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Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma
Get PDFBACKGROUND AND OBJECTIVE: Matrix metalloproteinases (MMPs) are a group of enzymes responsible for extracellular matrix breakdown. Increased activity of type 13 is involved in invasion of oral squamous cell carcinoma. This study was performed to compare the level of matrix metalloproteinase13 (MMP13) in saliva and serum of patients with oral squamous cell carcinoma and healthy controls.
METHODS: In this experimental in vitro study, 24 saliva and 24 serum samples were collected from patients with primary oral squamous cell carcinoma after histopathologic confirmation, whereas 21 saliva samples and 21 serum samples were collected from healthy subjects with mucosal health confirmation. Clinical examination was done for MMP-13 levels in saliva and serum, and the results were compared by ELISA.
FINDINGS: MMP-13 levels in serum (7.47±2.36) and saliva (8.42±2.69) of patients with oral squamous cell carcinoma compared to healthy subjects increased respectively by 5.39±1.90 and 6.72±2.11 (P= 0.002 and P= 0.025, respectively). The levels of MMP13 in saliva and serum to determine the existence of oral squamous cell carcinoma has a "good" diagnostic value, with sensitivity and specificity of 88% and 86% respectively for serum, and 88% and 71% respectively for saliva.
CONCLUSION: According to the results of this study, the levels of MMP13 in saliva and serum of patients with oral squamous cell carcinoma was higher than in healthy individuals and this biomarker had good diagnostic value in the diagnosis of oral squamous cell carcinoma
Evaluation of Systolic, Diastolic and Mean Arterial Blood Pressure in the First Trimester of Pregnancy as an Indicator for Predicting the Occurrence of Preeclampsia
Get PDFBACKGROUND AND OBJECTIVE: Preeclampsia is a common disease during pregnancy that may be associated with maternal and fetal mortality. Since the pathogenic process of preeclampsia begins during the first trimester of pregnancy, it is very difficult to identify biomarkers of early detection of preeclampsia. The aim of this study was to determine the predictive validity of systolic, diastolic and mean arterial blood pressure in the first trimester of pregnancy in the diagnosis of preeclampsia.
METHODS: This case-control study was performed on 200 pregnant women referred to Ayatollah Rouhani Hospital in Babol within a historical cohort. The data of the records of 100 pregnant women with preeclampsia diagnosis (case group) and 100 healthy women (control group) were filled in special forms and compared.
FINDINGS: According to ROC curve analysis, in the first trimester for systolic blood pressure at the cut-off point of 117.5, sensitivity of 56% and specificity of 70%, for diastolic blood pressure at the cut-off point of 72.5, sensitivity of 68% and specificity of 63% and for mean arterial pressure at the cut-off point of 87.5, sensitivity of 67% and specificity of 66% were calculated. Based on the area under the ROC curve, the diagnostic power was 0.706, 0.663 and 0.709, respectively (p<0.001).
CONCLUSION: The results of the present study indicate that arterial pressure can be used as an effective method in identifying women at risk for preeclampsia as a selection criterion in testing, treatment or prevention
Relationship between perfectionism with stress and athletic burnout
Get PDFBACKGROUND AND OBJECTIVE: : Retirement in sports has always caused many psychological problems for athletes and has had detrimental effects on their health. Given the importance of subject and role of psychological components, the aim of this study was to investigate the relationship between perfectionism with stress and athletic burnout.
METHODS: The statistical population of this descriptive-correlational study included all young national footballers. The sample size was 378 ones, selected using a quota sampling method. Data were collected through questionnaires of coping strategies for stress, perfectionism and athletic burnout. Kolmogorov-Smirnov tests, Pearson correlation coefficient and linear regression were applied to test the hypotheses. All data were analyzed using SPSS 24.
FINDINGS: The findings showed that there was a significant correlation between athletic burnout with positive perfectionism (- 0.622), negative perfectionism (0.555), problem-oriented strategy (-0.358) and emotion-oriented strategy (0.401). Totally, 56% of the variance in athletic burnout could be predicted via positive perfectionism (beta: 0.412), problem-oriented strategy (beta: 0.306), negative perfectionism (beta: 0.267) and emotion-oriented strategy (beta: 0.114).
CONCLUSION: Based on the findings of this study, planning to develop coaches’ awareness of coaching behaviors and to increase optimal, psychological and better performance of athletes, it seems necessary to use psychological variables such as perfectionism, stress and athletic burnout
Comparing the effect of kangaroo mother care and field massage on serum bilirubin level of term neonates with hyperbilirubinemia under phototherapy in the neonatal ward
Get PDFBackground: Several factors contribute to the effectiveness of phototherapy. The aim of this study was to compare the effect of kangaroo mother care (KMC) and field massage on bilirubin level of term neonates with hyperbilirubinemia under phototherapy in the neonatal ward. Methods: This double-blind clinical trial was performed on 90 term neonates aged 48 hours with hyperbilirubinemia, hospitalized in Fereydunkenar Hospital during 2018-2019. The infants were randomly divided into 3 groups of massage with phototherapy, KMC with phototherapy and control (received conventional phototherapy without KMC and massage). The massage group used field technique for three 15-minutes in 3 days and the KMC group received KMC for five 30 minutes in 3 days as well. In three groups, the serum bilirubin levels were compared at baseline, 24, 48, 72 hours after the onset and at the end of phototherapy. Moreover, the mean duration of phototherapy and hospitalization was compared during the treatment. Results: Serum bilirubin levels at baseline in the control, field massage and KMC groups were (17±1.38, 17.01±1.46 and 16.97±1.27mg/dl) and at the end of phototherapy were (6.97±0.47, 5.56±0.48 and 5.91±0.52 mg/dl) respectively. There was a significant difference between the intervention and control groups (p<0.001). The mean duration of phototherapy and hospitalization had no significant difference between two intervention groups (p>0.001), but it was significantly higher in control group than intervention groups (p<0.001). Conclusion: The use of massage or KMC with phototherapy, compared to the phototherapy alone, can reduce the bilirubin level, phototherapy duration and hospital stay
Evaluation of the morphometric variation of frontal sinus in cone-beam computed tomography (CBCT) of paranasal sinus
Get PDFIntroduction: The frontal sinus is the most variable part of the paranasal sinuses in terms of symmetry, anatomical features and degree of development. The aim of this study was to assess the morphometric changes of the frontal sinus in cone-beam computed tomography (CBCT) images.
Materials & Methods: In this cross-sectional study, 200 CBCT images were examined for anatomical variations such as the presence of frontal sinus, sinus symmetry, lateral frontal sinus extension (LFSE) to orbital roof, scalloping, septum and type of septum. Moreover, Crista Galli (CG) was divided into three equal segments of anterior, middle and posterior in order to have a precise criterion for determining the location of the frontal recess in coronal plane. The data were analyzed using ANOVA with T-test and Chi-square at significant level of P<0.05.
Results: Of 200 cases, 113 and 87 ones were male and female with the mean age of 18‒88 years. The results showed that frontal sinus was bilateral in all cases and symmetric in 113(57%) cases. The LFSE to orbital roof had a significant relationship with gender, so that at the external one-third, the LFSE was less frequent in women than men (P<0.001). The most frequent location of the frontal recess was in the posterior one-third of CG (85 (43%)) with significant difference (P=0.012).
Conclusion: In this study, frontal sinuses were rather symmetric, and the use of the anatomical CG marker in multiplanar (MPR) images was not feasible method for rapid detection of the frontal recess location in coronal plane
The effect of physical activity on sleep and quality of life of inactive elderly men
Get PDFBACKGROUND AND OBJECTIVE: Aging is an inevitable period of human life and the world's population is rapidly moving towards aging so that the sleep and quality of life (QoL) of these people have been considered with the advancement of science and attention to the population pyramid. Sleep disorders have a negative effect on the QoL of the elderly; therefore, the aim of this study was to answer the question of whether physical activity affects sleep and QoL of inactive elderly men (IEM).
METHODS: In this semi-experimental study, the population was 20 IEM. The data were collected using Pittsburgh Sleep Quality Index (PSQI) for measuring sleep disorders and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) for measuring QoL and exercise protocol. The exercise protocol used in this study was performed with an intensity of 60% of the maximum heart rate for 12 weeks and 3 sessions per week. The Shapiro-Wilks, parametric dependent t-test and Wilcoxon non-parametric tests were used and SPSS 21 was applied for statistical calculations.
FINDINGS: After exercise intervention, the mean score of sleep quality decreased from 8.1 to 6, which improved by 26%, and the mean score of QoL increased from 78.63 to 81.73, indicating a 4% improvement in QoL, representing that there was a significant relationship between the variables (P<0.001).
CONCLUSION: Physical activity improves the state of mobility by increasing the interest of older men in sports. Therefore, it is possible to prevent the occurrence of many sleep disorders and to increase the QoL by informing the authorities about the protocol of physical activities and its implementation
Removal of Metronidazole Antibiotic from Hospital Wastewater by Biosorbent Prepared from Plantain Wood
Get PDFBACKGROUND AND OBJECTIVE: The overuse of antibiotics in hospitals and the entry of these pollutants into water resources is one of the major challenges to the health of the community and the environment. Removal of antibiotics from hospital wastewater and other aquatic environments is possible through the adsorption process. This study was performed to evaluate antibiotic removal using plantain wood due to being cheapn and natural.
METHODS: In this in vitro study, the effect of pH (2, 4, 6, 8, 10 and 12), contact time (5, 10, 20, 40, 60, 80, 100 and 120 minutes), initial metronidazole concentration (10, 50 and 100 mg/L) and biosorbent dose (0.2, 0.4, 0.6, 0.8, 1, 1.2 and 1.4 g) on metronidazole removal rate in synthetic solution were evaluated, and the isothermal kinetic and thermodynamic results of the adsorption process were investigated in this study. Concentration of metronidazole in aqueous solution was measured by Hach DR 5000 UV-Vis Laboratory Spectrophotometer.
FINDINGS: Maximum removal of metronidazole (91%) was obtained at pH=6.5, 60 min, initial concentration of 50 mg/l, adsorbent dose of 0.8 g and 25 °C and maximum adsorption capacity (11.38 mg/g) was obtained at a dosage of 0.1 g. In this study, the reaction rate followed the pseudo-second order and adsorption isotherm followed Langmuir equation. The adsorption thermodynamic results showed that the adsorption process is physical in nature and is a spontaneous endothermic reaction.
CONCLUSION: The results of the study showed that biosorbent prepared from plantain wood is a natural material and has the ability to remove metronidazole antibiotics from hospital wastewater and other aquatic environments
Comparison of shear bond strength of a composite resin to resin modified and conventional glass ionomer using different bonding systems
Get PDFIntroduction: Glass ionomers are often used as a base under composite restorations in deep cavities by sandwich technique. The aim of this study was to compare the shear bond strength of composite to resin modified and conventional glass ionomer using total etch , self-etch and universal bonding systems.
Materials & Methods: Ninety glass-ionomer samples were prepared for this research: Fuji II (F II), IonoStar Plus (IS) and Fuji II LC (F II LC).Then the specimens were divided into 9 groups (n=10). The surface of the specimens were prepared with three types of bonding: Adper single bond2 (SB), Clearfil SE bond (SE) and Single bond Universal (SU).Then Z250 composite resin was applied on the glass ionomers. The specimens were incubated in distilled water for 24 hours at 37 ° C and then were tested for shear bond strength. The type of failure was determined by a ×40 stereomicroscope and the results of the study were analyzed by nonparametric statistical analysis and Kruskal Wallis test. P≤0.05 was considered significant.
Results: The highest shear bond strength was observed in the Fuji II LC + Single bond2 group. There was a statistically significant difference in the shear bond strength of the composite to the two glass ionomers F II and F II LC using SB and SU bonding systems (P=0.033 and P=0.040, respectively).There was no significant difference between the groups regarding the type of failure.
Conclusion: Unlike the Fuji II LC and IonoStar Plus glass ionomers, the shear bond strength of the composite to the Fuji II conventional glass ionomer is affected by the type of bonding system. Total-etch and self-etch bonding systems can be used effectively in sandwich technique. Using a resin modified glass ionomer with total etch bonding can improve the shear bond strength of the composite to the glass ionomer
Evaluation of Serum Vitamin D Levels in Patients with Carpal Tunnel Syndrome
Get PDFBACKGROUND AND OBJECTIVE: Low levels of vitamin D are associated with clinical effects such as gastrointestinal disorders, cardiovascular disorders, autoimmune disorders, neuropathic diseases, cancer and metabolic syndrome. Carpal Tunnel Syndrome (CTS) is the most common cause of compression neuropathy, which has recently been linked to vitamin D deficiency in the onset or severity of symptoms. Therefore, this study was performed to evaluate the serum levels of vitamin D in patients with carpal tunnel syndrome.
METHODS: This case-control study was performed on 100 patients referred to the neurology clinic of Ayatollah Rouhani Hospital with clinical symptoms of CTS for at least 3 months and 100 patients as a control group who referred to the same clinic for nerve conduction velocity test and did not show symptoms of CTS in clinical examination and electrophysiology. Patients' function, disease severity and pain were measured based on the Boston Carpal Tunnel Questionnaire (BCTQ). Serum vitamin D levels were also measured and compared between the two groups.
FINDINGS: The mean age of patients was 43.53±10.68 years and controls were 45.48±7.12 years. The mean serum vitamin D levels in patients and controls were 19.18±11.39 ng/dL and 21.39±15.93 ng/dL, respectively. In controls, 57 women suffered from vitamin D deficiency (p<0.05). There was no significant difference between the two groups in terms of disease severity, function status, pain severity, electrophysiological defect, involved hand, dominant hand and symptoms associated with vitamin D deficiency and there was a negative correlation in vitamin D levels with disease severity, function and pain of patients.
CONCLUSION: The results showed that there was a relationship between serum vitamin D levels and gender. In addition, a negative correlation was observed between serum vitamin D levels and patients' disease severity and function and electrophysiological defects
Comparison of Serum 25-Hydroxyvitamin D Levels in Children with and without Intussusception
Get PDFBACKGROUND AND OBJECTIVE: Intussusception is the most common cause of intestinal obstruction and one of the most common causes of abdominal emergencies in children, which can lead to significant mortality and morbidity if left untreated. Since vitamin D acts as a hormone in the body and plays an important role in preventing infectious and non-infectious diseases and regulating the intestinal immune response, this study was performed to investigate the relationship between vitamin D levels and the occurrence of intussusception.
METHODS: This case-control study was performed on 86 children under 6 years old and above the neonatal age referred to Amirkola Children's Hospital in 2017-2018. The diagnosis of intussusception was made by ultrasound and the control group (without intussusception) was selected from patients with elective surgery other than intussusception. Vitamin D levels of children were assessed and compared in the two groups of children with and without intussusception.
FINDINGS: In this study, 50 people were in the intussusception group and 36 people were in the control group. The mean age was 27.2±14.6 months in the intussusception group and 24.7±15.9 months in the control group (p=0.447). The mean serum 25-hydroxyvitamin D levels in children with intussusception was 36.5±14.4 ng/ml and in the control group was 32.7±13.1 ng/ml (p=0.212).
CONCLUSION: According to the results of the present study, there was no association between serum
25-hydroxyvitamin D levels in children with and without intussusception and this vitamin was not associated with the occurrence of intussusception