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Complementary: Green catalysis over red soil for pollutant removal
No full textOrganic dyes from industrial wastewater pollute water tables. Here proposed solution for environmental control relies on pristine red soil for adsorption and oxidative degradation of methylene blue. Soil analysis comprised XRD, spectroscopic (FTIR and Raman) and microscopic (SEM/EDS) techniques, while spectrophotometry was applied for dye quantification. The dominant soil mineral is kaolinite while Fe homogeneous distribution is witnessed in the α- and γ-FeO(OH) form. Dye adsorption was monitored for both soil and kaolinite, with rising removal under basic conditions due to methylene blue transformation. Theoretical modelling enabled insight into dye orientation over goethite crystallographic planes and estimation of binding energy. Soil/Fenton reagent achieved a substantial 93 % dye removal. An optimal oxidant concentration in the Fenton system was 10 mM. We confirmed the excellent performance of pristine red soil samples as naturally occurring adsorbents and catalysts in Fenton oxidation of environmental pollutants
3D tablete paracetamola i ko-procesnih ekscipijenasa izrađenih postupkom selektivnog laserskog sinteriranja
No full textThe aim of this work was to investigate a possibility of 3D printing (1) of orally disintegrating tablets (2) and prolonged release tablets (3) formulated with StarLac® (85 %, w/w) white native starch and 15 % (w/w) lactose monohydrate) and RetaLac® (50 % (w/w) lactose monohydrate and 50 % (w/w) hypromellose) as a co-processed excipients and paracetamol as an active ingredient (2). ..
Burnout and Competency Development Among Community Pharmacists: Exploring Patterns
No full textBackground The well-being and professional competence of pharmacists play a crucial role in effective healthcare delivery. ..
Expression analysis of microRNAs and cytokine mRNAs in pregnancies complicated by gestational hypertension
No full textObjectives: Gestational hypertension (GH) is one of the most common pregnancy-related complications, however, there is still insufficient knowledge about its development and molecular changes. The aim of our study was to examine the expression of miR-17, miR-29a and miR-181a, as well as TNF-α, IL-1β, IL-6 and IL-17 in women with GH and to investigate possible correlations between these parameters. Study design: The study included 64 pregnant women, placed either in the control or the GH group. Quantitative real-time PCR (qPCR) was used to determine expression levels of microRNAs and cytokines’ mRNAs. Main outcome measures: Expression levels of miRNAs (miR-17, miR-29a and miR-181a) and proinflammatory cytokines mRNAs (TNF-α, IL-1β, IL-6 and IL-17) in women with gestational hypertension were compared to the control group (healthy pregnant women). Results: No significant changes in microRNAs expression level were found between compared groups. TNF-α was significantly upregulated in the GH group compared to controls. Expression levels of other investigated cytokines did not differ between examined groups. ROC curve analysis indicated that TNF-α does not show sufficient ability to discriminate between CG and GH patients. TNF-α was significantly positively correlated with IL-1β and IL-17 and negatively correlated with miR-181a. Conclusions: Our results point to the involvement of proinflamatory cytokines in gestational hypertension. Although increased expression of TNF-α was found in the GH group, this cytokine did not show sufficient ability to discriminate between GH and healthy pregnancies
Development and Evaluation of the Reliability of a Semi-Quantitative Food Frequency Questionnaire to Assess the Intake in the Serbian Population
Get PDFAssessing dietary habits with validated questionnaires is crucial for achieving reliable results in health research. The aim of this study was the development and validation of a semi-quantitative food frequency questionnaire (FFQ) in an 18–30-year-old Serbian population. A total of 93 participants completed the FFQ and three 24 h dietary recalls (24 hR). Pearson and intraclass correlations between FFQ and 24 hR intakes were assessed and were de-attenuated and energy-adjusted. Bland–Altman plots were generated, and quintiles of energy, water, fiber, and macronutrient intake were analyzed with contingency tables. Adjustments for sex differences were included. The validity of the FFQ varied, with significant correlations for energy, carbohydrates, cholesterol, and vitamin B12, vitamin C and vitamin D. Misclassification rates were generally low. Bland–Altman plots indicated good agreement between methods. It can be concluded that the validated FFQ is a promising tool for dietary assessment in the Serbian population. Results for several nutrients align closely with previous studies. The new FFQ is a useful tool for dietary assessment in the Serbian population
Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms
No full textThe constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite portal and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study
Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent
No full textHydantoin derivatives are versatile structural motifs found in natural products
and various compounds with different biological or other properties. Due to
their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology
utilizing N-Boc protected amino acid amides for their preparation has been
described. The cyclisation process was accomplished using solid supported
PPh3 and CBr 4 as reagents affording substituted hydantoins in moderate to
good yields (40%–77%)
Uporedno spektrofotometrijsko određivanje 3-hidroksiflavona bazirano na kompleksima cinka i aluminijuma i njihovi antioksidatni profili
Get PDFAbstract
Flavonoids, as plant-derived compounds, were essential active components in traditional
medicine for centuries. Their potential or confirmed effects include antiviral, antimutagenic, antiinflammatory, antibacterial, vasodilatory, and anticancer properties. The promotion of a plantbased diet, along with the benefits of consuming flavonoids, has recently become increasingly
attractive. 3-Hydroxyflavone (3HF) is the structural spine of flavonols, an important subgroup of
flavonoids. Although 3HF itself does not exist in plants per se, it exerts many of its effects because
of its characteristics that allow it to prevent free radical generation. This work is focused on the
characterization of 3HF complexes with zinc(II) and aluminium(III) ions (Zn-3HF and Al-3HF,
respectively). Besides this, a simple, fast, and low-priced spectrophotometric method for 3HF
determination, with very low LOD and LOQ, based on Zn-3HF and Al-3HF formation, was
established. A slight advantage is given to the modification with Al3+ ion on pH 4.91, due to very
low LOD and LOQ values of 1.83×10-7 molL-1
, and 5.50×10-7 molL-1
, respectively, and a high
correlation coefficient, R =0.99986. Furthermore, the antioxidant ability of Zn-3HF, Al-3HF, and
parent 3HF was examined by the ABTS and DPPH tests. They brought the Zn-3HF complex to
the fore as a potential antioxidative agent.Flavonoidi, jedinjenja biljnog porekla, vekovima su bili veoma važne aktivne komponente u tradicionalnoj medicini. Veliki broj njihovih potencijalnih ili već potvrđenih efekata uključuje antivirusna, antimutagena, antiinflamatorna, antibakterijska, vazodilatatorna i antikancerogena svojstva. Promovisanje biljne ishrane, uz isticanje koristi konzumiranja flavonoida, u današnje vreme postalo je sve privlačnije. 3-Hidroksiflavon (3HF) je strukturni stub svih flavonola, važne klase flavonoida. Iako sam 3HF ne postoji u biljkama per se, on ispoljava mnoge svoje efekte zahvaljujući osobini da sprečava stvaranja slobodnih radikala. Ovaj rad je fokusiran na karakterizaciju kompleksa 3HF sa jonima cinka(II) i aluminijuma(III) (Zn-3HF i Al-3HF, respektivno). Izvršena je karakterizacija ovih kompleksa i razvijena brza i pristupačna metoda za spektrofotometrijsko određivanje 3HF, na osnovu formiranja kompleksa Zn-3HF i Al-3HF, sa veoma niskim vrednostima LOD i LOQ. Mala prednost je data modifikaciji sa Al3+ na pH 4,91 zbog izuzetno niskih vrednosti LOD i LOQ, 1,83×10-7 mol L-1 , odnosno 5,50×10-7 mol L-1 , kao i visokog koeficijenta korelacije, R=0,99986. Pored toga, antioksidativni kapaciteti sintetizovanih kompleksa Zn-3HF i Al-3HF, kao i samog 3HF, ispitani su DPPH i ABTS testovima i doveli su Zn-3HF kompleks u prvi plan za dalja ispitivanja kao potencijalnog antioksidativnog agensa
In situ Raman spectroscopy study of the oxidative polymerization of aniline in media of different acidity
No full textIn situ Raman spectroscopy was used for the first time to study the reaction intermediates/products of the
oxidative polymerization of aniline to polyaniline (PANI) with peroxydisulfate in aqueous solutions of different
initial acidity. Raman spectra were recorded for the drops of reaction mixture taken at various reaction times.
Five reaction systems with different pH of the monomer solution (pHmon), leading to 1-D nanostructured PANIs
(pHmon =5.8, 4.6 and 4.5) and granular PANIs (pHmon= 3.4 and 1.0) were explored. Spectral characteristics of
different reaction phases - athermal, exothermic and post-propagation were identified and correlated with the
proposed mechanisms of aniline polymerization and nanostructures formation. For the nanostructured PANIs,
the athermal phase was characterized by pronounced strengthening of the δ(N H)/ν(C––N)Q band at
1510–1520 cm 1, while the characteristic of the second exothermic phase was the strengthening of the ν(C~C)B/
ν(C~C)Phz band at c.a. 1636 cm 1 which becomes stronger than the ν(C––C)Q/ν(C~C)SQ band at c.a. 1590 cm–1.
For granular PANIs, the band at 1590 cm–1 was stronger than that at 1630 cm–1 for all reaction phases. For all
reaction systems, characteristic feature of the post-propagation phase was strengthening of the ν(C~N+•) band at
1330–1340 cm 1 due to delocalized polarons. For granular PANIs, the band associated with phenazine-like units
at c.a. 1415 cm 1 disappeared after the exothermic phase, while for nanostructured PANIs it was seen until the
end of the reaction. The obtained results are expected to be useful in further investigations of the intermediates/
products and mechanisms of polymerizations of other aromatic amines
Novi i značajni podaci o biljkama, algama i gljivama iz JI Evrope i susednih regiona, 16
Get PDFThis paper presents new records and noteworthy data on the following taxa in SE Europe and adjacent regions: diatoms Discostella asterocostata and Stephanodiscus hantzschii f. tenuis, red alga Bangia atropurpúrea, green alga Ulvapilifera, saprotro-phic fungi Didymella vitalbina and Phragmotrichum rivoclarinum, mosses Buxbau-mia aphylla, Sphagnum divinum, and Tortella fasciculata, monocots Anacamptis x nicodemi, Epipactis palustris, Epipogium aphyllum, and Gymnadenia frivaldii and dicots Androsace lactea, Drosera rotundifolia, Potentilla montenegrina, and Tozzia alpina subsp. carpathica are given within SE Europe and adjacent regions.U radu su prikazani novi i značajni podaci sa područja JI Evrope i susednih regiona o sledećim taksonima: dijatomejskim algama
Discostella asterocostata i Stephanodiscus hantzschii f. tenuis, crvenoj algi Bangia atropurpurea, zelenoj algi Ulva pilifera, saprofitskim
gljivama Didymella vitalbina i Phragmotrichum rivoclarinum, mahovinama Buxbaumia aphylla, Sphagnum divinum i Tortella fascicu-
lata, monokotilama Anacamptis × nicodemi, Epipactis palustris, Epipogium aphyllum i Gymnadenia frivaldii i dikotilama Androsace
lactea, Drosera rotundifolia, Potentilla montenegrina i Tozzia alpina subsp. carpathica