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Electrochemical Sensors, Biosensors, and Optical Sensors for the Detection of Opioids and Their Analogs: Pharmaceutical, Clinical, and Forensic Applications
No full textPharmaceutical opioids are intravenously or orally administered analgesics. While they are effective in relieving chronic and acute pain, their narrow window of therapeutic use contributes to the high occurrence of abuse. The associated abuse of this family of drugs can be correlated to the increase in dependency, overdose, and death of users. The negative effects of opioids extend beyond the physical and psychological effects experienced by the user to their unregulated synthesis and sale, which contribute to socioeconomic challenges and are a biproduct of this global public health epidemic. From clinical to point-of-care applications, the detection and real-time monitoring of this family of drug is critical in the fight to decrease abuse and improve use in clinical settings. Chromatographic separations and chromatography–mass spectrometry are traditional methods of opioid analyses, but the high cost, long analysis time, and absence of portability highlight the need for the development of fast, in situ, point-of-care analysis, or of community drug monitoring services. This review highlights recent electrochemical and optical (FTIR, Raman, colorimetric, and fluorescent) advances and biosensors for pharmaceutical and illicit opioid analysis. Specifically, an emphasis is placed on the detection of opioids and their metabolites in biological samples and in vitro cellular assays for clinical diagnosis and forensic applications. The challenges and prospects of the role of electrochemical sensors, biosensors, and optical sensors for opioid analysis in promoting clinical diagnosis, forensic study, point-of-care, and community drug monitoring services to reduce harm are also provided
Le dix-neuvième siècle : les mouvements littéraires français et la classe ouvrière
No full textThis presentation is an analysis of the connections between the different literary movements of 19th century France, such as romanticism, realism, and modernism, and how they were initiated by the French revolutions of 1830 and 1848. It covers the impacts of these revolutions on different prolific 19th century French writers such as Alphonse de Lamartine, Victor Hugo, Honoré de Balzac, and Charles Baudelaire, and how each writer prompted their respective movements
Who claims the federal adoption tax credit? Those who know about it
No full textThis research investigates which individuals are aware of and claim the federal adoption tax credit. Using a probit model, I find that the probability that one claims the credit increases with one\u27s income and is lower for Black adoptive parents compared to White ones. These discrepancies in usage stem from different probabilities of knowing about the credit. However, conditional on awareness, I find that the probability of claiming the credit is no different among members of differing income or racial groups, implying that a direct way to increase take-up of the tax credit could simply be increasing awareness of it
Flannery O\u27Connor and Storytelling Unit of Study
Get PDFThe Writing for Success grant sponsored by the federal Department of Education pioneered the creation of a standards-based fifth grade unit of study focused on Flannery O’Connor and the theme of local storytelling. This project utilizes an author study, digital humanities, and intensive writing instruction to engage students with an important Georgia writer and boost their interest and engagement with various forms of written and oral expression.
Through exposure to a variety of communication forms, including narrative, informational, and opinion writing in addition to oral history, poetry, song, and podcasting, students gain confidence in evaluating the context and audience of their desired message and utilizing communication styles that best match the message. Students also engage with local history through the anchor text Flannery O’Connor: A Girl Who Knew Her Own Mind and supporting text Everybody Has a Story to Tell: Stories of Flannery O’Connor’s Milledgeville, in addition to their own interviews with family and friends.
The culminating task asks students to create their own podcast episode using the skills they’ve learned over the course of the unit. Earlier assignments will have prepared them for a variety of podcasting styles, whether narrative, informational, or opinion based. This presentation seeks to share the unit of study with O’Connor scholars and encourage its dissemination to K12 schools in the state of Georgia. It seeks to review project outcomes and examine future potential for author study based K12 curriculum and promote engagement with O’Connor-related resources in the Milledgeville area, including Andalusia, Home of Flannery O’Connor, Ina Dillard Russell Library Special Collections, and Memory Hill Cemetery
1) Early Onset Osteopenia Assessments in College Aged Students
Get PDFIntroduction: Osteopenia and osteoporosis are diseases of severe bone mineral density loss. Approximately fifty-million individuals in the United States over the age of fifty suffer from osteopenia or osteoporosis; with seventy-five percent of cases effecting women. There has been a noted thirty-five percent increase in diagnoses of osteopenia and osteoporosis since 2008, with a dramatic increase in cases regarding women under thirty years of age. Typically, the onset of osteopenia and osteoporosis in women has occurred around fifty years of age, making these recent diagnoses of osteopenia and osteoporosis in young females quite alarming. As early onset osteopenia and osteoporosis are characterized by bone fragility, the potential for long-term consequences later in life due to structural deterioration is severe; particularly in the lower lumbar spine, pelvis, and femoral neck-head regions. As such, it is essential to implement early bone mineral density detection to facilitate the maintenance of healthy bone density and the remediation of deteriorating bone mineral density. Methods: Two-hundred and fifty, male and female, graduate and undergraduate students, of diverse racial backgrounds, between the ages of eighteen and thirty, were recruited for participation in the bone mineral density assessments. Assessments were conducted on an Encore Dual X-Ray Absorptiometry (DEXA) scanner. The Total-Body DEXA scan provided a complete densitometry assessment of bone mineral density by all regional sites, including head, arms, legs, ribs, spine, and pelvis. Data Analysis: Independent Sample T-tests were applied to assess participants bone mineral density in relation to known healthy values based on age and gender
Music in Stone: the application of Rasa theory on Jain temple architecture
No full textRasa theory is a theory of Indian aesthetics that defines a difference between the normal, everyday, personal emotions we experience, and the transcendent, universal emotions evoked by good art. Rasa theory attempts to define ‘good’ art, as well as explain how the universal transcendent art-emotions can be reached by looking at classic examples of theater, poetry, music, painting, and sculpture. Only recently in Western academia has architecture become a consideration in the application of rasa theory. With the beautiful and extravagant details major Jain temples such as Ranakpur, Dilwara, and Ellora are renowned for, I hope to investigate how these spaces can evoke rasa through their intended design and the application thereof. I hope to do this by first examining the basic concepts of rasa theory introduced by ancient Indian scholar Bharata Muni and explaining the importance of his theory in the study of understanding aesthetic philosophy, and then applying his theory by looking at how various aspects of rasa are applied in Jain temple architecture
Do Previous Grades Affect Current Parental Restrictions?
No full textPrevious literature has questioned whether the number of parental restrictions affect a child’s self-esteem; however, it has not been questioned if a child’s previous grades affect the number of future parental restrictions. To analyze this question, I am using the National Longitudinal Study of Adolescent to Adult Health, courtesy of Harris, et al. (1994-2018). My preliminary results show that there is no statistically significant effect of previous grades on future parental restrictions; however, the father figure’s level of education, the child’s past level of self-esteem, and child’s grade level proved to have an effect on parental restrictions. I found that a father figure’s level of education and a child’s grade level reduce the number of restrictions, while a child’s self-esteem increases the number of restrictions
Design and Synthesis of a Sol-Gel Colorimetric Sensor for Methamphetamine Detection
No full textA silica sol–gel colorimetric sensor was developed for more efficient detection of methamphetamine (MA). A more reliable RGB detector was designed and machined with the goal of consistent and accurate measurements while eliminating errors caused by human differences in the current RGB detector that relies on visual analysis. Simon’s reagents were entrapped within the polymeric network of the silica sol–gel matrix. The resulting sensor solution was contained within a micro-PCR tube, resulting in a more convenient and simple method of on-site testing by directly adding a sample MA solution. The sol–gel colorimetric sensor was synthesized to demonstrate the qualitative analysis of methamphetamine with digital image colorimetry using a Red-Green-Blue (RGB) basic color program. The interaction of the colorimetric Simon’s reagents, the functionality of the reagents, and the structural integrity of the doped silica sol-gel were examined using an RGB color program as well as validated using Ultraviolet/Visible (UV/Vis) spectroscopy. These results demonstrate that the sol–gel matrix has the potential to be used as an on-site colorimetric sensor for methamphetamine detection. Furthermore, the inherent nature of sol-gel sensor interaction gives potential for alternative drug sensors to be experimented with and explored. This presentation will highlight the experimental methodology and results of the sensor development
Parade- a dramaturgy casebook
No full textThe 1998 musical Parade, written by Alfred Uhry and Jason Robert Brown, is based on the 1913 murder of Mary Phagan and the subsequent 1915 lynching of Leo Frank as a result of antisemitic rhetoric. This research serves as a dramaturgical casebook on the show, breaking down the historical context of turn-of-the-century Georgia and the legacy of bigotry in the United States in relation to the play. This case study breaks down the authorial intent and background, of past productions while highlighting possible issues of how a show written in 1998 (and set in the 1900’s) would resonate with a current audience. In the musical Parade, Alfred Uhry and Jason Robert Brown show the legacy that white supremacy holds in the United States and the environment that enables bigotry. When performed, it can be an excellent example of how justice can be miscarried in favor of political convenience but also comes with the challenge of portraying sensitive imagery and topics