3631 research outputs found
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Rebecca Becky Brock Interviewed by Charlotte Aexel
Get PDFCharlotte Aexel interviews Becky Brock about being the first in her family to attend college and what Georgia State College for Women was like in 1965.
Listen to the podcast version here:
YouTube
https://youtu.be/XgFDYm092tU
Spotify
https://spotifyanchor-web.app.link/e/By5r78iRgMbhttps://kb.gcsu.edu/collectingthepast/1015/thumbnail.jp
Sandra Rosseter Interviewed by Juliann Mackiewicz
Get PDFJuliann Mackiewicz interviews Sandra Rosseter on beginning her journey at Georgia State College for Women and the impact of Flannery O’Connor.
Listen to the podcast version here:
YouTube
https://youtu.be/7aCyKiL9Sxo
Spotify
https://spotifyanchor-web.app.link/e/oKjIu9iRgMbhttps://kb.gcsu.edu/collectingthepast/1013/thumbnail.jp
Mechanisms Underlying Novel Roles of Rpt-1 in Long-term Synaptic Plasticity
Get PDFSynaptic plasticity refers to the changing of synaptic strength and underlies the ability of the nervous system to store information. A cellular process of increasing synaptic strength is long-term potentiation (LTP) which is thought to be critical for long-term memory consolidation. Many molecular processes such as new gene transcription and translation as well as protein degradation play a role in LTP. Regulated protein degradation occurs through the ubiquitin-proteasome pathway (UPP) in which ubiquitin-tagged substrate proteins are degraded by the 26S proteasome, a structure containing a 20S catalytic core and two 19S regulatory subunits. The UPP has also been shown to have a non-proteolytic role by participating in gene transcription, which is required for LTP. While previous work suggests a role of the proteasome regulatory particle Rpt1 in gene transcription, the precise amino acids within this subunit that are targets for cellular signaling that enable it to travel to the nucleus for transcriptional regulation have not been previously revealed. Chemical long-term potentiation (cLTP) on mouse hippocampal slices was used to induce synaptic strengthening. cLTP experiments were performed in the absence or presence of exogenous peptides. Each peptide was specifically designed to contain a different sequence that mutated amino acids that are targets for attachment of a Small Ubiquitin-like Modifier (sumoylation) or phosphorylation, both of which are hypothesized to regulate LTP. Immunohistochemistry was then performed with antibodies against a specific amino-acid sequence called an HA tag that was included in the Rpt1 peptides. By visualizing nuclear translocation of these mutants with immunofluorescence, efforts were made to determine what specific amino acids are required within Rpt1 to regulate transcription of memory-related genes. It was concluded that sumoylation and phosphorylation are likely necessary for nuclear translocation of Rpt1 as revealed by the experiments on mutant peptides. The results from the present study broadly suggest that the proteasome, specifically Rpt1, is likely to have a non-proteolytic role in long-term synaptic plasticity
Prevalence and Correlates of Tobacco Use in Rural Georgia
No full textObjectives. We assessed the prevalence and sociodemographic correlates of tobacco use among adults in rural Georgia. Methods. We used the National Adult Tobacco Survey questionnaire to collect data on current use of cigarettes; cigars, cigarillos, or small cigars; chewing tobacco, snuff, or dip; water pipes; snus; and pipes. Eligible participants were 18 years and older residing in selected rural county in South Georgia. Survey was conducted through phone calls, web-based and in person collection. Analyses were stratified by gender, age, race/ethnicity, and education. Results. County prevalence of current use was 20.8% for cigarettes; 19.6% for cigars, cigarillos, or small cigars, 13.3%% for e-cigarettes and 4% for smokeless tobacco such as chew, dip, or snus. Tobacco use in any form was greatest among respondents who were male, younger (25-44yrs), and lived in unincorporated area of the county. Cigarette and e-cigarette use was greatest among those with higher education compared to cigars, cigarillos, or small cigars which was greatest among lesser educated respondents. Conclusions. Cigarette use in this rural county is higher than state and national estimates. Evidence-based prevention strategies are needed to decrease tobacco use and the health and economic burden of tobacco-related diseases
Does party school rank affect applications?
No full textSyracuse University, the University of Texas at Austin, the University of Florida, Pennsylvania State University, and the University of Iowa all have one thing in common- they have all been previously ranked as a top party school in the US. I estimate whether being named the top party school has effect on university applications by using panel institution-level application data from IPEDS and party school rankings from Princeton Review. My preliminary results show there is no statistically significant effect on applications from being ranked as the top party school
Noah Pendrey
No full textThe LOFAR Two Meter Sky Survey (LOTSS) and the Faint Images of the Radio Sky at Twenty cm. Survey (FIRST) have both been creating catalogues of radio emitting galaxies across the Northern sky. We analyze detections and radio fluxes of binary interacting galaxies from the preliminary results of FIRST along with data from the newly released LOTSS catalogs. The sample of interacting galaxies was chosen from the K-band selected; Herschel observed set of gravitationally bound major merger candidates (H-KPAIRS) which include star forming members. These pairs have been the subject of studies with the Herschel Space Telescope. Our sample has IR derived dust masses and star formation rates (SFRs) based on the assumptions that IR emission is created by thermal sources. Newly measured spectral indexes (144-1400 MHz) including data from this early LOTSS reveal the contributions of thermal vs. non-thermal sources contributing to any far-infrared derived star formation rates (SFR) such as active nuclei. We also examine any morphological type dependence of our results such as statistical differences among the pairs categorized as spiral-spiral pairs of spiral elliptical pairs
Synthesis of Tetraethyl orthosilicate (TEOS)-based Sol-Gel Nanoparticles with Controlled Drug Release Properties
No full textWhile HIV and AIDS incidence has optimistically decreased in the United States, African Americans remain the foremost racial group implicated in burgeoning diagnoses. This disproportionate affinity is substantially forged from the scarce and discriminatory prevention care (PrEp) to which they are predisposed. Diverging from conventional routes of drug delivery will increase ease of use, thereby improving patient compliance and optimizing patient outcomes - the fundamental motivation for this undergraduate research project. Many biomolecules including drugs like Tenofovir disoproxil fumarate (TDF), HIV antiviral, can be released from sol-gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. Tetraethyl orthosilicate (TEOS)-based hydrogels, with drug-releasing properties, were formulated through TEOS hydrolysis followed by modifications to the volume and pH of the colloidal suspension. After entrapping and encapsulating fluorescein as a prototypical drug, the drug-release properties were investigated by altering the pH and age of the sol-gel nanoparticles. Ultraviolet/visible (UV/Vis) and fluorescence spectroscopy were used to monitor the fluorescein release. Future work includes imaging of the sol-gel nanoparticle using scanning electron microscope (SEM). The experimental methodology and preliminary results will be highlighted in the presentation
Reconstructing Fossil Lacustrine Plant Habit
No full textEvolution into aquatic habitats, including lacustrine (lake) environments, required vascular land plants to adapt by acquiring conservative growth forms and tissue types. These growth forms are found in zones ringing the shoreline of lakes. Plant distribution is strongly correlated with the duration and depth of water. Therefore, paleobotanist can contribute useful data regarding aquatic plant diversity, to aid in reconstructing ancient lake environments. In this contribution, we illustrate how the aquatic plants present, their preservation, and the sedimentology can help discern past wetland environments. Our study employs field data, collections, and published results to document the diversity and growth form of aquatic plants present at two localities: Paleocene localities in North Dakota and later environments from the Eocene Age Okanagan highland floras. Based on our findings, the North Dakota site represents deposits in a meandering stream system with oxbow lakes. In contrast, the Eocene lake systems in the Okanagan floras were deposited in deep lakes, in grabens, in a tectonically active region. The habits of the aquatic fossil plants found in the Okanagan floras, with the exception of water ferns, indicate that material from the river system feeding the lake contained marshes and oxbow lakes. These results indicate that fossil plant form is a good proxy to help sedimentologists assess surrounding environments to the those documented by a stratigraphic section
Alcohol Effects on Locomotor and Aggressive Behaviors of Betta splendens
No full textBetta splendens elicit aggressive dominance displays when presented with eliciting stimuli, such as a mirror or conspecific (e.g., Shapiro & Jensen, 2009). Previous findings showed alcohol decreased aggression in Betta fish, but its impact was unclear on movement since CNS depressants reduce locomotor behavior (Carvalho et al., 2015). In this study we assessed the effects of alcohol on aggressive dominance displays of Betta fish at varying doses and determined displays impacted by locomotor behavior. Following Carvalho et al. (2015), we assessed motor performance of 11 male Bettas using a 5x5-inch square open-field apparatus following alcohol exposure. The open field features matte white Plexiglas walls, a clear base, and a visible grid-like pattern. Test sessions lasted 15 minutes. Fish were first exposed to the apparatus for 15 minutes a day for three days without exposure to alcohol. Then, fish were tested in the open field after alcohol exposure (0 ml, 0.75 ml, 1.5 ml, or 2.5 ml) per 473 ml of water. Following a 5-minute alcohol exposure period, the fish were placed into the open field. Locomotor activity was calculated by the distance traveled by the number of gridlines crossed. Subsequent dominance display testing was conducted in home tanks once daily. During testing, subjects were exposed to alcohol for 5 minutes prior to exposure to a mirror for 2 minutes. To determine the effects of alcohol on locomotor behavior, we will conduct a one-way within-group ANOVA, with alcohol dose as the independent variable and line crosses in the open field as the dependent variable. To assess alcohol’s effect on aggressive displays, we will conduct a series of one-way within group ANOVAs with alcohol dose as the independent variable and amount and duration of displays as dependent variables. Results will further understanding of Betta fish behavior and psychoactive substances’ impact on aggression
Quantifying costs and benefits of alternative overwintering strategies in a southeastern population of Timber Rattlesnakes (Crotalus horridus)
Get PDFTemperate reptile populations are under strong selective pressure to minimize the costs of extreme winter temperatures. For high latitude and high elevation snake populations, this has often favored communal overwintering behavior, wherein large numbers of conspecifics aggregate at optimal sites given the limited availability of such features in the environment. Timber Rattlesnakes (Crotalus horridus) are distributed across a wide latitudinal gradient in North America, and therefore represent ideal models for exploring how variable winter selective regimes might favor different strategies. Here, we leverage a unique intermediate population of C. horridus from central Georgia, USA, that exhibits both communal and solitary overwintering. By combining remote videography, radio telemetry, and accelerometry from 2022 to present, we quantified relative costs and benefits of communal and solitary overwintering behaviors. Migration distance (mean±S.E.) for communal rattlesnakes (649.96±110.73) was significantly greater than that of solitary individuals (332.10±66.59) (t41.5=2.95, p=0.005). Binomial logit models revealed a positive effect of daily maximum temperature on basking frequency across all rattlesnakes (ES=0.87±0.15, pp=0.03). Despite higher travel costs incurred by communal snakes, individuals might trade-off these costs for increased winter basking opportunities. However, we also documented individual plasticity in this system, with several rattlesnakes shifting between communal and solitary sites across years. Moving forward, we will incorporate temperature datalogging at overwintering sites and physiological monitoring of snakes to better understand the proximate and ultimate drivers of these alternative overwintering strategies