3872 research outputs found
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Role of Teaching Assistants in NKU Organic Chemistry Course-Based Undergraduate Research Experience (CURE) Labs
No full text2021 Celebration of Student Research and Creativity presentation"In the traditional lab setting, many organic chemistry students find themselves following step-by-step instructions provided by the instructor and/or lab manual. This method does not allow the student to fully understand the underlying concepts or learn to problem solve in the lab. Course- Based Undergraduate Research Experiences (CURE) labs allow students to think critically about the science behind what they are doing, and problem solve along the way. However, running such a complex lab has proven too difficult for a single instructor, thus requiring the help of two teaching assistants to help with the utilization of important lab equipment as well as general lab procedures and
protocols."https://youtu.be/ev7IpcR1zQ
Image Processing of Transiting Exoplanets with the NKU 14-inch Telescope
No full text2021 Celebration of Student Research and Creativity presentation"NKU’s Schneider Observatory, located on campus atop Founder’s Hall, features a 14-inch Schmidt- Cassegrain telescope mounted on a German equatorial mount with computer control capabilities. The high precision of this telescope system allows us to perform differential photometry of variable objects with sufficient sensitivity to detect exoplanets. Research is continuing on developing a custom image processing pipeline, which will enable us to produce light curves with complete control over the processing techniques. In this presentation, we will discuss the preliminary data we have been able to obtain with the telescope as well as the benefits and challenges of constructing an image
processing pipeline from scratch."https://youtu.be/0qBNUdeSU7
Grief and the Impact of Spiritual Beliefs
No full text2021 Celebration of Student Research and Creativity presentation"Loss and Grief is a topic that impacts everyone in the world. Many individuals struggle with the grief process and the negative effect it can have on one’s life, including one’s own mental health. The purpose of this study is to gain an understanding of how one’s Spiritual beliefs may impact their grief journey. Several interviews were completed to gain a firsthand account of how their spiritual beliefs impacted their grief process. These results will help the mental health field gain a deeper understanding of how our belief systems can impact grief in a positive way."https://youtu.be/_JSMx9v5If
The Impact of tRNA-Phe Anticodon Loop Modifications on Oxidative Stress Recovery in Saccharomyces cerevisiae
No full text2021 Celebration of Student Research and Creativity presentation"Transfer RNA anticodon loop modifications in the form of 2`-O methylations are critical for efficient translation in Saccharomyces cerevisiae (brewer’s yeast). The methyltransferase Trm7 associates with proteins Trm732 and Trm734 to methylate the thirty-second (C-32) and thirtyfourth (G- 34) nucleotides of tRNA- Phe, respectively. Yeast strains lacking either modification show healthy phenotypes, but sick growth is exhibited when both modifications are absent.
Because oxidative stress necessitates efficient protein production, translational deficiencies may be magnified in trm732Δ and trm734Δ exposed to oxidative stress. It is established that trm7Δ mutants show lowered oxidative stress resistance, but the relative extent of trm732Δ and trm734Δ stress resistance is less understood. Spot tests confirm lowered stress resistance in trm7Δ mutants, but not in trm732Δ and trm734Δ mutants."https://youtu.be/LHdM1pzzO3
In vitro reconstitution of the shikimate pathway: a new tool for probing MST enzyme mechanisms
No full text2021 Celebration of Student Research and Creativity presentation"The MST enzymes (menaquinone, siderophore, tryptophan) are structurally homologous proteins that utilize chorismate in the biosynthetic pathways that generate aromatic amino acids, folate, quinones, and siderophores. Inhibitors of these enzymes could serve as new antibiotics. To help inform inhibitor design our lab will measure kinetic isotope effects in MST enzymes using isotopically labeled chorismate.
Chorismate is naturally synthesized in bacteria, fungi, and plants with the seven-enzyme shikimate pathway. Here we report the in vitro reconstitution of the shikimate pathway utilizing heterologously expressed shikimate enzymes combined with substrates and cofactors in a one-pot reaction to generate chorismate."https://youtu.be/0xtmTZ1IMn
Impact of Maternal Helminths on Learning and Memory
No full text2021 Celebration of Student Research and Creativity presentation"Neuroinflammation can occur during development and cause cognitive impairments. Helminths have been shown to reduce cognitive disfunction and inflammation if given to mom and pups, but never if given to moms before she has her pups. We hypothesize that maternal helminth colonization will reduce the cognitive impairment associated with neonatal E. coli infection and an LPS injection in adulthood. We also hypothesize that maternal helminth colonization will reduce neuroinflammation in pups following an E. coli infection. Mom rats were inoculated with helminths to act as anti- inflammatories to observe effects on her offspring early in life and when they are trying to learn as adults.
PCR arrays were run on the tissue of the hippocampus of P1 and P4 pups. Context Pre-Exposure Facilitation Effect was then performed on P60 rats to evaluate freezing on the third day.
Results showed that there was a significant difference between females and males, with females freezing more than males, especially when given LPS. Rearing and grooming showed no significant difference. The PCR arrays on the P1 and P4 pups showed change in neonatal brains depending on mom treatment, sex, and age. We can start to see more gene expression within certain genes depending on the gender and treatment the mom received and the age of the neonates. In conclusion, adult female rats froze more than males, but more research will continue as more rats are added to the Context PreExposure Facilitation Effect paradigm. In neonatal brains, there are various variables affecting cytokines. Those variables include maternal treatment, sex, and age. Research will continue as more rats are added to explore these findings."https://youtu.be/Vcrbkq_DQ5
The Effect of Health Disparities on Academic Success
No full text2021 Celebration of Student Research and Creativity presentation"Health disparities are preventable differences in health resulting from a social problem that disproportionately affects marginalized populations.
The purpose of this study is to determine how disparities in health affect academic performance. Data was collected through a crosssectional study using non-probability, simple random sampling survey distributed through social media. Results showed that health status had no effect on academic performance however data may have been significantly impacted by the pandemic occurring at the time of data collection. The results of future research that examines the intersectionality of gender and racial identities can be used to advocate for increased accessibility to
health care for students"https://youtu.be/B6EztGg1KU
Understanding Drug Addiction in the United States
No full text2021 Celebration of Student Research and Creativity presentation"The number of individuals effected by drug addiction is increasing each year. Addiction can come in many ways whether it be Alcohol, narcotics, or opioids, people fall victim every day Many people are perplexed as to why or how some become addicted to drugs. They may falsely believe that drug users lack moral values or motivation, and that they should simply choose to avoid using drugs. This presentation will inform you on what drug addiction is and how these individuals get treated. It will also explain opioid abuse and discuss interdisciplinary perspectives from different social sciences and explain how each discipline can contribute to this individual. Also provide an understanding that there is
lack of treatment these individuals face daily."https://youtu.be/8oWbISHQnP
Perceptions of Law Enforcement and Social Work Collaboration
No full text2021 Celebration of Student Research and Creativity presentation"Nationally, crime incidents increasingly gain media attention. Media sources increasingly criticize police, suggest they are given too much authority/responsibility and argue that situations would have been better addressed by social services. This study explores the perceptions of individuals that have had previous interaction(s) with law enforcement, and if they feel their situation would have been better addressed by social services. Data is collected virtually via a self- administered 5-minute survey. This research will result in targeted policy initiatives and improved social service interventions for law enforcement interactions, as well as an improved and targeted research focus based on these preliminary results."https://youtu.be/civ34k8oSl
A Comparison of Tropinone Derivative Synthesis Protocols in an Undergraduate Research Chemistry Course Laboratory
No full text2021 Celebration of Student Research and Creativity presentation"Heterocyclic compounds are ideal candidates for pharmaceutical compounds. They are used as mediums in the synthesis of anticancer medicines. I80- H37 is one such possible molecule created by direct heteroarylation via Palladium catalyst. I80-H37 is a heterocyclic compound featuring a tropinone scaffold with a single nitrogen group.
Physiochemical properties were analyzed using Molinspiration and Percepta software to determine the compound's active drug potential. This study compares different methods for synthesizing I80-H37 to increase production efficiency and the potential efficacy of I80-H37 as a vehicle for anticancer drug delivery."https://youtu.be/Qwz6ATMBoL