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GENOTOXICITY ASSESSMENT OF CONVENTIONAL AND CAD/CAM DENTURE BASE MATERIALS
Get PDFAim: In prosthodontics, polymethyl methacrylate (PMMA) has been widely used. Their biocompatibility and potential genotoxicity remain a concern due to the residual monomer release. Computer-aided design and manufacturing (CAD/CAM) denture base materials have emerged and offered some improved mechanical and physical properties compared to the standard conventional heat-cured denture base material. However, their long-term biocompatibility remains unstudied. Therefore, this study evaluates the genotoxicity effects of conventional and CAD/CAM denture base materials on human gingival fibroblasts (HGFs). Methodology: Disk-shaped samples were fabricated of six denture base resins, including heat-cured PMMA, milled PMMA, and four 3D-printed resins. HGFs were exposed to the extracts of these materials after incubation in a cell culture medium for 1 and 7 days. Then, DNA double-strand breaks (DSBs) were quantified using the γ-H2AX assay. Statistical analysis compared DNA damage levels across groups. Results: All materials showed initial DNA damage at baseline exposure (1 day). However, after 7 days, significant differences emerged. The 3D-printed resins (Ivoclar Ivotion Base Print and Sprintray High Impact Denture Base) showed the highest reduction in DNA damage, while heat-cured PMMA showed the least improvement. The other 3D-printed and milled PMMA resins displayed intermediate recovery. Conclusion: None of the investigated materials has reached the γ-H2AX genotoxicity threshold. CAD/CAM fabricated denture bases showed superior biocompatibility in both time points, likely due to optimized polymerization and reduced leaching monomer
Gendered Disabilities Project Report
Get PDFThis report presents our yearly progress in the third year of the Gendered Disabilities Project that aims to collect data and create a digital database on the experiences of Muslim women as people with disability or caretakers, including their access to healthcare services. With the outbreak of the COVID-19 pandemic, which has influenced the structure of our research and has strong implications for our research topic, we have integrated the issue into our themes. Meanwhile, we adapted our methodology to the measures and thus conducted the interviews virtually. The remainder of this report first focuses on the integration of COVID19 research into the project, followed by the statistics of this year, and then concludes with the Disabilities Conference. Originally published in 2022
Antibiotic Resistome Changes Associated with Different Types of Corrosion Inhibitors When Chlorine is Used as a Disinfectant
No full textDrinking water distribution systems contain chlorine and metals that can promote antibiotic resistance. Corrosion inhibitors are required to prevent the leaching of metals into drinking water. While utilities have a choice of which corrosion inhibitor they employ, the impact of corrosion inhibitor type when combined with chlorine on antibiotic resistance is unknown. The objective of this research was to understand the impacts of zinc orthophosphate, sodium orthophosphate, and sodium silicate, three commonly used corrosion inhibitors, on antibiotic resistance when mixed with chlorine. Culture-based plating was paired with metagenomics analysis on lab-scale microcosms. The addition of all three corrosion inhibitors resulted in a significantly higher absolute abundance of antibiotic resistant bacteria with resistance to rifampicin, sulfamethoxazole, and vancomycin, while the addition of phosphate-based inhibitors (sodium orthophosphate and zinc orthophosphate) at 1 mg/L also resulted in significantly higher absolute abundance of ampicillin-resistant bacteria. Exposure to all three types of corrosion inhibitors and free chlorine led to significantly higher abundances of ARGs conferring resistance to the target antibiotics used in the phenotypic assessment. Observed changes in the resistomes compared to the controls were influenced by an enrichment in ARGs responsible for multidrug resistance and resistance to peptide antibiotics. In general, most of the ARGs were associated with chromosomes, but a significant increase in the number of ARGs colocated with plasmid and integron sequences was observed. In contrast, the abundance of viral-associated ARGs decreased in the treatments compared to the controls. These results highlight the importance of corrosion inhibitor selection and the potential impacts on antibiotic resistance in potable water systems
Corrigendum to: Health Equity and Children with Medical Complexity/Children and Youth with Special Health Care Needs: A Scoping Review [Journal of Pediatric Health Care 38/2 (2024) 210-218]
No full textThe author regrets that the printed version of the above article contained a number of paragraphs without proper citations. The correct and final version follows. The authors would like to apologise for any inconvenience caused. The author used the terms Children with Medical Complexity (CMC) and Children and Youth with Special Health Care Needs (CYSHCN) interchangeably in this article. These terms, as they are currently used today, are further explained in a Letter to the Editor from David Geyer PhD, RN, CPNP-PC, published in the J Pediatr Health Care. (2024). 38, 789-790
Professional Skills for Behavior Analysts: A Survey on the Proficiency and Importance of Hard and Soft Skills
No full textIndividuals seeking certification as board certified behavior analysts (BCBAs) require training in both hard and professional (soft) skills. Trainees seeking certification complete coursework, supervised fieldwork experience, and a BCBA exam that assesses mastery of hard skills. However, training and mastery of soft skills is not as defined. BCBAs are also expected to maintain these skills throughout their career. Previous research has shown that soft skills are viewed as important by clients and their caregivers but are not consistently demonstrated from those providing services. Research also suggests that BCBA trainees may not consistently receive training on soft skills. The current study presents the results of a survey distributed to individuals who supervise BCBAs on the proficiency of hard and soft skills demonstrated by their supervisees. The results suggest future directions for the research and training of soft skills for current and future BCBAs
