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The Role of Self-Compassion and Social Anxiety in the Relationship Between Cognitive Distortions and Emotional Eating
No full textThis study aimed to examine the mediating role of self-compassion and social anxiety in the relationship between cognitive distortions and emotional eating. The research was carried out on 406 adult individuals between the ages of 18 and 25 years living in different regions of Turkey. To measure research variables, Liebowitz social anxiety, thought types, self-sensitivity, and the Turkish emotional eating scale were used. The scales were distributed to the participants online. The data were analyzed through the SPSS program. In the study, it was determined that self-compassion predicted emotional eating negatively and social anxiety predicted emotional eating positively. According to the results of the serial mediation analysis, it was determined that self-compassion and social anxiety mediated the relationship between cognitive distortions and emotional eating separately. © 2025 Elsevier B.V., All rights reserved
YEMEK YEMENİN TIBBİLEŞTİRİLMESİ VE YEME BOZUKLUKLARI
No full textThis study focuses on building a sociological framework for eating conditions which are defined as eating disorders. The prevalence of eating disorders is increasing in different parts of the world where they are observed in different age groups. In the study, based on Foucault's conceptual framework, the concepts of biopower and governmentality- the combination of techniques to manage the self and management of others- are used. In this context, medicalization, which enables social issues to be addressed as matters open to medical intervention, is considered as a technology of governmentality. The historical dimensions of control of eating and food production are assessed in the study in order to isolate the socio-cultural setting in which these medical categories are created. Eating disorders are discussed within the framework of social developments such as globalization, Western and especially US-based nutritional practices and the spread of its understanding of an ideal body throughout the world, the profit-based operation of the food industry, including diet foods and food insecurity. As can be seen in the eating disorder categories based on 'excessive' control of eating (anorexia) or loss of control (binge eating), these conditions can be evaluated in terms of social control of the female body and as areas of governmentality where biopower becomes operational. The presentation of food and eating on social media is also discussed in terms of #foodporn, ASMR and mukbang contents.Bu çalışma yeme bozukluğu olarak tanımlanan ve gün geçtikçe dünyanın farklı yerlerinde görülme sıklığı artan, farklı yaş gruplarında görülür hale gelen yeme durumlarına ilişkin, sosyolojik bir çerçeve sunmaya odaklanmaktadır. Çalışmada Foucault’nun kavramsal çerçevesi temelinde biyoiktidar ve kendini ve başkalarını yönetme tekniklerinin birleşiminde yer alan yönetimsellik kavramları kullanılmaktadır. Sosyal meselelerin tıbbi müdahaleye açık durumlar olarak ele alınmasını sağlayan tıbbileştirme süreci bu bağlamda bir yönetimsellik teknolojisi olarak ele alınmıştır. Günümüzde tıbbi kategoriler olarak ele alınan durumların ortaya çıktığı sosyo-kültürel alanı izole edebilmek adına çalışmada yemenin kontrolünün ve gıda üretiminin tarihsel boyutları değerlendirilmiştir. Yeme bozuklukları, küreselleşme, Batı ve özellikle ABD kaynaklı beslenme pratikleri ve ideal beden anlayışının dünya geneline yayılması, diyet gıdaları da kapsayacak şekilde gıda endüstrisinin kar temelli işleyişi ve gıda güvencesizliği gibi toplumsal gelişmeler temelinde ele alınmıştır. Yemenin ‘aşırı’ kontrolü (anoreksi) ya da kontrolün kaybı (tıkınırcasına yeme) üzerine kurulu yeme bozukluğu kategorilerinde de görüldüğü gibi bu durumlar kadın bedeninin sosyal kontrolü ve biyoiktidarın işlerlik kazandığı yönetimsellik alanları olarak değerlendirilmiş ve yemeğin ve yemek yemenin sosyal medyadaki sunumu #foodporn, ASMR ve mukbang gibi sosyal medya içerikleri temelinde analiz edilmiştir
Nusinersen for children with type I spinal muscular atrophy: 4 years' clinical experience in Turkish cohort
No full textBackground: SMA Type 1 is the most severe form of spinal muscular atrophy with early symptom onset, limited motor development, and poor prognosis. Recent genetic-based therapies, such as nusinersen, have transformed disease outcomes. We aimed to evaluate the long-term effects of nusinersen on motor, bulbar, and respiratory functions in both symptomatic and presymptomatic SMA Type 1 patients over a period of up to 4 years. Methods: This prospective, non-interventional study included 310 patients with genetically confirmed spinal muscular atrophy at 24 pediatric neurology centers in Turkey. Patients treated with nusinersen were divided into five age-based cohorts at treatment initiation: Cohort A (0-3 months), Cohort B (4-6 months), Cohort C (7-12 months), Cohort D (13-24 months), and Cohort E (>24 months). Efficacy was assessed using the CHOP-INTEND and WHO Motor Milestone Scale. This study also analyzed the respiratory support needs, gastrostomy requirements, and mortality rates across cohorts. Results: Patients treated before 12 months of age showed the most significant improvements in motor milestones, with 58.7% of Cohort A achieving independent sitting. CHOP-INTEND scores increased notably in all cohorts, with the largest improvement observed in Cohort A (93.5%). Ventilator and gastrostomy requirements decreased in the early treated cohorts. Adverse events were rare, with one discontinuation due to hydrocephalus. The overall mortality rate was 21.3%, with most of the deaths occurring within the first year. Interpretation: Nusinersen treatment initiated before 12 months of age, especially before 3 months of age, yielded the most favorable motor outcomes in patients with SMA type 1. Early initiation is associated with improved motor milestones and reduced need for ventilatory support. However, no significant improvements were observed in the bulbar function or in patients requiring extensive respiratory support.The author(s) declare that no financial support was received for the research and/or publication of this article
A new method for the evaluation of cervical dystonia
No full textObjectives: The study aimed to develop a measurement method that yielded objective data for the clinical assessment of cervical dystonia using a Kinect camera system. Patients and methods: This double-blind, parallel-group method development study included 22 patients with cervical dystonia (3 males, 19 females; mean age: 47 years; range, 34 to 60 years) and 20 healthy individuals (13 females, 7 males; mean age: 32 years; age range, 22 to 65). Using cameras and a computer software, the head-neck postures of 40 healthy participants were recorded in the virtual environment. Using the device, 22 patients with cervical dystonia were examined both at rest and while moving with different parts of the body. Two different experts evaluated and scored the cases using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and the Tsui scale. Results: A three-way comparison revealed interclass correlations between the coefficients of 0.799 (79.9%) and 0.784 (78.4%) for at rest and with movement, respectively. The two-way comparison of the experts revealed correlation coefficients of 0.717 (71.7%) and 0.692 (69.2%) for at rest and with movement, respectively. A three-way comparison of the device and Expert 1 and Expert 2 TWSTRS scores revealed interrater agreement values of 0.6 and 0.8 (good) and 0.6 and 0.8 (good) while at rest and with movement, respectively. A three-way comparison of the device and Expert 1 and Expert 2 Tsui scores revealed interrater agreement values of 0.6 and 0.8 (good) and 0.4 and 0.6 (moderate) while at rest and with movement, respectively. Conclusion: The newly developed system was a sensitive tool for use in the kinematic evaluation of patients with cervical dystonia and could prove beneficial in diagnosis and treatment follow-up. © 2025 Elsevier B.V., All rights reserved
Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM)
No full textHuman biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals. The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established a global human biomonitoring community network (HBM Global Network) to develop a guidance to define the minimum information to be collected and reported in HBM, called the Minimum Information Requirements for Human Biomonitoring (MIR-HBM). This work builds on previous efforts to harmonize HBM worldwide. The MIR-HBM guidance covers all phases of HBM from the design phase to the effective communication of results. By carefully defining MIR for all phases, researchers and health professionals can make their HBM studies and programs are robust, reproducible, and meaningful. Acceptance and implementation of MIR-HBM Guidelines in both the general population and occupational fields would improve the interpretability and regulatory utility of HBM data. While implementation challenges remain-such as varying local capacities, and ethical and legal differences at the national levels, this initiative represents an important step toward harmonizing HBM practice and supports an ongoing dialogue among policymakers, legal experts, and scientists to effectively address these challenges. Leveraging the data and insights from HBM, policymakers can develop more effective strategies to protect public health and ensure safer working environments.HBM Global Network; ECETOC; International Society for Exposure Science (ISES) European Regional Chapter, working group on Human biomonitoring (ISES Europe HBM working group)We would like to thank all the experts active in the International Society for Exposure Science (ISES) European Regional Chapter, working group on Human biomonitoring (ISES Europe HBM working group) and the HBM Global Network for their support and contributions. Additionally, special thanks to ECETOC for supporting this initiative and development of www.FAIREHR.complatform
Time-Dependent Effects of Low-Intensity Pulsed Ultrasound on Apoptosis and Autophagy in Malignant Melanoma Stem Cells
No full textCancer stem cells (CSCs) in malignant melanoma contribute to therapeutic resistance and tumour recurrence. While low-intensity pulsed ultrasound (LIPUS) has been proposed as a non-invasive strategy to induce cell death, its effects on CSC-specific apoptotic and autophagic responses remain unclear. This study aimed to explore the time-dependent effects of LIPUS on apoptosis and autophagy in CD133+ melanoma CSCs and CD133? non-stem melanoma cells. Human melanoma cells (CHL-1) were sorted via FACS into CD133+ and CD133? populations. Cells were exposed to LIPUS (1 MHz, 20% duty cycle, 1 W/cm2) for 1, 5, and 10 min. Protein expression levels of Caspase-3, Caspase-8, mTOR, and LC3 were evaluated via immunofluorescence and quantified by image-based analysis. Both cell populations showed significant increases in Casp3, Casp8, mTOR, and LC3 intensities following LIPUS application. Notably, CD133+ cells exhibited delayed but sustained increases in Casp3 and LC3 expression, while CD133? cells responded more rapidly. mTOR activity demonstrated distinct temporal dynamics between the two groups, suggesting differential modulation of autophagy-related pathways. LIPUS triggers temporally distinct apoptotic and autophagic responses in melanoma CSCs and non-stem cancer cells. These findings suggest a potential therapeutic avenue to selectively disrupt CSC survival mechanisms using mechanical stimulation. © 2025 Elsevier B.V., All rights reserved
Evaluation of Management Effectiveness of an Outstanding Marine Protected Area in Southwest Coast of Türkiye: On the Road to 30 by 30
No full textThe global increase in Marine Protected Areas (MPAs) is driven by international goals, like the Aichi Targets (2010) and the Kunming Global Biodiversity Framework (2023), which aim for 30% of land and sea to be protected by 2030. Despite these ambitious targets, experts agree that numerical goals alone are insufficient to address biodiversity loss and ensure ecosystem functionality. This has sparked significant research on the effective management of MPAs, highlighting the importance of biological, socio-economic, and managerial resilience. Various tools have been developed to support these aspects. However, even in areas with management plans, enforcement, and monitoring, stakeholder involvement in assessment processes is vital to equitable and sustainable management. Using G & ouml;kova MPA as a case study, this research evaluated its management over a three-year period by applying an assessment tool previously used by co-managing actors. Findings indicate that assessment results can vary depending on who conducts them, and structural challenges, such as coordination issues among governing bodies and overlapping authorities, further complicate management. These insights have been used to formulate recommendations for policymakers and conservation practitioners, emphasizing that reaching the 30 by 30 target requires not only increased area coverage but also improved management practices that incorporate stakeholder perspectives to achieve sustainable management of natural resources
Topical application of amniotic membrane extract at a clinically correlated dose is effective in limiting complications in an experimental ocular alkaline burn model
No full textThe purpose of this study is to investigate the clinical and histopathological effectiveness of topical amniotic membrane extract (AME) applied at a clinically relevant dose in an experimental corneal alkaline burn model and to compare the results with amniotic membrane transplantation (AMT) as one of the most frequently used biologically based treatment options. To create an alkaline burn model, NaOH-impregnated filter paper was applied to all rabbits for 30 s. Rabbits were divided into 3 groups: Group 1 (n = 6): AME eye drop; Group 2 (n = 6): AMT; Group 3 (n = 4): control group. AME eye drops were applied as 1 drop 4 times a day for 28 days. Clinical findings including corneal opacity, corneal vascularization, limbal stem cell deficiency (LSCD) was evaluated and graded in accordance with the updated literature. On day 28, corneas were histopathologically examined under the light microscope. Stromal inflammation, stromal fibrosis, intraepithelial edema, and corneal vascularization were scored in each group. When the groups were compared clinically, corneal opacity was significantly (p = 0.009) lower in the AME group. While lower LSCD grades were observed in the AME group, this difference was not significant (p > 0.05). Histopathologically; in the AME group, stromal inflammatory cell inflammation, corneal vascularization, intraepithelial edema, stromal fibrosis, and metaplastic epithelial layer thickness were significantly (p = 0.004; p = 0.022; p = 0.008; p = 0.002; p = 0.002, respectively) lower than the other groups.In this study, it was shown that AME eye drops were clinically and histopathologically more successful in providing corneal healing than the AMT and control groups in the ocular alkaline burn model. These findings are valuable as they show that AME eye drops may be an easy-to-apply biologically based treatment alternative to AMT in chemical burns.Health Institutes of Turkiye (TUSEB) [11955-2022-01/A]; Ege University Project Coordination Center, Izmir, Turkey [TOA-2020-21402, TS-ADP-2022-24091]This study received funding from: Health Institutes of Turkiye (TUSEB) , grant number: 11955-2022-01/A, Ege University Project Coordination Center, Izmir, Turkey (Project No: TOA-2020-21402 and TS-ADP-2022-24091)
Lise öğrencilerinde sosyal medya bağımlılığının sınır kişilik özellikleri ile sahte benlik algısı açısından incelenmesi
No full textSosyal medya bağımlılığı, insanın sosyal medya kullanımı konusunda denetimini yitirmesi ve bu durumun sosyal, akademik ve duygusal işlevselliği olumsuz yönde etkilemesiyle tanımlanan bir davranışsal bağımlılık türüdür. Bu çalışma, lise kademesindeki öğrencilerin sosyal medya bağımlılığı düzeyini belirlemeyi ve sosyal medya bağımlılığının sahte benlik algısı, sınır kişilik özellikleri ve sosyodemografik değişkenlerle olan ilişkisini incelemeyi amaçlamaktadır. 2023–2024 eğitim-öğretim yılı içinde İzmir ili Çiğli ilçesindeki liselerde öğrenim gören 10.784 öğrenci araştırma evrenini oluşturmaktadır. Epi Info programı ile %50 prevalans, %4'lük hata payı ve desen etkisi 2 kabul edilerek belirlenen 1136 kişi minimum örnek büyüklüğü olarak belirlenmiştir ve okullara göre tabakalı küme örnekleme yöntemiyle bu örnekleme ulaşılmıştır. Sosyal medya bağımlılığı bu çalışmanın bağımlı değişkeni olarak ele alınmış, bağımsız değişkenler ise sahte benlik algısı, sınır kişilik özellikleri, cinsiyet, yaş, okul türü ve akademik başarı düzeyidir. Veriler Sosyal Medya Bağımlılığı Ölçeği, Sahte Benlik Algısı Ölçeği, Sınır Kişilik Özellikleri Formu ve Kişisel Bilgi Formu ile toplanmıştır. Analizlerde SPSS 22.0 programından yararlanılmış ve anlamlılık düzeyi p<0.05 olarak alınmıştır. Tanımlayıcı istatistiklere ek olarak, iki değişkenli analizlerde Kruskal-Wallis ve Mann-Whitney U testleri; çok değişkenli analizlerde ise çoklu lineer regresyon analizi uygulanmıştır. 1215 kişiden analiz yapılabilir veri toplanmıştır (%97,3 kapsayıcılık). Katılımcıların yaş ortalaması 15,83±1,07 olup %54,7'si kız ve %45,3'ü erkektir. Regresyon bulgularına göre, sahte benlik algısının yüksek olması (B=0,002; %95 GA; p<0,001), sınır kişilik özelliklerinin yüksek olması (B=0,004; %95 GA; p<0,001), okul başarı düzeyinin düşük olması (B=-0,0012; %95 GA; p<0,001) ve cinsiyetin kız olması (B=-0,024; %95 GA; p=0,004) sosyal medya bağımlılığı puanlarının anlamlı yordayıcılarıdır. Bulgular, sosyal medya bağımlılığının benlik gelişimi ve kişilik yapılanmalarıyla ilişkili çok boyutlu bir olgu olduğunu göstermektedir. Bu nedenle okul temelli psikoeğitim programları ve önleyici ruh sağlığı çalışmaları teşvik edilmelidir.Social media addiction is a type of behavioral addiction characterized by an individual's loss of control over social media use, which negatively affects social, academic, and emotional functioning. This study aims to determine the level of social media addiction among high school students and to examine its relationship with false self-perception, borderline personality traits, and various sociodemographic variables. The study population consists of 10,784 students enrolled in high schools in the Çiğli district of İzmir province during the 2023–2024 academic year. Based on a 50% prevalence rate, a 4% margin of error, and a design effect of 2 using the Epi Info program, the minimum sample size was calculated as 1136. A stratified cluster sampling method was employed according to schools. Social media addiction was considered the dependent variable in this study, while the independent variables included false self-perception, borderline personality traits, gender, age, school type, and academic achievement. Data were collected using the Social Media Addiction Scale, False Self-Perception Scale, Borderline Personality Traits Form, and Personal Information Form. Data analysis was conducted using SPSS 22.0 software, with a significance level set at p<0.05. In addition to descriptive statistics, Kruskal-Wallis and Mann-Whitney U tests were used for bivariate analyses, and multiple linear regression was used for multivariate analyses. Usable data were obtained from 1215 participants (97,3% coverage). The mean age of participants was 15.83 ± 1.07, with 54.7% female and 45.3% male. According to the regression findings, higher levels of false self-perception (B=0.002; 95% CI; p<0.001), higher borderline personality traits (B=0.004; 95% CI; p<0.001), lower academic achievement (B=-0.0012; 95% CI; p<0.001), and being female (B=-0.024; 95% CI; p=0.004) were significant predictors of social media addiction scores. These findings indicate that social media addiction is a multidimensional phenomenon associated with self-development and personality structure. Therefore, school-based psychoeducation programs and preventive mental health efforts should be encouraged. Keywords: Social media addiction, false self-perception, borderline personality traits, adolescents
Preparation, Optimization, and Stability of Isosulfan Blue-Loaded Human Serum Albumin-Structured Nanocolloids
No full textIn an attempt to develop nanoparticles for drug delivery systems, human serum albumin (HSA), a protein carrier for drugs, is a suitable choice. HSA nanoparticles have been widely used in drug delivery systems and have applications in various diseases. The administration of HSA nanoparticles, particle size, surface charge, and drug loading are important parameters to consider. The present study aimed to develop HSA-based nanoparticles containing isosulfan blue (ISB) dye by using a nanoprecipitation procedure. The developed nanoparticles were characterized by scanning electron microscopy and dynamic light scattering (DLS). The effects of factors such as solvent/nonsolvent ratio, pH, cross-linker, dye, and surfactant concentration on the physicochemical parameters of the formulations were optimized. Also, in vitro stability studies of nanoparticles were measured in different conditions for up to 3 months. According to the results obtained, the spherical nanoparticles had particle sizes of 93.88 +/- 1.86 and 113.90 +/- 1.91 nm, PdI values of 0.19 +/- 0.01 and 0.44 +/- 0.02, and negative charges of -26.0 +/- 2.87 and 57.4 +/- 3.86 mV. The loading amount of ISB for ISB-HSA nanoparticles was 15-20%. Also, nanoparticle formulations were stable under different conditions and did not exhibit a substantial change in DLS results. Current sentinel lymph node tracers, like free ISB, suffer from rapid clearance (<2 h) and photodegradation. This study develops stable HSA nanocolloids to overcome these limitations. In conclusion, ISB dye-loaded HSA nanoparticles in stable nanocolloidal structures with ideal properties were prepared.TUBITAK [117S517]The financial support for this work was provided by TUBITAK (Grant No:117S517