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Coordination Chemistry of the Antimony(III) and Bismuth(III) Cations using Bis(α-iminopyridine) as Ligand
No full textBis(alpha-iminopyridine) L has been employed as the redox non-innocent Schiff-base ligand to coordinate with cationic antimony(III) and bismuth(III) centers. Mono- and di- cationic compounds: [LSbCl2][CF3SO3] 1, [LBiCl2][CF3SO3] 2, [LSbCl2]2[Sb2Cl8] 3, [LBiCl2]2[Bi2Cl8] 4, [LSbCl][CF3SO3]2 5, [LBiCl][CF3SO3]2 6 have been isolated and characterized using single crystal X-ray crystallography in the solid-state and solution-state NMR studies. These compounds have been prepared from PnCl3 (Pn=Sb, Bi) and chloride abstracting agent such as Me3SiCF3SO3 or AgCF3SO3 in the presence of L. The Bi tri-cationic species forms heteroleptic compound 7, being coordinated by two types of Schiff-base donors L and L′. The latter has been in situ generated by the cleavage of one of the two imines present in L
Beware of the Unexpected: Acute Coronary Thrombosis Following the Mildly Symptomatic COVID-19 Infection and Two Different Therapeutic Options
Get PDFCOVID-19 infection was declared a pandemic in March 2020 and is responsible for high morbidity and mortality around the globe. Although the most common clinical presentation is respiratory, cardiac complications are common and create new challenges for healthcare. We discuss two mildly symptomatic outpatients with COVID-19 presenting with acute ST-elevation myocardial infarction (STEMI) and high coronary thrombus burden without atherosclerotic plaque. Our report describes two different therapeutic approaches that illustrate the challenges encountered in the management of disseminated coronary thrombosis in patients with STEMI and COVID-19. Clinicians should be aware of the high pro-coagulant state caused by COVID-19, even in mildly symptomatic outpatients, and aggressive pharmacological therapy may be an effective alternative treatment option to percutaneous coronary intervention
Investigation of MIF gene promoter variations and their haplotypes in the Alzheimer disease in Turkish population: (Combined effect of two MIF gene promoter variations may play a role in Alzheimer’s disease)
Get PDFIn Alzheimer’s disease, which is characterized by amyloid plaques and neurofibrillary tangles in the brain tissue, many components such as acute phase proteins, cytokines, and proteases contribute to the progression of the disease or are part of the pathological process. The macrophage migration inhibitory factor (MIF) gene encodes a cytokine, which is secreted by lymphocytes, and has a role in the pathogenesis of autoimmune/inflammatory diseases such as rheumatoid arthritis. The purpose of this study to investigate the association between Alzheimer disease and MIF gene promoter polymorphisms. The 205 patients with Alzheimer disease (AD) and 130 age-sex matched healthy individuals were investigated in terms of MIF -173 G/C and MIF −794 CATT polymorphisms. The genotyping of MIF -173 G/C was determined using the RT-PCR method. MIF-794 CATT polymorphism was analyzed using PCR and DNA Sequencing. In terms of binary genotypes and haplotypes, the 5/5-GC (p = 0.004), 6/7-GG (p = 0.02) and, 6/6-GG (p = 0.026) binary genotypes, and 5-C (p = 0.003), 7-G (p = 0.026) and 6-G (p = 0.025) haplotypes were differed significantly between the patients and the controls. This is the first study investigating the relationship between AD and MIF in terms of different genotypes, haplotypes and, alleles. The fact that the binary genotype and allele distributions are significantly different between the patient and control group, suggests that this MIF variants may play a role in the pathogenesis of AD. © 202
The prognostic effect of immunohistochemical staining rates in patients with non-muscle-invasive bladder cancer
No full textContext: Despite the follow-up protocols developed in non-muscle-invasive bladder cancer patients, progression and recurrence could not be prevented. Aims: We aimed to investigate whether proteins such as OCT-4, CD47, p53, Ki-67, and Survivin, which increase in bladder cancer cells, can be used as prognostic markers for patients with non-muscle-invasive bladder cancer. Settings and Design: The study included a total of 89 patients with newly diagnosed non-muscle-invasive bladder cancer between January 2015 and December 2020. Materials and Methods: Levels of OCT-4, CD47, p53, Kİ-67, and Survivin proteins in cancer cells were determined with a semi-quantitative immunohistochemical experiment. Pathological data and survival rates were compared according to the staining rates. Statistical Analysis Used: Data obtained in the study were analyzed statistically with SPSS 22.0 (SPSS, Chicago, IL, USA). Results: The mean age of the patients was 64.25 ± 9.91 years, and the median follow-up period was 55 months. Recurrence rate was determined to be 36% (n = 32), and the rate of progression at 40.4% (n = 36). The staining rates were stronger for each marker in the progression group and advanced-stage tumors (p < 0.001). The findings of the multivariate analysis carried out as part of the study showed that older age and higher tumor stage were independent risk factors for recurrence-free survival (HR = 1.048 and 7.074, respectively; P = 0.02). Also, higher tumor stages, diameters, and grades were associated with reduced progression-free survival (HR = 0.105, 0.395, 0.225, respectively; P < 0.05). Conclusions: Although immunohistochemical staining rates are promising, it is more appropriate to use tumor characteristics when assessing survival rate in patients with non-muscle-invasive bladder cancer
Digital twin and human digital twin for practical implementation in Industry 5.0
No full textTechnology, mass customization, and advanced manufacturing are all undergoing rapid change. Since they can now be used in conjunction with advances in artificial intelligence and human-computer interaction, robots are becoming even more significant. However, humans keep their importance in manufacturing as the most dynamic factor in the system. At this point, Industry5.0 proposes a solution, a strong neces- sity to increase productivity while not removing human workers from the manufacturing industry. It is a requirement that people and machines collaborate and progress with each other's strengths to develop an industrial ecosystem that is more effective, productive, and sustainable. In this chapter, the authors discussed the industry's historical development as well as some supporting technologies and potential applicationsfor Industry 5.0, especially digital twin and human digital twin technologies, implementations, and their key points. Also, the components, benefits, and difficulties of these concepts were mentioned
The prognostic value of C-reactive protein/albumin ratio in acute mesenteric Ischemia
No full textDiagnosis of acute mesenteric ischemia (AMI) in its early stages is important for reversing ischemic damage. The CRP to albumin (CRP/Alb) ratio has been defined as an inflammatory indicator and is associated with the severity of inflammation and mortality rates. However, the prognostic value of CRP/Alb has not been evaluated in patients with AMI. Here, we aimed to examine the prognostic significance of CRP/Alb and compare it with other inflammatory markers. Materials and Methods: In this retrospective, case-control study, we included patients diagnosed with AMI at the emergency department between January 1, 2016, and December 31, 2020. In addition to demographic characteristics, lactate, D-dimer, white blood cell (WBC), CRP/Alb, and neutrophil/lymphocyte ratio (NLR) were recorded. Testing characteristics of CRP/Alb in predicting in-hospital mortality were studied. Results: The mean age of 132 patients was 66.48 ± 15.95 years and 71 (53.8%) of them were male. The cut-off value obtained using the receiver operating characteristic (ROC) curve for in-hospital mortality was a CRP/Alb ratio of >1.32 (sensitivity, 93.65%; specificity, 69.57%; +LR, 3.08; −LR,.091; AUC,.782; 95% CI,.70-.85; P <.0001). The comparison of ROC curves between CRP/Alb and WBC, NLR, and lactate revealed a statistically significant difference (P <.05), whereas there was not any statistically significant difference between the ROC curves of CRP/Alb and D-dimer (P =.47). Conclusion: C-reactive protein/albumin ratio is a powerful predictor of in-hospital mortality for AMI patients. It was superior to WBC, NLR, and lactate. It could be used to determine low-risk patients and help clinicians with treatment options
Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia
No full textThis is the first study to evaluate both the dynamic thiol-disulfide homeostasis and ischemia-modified albumin (IMA) levels in patients with chronic lymphocytic leukemia (CLL). Twenty-nine patients with CLL and 20 controls were included in the study. The dynamic thiol-disulfide balance was determined by the newly developed colorimetric method by Erel. IMA levels were determined by the cobalt binding test. We found that total antioxidant status levels were lower while total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly higher in patients with CLL than controls. Moreover, native and total thiol levels were found to be statistically significant between the study and control groups (p<0.001), whereas no statistically significant difference was noted for IMA levels (p=0.365). A negative correlation was observed between native and total thiol levels, leukocyte, lymphocyte, and TOS. Total bilirubin showed positive correlation with direct bilirubin and alkaline phosphatase. In addition, IMA levels showed a positive correlation with OSI. This study highlights measurement of native and total thiol and IMA levels in patients with CLL for the first time. Dynamic thiol-disulfide homeostasis may contribute in the pathophysiological mechanism, and follow-up to disease in patients with CLL
Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
No full textOrgan toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side effects of long-term MTX use. The present study unveils new confirmations as regards the remedial effects of morin on MTX-induced hepatocellular injury through regulation of oxidative stress, apoptosis and MAPK signaling
Investigation of temporal variation of groundwater salinity potential using AHP-based index
No full textIn this study, a Groundwater Salinity Index (GSI) was developed to monitor the salinity potential and water quality of freshwater aquifers adjacent to Lake Tuz, one of the world’s hypersaline lakes. The hierarchical structure of the index was designed by using the Analytical Hierarchy Process and eight different parameters that cause groundwater salinity. In addition to the index, a classification system based on GSI scores is proposed that evaluates salinity potential in three different categories as “high,” “medium,” and “low.” In order to evaluate the temporal variation of salinity potential, the GSI was applied to the results of the water chemistry analysis carried out in 2012 and 2019. Prediction maps showing the salinity potential were obtained using GSI scores and the Kriging interpolation process. According to the index scores and maps, it was determined that the salinity potential rose towards the inner parts of the region because of the increasing salinity rate of groundwater as approximately 15%. The fields with the highest salinity potential are concentrated in the western regions along the shore of Lake Tuz. The groundwater closer to the lake has the characteristics of NaCl facies. Due to the mixing of NaCl and CaHCO3 water facies at various rates, different water types have emerged in the region. Freshwater aquifers located close to Lake Tuz were mainly contaminated by Lake Tuz and the groundwater that has a high salt content as a result of water–rock interaction
Evaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infection
Get PDFAim: The current study aimed to evaluate the effects of caspase-8 (CASP8) and mitogen-activated protein kinase 1 (MAPK1) gene expression levels and their products on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: A total of 40 patients (men, 15 [37.5%]; women, 25 [62.5%]) with COVID-19 infection were included in the current study. The patients were divided into four main groups based on disease severity: mild (n = 7), moderate (n = 10), severe (n = 14), and critical (n = 9). Individuals aged < 18 years and pregnant women were excluded. Patients were classified according to the World Health Organization (WHO) classification system (WHO/2019-nCoV/clinical/2021.1). Results: Considering all groups, statistically significant differences were detected among all groups for both CASP82−ΔΔCt (p = 0.006) and MAPK1 2−ΔΔCt values (p = 0.015). Moreover, statistically significant differences were detected between mild and moderate (p = 0.013), moderate and critical (p = 0.018), and severe and critical (p = 0.023) groups for lymphocytes. Conclusion: The CASP8/MAPK1 expression levels and/or its products are essential in preventing injury caused by COVID-19 infection. They play crucial roles in maintaining cellular homeostasis and viability. Furthermore, CASP8/MAPK1 levels can provide information about disease severity