22297 research outputs found
Sort by
Genetic Variants of lncRNA MALAT1 Exert Diverse Impacts on the Risk and Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma.
No full textThe long noncoding (lnc)RNA,?metastasis-associated lung adenocarcinoma transcript 1?(MALAT1), plays a crucial role in the development of hepatocellular carcinoma (HCC). However, potential genetic variants (single nucleotide polymorphisms, SNPs) in?MALAT1?that affect the susceptibility and progression of HCC have rarely been explored. Three tagging SNPs, viz., rs3200401 C > T, rs619586 A > G, and rs1194338 C > A, in MALAT1 were genotyped by a TaqMan allelic discrimination assay in 394 HCC patients and 1199 healthy controls. A stratified analysis showed that younger patients (<55 years) with the MALAT1 rs619586 G allele had a decreased risk of HCC under a codominant model (AOR = 0.289, 95% CI: 0.108-0.773, p = 0.013) and dominant model (AOR = 0.286, 95% CI: 0.107-0.765, p = 0.013). Female patients and patients with a smoking habit who carried the CA + AA genotype of rs1194338 had a lower risk of developing vascular invasion (p = 0.049) and a high Child-Pugh grade (B or C) (p = 0.036), respectively. Under the dominant model, smokers with the MALAT1 rs3200401 CT + TT genotype had a higher frequency of hepatitis B virus (HBV) infection (p = 0.034). Moreover, the aspartate aminotransferase was higher in patients with the rs3200401 CT + TT genotype. Furthermore, analyses of clinical datasets revealed that MALAT1 expression level was gradually unregulated during HCC development from normal liver, cirrhotic liver, dysplastic liver to HCC and correlated with poor survival rates in HCC patients, especially in the hepatitis virus-infected population
Promoting Student Nurses’ Meaningful Life,Positive Beliefs and Well-Being ThroughTeaching Interventions: A Pre-Experimental Study
No full text多媒體衛教資源於提升女性更年期知識之成效
No full text探討以多媒體衛教資源 以多媒體衛教資源 -「婦女更年期保健手冊 「婦女更年期保健手冊 - 迎接人生新旅程(2014 版)」介入措施 對女性更年期知識提升之成效。
研究方法
本研究採前後測研究設計，以立意取樣方式徵求同意之40-60 歲女性為研究對象共60 名，再隨機分派至實驗組與對照。提供多媒體資源衛教 介入措施，對照組則無。資料收集分別為前測和4 週後測，成果測量以更年期知識量表評量其成效。
研究結果
研究結果顯示兩組前後測分數略有增加但無統計上之顯著性差異：實驗組更年期知識量表平均分數從89.77 提升至93.77 (p=.280)=.280)，控制組更年期知識量表平均分數則從72.83 增加為78.03(p=.135)。進一步分析更年期知識量表的四個範疇 ( 包括: 更年期認知、更年期身心變化、更年期保健及荷爾蒙替代療法)，發現兩組略有差異；在實驗組方面，其後測平均得分以「更年期身心變化」得分最高(Mean=.82, SD=.20)， 「荷爾蒙替代療法」平均得分均最低(Mean=.64, SD=.24)。而控制組在後測平均得分則以「更年期認知」得分最高(Mean=.70, SD=.26)，「荷爾蒙替代療法」平均得分均最低(Mean=.46, SD=.30)。
護理應用
更年期知識量表顯示婦女「荷爾蒙替代療法」方面的知識得分最低，建議未來可針對 建議未來可針對該範疇增加衛教措施，以提升婦女對此範疇的了解。同時針對多媒體衛教資源介入措施的設計 能有更合適之衛教內容更合適之衛教內容與策略，以增進婦女更年期知識及生活適應