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The genomic diversity and antimicrobial resistance of Non-typhoidal Salmonella in humans and food animals in Northern India.
Get PDFINTRODUCTION: Non-typhoidal Salmonella (NTS) serovars are the leading global cause of gastroenteritis and have established reservoirs in food animals. GAP STATEMENT: Due to a lack of surveillance, there is limited information on the distribution of NTS serovars in India. AIM: Here, we investigated the epidemiology, sequence types, serovar distribution, phylogenetic relatedness, and antimicrobial resistance patterns of NTS in humans and animals across a large geographic area in Northern India. METHODOLOGY: We collected stool samples from patients with diarrhea who presented to 14 laboratories in Chandigarh and from five states in India (Punjab, Haryana, Uttarakhand, Himachal Pradesh, and Rajasthan). We sequenced the genomes and analyzed 117 NTS organisms isolated from humans and animals. Minimum inhibitory concentrations (MICs) were estimated using a Vitek2 system. RESULTS: The prevalence of NTS in participants presenting to our study with diarrhea was 1.28 %, affecting all age groups. All NTS caused moderate to severe diarrhea. We found a high diversity of serovars with considerable serovar and sequence types (STs) overlap and phylogenetic closeness between isolates from human infections and food animals. We report serovars such as S. Agona, S. Bareilly, S. Kentucky, S. Saintpaul, and S. Virchow, causing human infections from north India for the first time. Among the different food-producing animals, pigs appeared to be a key source of human infections. Twenty-eight percent (28 %) of the NTS isolates were multi-drug resistant (MDR), and human isolates showed a higher proportion of resistance. A higher level of contamination of meat samples in our study (8.4 %) potentially suggests a close association of NTS serovars with the food chain and high transmission risk in north India. CONCLUSIONS: This study provides information on AMR genes and plasmid replicons associated with different serovars and highlights the role of food animals in AMR dissemination in our region
Sociodemographic characteristics, community engagement and stigma among Men who have Sex with Men (MSM) who attend MSM-led versus public sexual health clinics: A cross-sectional survey in China.
Get PDFCommunity-based sexual health services are recommended to increase sexually transmitted disease (STD) testing among men who have sex with men (MSM). Pilot study data from multiple sites found that MSM in Guangzhou who use public STD clinics were found to have different sociodemographic characteristics, lower community engagement, and increased social cohesion, compared to MSM who use MSM-led clinics
Prevalence of Chagas disease among Latin American immigrants in non-endemic countries: an updated systematic review and meta-analysis.
Get PDFBACKGROUND: Chagas disease (CD), endemic in 21 Latin American countries, has gradually spread beyond its traditional borders due to migratory movements and emerging as a global health concern. We conducted a systematic review and meta-analysis of available data to establish updated prevalence estimates of CD in Latin American migrants residing in non-endemic countries. METHODS: A systematic search was conducted in MEDLINE/PubMed, Embase, Cochrane Library, Scopus, Web of Science, and LILACS via Virtual Health Library (Biblioteca Virtual em Saúde - BVS), including references published until November 1st, 2023. Pooled prevalence estimates and 95% confidence intervals (CI) were calculated using random effect models. Heterogeneity was assessed by the chi-square test and the I2 statistic. Subgroup analyses were performed to explore potential sources of heterogeneity among studies. The study was registered in the PROSPERO database (CRD42022354237). FINDINGS: From a total of 1474 articles screened, 51 studies were included. Studies were conducted in eight non-endemic countries (most in Spain), between 2006 and 2023, and involving 82,369 screened individuals. The estimated pooled prevalence of CD in Latin American migrants living in non-endemic countries was 3.5% (95% CI: 2.5-4.7; I2: 97.7%), considering studies in which screening was indicated simply because the person was Latin American. Per subgroups, the pooled CD prevalence was 11.0% (95% CI: 7.7-15.5) in non-targeted screening (unselected population in reference centers) (27 studies); in blood donors (4 studies), the pooled prevalence was 0.8% (95% CI: 0.2-3.4); among people living with HIV Latin American immigrants (4 studies) 2.4% (95% CI: 1.4-4.3) and for Latin American pregnant and postpartum women (14 studies) 3.7% (95 CI: 2.4-5.6). The pooled proportion of congenital transmission was 4.4% (95% CI: 3.3-5.8). Regarding the participants' country of origin, 7964 were from Bolivia, of which 1715 (21,5%) were diagnosed with CD, and 21,304 were from other Latin American countries of which 154 (0,72%) were affected. INTERPRETATION: CD poses a significant burden of disease in Latin American immigrants in non-endemic countries, suggesting that CD is no longer a problem limited to the American continent and must be considered as a global health challenge. FUNDING: This study was funded by the World Heart Federation, through a research collaboration with Novartis Pharma AG
Women 's perception on the quality of maternal and newborn care during the COVID-19 pandemic in German-speaking countries: Findings from the IMAgiNE EURO project comparing data from Germany, Switzerland and Austria.
Get PDFPROBLEM: Restrictions during the COVID-19 pandemic compromised maternal and newborn care. BACKGROUND: Countries in the German speaking area share several clinical care guidelines but differed significantly in the strictness of COVID-19 protective measures. AIM: To investigate the quality of maternal and newborn care (QMNC) during the COVID-19 pandemic in the German-speaking area and explore associations between the reorganisational changes due to COVID-19 and QMNC, as described with WHO Standards-based Quality Measures. METHODS: As part of the IMAgiNE EURO study (ClinicalTrials.gov: NCT04847336), we conducted an online survey on the QMNC in the German-speaking area, including women who gave birth in Germany, Switzerland, and Austria. Descriptive statistics, Spearman rank correlation coefficient and multivariable quantile regression were used. FINDINGS: Out of a total of 70,721 women accessing the online questionnaire, 1,875 were included (Germany: n = 1,053, Switzerland: n = 494, Austria: n = 328). Significant differences across countries were found in Quality Measures. In Switzerland, women scored Quality Measures more favourable than in Germany and Austria in all four sub-indexes of QMNC. In Austria, Quality Measures gaps in the sub-index 'Experience of care' were higher. The sub-index 'Reorganisational changes due to COVID-19' correlated weakly to strongly with the other sub-indexes (between r = 0.33 and r = 0.62, p < 0.001 for all correlations). DISCUSSION: Midwives and other health professional should pay particular attention to the provision of respectful, high-quality care. CONCLUSION: To effectively improve QMNC, further research is essential to monitor the quality of care and develop targeted interventions beyond the COVID-19 pandemic addressing inherent challenges in the organisation and delivery of care
To what extent did mortality from COVID-19 in England and Wales differ for migrants compared to non-migrants in 2020 and 2021? A descriptive, observational study.
Get PDFSeventeen percent of people living in the UK are migrants. In high-income countries, migrants have been shown to have better all-cause mortality but worse mortality for some specific causes such as infectious diseases. This observational study aims to quantify the extent to which mortality from coronavirus disease 2019 (COVID-19) differed between migrants and non-migrants for the population of England and Wales, 2020-2021. We use Official National Statistics data to compare mortality from COVID-19 in 2020 and 2021 by country/region of birth, expressed as the standardized mortality ratio with those born in England and Wales as the reference population. Migrants from 17 of 19 countries/regions examined had higher mortality from COVID-19 than non-migrants. The highest mortality was those born in Bangladesh (females SMR = 3.39, 95% CIs 3.09-3.71; males 4.41, 95% CIs 4.09-4.75); Pakistan (females 2.73, 95% CIs 2.59-2.89; males 3.02, 95% CIs 2.89-3.14); and the Caribbean (females 2.03, 95% CIs 1.87-2.20; males 2.48, 95% CIs 2.37-2.60). Migrants born in Antarctica and Oceania (females 0.54, 95% CI 0.42-0.40; males 0.71, 95% CI 0.51-0.88), and North and Central America (females 0.95, 95% CI 0.80-1.11; males 0.85, 95% CI 0.72-0.99) had lower mortality than non-migrants. Most migrant populations had higher mortality from COVID-19 than non-migrants in England and Wales. Policy-makers must work to integrate migration status into routine data collection to inform future research and understand the causes of the inequalities seen
Looking for the future - Hope and adolescent risk behaviour in rural KwaZulu-Natal, South Africa.
Get PDFABSTRACTWe investigate the relationship between hope and risky behaviour and the role of migration among young people in northern KwaZulu-Natal, South Africa. We use data from a cohort of n = 5248 adolescents and young adults (AYA) aged 13-35 recruited and followed up in 2017-2019. We conducted a structured quantitative survey to assess levels of hope among AYA using a validated tool/scale. 44% of participants were aged 13-17 years, 63% were still in school, 66% were from rural areas, and 26% were from food insecure households. The mean hope total score was 31.7. The mean hope score was lower for females compared to males -0.43(95%CI; -0.64, -0.21) and lower for those out of school and not matriculated compared to those in school -0.72(95%CI; -1.1, -0.32). Young people who had experienced violence had a lower mean hope score than those who had not -0.28(95%CI: -0.50, -0.06). Those out of school, matriculated and unemployed were more likely to migrate than those in school (aOR = 1.60, 95%CI; 1.25, 2.05). AYA who were food insecure were also more likely to migrate (aOR = 1.23, 95%CI; 1.05, 1.43). Our findings suggest a need for structural interventions that address employment and education needs and harmful gender norms for older AYA
Practice of clean intermittent catheterisation in children with spina bifida: a scoping review
Get PDFBackground: Spina bifida is a congenital neural tube defect, where there is incomplete
formation of the spinal cord and vertebrae, resulting in abnormal development of the neural
tube. This affects bladder function and urinary incontinence. Clean Intermittent Catheterization
(CIC) is used to manage bladder and bowel management.
Objectives: This study aims to scope evidence on the facilitators and barriers to usage and
practice of CIC in children with spina bifida in low-income countries.
Method: We searched databases including PubMed, Web of Science and SCOPUS, and
screened articles for inclusion following the PRISMA-ScR guidelines. The search terms
included ‘Spina Bifida ([continence management] AND [clean intermittent catheterisation])
AND ([barriers to Clean Intermittent Catheterisation] OR [Low Income Countries]) OR
(myelomeningocele)’. Full-text assessment for eligibility excluded 202 articles. Twenty-two
articles were reviewed and twelve full-text articles were excluded because of limited content.
Ten articles published in English between 2004 and 2023 were selected for review.
Results: Barriers in practicing CIC include pain and discomfort in catheter insertion, stigma
and fears; inaccessibility of public toilets, unavailability of appropriate catheters, difficulty in
positioning, limited quality of teaching and challenges with accessing supplies. Facilitators
include starting CIC in infancy, follow-up by healthcare providers, support from family and
community members, quality of training, continuous practice of CIC, utilisation of lubricants,
reuse of catheters and other low-cost materials.
Conclusion: Our review summarises facilitators and barriers to CIC and provides
recommendations for further research, which includes the involvement of family members
and community-based rehabilitation workers.
Contribution: This article contributes to a better understanding of CIC use in low-income
countries
Does work modify the relationship between violence and mental health among young people? Evidence from the Violence Against Children Surveys in Uganda, Nigeria and Colombia.
Get PDFBACKGROUND: Considering the well-established link between experiencing violence in childhood and poor mental health, it is important to understand the role of contextual factors in which young people live, learn, work, and play. Evidence has highlighted the importance of work as a contextual factor in the lives of young people, but it is unclear whether being in work mitigates, entrenches, or exacerbates the association between violence against children and poor mental health. METHODS: This study is based on nationally representative data of males and females aged 13-24 years who completed the Violence Against Children Surveys in Nigeria, Uganda, and Colombia. We used multivariable logistic regression models to explore the association between lifetime violence and past 30-day mental distress, and explored whether working in the past year modified this association. All analyses were age- and sex-stratified and conducted separately in each country. RESULTS: We found a high prevalence of lifetime violence among young people in all three countries and strong associations between violence and mental distress. In Colombia, there was strong evidence (P-value for interaction = 0.014) that work in the past year (adjusted odds ratio (aOR) = 0.42; 95% confidence interval (CI) = 0.07-2.57) reduced the risk of mental distress among girls who had experienced violence compared to not working in the past year (aOR = 6.12; 95% CI = 2.60-14.41). There was also evidence among boys in Nigeria (P-value for interaction = 0.045), where there was a reduction in risk of mental distress among those not in work in the past year (aOR = 0.99; 95% CI = 0.46-2.13) compared to those in work in the past year (aOR = 2.10; 95% CI = 1.32-3.33). There was also a pattern of effect modification by work in the association between childhood violence and mental health in other population groups, with variation by country, sex, and age groups. CONCLUSIONS: Our findings suggest that work can mitigate, entrench, or exacerbate risk of mental distress among young people who have experienced violence, depending on their age, sex, and country of residence. While additional research is needed to explore these mechanisms, this highlights the importance of work as a contextual factor in the lives of young people and points to the need for safe and secure workplaces and the integration of context-specific interventions into workplaces for young people
Using models and maps to inform Target Product Profiles and Preferred Product Characteristics: the example of Wolbachia replacement.
Get PDFBACKGROUND: The global prevalence of diseases transmitted by Aedes aegypti mosquitoes, such as dengue, Zika and Yellow Fever, is increasing, but development of promising new mosquito control technologies could reverse this trend. Target Product Profiles (TPPs) and Preferred Product Characteristics (PPCs) documents issued by the World Health Organization can guide the research and development pathways of new products and product combinations transitioning from proof of concept to operational use. METHODS: We used high resolution global maps of the case and economic burden of dengue to derive programmatic cost targets to support a TPP for Wolbachia replacement. A compartmental entomological model was used to explore how release size, spacing and timing affect replacement speed and acceptability. To support a PPC for a hybrid suppress-then-replace approach we tested whether Wolbachia replacement could be achieved faster, more acceptably or at a lower cost if preceded by a mosquito suppression programme. RESULTS: We show how models can reveal trade-offs, identify quantitative thresholds and prioritise areas and intervention strategies for further development. We estimate that for Wolbachia replacement to be deployable in enough areas to make major contributions to reducing global dengue burden by 25% (in line with 2030 WHO targets), it must have the potential for cost to be reduced to between 0.24 (USD) per person protected or less. Suppression can reduce the number of Wolbachia mosquitoes necessary to achieve replacement fixation by up to 80%. A hybrid approach can also achieve fixation faster and potentially improve acceptability, but may not justify their cost if they require major new investments in suppression technologies. CONCLUSIONS: Here we demonstrate the value dedicated modelling can provide for interdisciplinary groups of experts when developing TPPs and PPCs. These models could be used by product developers to prioritise and shape development decisions for new Wolbachia replacement products
Thinking politically about intersectoral action: Ideas, Interests and Institutions shaping political dimensions of governing during COVID-19.
Get PDFOur paper examines the political considerations in the intersectoral action that was evident during the SAR-COV-2 virus (COVID-19) pandemic through case studies of political and institutional responses in 16 nations (Australia, Belgium, Brazil, Ethiopia, India, New Zealand, Nigeria, Peru, South Africa, South Korea, Spain, Taiwan, Thailand, Vietnam, UK, and USA). Our qualitative case study approach involved an iterative process of data gathering and interpretation through the three Is (institutions, ideas and interests) lens, which we used to shape our understanding of political and intersectoral factors affecting pandemic responses. The institutional factors examined were: national economic and political context; influence of the global economic order; structural inequities; and public health structures and legislation, including intersectoral action. The ideas explored were: orientation of governments; political actors' views on science; willingness to challenge neoliberal policies; previous pandemic experiences. We examined the interests of political leaders and civil society and the extent of public trust. We derived five elements that predict effective and equity-sensitive political responses to a pandemic. Firstly, effective responses have to be intersectoral and led from the head of government with technical support from health agencies. Secondly, we found that political leaders' willingness to accept science, communicate empathetically and avoid 'othering' population groups was vital. The lack of political will was found in those countries stressing individualistic values. Thirdly, a supportive civil society which questions governments about excessive infringement of human rights without adopting populist anti-science views, and is free to express opposition to the government encourages effective political action in the interests of the population. Fourthly, citizen trust is vital in times of uncertainty and fear. Fifthly, evidence of consideration is needed regarding when people's health must be prioritized over the needs of the economy. All these factors are unlikely to be present in any one country. Recognizing the political aspects of pandemic preparedness is vital for effective responses to future pandemics and while intersectoral action is vital, it is not enough in isolation to improve pandemic outcomes