe etmiştir. Akuakültür çiftliklerinde toplu balık ölümleriyle ilişkilendirilen Vibrio spp. patojen suşlarıyla mücadelede doğal bir yaklaşım olarak bitki ekstraktlarının etkinliği gösterilmiştir. Bulgular bu yaklaşımın antimikrobiyallere dirençli balık patojenlerine yönelik, bitkisel ekstraktların kemoterapötiklere alternatif tedavi edici araçlar olarak kullanılmasını desteklemektedir
Investigation of mutations in early-onset Parkinson's disease through next-generation sequencing analysis
No full textObjectives: This study aimed to expand our understanding of the genetic basis of Parkinson's disease (PD) by investigating individuals diagnosed with early onset PD (EOPD) or those with a suspected genetic predisposition to PD. Patients and methods: Thirty patients (18 females, 12 males; mean age: 33.2 +/- 6.4 years; range, 15 to 48 years) diagnosed with EOPD between January 2018 and December 2019 were included in the study. A targeted next-generation sequencing analysis was conducted on 10 genes (SNCA, LRRK2, VPS35, PARK2, PINK1, PARK7, ATP13A2, PLA2G6, FBXO7, DNAJC6) known to be associated with PD etiology. Additionally, the MLPA method was used to investigate eight genes (SNCA, PARK7, LRRK2, ATP13A2, PINK1, GCH1, PRKN, and UCHL1) for large deletions and duplications. Results: Mutations in PD-associated genes were identified in seven out of the 30 patients included in the study. Four patients exhibited mutations in the PRKN gene: three had defined deletion mutations (exon 5 deletion, exon 2 deletion, and exon 3 and 4 deletion), and one had a splice site mutation newly identified in this study (c.1083+1delG). Two patients displayed a point mutation in the PLA2G6 gene (c.1705C>T), and one patients had a point mutation in the PINK1 gene (c.1247C>T). The clinical and genetic characteristics of these patients were analyzed to explore genotype-phenotype correlations. Conclusion: This study is one of the few in T & uuml;rkiye to examine the molecular etiology of EOPD. The identified mutations in the PRKN, PLA2G6, and PINK1 genes provide valuable insights into genotype-phenotype correlations in PD cases and contribute to the existing literature.Ege University Scientific Research Projects Coordination Unit (Ege BAP) [TTU-2020-21811]Funding: The project numbered TTU-2020-21811 was supported by the Ege University Scientific Research Projects Coordination Unit (Ege BAP)
Sustainable logistics: innovative orientations and global trends in scientific research
No full textPurpose: The purpose of this study is to identify key topics in the scientific literature on sustainable logistics, reveal important interdisciplinary relationships and identify leading researchers in the sector. The relationship between these emerging structures and also the correct understanding of the structures that will evolve in the future is of great importance for the strategic decision-making processes of companies. Design/methodology/approach:In the study prepared for this purpose, the Web of Science (WoS) data have been used. It addresses the use of advanced methods such as social network analysis (SNA) and techmining in sustainable transportation and logistics. While SNA focuses on identifying interdisciplinary collaborations and key actors in the scientific world by examining the relationships and interactions between scientific publications, technology mining is used to understand innovative trends and technological developments in this field by extracting technological terms and concepts in scientific texts. SNA highlights the connections between these topics, whereas technology mining is used to uncover new technological trends and innovative solutions. Findings: In this study, the researchers focused on a wide range of issues in the fields of logistics and transportation. The findings on logistics, sustainability, supply chain management, machine learning, COVID-19 impacts, the role of China and India, artificial intelligence, innovation, the Internet of Things (IoT), blockchain, uncertainty and case studies reveal a multi-faceted structure. Also, it can be seen that significant emphasis is placed on the complexity of logistics processes. While the association of high aggregate constraints appears to concentrate a significant cumulative importance on certain aspects of logistics, it can be said that these concepts point to potentially critical operational elements. Research limitations/implications The authors did use only WoS records to reach their aim. This study can be extended with other major databases such as Scopus. Practical implications SNA mode and structural hole analysis enable clear visualization of cluster separations and uncover gaps in networks where connections are sparse. By identifying structural holes, researchers can bridge disconnected clusters, fostering collaboration and innovation through the integration of diverse perspectives. Low aggregate constraint values highlight niche topics, supporting deeper exploration and specialized research. Structural hole analysis further identifies key nodes that act as brokers, enhancing connectivity and resource flow. Together, these methods optimize networks, uncover untapped opportunities and contribute to a detailed understanding of research landscapes, driving targeted innovations and impactful advancements in specialized fields. Social implications The study's findings highlight significant social implications by emphasizing sustainability, collaboration and technological innovation in transportation and logistics. Insights into global collaborations and contributions of key players like China and India underscore the importance of international partnerships in addressing complex challenges. With the integration of machine learning, IoT and blockchain enhances efficiency, transparency and resilience in logistics systems, benefiting societies by improving supply chain reliability. In addition, the focus on sustainability and support strategies for crisis adaptation and long-term resilience, fostering equitable development. Originality/value The authors combined SNA, bibliometrics and machine learning to see collaborations and technological innovations in transportation and logistics. The authors can identify the global collaborations and contributions of key players to underscore the importance of international partnerships in addressing complex challenges
BALKANLAR GAZETESİNE GÖRE 31 MAYIS 1915 SEÇİMLERİNDE SELÂNİK’TE SİYASİ HAYAT
No full text31 Mayıs (13 Haziran) 1915 seçimleri Balkan Savaşları’nın ardından topraklarını büyüten Yunanistan’da yapılan ilk seçimlerdir. Seçim sürecinde siyasi partiler Selânik’te örgütlenmeye büyük önem vermiş ve bu şehirde zafer elde etmek için yoğun gayret sarf etmişlerdir. Seçimlerde, ülke genelinde Venizelos’un liderliğindeki Liberal Parti birinci olmuş ve Yunan Parlamentosu’nda çoğunluğu elde etmiştir. Selânik’te ise ülke genelinin tam tersi bir sonuç ortaya çıkmıştır. Yunanistan’daki genel sonuçların aksine Selânik’teki seçimleri liberaller değil kralcılar kazanmıştır. Bu çalışmanın temel amacı Selânik’teki seçim sonucuyla ülke genelindeki seçim sonuçları arasındaki farklılığın nedenlerini ortaya koymaktır. Ayrıca Selânik’in kozmopolit yapısının seçim sonuçlarına etki edip etmediği tespit edilmeye çalışılacaktır. Seçimlerin öncesinde Yunanistan’da yaşanan siyasi gelişmeler, dış politikadaki farklı düşüncelerin iç siyasete yansımaları, Cihan Harbi’nin Yunanistan’a etkileri, partilerin Selânik’teki siyasi faaliyetleri, Selânik’te yaşayan Müslümanların seçim sürecinde nasıl bir tutum sergilediği, mebus adaylarının belirlenme sürecinde yaşanan gelişmeler, basındaki polemikler, şehirdeki gerginlikler ve seçim sonuçları bu çalışmada incelenmektedir
Targeting leukemic stem cells: enhanced eradication via tivantinib (ARQ197) and asciminib (ABL001) with molecular docking-guided screening of therapeutic derivatives
No full textThis study is the first to investigate the therapeutic potential of a mono/combination treatment with the selective phase III BCRMedical Biology Laboratory at Ege UniversityAll experiments were carried out in the Medical Biology Laboratory at Ege University
Safety of Current Therapies for Cardiogenic Cerebral Embolism: A Systematic Review
No full textBackground: Cardiogenic cerebral embolism (CCE) accounts for approximately 20% of ischemic strokes and presents with severe neurological deficits and high mortality rates. The safety and effectiveness of current therapeutic strategies remain under evaluation. This systematic review aims to assess the safety profiles of current therapies, including thrombolysis, endovascular thrombectomy, anticoagulants, and antiplatelets, in patients with CCE. Methods: A systematic search was conducted in Web of Science, Scopus, and PubMed for studies published up to May 2024. Articles were screened using the Rayyan intelligence tool, and their quality was assessed using the JBI critical appraisal tool. The review included randomized controlled trials (RCTs) and observational studies evaluating the safety and outcomes of different CCE treatment modalities. Results: Ten studies met the inclusion criteria. Endovascular thrombectomy demonstrated improved functional outcomes with a reduced risk of mortality, although symptomatic intracranial hemorrhage (sICH) rates were comparable to other therapies. Intravenous thrombolysis with alteplase was associated with increased sICH risk but reduced 90-day mortality. Direct oral anticoagulants (DOACs), including apixaban and edoxaban, showed a favorable safety profile with no significant increase in intracranial bleeding. Antiplatelet therapy, particularly low-dose tirofiban, demonstrated reduced in-hospital mortality without increasing hemorrhagic risk. Conclusion: While current therapies for CCE improve outcomes, their safety profiles vary. Endovascular thrombectomy appears effective for severe cases, whereas DOACs provide a safe alternative for long-term anticoagulation. Further large-scale trials are needed to refine treatment guidelines and minimize hemorrhagic risks. © 2025 Elsevier B.V., All rights reserved