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Is Arizona’s Senate Bill 1070 a degenerative policy? Latinos say yes, and no. Implications for Latinos and Democracy in a Trump World
Get PDFSchneider and Ingram’s theory of policy design (1997) states that policy making includes a process through which knowledge is socially constructed and is a domain in which power elites are able to manipulate symbols, rhetoric, images, and distort logical lines of inquiry to justify policies that privilege certain social groups while stigmatizing and disenfranchising others. Policies act as lessons, and individuals, in turn, then internalize messages on their value to society based on the policies that are assigned to them. Using qualitative data in the form of in-depth interviews conducted with Latinos in Arizona, this paper asks, Is Arizona’s Senate Bill 1070 a degenerative policy? Findings show that a degenerative policy as S.B. 1070 causes harm by obstructing the political integration of Latinos and Latino immigrants in the United States, as they report feeling increasingly targeted by the state and repeatedly portrayed as criminals and security threats. As a result, Latinos tend to alienate and have little to no desire to engage in conventional forms of political participation. Especially given the fact that Donald Trump is now president, public administration as the action part of government has the opportunity to play a crucial role in changing these dynamics into a more positive scenario, one in which democracy is strengthened rather than stifled, that upholds key values of social justice and equity in its interactions with the constituents it serves (especially by street-level bureaucrats), and is devoted to community building and improvement
COVID-19 and Mass Sections in Business Education: Adaptation and Innovation Stemming from the Emergency Online Transition
Get PDFThis paper describes three instructional design cases impacting over 3,500 students annually and taught by midcareer female mass section faculty from one of the largest business schools at a tier-one public research university in the Southern region of the US. The three instructors of mass sections describe how they transitioned their face-to-face or hybrid courses from “Emergency Response Teaching” mode to considered distance learning implementation during the COVID-19 crisis. The cases include discussions of learning management system supplements, improvements to peer-to-peer interactions, course structure changes impacting student success, and remote experiential learning group projects featuring community partners. The challenges and solutions described may offer insights to educators and instructional designers
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Racial disparity in drug disposition in the digestive tract
Get PDFThe major determinants of drug or, al bioavailability are absorption and metabolism in the digestive tract. Genetic variations can cause significant differences in transporter and enzyme protein expression and function. The racial distribution of selected efflux transporter (i.e., Pgp, BCRP, MRP2) and metabolism enzyme (i.e., UGT1A1, UGT1A8) single nucleotide polymorphisms (SNPs) that are highly expressed in the digestive tract are reviewed in this paper with emphasis on the allele frequency and the impact on drug absorption, metabolism, and in vivo drug exposure. Additionally, preclinical and clinical models used to study the impact of transporter/enzyme SNPs on protein expression and function are also reviewed. The results showed that allele frequency of the major drug efflux transporters and the major intestinal metabolic enzymes are highly different in different races, leading to different drug disposition and exposure. The conclusion is that genetic polymorphism is frequently observed in different races and the related protein expression and drug absorption/metabolism function and drug in vivo exposure can be significantly affected, resulting in variations in drug response. Basic research on race-dependent drug absorption/metabolism is expected, and FDA regulations of drug dosing adjustment based on racial disparity are suggested
Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms
Get PDFChrysin is a promising naturally occurring flavonoid mainly found in honey and propolis. Although chrysin\u27s biological activities have been demonstrated and the mechanism of actions has been determined using in vitro and in vivo models, results from the current clinical studies were largely negative. A potential reason for chrysin\u27s low efficacy in humans is poor oral bioavailability. In this paper, we reviewed the preclinical and clinical pharmacokinetics studies of chrysin and analyzed the mechanism of poor in vivo efficacy with emphasis on its bioavailability and ADME mechanism. Low aqueous solubility, rapid metabolism mediated by UGTs and SULT, efficient excretion through efflux transporters including BCRP and MRP2 are the major reasons causing poor systemic bioavailability for chrysin. However, because of efficient enterohepatic recycling facilitated by phase II metabolism and efflux, chrysin\u27s bioavailability in the low GI tract is high. Thus, chrysin can be ideal for treating diseases in the terminal ileum and colon (e.g., carcinoma, local infection) since it is localized in the lower GI tract with limited delivery to other organs
Pharmacokinetic model analysis of supralingual, oral and intravenous deliveries of mycophenolic acid
Get PDFMycophenolic acid (MPA) is commonly used for organ rejection prophylaxis via oral administration in the clinic. Recent studies have shown that MPA also has anticancer activities. To explore new therapeutic options for oral precancerous/cancerous lesions, MPA was designed to release topically on the dorsal tongue surface via a mucoadhesive patch. The objective of this study was to establish the pharmacokinetic (PK) and tongue tissue distribution of mucoadhesive MPA patch formulation after supralingual administration in rats and also compare the PK differences between oral, intravenous, and supralingual administration of MPA. Blood samples were collected from Sprague Dawley rats before and after a single intravenous bolus injection, a single oral dose, or a mucoadhesive patch administration on the dorsal tongue surface for 4 h, all with a dose of 0.5 mg/kg of MPA. Plots of MPA plasma concentration versus time were obtained. As multiple peaks were found in all three curves, the enterohepatic recycling (EHR) model in the Phoenix software was adapted to describe their PK parameters with an individual PK analysis method. The mean half-lives of intravenous and oral administrations were 10.5 h and 7.4 h, respectively. The estimated bioavailability after oral and supralingual administration was 72.4% and 7.6%, respectively. There was a 0.5 h lag-time presented after supralingual administration. The results suggest that the systemic plasma MPA concentrations were much lower in rats receiving supralingual administration compared to those receiving doses from the other two routes, and the amount of MPA accumulated in the tongue after patch application showed a sustained drug release pattern. Studies on the dynamic of drug retention in the tongue after supralingual administration showed that ~3.8% of the dose was accumulated inside of tongue right after the patch removal, ~0.11% of the dose remained after 20 h, and ~20.6% of MPA was not released from the patches 4 h after application. The data demonstrate that supralingual application of an MPA patch can deliver a high amount of drug at the site of administration with little systemic circulation exposure, hence lowering the potential gastrointestinal side effects associated with oral administration. Thus, supralingual administration is a potential alternative route for treating oral lesions