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Measurement of Oxidative Stress to Allow the Development and Use of New Therapies in Lower Urinary Tract Dysfunction: Ici-rs 2025
No full textAIMS:Evaluate current knowledge of the physiological and clinical consequences of oxidative stress on the development of lower urinary tract dysfunction (LUTD), identify clinically relevant biomarkers and potential therapeutics.METHODS: This review summarizes topics discussed during Proposal #7 at the International Consultation on Incontinence Research Society 2025 meeting and derives a consensus of future research directions.RESULTS: Pelvic ischemia/hypoxia can result in LUTD including detrusor over-/underactivity, bladder pain syndrome and nocturia. Major causes of bladder ischemia include aging, atherosclerosis and bladder outlet obstruction. The bladder wall undergoes physiological cycles of ischemia and reperfusion with normal filling and emptying: thus, infrequent voiding habits, co-morbidities and some medications can exacerbate LUTD. Ischemia can lead to oxidative stress which is an increase in reactive oxygen species (ROS), superoxide and the hydroxyl radical, over enzymatic antioxidants, superoxide dismutase and glutathione peroxidase. ROS can be generated by monoamine, xanthine and nicotinamide adenine dinucleotide phosphate oxidases, but the main source is dysfunctional mitochondria. Biomarkers of oxidative stress such as 8-hydroxydeoxyguanosine, indicative of DNA damage, can be measured in plasma and urine. Soluble guanylate cyclase activators have been recently demonstrated to have beneficial actions in several LUTD by ameliorating prostatic hyperplasia, bladder overactivity, cellular senescence and fibrosis.CONCLUSION: Many LUTD were identified as having links to oxidative stress. There are still questions regarding correlation of the severity of oxidative stress to LUTD symptomology, the selectivity of biomarkers and the most efficacious druggable target. These were considered key research directions for future studies
A multi-focal model of Chinese tourists' well-being
Get PDFDespite the significant rise in research interest exploring the psychological benefits of tourism experiences, current concepts of well-being in tourism are largely shaped by Western perspectives. A new model, titled the multi-focal model of Chinese tourists' psychological well-being (Fig. 1), extends the Confucian psychological well-being perspective from one- dimensional to two-dimensional by acknowledging the influences of individualism and globalization toward modern Chinese tourists (Wong et al., 2024). It represents efforts toward revealing the pivotal dimensions of psychological well-being concerning tourism activities from a non-Western lens. As Chinese tourists are the largest outbound market in the world (Chen et al., 2023), this framework provides an alternative perspective to analyse their motivations and intentions in the tourism context. It extends the traditional one-dimensional Confucian perspective of well-being to include both eudaimonic and hedonic aspects, blending traditional and modern lenses. The model categorizes the Confucian dimensions identified from the literature review into two main groups: The traditional lens and the modern lens. The traditional lens contains the dimensions related to the Confucian virtues and collectivism that guide tourists to a virtuous life. The modern lens includes dimensions unrelated to Confucian teachings, influenced by individualism, globalization, mass media and social media (Hsu and Huang, 2016). An empirical study will be conducted to validate the multi-focal model and further explore the key factors contributing to Chinese tourists' psychological well-being, offering new insights into how traditional and modern influences shape their tourism experiences
Papua and New Guinea housing commission 1968 – 1983: Optimism within islands of practice in the provision of housing
No full textExtract:When on September 16, 1975, Papua New Guinea gained independence and became the newest island-nation-state in the Pacific region, processes of decolonisation were already underway.Amongst the issues facing the new nation-state was an acute and persistent housing shortage, a crisis that had been described in detail by Balwant Singh Saini in a 1973 report commissioned by Michael Somare, the Chief Minister of Papua and New Guinea, titled “Urban Housing in Papua New Guinea.” In response to the report, the mandate of the Territory of Papua and New Guinea Housing Commission (TPNG HC), formed in 1968 to provide housing for public servants and their families, was broadened.At Independence the rebadged National Housing Commission (NHC) was tasked with strategies for housing all Papua New Guinean migrant workers. But because attention in the lead-up to Independence was focused on urgent governance issues (the drafting of a new constitution, the floating of a new currency), the NHC, unhitched from the Commonwealth andwith limited interdepartmental exchange or oversight, sustained a culture that supported architectural experimentation: an island of innovative practice in a sea of bureaucratic uncertainty
‘Just Enough’ Parenting Support: Piloting a 3-session live and online parenting program for the prevention and treatment of disruptive behaviour problems in young children
No full textFinding the root cause: Embedding vegetable education into pre-health professional programs using an iterative mixed-methods approach
No full textReduced consumption of fruits and vegetables is linked to an increased risk of noncommunicable diseases and chronic health issues. With health professionals at the frontline of patient care, there has been an identified need to enhance vegetable education throughout training programs. In undertaking this curriculum change, Design-Based Research (DBR) presents a modern framework highly suitable for health professional programs due to its focus on co-development with a variety of stakeholders. This study aimed to utilise a DBR approach to develop insights and recommendations into what would constitute an effective and evidence-based vegetable curriculum that can be embedded within a pre-health professional course. This study underwent a five-phase iterative process of DBR with a mixed-methods research approach used to collect both quantitative and qualitative data to explore stakeholders’ perceptions. The results provide three evidence-based recommendations for educators and curriculum developers to assist in the creation and embedding of vegetable education into a pre-health professional curriculum. Firstly, this study highlights that any resource or curriculum change should be simple, focussing on reiterating the regional government’s recommended intake of vegetables and fruits. Moreover, any resource should involve hands-on activities such as laboratories or workshops and be embedded directly into the curriculum rather than self-study options. With the five phases, DBR provides an ideal framework for educational research due to its iterative design and the engagement of stakeholders
Children, families, and immigration enforcement
No full textAlthough there is now a large and sophisticated literature on ethical or moral matters relating to family immigration and immigration enforcement, the intersection of these topics has not been greatly explored. This is unfortunate, as particular and difficult normative issues arise in relation to immigration enforcement when applied to children and to families where some members are unauthorized migrants and others are citizens or authorized migrants (“mixed-status” families). This chapter addresses this deficit, explaining some of these special difficulties and providing suggestions as to how they may be addressed
Supporting music production education through Artificial Intelligence tools
No full textEducating musicians in music production necessitates student engagement with a wide range of music technologies. It also involves the development of specific knowledge regarding techniques, theoretical application and the technical operation of these tools. Supporting students to navigate the complexities of engagement with such a diverse range of practice-based activities is relevant to supporting music production education. Developing a range of strategies to support student learning can be beneficial to curriculum delivery design. The fluidity of learning enabled through online access to on-demand information extends the scope of possibility regarding when and where learning occurs. Engagement with using music technology tools can involve knowledge and skill development as part of the process of music production. In practice-based activities like music production, the processes of learning and creating have become interchangeable. Previous studies have investigated how just-in-time resources can be utilised to support music production education using mobile or other information technologies. Just-in-time resources can improve student engagement by making learning more accessible, personalised and relevant to their current focus. Generative artificial intelligence tools have exhibited potential for extending the sophistication, scope and application of engagement with just-in-time learning. The design of just-in-time learning resources that harness the power of artificial intelligence tools has enhanced the potential of supporting resources for practice-based activities like music production. This chapter revisits the key design principles of just-in-time learning identified through previous studies and discusses exploratory opportunities for just-in-time learning to be expanded by the addition of artificial intelligence tools
Editorial: Health professions education at a time of triple planetary crises
Get PDFThis Research Topic, “Health professions education at a time of triple planetary crises,” includes nine articles that explore various dimensions of how health professions education must respond to the interrelated crises of a changing climate, biodiversity loss, and pollution. Collectively referred to as a “Triple Planetary Crisis,” this phrase is no longer metaphorical. In late 2023, editors of more than 200 health journals urged the World Health Organization (WHO) to declare this interconnected climate-nature crisis a global health emergency, warning that it meets all the criteria for severity, international impact, and urgency of action (1). Separating the climate and nature (biodiversity loss and pollution) crises has led to fragmented responses and missed opportunities in terms of synergistic solutions. It is important to understand that the Planetary Health crisis encompasses climate change, biodiversity loss and pollution and needs to be addressed urgently. Subsequently, the development of eco-ethical leadership for dealing with planetary changes is an imperative in healthcare professions education (2)
Blockchain-enabled value co-creation in construction projects: evidence from a moderated mediation model in China
No full textBlockchain is reshaping value co-creation in construction projects. Although previous studies have recognized the value of blockchain in construction, its effects on value co-creation and boundary conditions remain empirically underexplored. This study develops a conceptual framework linking blockchain and construction project value co-creation based on organizational information processing and dynamic capabilities views. A questionnaire survey was conducted, and the framework was tested using partial least squares structural equation modelling. The results show that blockchain significantly facilitates integration management and stakeholder collaboration, both of which enable value co-creation in construction projects. Moreover, government support positively moderates the relationship between blockchain and stakeholder collaboration, while its moderating effect on the relationship between blockchain and integration management is insignificant. The moderating role of task–technology fit between blockchain, integration management and stakeholder collaboration is also confirmed. These findings contribute to the literature on blockchain implementation and value co-creation in construction projects and offer practical insights for policymakers and practitioners involved in project management and policy formulation
Inflammatory bowel disease
No full textThe purpose of this activity is to demonstrate how general practitioners can identify people with inflammatory bowel disease early by maintaining a high index of suspicion and ordering faecal calprotectin tests when inflammatory bowel disease symptoms are present