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What do We Know About Albumin Formulations?
No full textAlbumin is a natural material that covers nearly 60 per cent of the human proteome and is utilised as a buffering protein that helps transport various xenobiotics in the body. Pharmaceutically, it is used for the treatment of hypovolemia in patients with chronic conditions. Albuminbased Abraxane® (paclitaxel-albumin nanoparticles) is a billion-dollar drug for treating various cancer conditions. It helped to provide an organic solvent-free formulation of a hydrophobic drug (paclitaxel). There has been an exponential rise in the research to explore various applications of albumin as a biomaterial for therapeutic and formulation development applications. As a pharmaceutical biomaterial, albumin can be moulded to form nanoparticles, hydrogels, nanofibers, and films. This article highlights key aspects, such as the synthesis and application of albumin as a pharmaceutical excipient in developing dosage forms
The “Valley of Opportunity”: Morality in a Shoe Empire
No full textGeorge F. Johnson followed in his father’s footsteps as a factory worker in the 1800s. While learning all of the different processes that went into making good quality shoes, he realized the importance of having a dedicated workforce that was behind the scenes, ensuring even the most obscure details were attended to. Through hard work, Johnson rose through the ranks of a shoe manufacturing company and eventually became part of the executive leadership team. However, unlike most who rose to this position, he did not forget where he came from and how much hard work it took to produce these goods. Embracing ideas about the importance of ethical actions that emerged from The Second Great Awakening, he instilled practices in his company that put employees first. This paper will show how George F. Johnson truly embraced ideas from the Second Great Awakening, how he implemented ethical policies and a “Square Deal” for all employees, and the overall effect this had on the Endicott-Johnson Shoe Company
Maggot Debridement Therapy vs. Negative Pressure Wound Therapy and Their Effectiveness on Tissue Healing on Older Adults
No full textChronic ulcers, particularly prevalent in older adults, significantly impact patients\u27 quality of life, leading to prolonged hospital stays and increased healthcare costs. This study explores the efficacy of two common therapies, Negative Pressure Wound Therapy (NPWT) and Maggot Debridement Therapy (MDT), in promoting tissue healing for chronic ulcers in adults aged 60 and older. A methodical search was conducted using databases such as CINAHL, PubMed, EBSCO, and ProQuest, employing specific search strategies and inclusion/exclusion criteria. Four high-quality Level 1 randomized controlled trials were selected for analysis, comparing NPWT and MDT in various settings. The results indicate that MDT exhibits superior effectiveness in promoting wound healing compared to NPWT. The studies also highlight the importance of considering patient comorbidities, such as Peripheral Vascular Disease, Diabetes, and immobility, in selecting the most appropriate therapy. Furthermore, the analysis touches upon psychosocial implications, cost-effectiveness, and the need for patient education in wound management. In conclusion, MDT emerges as the preferred treatment for chronic ulcers in older adults, emphasizing the significance of efficient healing to enhance the patients\u27 quality of life
An Overview and Analysis of The Wire’s First Season
No full textIn the Fall of 2023, I had the great pleasure of studying the first season of an HBO drama from the 2000s called The Wire. In this paper, I analyze how creator David Simons made relevant cultural commentary about American capitalism and its effects on the citizens of our cities, specifically Baltimore. Simon derives his knowledge of Baltimore from his years spent as a crime reporter at The Baltimore Sun, which had a profound influence on the realism displayed in the show. This first season of The Wire proves to be sophisticatedly complex, stepping away from traditional cop shows at the time. Throughout the paper, I will explain specifically how The Wire is different from other television shows and why its impact demands understanding
Brokering Reproductive Justice: Solidarity Rhetoric in Senator Wendy Davis’s Texas Filibuster
No full textCardiovascular adverse events associated with triptans for treatment of migraine: a pharmacovigilance study of the FDA adverse event reporting system (FAERS)
No full textThe purpose of this study was to determine the relationship between triptans (sumatriptan, rizatriptan, and zolmitriptan) and cardiovascular (CV) adverse events with data from the FDA Adverse Event Reporting System (FAERS). FAERS database was used to collect data on triptans from 1997 to 2023. Disproportionality methods were utilized to quantify triptan-associated CV events and to identify the potential risk. The reporting odds ratio was used to identify the risk signals. CV outcomes related to age, sex, clinical results, and other factors were also examined for triptans; 820 reports involving the triptans were recognized as CV adverse events out of total of 12 699 reports that were gathered from on FAERS database. Women reported more CV adverse events with rizatriptan and zolmitriptan as compared to men. The CV adverse event risk was highest among individuals aged 18-64. Clinical outcome analysis showed that sumatriptan carries a higher CV risk than rizatriptan and zolmitriptan, and most deaths and serious cases have been documented for sumatriptan. The patients prescribed sumatriptan or zolmitriptan were at a higher risk of reporting CV events for chest pain and chest discomfort, compared to rizatriptan. This finding may provide support for the clinical observation and risk evaluation of triptan treatment
A Pre-Matriculation Pharmacy Calculations Module Enhances Student Performance in First Year Pharmacy Calculations Course.
No full textLeading Biologics in Pharmacy Practice: The Role of Pharmacists
No full textEvaluate the current approaches to handling biologics, identify challenges associated with their storage and preparation, and emphasize the critical role of pharmacy education in ensuring safe and effective management of biologics
