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Anksiyete ve obsesif kompulsif bozuklukta siberkondri ve yaşam kalitesi: bir üniversite kliniğinden kesitsel bir değerlendirme
No full textAim: Cyberchondria refers to excessive internet searches for medical knowledge. Studies evaluating cyberchondria in the psychiatric clinical population are scarce. We aimed to investigate the relationship between cyberchondria and general anxiety, health anxiety, and quality of life scores of patients diagnosed with anxiety disorders or obsessive-compulsive disorder. Materials and Methods: Sociodemographic, clinical, and internet use-related data of the patients who applied to the psychiatric outpatient clinic of a university hospital were collected. Sixty-one patients with anxiety disorders (n = 34), obsessive-compulsive disorder (n = 22), or both were included. Hamilton Anxiety Rating Scale (HARS), Cyberchondria Severity Scale (CSS), Anxiety Sensitivity Index-3 (ASI-3), Health Anxiety Inventory Short Version (SHAI), Adult Separation Anxiety Questionnaire (ASA), and Short Form 36 (SF-36) were applied. Results: Most visited websites were social media (86.9%), more than half of the participants did online research about psychiatric disorders, half of those felt relief, and 10% changed or stopped their medication after online searches. CSS scores were associated with SHAI (p = .007), HARS (p = .022), absence of psychiatric comorbidity (p = .005), and average time spent on the internet per day (p < .001) in regression analysis. SF-36 social functioning scores were negatively correlated with CSS scores (r = -.276, p = .036). Anxiety disorders and obsessive-compulsive disorder patients did not differ significantly in terms of CSS scores (p = .650, t = .457). Conclusion: Considering the increasing digitalization and internet use, research is needed to navigate the development of appropriate interventions by examining the concept of cyberchondria and its relationship with mental disorders.Amaç: Siberkondri, tıbbi bilgiye erişim amacıyla yapılan aşırı düzeyde internet araması anlamına gelir. Psikiyatrik klinik popülasyonda siberkondriyi değerlendiren çalışmalar az sayıdadır. Çalışmamızda anksiyete bozukluğu veya obsesif kompulsif bozukluk tanısı alan hastalarda siberkondri düzeyleri ile anksiyete, sağlık anksiyetesi ve yaşam kalitesi puanları arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Bir üniversite hastanesinin psikiyatri polikliniğine başvuran hastaların sosyodemografik, klinik ve internet kullanımına ilişkin verileri toplandı. Anksiyete bozukluğu (n = 34), obsesif kompulsif bozukluk (n = 22) veya her iki tanının birlikte görüldüğü toplam 61 hasta çalışmaya dahil edildi. Katılımcılara Hamilton Anksiyete Değerlendirme Ölçeği (HADÖ), Siberkondri Ciddiyet Ölçeği (SCÖ), Anksiyete Duyarlılığı İndeksi 3 (ASİ-3), Sağlık Anksiyetesi Ölçeği Kısa Formu (SAÖ-KF), Yetişkin Ayrılma Anksiyetesi Anketi (YAAA) ve Kısa Form 36 (SF-36) uygulandı. Bulgular: En çok ziyaret edilen websitelerinin sosyal medya (%86,9) olduğu, katılımcıların yarısından fazlasının psikiyatrik bozukluklarla ilgili çevrim içi araştırma yapmış olduğu, araştırma sonrasında yarısının rahatlama hissi yaşadığı ve %10'unun çevrim içi aramalar sonrasında ilaçlarını değiştirmiş veya bırakmış olduğu saptandı. Regresyon analizinde SCÖ puanları SAÖ-KF (p = .007), HADÖ (p = .022), psikiyatrik komorbiditenin olmaması (p = .005) ve günlük internette geçirilen ortalama süre (p < .001) ile ilişkiliydi. SF-36 sosyal işlevsellik puanları ile SCÖ puanları arasında negatif korelasyon görüldü (r = -.276, p = .036). Anksiyete bozuklukları ve obsesif-kompulsif bozukluk tanı grupları arasında SCÖ puanları açısından anlamlı bir fark bulunmadı (p = .650, t = .457). Sonuç: Artan dijitalleşme ve internet kullanımı göz önüne alındığında, siberkondri kavramını ve bunun psikiyatrik hastalıklarla ilişkisini inceleyerek uygun müdahalelerin geliştirilmesine yön verecek araştırmalara ihtiyaç vardır
Batı Anadolu'nun Türk dönemi kentleşme sürecinde Birgi, Ayasuluk ve Tire
No full textBatı Anadolu, insanlık tarihinin kadim coğrafyalarından birini teşkil etmektedir. Tarih boyunca pek çok medeniyete ev sahipliği yapan bölgede, kent olarak tanımlanabilecek ilk yerleşme bulgularıyla MÖ III. binyılın özellikle ikinci yarısından itibaren karşılaşılmaktadır. Bölge özellikle Antik Çağ'dan itibaren büyük bir gelişim göstermiş, bir kısmı günümüze de ulaşabilen önemli kent merkezleri teşekkül etmiştir. Batı Anadolu'nun yerleşme tarihi bakımından önemli bir dönüm noktasını, XIV. yüzyılın başlarında bölgede Türk beyliklerinin ortaya çıkışı oluşturmaktadır. Bu beyliklerden biri olan Aydınoğulları Beyliği, Aydınoğlu Mehmed Bey tarafından Küçük Menderes Vadisi'nin verimli toprakları üzerinde kurulmuştur. Beyliğin ilk başkenti Birgi olmakla birlikte, idare merkezi XIV. yüzyılın ortalarından sonra Ayasuluk'a taşınmıştır. Beyliğin hâkim olduğu kentlerden biri olan Tire ise özellikle XV. yüzyıldan itibaren büyük bir gelişme göstermiş ve Osmanlılar döneminde Aydın Sancağı'nın idari merkezi konumuna gelmiştir. Birgi, Ayasuluk ve Tire, Türk dönemi öncesine kadar uzanan tarihi birer geçmişe sahiptir. XIV. yüzyıldan itibaren ise birer Türk-İslam kenti olarak gelişim göstermişlerdir. Her üç kent de günümüze kadar muhafaza edilebilmiş yerleşim dokularıyla, Batı Anadolu'nun Türk dönemi kentleşme sürecinin analiz edilebilmesi açısından iyi birer örnek teşkil etmektedir. Birgi, Ayasuluk ve Tire, Bizans dönemi kaleleri etrafında teşekkül etmiş kentlerdir. Roma ve Bizans imparatorluklarından alınan kentsel miras, Türk döneminde inşa edilen mescit, cami, zaviye, medrese, türbe, han, hamam ve köprü gibi yapılarla önemli bir değişim geçirmiştir. Özellikle mescit, cami ve zaviyelerin iskân oluşturan yapılar olarak gerek sur içi gerekse de sur dışı alanlarda yeni mahallelerin kurulmasına öncülük ettiği görülmektedir. Kentin çeşitli noktalarında ortaya çıkan mahalleler, yüzyıllar içerisinde değişim geçirerek nüfusları artıp azalabilmektedir. Kentlerin gelişmişliğinin bir göstergesi olan medreseler, genellikle kentin belirli mahallelerinde yoğunlaşmaktadır. Çarşı dokusu ise her daim dış kale surlarının aşağısındaki mahallerde oluşmuştur. Birgi ve Ayasuluk'un ticari dokusu bugün neredeyse tamamen ortadan kalkmış durumdadır. Buna mukabil Tire'de han, bedesten ve dükkânlardan oluşan ticari doku hala büyük ölçüde mevcuttur. Nitekim kent, XV. yüzyıldan beri de Anadolu'nun önemli ticaret merkezleri arasında yer almaktadır. Konutlar, köprüler ve defin alanlarını oluşturan mezarlıklar, kent dokusunu oluşturan diğer unsurlardır.Western Anatolia constitutes one of the ancient geographies of human history. In the region, which has been home to many civilizations throughout history, the first settlement findings that can be defined as cities are encountered especially from the second half of the third millennium BC. The region has shown a great development especially since Antiquity, and important urban centers have been formed, some of which have survived to the present day. An important turning point in the settlement history of Western Anatolia is the emergence of Turkish principalities in the region in the early XIVth century. Aydıno ulları Principality, one of these principalities, was founded by Aydıno lu Mehmed Bey on the fertile lands of the Küçük Menderes Valley. Although the first capital of the principality was Birgi, the administrative center was moved to Ayasuluk after the middle of the XIVth century. Tire, one of the cities dominated by the principality, showed a great development especially from the XVth century onwards and became the administrative center of Aydın Sanjak during the Ottoman period. Birgi, Ayasuluk and Tire have a historical background dating back to the pre- Turkish period. From the XIVth century onwards, they developed as Turkish-Islamic cities. All three cities are good examples for analyzing the urbanization process of Western Anatolia during the Turkish period with their preserved settlement patterns. Birgi, Ayasuluk and Tire are cities built around Byzantine castles. The urban heritage inherited from the Roman and Byzantine empires underwent a significant transformation with the construction of mosques, mosques, zawiyas, madrasas, tombs, inns, baths and bridges during the Turkish period. Especially masjids, mosques and zawiyas, as settlement-forming structures, pioneered the establishment of new neighborhoods both inside and outside the city walls. The neighborhoods that emerged at various points in the city may increase or decrease in population as they change over the centuries. Madrasahs, which are an indicator of the development of cities, are generally concentrated in certain neighborhoods of the city. The bazaar texture, on the other hand, has always been formed in the neighborhoods below the outer castle walls. The commercial fabric of Birgi and Ayasuluk has almost completely disappeared today. In Tire, on the other hand, the commercial fabric consisting of inns, bedestens and shops still exists to a great extent. As a matter of fact, the city has been one of the important commercial centers of Anatolia since the XVth century. Houses, bridges and cemeteries are other elements of the urban fabric
Pathophysiology of Endoplasmic Reticulum Stress and the Potential Role of Dexmedetomidine as a Modulator
No full textEndoplasmic reticulum (ER) stress is a fundamental process that profoundly influences immune cell function and plays a critical role in the development and progression of various physiological and pathological conditions. Understanding the underlying mechanisms of ER stress and its implications for cellular function and disease pathogenesis is of paramount importance in developing targeted therapeutic interventions. Dexmedetomidine, an alpha-2 adrenergic agonist primarily used as a sedative, has emerged as a potential modulator of ER stress. This review aims to explore the impact of Dexmedetomidine on ER stress within immune cells and its potential therapeutic implications. Dexmedetomidine exhibits the remarkable ability to inhibit the activation of ER stress pathways, preserve protein synthesis, and suppress apoptosis mediated by ER stress markers. Furthermore, Dexmedetomidine exerts regulatory effects on immune cells and inflammation by reducing the production of proinflammatory cytokines and modulating immune functions. These compelling findings suggest that Dexmedetomidine holds significant promise as a valuable therapeutic tool for conditions characterized by dysregulated ER stress and immune dysfunction.Student Research Committee, Tabriz University of Medical Sciences [IR.TBZMED.VCR.REC.1403.117]This work was supported by Student Research Committee, Tabriz University of Medical Sciences (IR.TBZMED.VCR.REC.1403.117)
Silver Nanoparticles for Anticancer and Antibacterial Therapy: A Biogenic and Easy Production Strategy
No full textMetal nanoparticles are very valuable products due to their wide range of uses. Among these silver nanoparticles are beneficial products used in many fields, especially in medicine, due to their antibacterial properties. This research aimed to produce silver nanoparticles (Ag NPs) that are both affordable and environmentally friendly. For this purpose, Ag NPs were quickly obtained from domestic waste components of the carrot plant (Daucus carota L.). The UV-vis spectrophotometric, TEM, AFM, FE-SEM, STEM, EDX, XRD, and DLS analyses were performed to determine the properties of the obtained Ag NPs. It has been found that their surface charge is -21.8 mV, with a maximum absorbance at a wavelength of 421.37 nm, spherical appearance, and an average size distribution of 85.41 nm. The anticancer and antibacterial activities of the produced Ag NPs were investigated by MTT and microdilution. The synthesized Ag NPs showed the most significant antimicrobial effect on Pseudomonas aeruginosa ATCC 27833 with microdilution and low concentration. However, they were also determined to be effective on Bacillus subtilis ATCC 11774 and on Candida albicans ATCC 10231 pathogenic strains. In fact, the effective concentrations of Ag NPs on these strains were significantly lower than the antibiotics used. Furthermore, aside from exhibiting a superior anticancer impact on CaCO-2 cancer cells, it was established that Ag NPs also had remarkable efficacy in inhibiting U118 and Skov-3 cancer cells.Ministry of Education and Science of Ukraine; National Research Foundation of Ukraine [2020.02/0100]; Slovak Grant Agency VEGA [APVV-21-0335]; SAIA (Slovak Academic Information Agency); National Scholarship Programme of the Slovak Republic [1128327]; European Union; [0122U000874]; [0124U003406]This work was supported in part by the Ministry of Education and Science of Ukraine (Projects Nos.: 0122U000874 and 0124U003406), the National Research Foundation of Ukraine (Project No.: 2020.02/0100 Development of new nanozymes as catalytic elements for enzymatic kits and chemo/biosensors), the Slovak Grant Agency VEGA (Project No.: APVV-21-0335). Taras Kavetskyy also acknowledges the SAIA (Slovak Academic Information Agency) for scholarship in the Institute of Physics of Slovak Academy of Sciences in the framework of the National Scholarship Programme of the Slovak Republic. This work has also received funding through the MSCA4Ukraine project (Grant No.: 1128327), which is funded by the European Union
Task-related fluctuations in action-state orientation: roles of anticipated task difficulty and task-related affect
No full textAction-state orientation (ASO) refers to regulatory modes influencing intention initiation and goal pursuit. While ASO pertains to both dispositional and time- and context-sensitive states, extant research predominantly focuses on individual differences in ASO, leaving within-person dynamics and situational antecedents underexplored. Addressing this gap, the study explored task-related fluctuations in ASO (ASO-T) and its relationship with task-related affect and anticipated task difficulty. Both the pilot study (Nperson = 62, Nmeasurement = 248) and the main study (Nperson = 165, Nmeasurement = 660) employed a biweekly data collection. However, in the main study, the assessment of anticipated task difficulty and other measures was temporally separated. Results of the pilot study indicated that the measurement of ASO-T is a reliable and valid instrument and ASO-T displays substantial within-person variation. The main study findings showed that task-related negative affect, but not positive affect, mediates the relationship between anticipated task difficulty and two forms of ASO-T (hesitation and preoccupation). Additionally, task-related positive affect was more strongly related to ASO-T than task-related negative affect. These findings confirm ASO-T as a context-sensitive and malleable construct and extend the ASO research by shedding light on task-related, situational antecedents of ASO-T
Hydrophobic and Catalytic Properties MOF Decorated Cotton Fabrics: Comparison of Biopolymeric Coating and Chemical Modification
No full textEnvironmental contamination from pharmaceutical residues and oily wastewater poses serious challenges for modern water treatment technologies. In this study, we developed multifunctional, highly hydrophobic cotton textiles through in situ growth of ZIF-8 and cobalt-doped ZIF-8 (Co/ZIF-8) on cotton fabrics at room temperature using a simple immersion method. To further enhance hydrophobicity, the coated fabrics were treated with octadecylamine (OA) and beeswax (BW), resulting in water contact angles ranging from 116 degrees to 132 degrees. The modified fabrics were evaluated for their catalytic performance in degrading oxytetracycline hydrochloride (OTC-HCl) via peroxymonosulfate (PMS)-based advanced oxidation processes (AOPs). Results showed significant improvement in degradation efficiency, with Co/ZIF-8@CT achieving 85.9% and ZIF-8@CT 69.9% degradation, compared to just 23.57% without a catalyst. Coating with OA and BW slightly reduced the degradation rate (62.3% and 60.8%) due to restricted molecular diffusion. Additionally, the treated textiles demonstrated high oil-water separation efficiencies (86-97%) and excellent self-cleaning performance, effectively removing Methylene Blue powder from their surfaces. These properties highlight the potential of the developed materials in addressing both pharmaceutical pollution and oily wastewater. Overall, the study presents a scalable, low-temperature strategy for fabricating reusable, multifunctional textiles for advanced environmental remediation and sustainable wastewater treatment applications.Scientific and Technological Research Council of Turkiye [124 M775]; Cankimath;rimath; Karatekin University Scientific Research Project Fund [MF081123B21]This study has been supported by the Scientific and Technological Research Council of Turkiye (Project Number: 124 M775) and by Cank & imath;r & imath; Karatekin University Scientific Research Project Fund (MF081123B21)
Genome-wide association of gene regions controlling selenium and magnesium accumulation in walnuts (Juglans regia L.)
No full textWalnut (Juglans regia L.) is one of the most economically important species. It is of great importance to the food industry due to its nutritional value, and high content of many beneficial components such as macro and microelements. In the current study, the aim was to determine markers of single nucleotide polymorphism (SNP) associated with the gene(s) controlling the accumulation of Selenium (Se) and Magnesium (Mg) in walnuts. Se and Mg concentrations were measured in 154 genotypes of Juglans regia in 2021 and 2022. A total of 16,473 SNP markers were used for association mapping to analyze the marker-trait associations. The Se and Mg concentrations exhibited a normal distribution pattern with high heritability values (0.96 for Se and 0.98 for Mg) for the two years. Association mapping analysis was carried out with TASSEL software (v5.2.87) using the mixed linear model method. The result was that 17 markers for Se and 15 markers for Mg were significantly associated. A total of 189 and 86 putative candidate genes were detected for markers significantly associated with the Se and Mg levels, respectively. Among these genes, 33 genes are involved in ion binding, one gene in the binding and transport of Mg ions, 10 in hormone metabolism, and 53 in DNA and RNA binding. These potential candidate genes and markers observed in this study can be used in marker-assisted breeding programs to improve biofortified walnut varieties and further explore the genetic mechanisms underlying the Se and Mg accumulation. © 2025 Elsevier B.V., All rights reserved
Ebelerin epizyotomi uygulaması hakkındaki görüş ve deneyimleri: Bir karma yöntem çalışması
Full text linkBu araştırma, doğumhanede çalışan ebelerin epizyotomiye ilişkin görüş ve uygulamalarını incelemek ve elde edilen bulguları kavramsal olarak analiz etmek amacıyla, açıklayıcı ardışık desenle tasarlanmış karma desenli bir çalışma olarak gerçekleştirilmiştir. Araştırmanın birinci aşamasında kesitsel ve tanımlayıcı tipte nicel bir çalışma yürütülmüş; ikinci aşamada ise fenomenolojik desenli nitel bir araştırma uygulanmıştır. Çalışma, Türkiye'nin doğusunda Mardin ve batısında İzmir illerinde yer alan çeşitli hastanelerde doğumhane birimlerinde çalışan ebelerle gerçekleştirilmiştir. Araştırmanın nicel aşamasında, evrenin %67.42'sine ulaşılmış ve toplam 149 ebe örneklem olarak belirlenmiştir. Nitel aşamada ise amaçlı örnekleme yöntemiyle seçilen 11 ebe ile derinlemesine görüşmeler yapılmıştır. Araştırmanın nicel verileri, SPSS 25.0 programı kullanılarak analiz edilmiştir. Verilerin değerlendirilmesinde tanımlayıcı istatistikler ve ki-kare testi uygulanmıştır. Nitel veriler ise Max Qualitative Data Analysis (MAXQDA) programı ile analiz edilerek temalar ve alt temalar oluşturulmuştur. Elde edilen nicel bulgulara göre, ebelerin yaş ortalaması 32.88±8.37 yıl olup, mesleki deneyim süreleri ortalama 10.25±9.55 yıldır. Çalıştıkları hastanelerde haftalık ortalama doğum sayısı 40.12±29.45 iken, epizyotomi uygulanan doğum sayısı 23.08±20.79 olarak belirlenmiştir. Ebelerin %83.2'si Türkiye'deki primipar doğumlarda epizyotomi oranını yüksek bulduğunu ifade ederken, multipar doğumlarda bu oran %17.4 olarak saptanmıştır. Epizyotomi uygulama nedenleri arasında en sık belirtilen faktörler; fetal makrozomi (%84.6), primiparite (%49.7) ve hekim istemi (%19.5) olmuştur. Ebelerin %65.1'i epizyotomi kararını kendilerinin verdiğini ifade etmiş, %86.6'sı ise gebenin perine durumunun bu kararda etkili olduğunu belirtmiştir. Primipar doğumlarda rutin epizyotomiye karşı olan ebelerin %48.8'inin, multipar doğumlarda ise %10'unun epizyotomi uyguladığı saptanmıştır. Primipar doğumlarda epizyotomi uygulama sıklığı ile rutin epizyotomi gerekliliği görüşleri arasında anlamlı bir fark bulunmuştur (p<0.05). Nitel veriler doğrultusunda, ebelerin epizyotomiye yaklaşımı, fizyolojik sürece karşı risk odaklı karar verme eğilimleri ve epizyotomi oranlarını düşürmeye yönelik önerileri olmak üzere üç ana tema oluşturulmuştur. Ebeler, epizyotominin gerekliliği konusunda farklı görüşlere sahipken, perine bütünlüğünü korumaya yönelik eğitimlerin ve uygulamaların epizyotomi oranlarını azaltabileceğini vurgulamışlardır. Özellikle doğuma hazırlık eğitimlerinin yaygınlaştırılması, doğumda aktif katılımın teşvik edilmesi ve ebelerin karar verme yetkinliklerinin artırılması gerektiği belirtilmiştir. Sonuç olarak, ebelerin epizyotomi uygulamasına yönelik kararlarında mesleki deneyim, kurumsal politikalar ve hekim etkisi gibi faktörler önemli rol oynamaktadır. Ebelerin epizyotomi oranlarını düşürmeye yönelik olumlu yaklaşımları desteklenmeli ve bu doğrultuda eğitim ve farkındalık programları düzenlenmelidir. Araştırmanın bulguları, doğum hizmetlerinin geliştirilmesine yönelik politika yapıcılar ve sağlık yöneticileri için önemli bir kaynak niteliğindedir.This study was conducted as an explanatory sequential mixed-methods research, designed to examine the views and practices of midwives working in delivery rooms regarding episiotomy, and to conceptually analyze the findings. In the first phase of the study, a quantitative, cross-sectional, and descriptive design was employed, followed by a qualitative study with a phenomenological approach in the second phase. The research was carried out with midwives working in delivery units of various hospitals located in Mardin (eastern Turkey) and Izmir (western Turkey). In the quantitative phase, 67.42% of the target population was reached, and a total of 149 midwives were included in the sample. In the qualitative phase, in-depth interviews were conducted with 11 midwives selected through purposive sampling. Quantitative data were analyzed using SPSS 25.0. Descriptive statistics and Chi-square tests were used to evaluate the data. Qualitative data were analyzed using the Max Qualitative Data Analysis (MAXQDA) program, and themes and sub-themes were created accordingly. According to the quantitative findings, the mean age of the midwives was 32.88±8.37 years, and their average professional experience was 10.25±9.55 years. The average weekly number of births in the hospitals where they worked was 40.12±29.45, and the mean number of births involving episiotomy was 23.08±20.79. While 83.2% of the midwives stated that the episiotomy rate in primiparous births in Turkey is high, the corresponding figure for multiparous births was 17.4%. The most frequently cited reasons for performing an episiotomy were fetal macrosomia (84.6%), primiparity (49.7%), and physician request (19.5%). While 65.1% of the midwives indicated that they make the episiotomy decision themselves, 86.6% reported that the condition of the perineum influenced this decision. Among the midwives who opposed routine episiotomy in primiparous births, 48.8% still reported performing it; this rate was 10% in multiparous births. A statistically significant difference was found between the frequency of episiotomy practice and the perception of its necessity in primiparous births (p<0.05). Based on the qualitative data, three main themes were identified: midwives' approaches to episiotomy, risk-oriented decision-making tendencies versus physiological processes, and suggestions for reducing episiotomy rates. While midwives held varying opinions on the necessity of episiotomy, they emphasized that training and practices aimed at preserving perineal integrity could reduce episiotomy rates. In particular, the importance of widespread childbirth preparation education, promoting active participation during labor, and strengthening midwives' decision-making competencies was highlighted. In conclusion, professional experience, institutional policies, and physician influence play significant roles in midwives' decisions regarding episiotomy. Supportive measures should be implemented to encourage midwives' positive attitudes toward reducing episiotomy rates, and educational and awareness programs should be organized accordingly. The findings of this study provide valuable insights for policymakers and healthcare managers aiming to improve maternity care services
Vibrational spectroscopic, thermophysical, and structural properties of two Antarctic howardites: EET 87503 and QUE 97001
No full textThis study uses optical microscopy, Raman spectroscopy, differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) to examine the Antarctic howardite meteorites EET 87503 and QUE 97001. DSC results revealed troilite phase transitions in EET and QUE at 146.66 and 147.50 °C, corresponding to 0.26 % and 0.13 % troilite content, respectively. TGA indicated minor weight loss (<1 %) in both samples, with EET showing 0.399 % and QUE 0.638 % weight loss upon heating up to 1200 °C. Raman spectroscopy confirmed the presence of key minerals, including enstatite, ferrosilite, diopside, forsterite, ilmenite, and anorthite, as well as, in the case of the QUE 97001 meteorite, monticellite, a rare magnesium-end-member silicate olivine type mineral, providing insights into the complex thermal and impact histories of these howardites. The present findings appear as a contribution to a better understanding of the mineralogy and thermal evolution of this type of meteorites, linking them to potential parent bodies such as asteroid 4Vesta. © 2025 Elsevier B.V., All rights reserved
Periferik sinir sistemi yenilenmesinde kök hücre ve biyomateryallerin rolü
No full textPeripheral nerve injuries present significant challenges to patients and require intensive and costly treatments. The utilization of biomaterials is an effective treatment method. Personalized biomaterials are promising for the regeneration of damaged peripheral nerves. Stem cells have an important role in modern treatment methods because of their properties and promise to solve diseases requiring tissue regeneration, such as peripheral nerve damage. In this review, we aimed to investigate the relationship between stem cells and biomaterials, considering their different origins and potential compatibility in facilitating the regeneration of peripheral nerve injury.Periferik sinir yaralanmaları hastalar için önemli zorluklar teşkil eder ve yoğun ve maliyetli tedavi gerektirir. Biyomalzemelerin kullanımı tedavi için etkili bir yöntem sunar. Kişiselleştirilmiş biyomalzemeler hasarlı periferik sinirlerin rejenerasyonu için umut vaat eder. Özellikleri göz önüne alındığında kök hücreler, modern tedavi yöntemlerinin temel bir yönünü temsil eder ve bu durum ve diğerlerinin ele alınması için umut sunar. Bu derlemede, kök hücreler ve biyomalzemeler arasındaki ilişkiyi, çeşitli kökenlerini ve periferik sinir hasarının rejenerasyonunu kolaylaştırmadaki potansiyel uyumluluklarını göz önünde bulundurarak araştırmayı amaçlıyoruz