Dartmouth Institute for Health Policy and Clinical Practice
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Appalachia Winter/Spring 2009: Complete Issue
Get PDFWinter/Spring 2009 - Volume LX, Number 1 - issue #227. What are we afraid of? Facing up to grizzlies, ghosts, wolves, crevasses—and ourselves
The Evolution of Open Access
Get PDFThe Open Access landscape is changing rapidly. With the OSTP’s “Nelson Memo” mandating public access without embargo for all federally funded research by 2026, we can expect significant shifts in the research publishing ecosystem. It is in this wider context that the Dartmouth Libraries decided to shift strategies in funding Open Access, including the long-standing APC Fund. In this workshop, we cover questions about these shifts including the advance of different Open Access policies and public access mandates, the way publishers have adapted their models, the values that inform the Libraries’ public access strategy, and the continued support available for faculty who wish to publish Open Access. The Libraries’ commitment to open and public access remains robust
Regulation of Lipid Composition of the Golgi during Tissue Formation: Where Does PI 4-Kinase Stand?
No full textFour Wheel Drive (Fwd), the Drosophila homologue of PI 4-kinase IIIβ, is a conserved phosphatidylinositol 4-kinase (PI4K) that localizes to the Golgi apparatus and functions in protein trafficking from the Golgi to the plasma membrane. The goal of this project was to determine how the localization of Fwd to the Golgi is regulated during early embryogenesis in Drosophila. Our initial observations suggested that Fwd was only localized to a subset of Golgi apparatus, raising the question of whether distinct types of Golgi apparatus exist in early Drosophila embryos. By optimizing imaging conditions, we found that many Golgi compartments initially identified as Fwd-negative showed weak Fwd-GFP signals, arguing against the existence of a sub-population of Golgi that completely lack Fwd. In addition, we found that phosphatidylinositol 4-phosphate (PI4P), the lipid product of PI4Ks, were both strongly enriched on the plasma membrane and weakly associated with intracellular puncta-like structures. These intracellular signals appear to overlap with Fwd-GFP, suggesting that Fwd colocalizes with its lipid product on the Golgi apparatuses. Together, our findings demonstrate that Golgi apparatuses differ in their capacity to recruit Fwd, which may impact their rate of PI4P production. These observations raise the question of how the activity of individual Golgi apparatuses are regulated in developing tissues.https://digitalcommons.dartmouth.edu/wetterhahn_2024/1003/thumbnail.jp
Beyond average: The active processing of information in ensemble perception
No full textEnsembles can be found in daily life. Surveying faces in a crowd, generalizing states of objects (ex. clean vs. dirty tables in a restaurant)---they all require computing averages. Previous studies have shown that observers can quickly and automatically extract information about means of groups. Through a task of reporting orientations of sets of triangles, we hypothesized that participants should be more accurate when averaging large groups than remembering individual items.https://digitalcommons.dartmouth.edu/wetterhahn_2024/1007/thumbnail.jp