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Induction of Thymidylate Synthase Associated with Multidrug Resistance in Human Breast and Colon Cancer Cell Lines
No full textABBREVIATIONS: 5-FU, 5-fluorouracil; FdUMP, 5-fluoro-2'-deoxyuridine-5'-monophosphate; TS, thymidylate synthase; 5,1 0-methylene-H4PteGIu
Clinical Neuroscience Branch, Nationallnstitute of Mental Health, and Laboratory of Clinical Studies, Nationalinstitute of AlcoholAbuse and Alcoholism
No full textuntitled
No full textAbstract. -Asthma is a major epidemic affecting up to one third people in developed countries over the last decades, and making a crucial impact on morbidity rates. The classical characters of asthma in human are airway inflammation, airway hyperreactivity, and airway remodeling. Hygiene hypothesis, inflammation cells and signaling pathway in asthma were involved in Toll-like receptors (TLRs). TLRs are a kind of pattern recognition receptors, which are important in recognition of various pathogens. TLRs have been seen as a key target for asthma treatment, so a promising approach for asthma treatment was adopted to the multiwayly modulating toll-like receptors way
Composites with tuned effective magnetic permeability
No full textRev. Lett. 84, 4184 ͑2000͔͒ have shown that the effective magnetic permeability, , of free space can be rendered negative over a certain frequency range by a periodic arrangement of very thin conductors with suitable magnetic resonance properties, the so-called split-ring resonators. Because of its rather bulky architecture, this structure does not lend itself to a proper integration into a reasonably thin real composite structural panel. To remedy this fundamental barrier, we invented a new magnetic resonator consisting of very thin folded plates that are suitably nested within one another to form folded-doubled resonators ͑FDRs͒ that can be integrated into an actual composite panel. Measurements, using a focused beam electromagnetic characterization system combined with time-domain numerical simulations of the reflection and transmission coefficients of such a composite slab have revealed that indeed the composite has a negative over a frequency range of about
Basic Research Program of China (2005CB522901) and the National Natural Science Foundation of China
Full text linkWe have previously shown that Toll-like receptor (TLR)-activated murine nonparenchymal liver cells [(NPC); Kupffer cells (KC), liver sinusoidal endothelial cells (LSEC) ] T he hepatitis B virus (HBV) is a hepatotropic DNA virus that can lead to chronic hepatitis, which can be complicated by the development of liver cirrhosis and hepatocellular carcinoma. Current approved therapeutic strategies for treatment HBV include interferon-alpha (IFN-␣) and nucleoside and nucleotide analogs. 1,2 However, only a minority of patients that are treated with these agents show a long-term sustained response with "eradication" [for example, hepatitis B surface antigen (HBsAg) loss] of the virus
Composition profiling of InAs quantum dots and wetting layers by atom probe tomography and cross-sectional scanning tunneling microscopy Citation for published version (APA): Composition profiling of InAs quantum dots and wetting layers by atom probe tomo
No full textPlease check the document version of this publication: • A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement: www.tue.nl/taverne Take down policy If you believe that this document breaches copyright please contact us at: [email protected] providing details and we will investigate your claim. This study compares cross-sectional scanning tunneling microscopy and atom probe tomography. We use epitaxially grown self-assembled InAs quantum dots (QDs) in GaAs as an exemplary material with which to compare these two nanostructural analysis techniques. We studied the composition of the wetting layer and the QDs, and performed quantitative comparisons of the indium concentration profiles measured by each method. We show that computational models of the wetting layer and the QDs, based on experimental data, are consistent with both analytical approaches. This establishes a link between the two techniques and shows their complimentary behavior, an advantage which we exploit in order to highlight unique features of the examined QD material
South Africa 5 Young Researchers & Elite Club
No full textAn analytical strong method, the homotopy analysis method (HAM), is employed to study the mixed convective heat transfer in an incompressible steady two-dimensional viscoelastic fluid flow over a wedge in the presence of buoyancy effects. The twodimensional boundary-layer governing partial differential equations (PDEs) are derived by the consideration of Boussinesq approximation. By the use of similarity transformation, we have obtained the ordinary differential nonlinear (ODE) forms of momentum and energy equations. The highly nonlinear forms of momentum and energy equations are solved analytically. The effects of different involved parameters such as viscoelastic parameter, Prandtl number, buoyancy parameter, and the wedge angle parameter, which is related to the exponent of the external velocity, on velocity and temperature distributions are plotted and discussed. An excellent agreement can be seen between the results and the previously published papers for (0) and (0) in some of the tables and figures of the paper for velocity and temperature profiles for various values of viscoelastic parameter and Prandtl number. The effects of buoyancy parameter on the velocity and temperature distributions are completely illustrated in detail
Group Classification of a Generalized Lane-Emden System
No full textWe perform the group classification of the generalized Lane-Emden system + + ( ) = 0, + + ( ) = 0, which occurs in many applications of physical phenomena such as pattern formation, population evolution, and chemical reactions. We obtain four cases depending on the values of n
Leiv Eirikssons vei 39, NO-7491 Trondheim, Norway, 4 Physics of Geological Processes
No full textSince the first reconstruction of the supercontinent Pangaea, key advances in plate tectonic reconstructions have been made • compared with plate tectonic reconstructions for the corresponding period. We did not detect oceanic plate remnants from the Carboniferous period (∼300-360 Myr ago), or before, suggesting that the tomographic visibility of subduction is limited to the past 300 Myr. Since the first qualitative plate reconstruction of the supercontinent Pangaea was determined by fitting palaeoclimatic belts and modern continental margins, key advances in plate reconstructions have been made with the development and use of palaeomagnetic apparent polar wander paths, ocean floor magnetic anomalies and hotspot reference frames 1,2 , leading to global plate tectonic reconstructions Seismic tomography studies of the mantle have allowed for increasingly detailed correlations between deep mantle structure, mostly focused on presumed remnants of subducted plates and plate tectonic evolution Here, independently of any reconstruction model, we carry out a global interpretation of positive seismic anomalies in the lower mantle based on the assumptions that these reflect relativel