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Hotspot hypothesis on Oscheius tipulae using CRISPR/Cas9
Get PDFSpecies within a converging or shared gene regulatory network (GRN) can have the instance where a gene may be gained and lost over time due to the evolution of that GRN. As an example of this, one gene of interest that seems to affect tail tip morphogenesis (TTM) among nematodes is dmd-3. In one of the species of nematodes, C. elegans, dmd-3 was found to be required and sufficient for TTM. Knowing this, a hypothesis was made that dmd-3 is a repeatedly co-opted gene (master regulator), also known as an evolutionary hotspot, where it would be a gene that was required and sufficient to bring about TTM among all nematodes that have the ability to display TTM – this is the hotspot hypothesis. Our results from the experiment did not support the hotspot hypothesis, where even though an O. tipulae sample contained the mutation to yield dmd-3 (-), TTM still occurred. Taking these results into account, it can be concluded that dmd-3 did not play a role in TTM and is not conserved from evolution in the GRN. This tells us how the evolution of the GRN could potentially occur through mutations in cis-regulatory elements (CREs), co-option of transposable elements (TEs) as new CREs, loss of transcriptional inputs in existing CREs, and/or remodeling of CREs (Carroll 2008)
Unfolding Entrepreneurial Resourcefulness: A Systematic Literature Review
Get PDFPurpose– Literature on entrepreneurial resourcefulness (ER) has grown constantly in the last two decades. ER is a construct that describes the specific behavior of entrepreneurs, focusing on the generation and deployment of resources to pursue an opportunity. Since the ER literature has expanded and diversified, the purpose of this study is to integrate its findings with existing knowledge about the construct.
Design/methodology/approach–Thestudyappliesasystematicliteraturereview approach, following the methodology of Tranfield et al. (2003). The authors identify and synthesize 31 studies focusing on ER.
Findings– The literature on ER can function on four different levels: (1) individual, (2) organizational, (3) contextual, and(4) effectual level. Studies on ERconcentrate oneither theindividualortheorganizational level, with the contextual and effectual levels appearing as additional study categories for the studies. Behind this categorization, research views ER either as an antecedent influencing a specific effect or as an outcome resulting from a particular context.
Originality/value– This paper is the first of its nature, structuring the existing ER research and proposing a research agenda on ER with seven concrete research avenues and their research questions. Based on the systematic literature review, the authors develop a framework consolidating the interrelations of the different levels
Innovation In Nonprofit Organizations In The Post-pandemic Era: An Exploratory Study
Get PDFUsing firsthand insights from nonprofit executives, our study aims to contribute to a refined understanding of innovation within nonprofit organizations, particularly in the aftermath of a disruptive event – the COVID pandemic.
Design/methodology/approach
We adopted an inductive, qualitative approach based on in-depth personal interviews with executives of ten nonprofit organizations operating in the Northeast of the United States.
Findings
Our study uncovers the main challenges facing nonprofit organizations in the aftermath of the global pandemic. Our findings provide empirical evidence of how nonprofit organizations responded to these challenges through innovative efforts. We also have identified the innovation-enabling factors and types of innovation that allowed nonprofit organizations to sustain their services and social mission in the aftermath of this disruptive event.
Originality/value
By capturing the perspectives of nonprofit leaders, we contribute to the literature on how nonprofit organizations and nonprofit leaders pursue innovation after a disruptive event that dramatically alters routines and established practices
Reference Book Area 2012
No full textReference book area, 2012.https://digitalcommons.sacredheart.edu/libraryhistoryphotos/1049/thumbnail.jp
Gloria Naylor Discussion
No full textGloria Naylor discussion, Ryan Matura Library June 2009.https://digitalcommons.sacredheart.edu/libraryhistoryphotos/1089/thumbnail.jp
Library Resource Center
No full textNew library resource center at CHE, 2017.https://digitalcommons.sacredheart.edu/libraryhistoryphotos/1081/thumbnail.jp
Whole Blood in Trauma
No full textHemorrhage is a leading cause of death in trauma patients. Whole blood administration in trauma has gained a renewed interest in recent years, however the concept is not new at all, with its origins spanning over 100 years. Field experience in United States’ military conflicts has provided important data on the efficacy of whole blood in reducing mortality and amount of blood product administration. Civilian trials however have not necessarily shown similar results. The safety of whole blood however does not seem to be in question given the available data, and is an acceptable option for blood replacement in the hemorrhaging trauma patient
The Efficacy of Purified Pollen Extract for Reducing Vasomotor Symptoms in Women: A Systematic Review and Meta-Analysis
No full textImportance: Menopause impacts the quality of life for women, with symptoms varying from hot flashes to night disturbances. When menopausal hormonal therapy is contraindicated or women refuse menopausal hormonal therapy, many consider alternatives such as pollen extract for treating vasomotor symptoms.
Objective: This meta-analysis focuses on the impact of using purified pollen extract as a treatment option to reduce vasomotor symptoms in women, specifically focusing on symptoms such as hot flashes, night disturbances, myalgias, and depression.
Evidence review: A comprehensive literature search was conducted using the following Boolean search string women OR females AND purified pollen OR pollen extract OR cytoplasmic pollen OR Bonafide OR Femal OR Estroven OR Serelys AND menopausal symptoms OR vasomotor symptoms OR hot flashes OR night sweats OR sleep disturbance. Publications in English from 2003 to the present were included. To assess the risk of bias, authors used the Cochrane Risk-of-Bias 2 for a randomized controlled trial and Risk-of-Bias in Non-Randomized Studies of Interventions (ROBINS-I) for observational studies. Using ReviewManager, a Der Simonian-Laird random-effects model meta-analysis was conducted to determine the standardized mean differences (SMDs) in the outcomes for each study.
Findings: Five articles were retained: one randomized controlled trial and four observational studies (N = 420). An overall decrease in scores from the baseline of studies compared with a 3-month follow-up after purified cytoplasm of pollen (PCP) treatment was recognized when compiling the data. Overall, there was significant improvement across all outcomes at 3 months: hot flashes demonstrated an overall improvement in SMD of -1.66 (P \u3c 0.00001), night disturbance scores were improved with an SMD of -1.10 (P \u3c 0.0001), depression scores were improved with an SMD of -1.31 (P \u3c 0.0001), and myalgia had an improvement in SMD of -0.40 (P \u3c 0.00001). When controlled studies were pooled for meta-analysis, outcomes, however, were no longer statistically significant.
Conclusions and relevance: Evaluating the risk-to-benefit ratio of alternative therapies, such as PCP extract, is important to care for women who cannot take traditional vasomotor symptom therapies. Pooled data from controlled studies evaluating PCP extract suggest that vasomotor symptom improvements seen in noncontrolled studies may have been due to the placebo effect; however, its use was not associated with significant adverse effects
Faculty Publications 2022
No full textFaulty publications, 2022.https://digitalcommons.sacredheart.edu/libraryhistoryphotos/1071/thumbnail.jp
Building Teacher Resiliency To Alleviate Burnout: An Action Research Study In An Urban Middle School
Get PDFThis mixed-methods research was completed as part of an Improvement Science Dissertation in Practice (ISDiP) study, which implemented a peer coaching cycle intervention that sought to build resiliency and alleviate teacher burnout in an urban middle school. The resiliency intervention was created based on the results of environmental scans, Maslach (2018) Burnout Inventory results, and a teacher survey which informed root causes. The research questions explored how the peer coaching intervention influenced teacher burnout and what components of the intervention were perceived as most useful. The study used non-probability convenience sampling of seventh-grade teachers. The intervention included six resiliency categories focused on student social-emotional learning (SEL), teacher social-emotional competencies, restorative practices, mindfulness, positive behavior intervention system (PBIS), and self-care. After each lesson, participants completed an exit ticket and the Daniilidou and Platsidou (2018) Teacher Resiliency Sub-Scale. After the coaching concluded, the researcher conducted exit interviews and facilitated the postsurveys. Paired t-tests indicated significance in decreased burnout and increased resiliency