Rzeszów University
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The risk of recurrence of Crohn's disease after rescue procedures and the levels of selected metalloproteinases in the wall of the gastrointestinal tract
No full textPromotor: dr hab. n. med. David Aebisher, prof. UR - 76 s.Wstęp: Choroba Leśniowskiego-Crohna jest nieswoistą
chorobą zapalną jelit, która jest przewlekłą chorobą
obejmującą jelito kręte i/lub jelito grube. Jednocześnie
może dotyczyć każdej innej części ludzkiego ciała, czyli
od ust do odbytu. Objawy są bardzo uciążliwe i
powodują znaczne obniżenie jakości życia, a czasem
nawet kalectwo i trwałe uszkodzenie przewodu
pokarmowego, który do końca życia wymaga żywienia
dojelitowego lub pozajelitowego.
Cel: Celem pracy było zbadanie metaloproteinaz
tkankowych jako markerów nawrotu choroby
Leśniowskiego-Crohna.
Metodyka: Grupy eksperymentalne obejmowały 30
pacjentów w wieku od 23 do 70 lat, ze średnią wieku
40,4 lat. Zebrane tkanki zamrożono, a następnie
rozdrobnione tkanki homogenizowano buforem Ripa
Lysis na lodzie. Supernatant otoczono i cztery
metaloproteinazy - MMP 3, MMP 7, MMP 8 i MMP 9 -
analizowano za pomocą testu immunoenzymatycznego
z użyciem zestawów SEA101HU, SEA102Hu, SEA103Hu i
SEA553Hu (Cloud-Clone Corp., Kata, TX, USA).
Wszystkie analizy chemiczne przeprowadzono w trzech
powtórzeniach. Zawartość metaloproteinazy wyrażono
jako średnią ± odchylenie standardowe.
Wyniki: W wyniku oznaczeń potwierdzono, że MMP 3 i
MMP 8 istotnie wpływały na możliwość nawrotu
choroby Leśniowskiego-Crohna. Natomiast MMP7 i
MMP 9 nie wykazały wpływu na nawrót choroby
Leśniowskiego-Crohna.
Wnioski: Badania wykazały, że oznaczenie stężeń
metaloproteinaz pacjentów mogą przyczynić się do
dokładnej analizy następstw związanych z obecnością
czynników wywołujących chorobę.Introduction: Crohn's disease is an inflammatory bowel
disease that is a chronic disease involving the ileum
and/or large intestine. At the same time, it can affect
any other part of the human body, from the mouth to
the anus. The symptoms are very troublesome and
cause a significant reduction in the quality of life, and
sometimes even disability and permanent damage to
the gastrointestinal tract, which requires enteral or
parenteral nutrition for the rest of life.
Aim: The aim of the study was to investigate tissue
metalloproteinases as markers of Crohn's disease
recurrence.
Methods: The experimental groups included 30
patients aged 23 to 70 years, with a mean age of 40.4
years. The harvested tissues were frozen and then the
comminuted tissues were homogenized with Ripa Lysis
buffer on ice. The supernatant was capped and four
metalloproteinases - MMP 3, MMP 7, MMP 8 and MMP
9 - were analyzed by enzyme immunoassay using kits
SEA101HU, SEA102Hu, SEA103Hu and SEA553Hu
(Cloud-Clone Corp., Kata, TX, USA). All chemical
analyzes were performed in triplicate.
Metalloproteinase content was expressed as mean ±
standard deviation.
Results: The tests confirmed that MMP 3 and MMP 8
significantly affected the possibility of recurrence of
Crohn's disease. In contrast, MMP7 and MMP 9 showed
no effect on Crohn's disease recurrence.
Conclusions: Studies have shown that the
determination of patients' metalloproteinase
concentrations can contribute to a thorough analysis of
the consequences associated with the presence of
disease-causing agents
Effectiveness of health education on knowledge, attitude and practice regarding junk food consumption among interns in a tertiary health care center in Chennai, India – a quasi-experimental study
No full textEthical approval obtained from the Institutional Ethics Committee, Government Medical College, Omandurar Government Estate, Chennai (IEC approval No: 68/IEC/GOMC/2022).Introduction and aim. Junk foods are defined as any of various pre-packaged foods that are high in calories but low in nutritional value. This study was done to evaluate the effect of health education intervention on the knowledge, attitude, and practices regarding junk food consumption among MBBS interns at the tertiary health care center in Chennai, India.
Material and methods. This was a quasi-experimental study conducted from January to March 2023 among 105 CRMIs of a Government medical college in Chennai, India. After getting Institutional Ethics Committee approval, data was collected using a pretested self-administered semi structured questionnaire before and after health education intervention.
Results. The majority (55.2%) of the respondent interns were hostellers. There was a significant increase in the knowledge (p<0.001), healthy attitude (p<0.001), and healthy practice (p<0.001) concerning junk food intake following health education intervention.
Conclusion. Routine repeated sessions promoting health should be implemented in the medical curriculum in order for our future physicians to live a long healthy life as well as to set a good exampl
Ukrainian secular intelligentsia of the late 18th and first half of the 19th century: its origins, upbringing and role in social and political life (as illustrated by the Lviv Stauropegion Institute)
No full textW niniejszym tekście przeprowadzono analizę udziału ukraińskiej świeckiej inteligencji końca XVIII i pierwszej połowy XIX wieku w kulturze, nauce oraz polityce Galicji. Wykazano, że do 1848 roku jedyną świecką instytucją reprezentującą inteligencję ukraińską był Lwowski Instytut Stauropigialny. Dominującą grupę wśród świeckiej inteligencji ukraińskiej stanowili urzędnicy administracji państwowej. Ze względu na pochodzenie społeczne były to głównie osoby wywodzące się z rodzin duchowieństwa greckokatolickiego, rzadziej z rodzin inteligencji. W pierwszej połowie XIX wieku wspólnie z duchowieństwem greckokatolickim kierowali ruchem narodowym Ukraińców w Galicji Wschodniej.This text analyses the participation of the Ukrainian secular intelligentsia of the late 18th and first half of the 19th century in the culture, science and politics of Galicia. It shows that until 1848, the only secular institution representing Ukrainian intelligentsia was the Lviv Stauropegion Institute. The predominant group among the Ukrainian secular intelligentsia were officials of the state administration. Due to their social origin, they were mainly from families of the Greek Catholic clergy, less often from families of the intelligentsia. In the first half of the 19th century, together with the Greek Catholic clergy, they led the national movement of Ukrainians in Eastern Galicia
Improving diabetes mellitus care in Nigeria – health promotion and education perspectives
No full textIntroduction and aim. In this review, we suggest ways to improve diabetes mellitus (DM) care in Nigeria from a Health Promotion and Education (HPE) perspective by addressing the gap in DM care through the adoption of strategies from the Ottawa Charter and National Health Promotion Policy (NHPP) guidelines.
Material and methods. This review conducted a comprehensive literature search on Africa Journal Online, PubMed, Google Scholar, and Science Direct, from 1986 to 2023, using relevant keywords.
Analysis of the literature. The adoption of the Ottawa charter and NHPP remains a key strategy in addressing the gap in DM care in Nigeria. This could be achieved by the adoption of population-focused multi-sectoral interventions encompassing legislation, regulation, and fiscal measures, creating sustaining and expanding health-promoting environments to reduce modifiable risk factors, and reorienting the primary health care services to aid the diagnosis, treatment and rehabilitation of DM patients.
Conclusion. This review concluded that the government and other critical stakeholders should adopt the HPE strategies that covers increased financing, strict legislation on DM modifiable risk factors, reorientation of the primary healthcare system, and capacity building for HPE practitioners into DM care in Nigeria as a strategy to improving DM care and prevention in Nigeria
Social support for older people in the perspective of the functioning of the social assistance system
No full textW okresie znaczących zmian demograficznych przejawiających się znacznym wzrostem liczby osób starszych szczególnie ważne staje się pytanie o aktualne oblicze starości. Starzenie się jest procesem nieuniknionym, naturalnym, nierozerwalnie związanym z upływem czasu. Jest to okres trudny i ze względu na specyficzne potrzeby osób starszych stawia przed państwem oraz jego organami konieczność tworzenia takiej polityki, która pozwoli zapewnić tej grupie osób godne warunki życia. Zasadnicze znaczenie ma zapewnienie właściwych podstaw socjalno-ekonomicznych egzystencji seniorów przede wszystkim poprzez działania z obszaru polityki społecznej (głównie w ramach ubezpieczenia społecznego, ochrony zdrowia i pomocy społecznej). Dla seniorów bardzo ważnym elementem prawidłowego funkcjonowania jest system wsparcia. Może on przybierać formę formalną i nieformalną. Celem artykułu jest analiza i ocena formalnych form wsparcia społecznego osób starszych w perspektywie funkcjonowania systemu pomocy społecznej.In a period of significant demographic changes manifested by a significant increase in the number of older people, the question about the current face of old age becomes particularly important. Aging is an inevitable, natural process, inextricably linked to the passage of time. This is a difficult period and due to the specific needs of older people, it is necessary for the state and its bodies to create a policy that will ensure decent living conditions for this group of people. It is essential to ensure proper social and economic foundations for the existence of seniors, primarily through activities in the area of social policy (mainly within the framework of social insurance, health care and social assistance).For seniors, a support system is a very important element of proper functioning. It may take formal and informal form. The aim of the article is to analyze and evaluate formal forms of social support for older people in the perspective of the functioning of the social assistance system
The Examination of the Popularity and Development of the CodeCup Team Competition
No full textInternational Informatics Olympiad in Teams (IIOT) is a competition for teams of high school students, organized since 2017. Hungary first participated in 2021. CodeCup, our national qualifier competition, gradually gained popularity over the past three years. In 2023–2024, teams have competed in four qualifying rounds. The goal of our research was to find means of increasing the number of competitors in CodeCup, and potentially in other national qualifier competitions as well. Primarily, we wanted to measure the effects of recent changes in the competition rules. We examined trends in the participation of the last three years: the list of involved schools, the age and gender distribution of students, with special regard to the impact of Program’Petition, a lightweight teer of CodeCup, launched in 2023. The results show that the number of schools has not changed significantly, but the number of competitors and the ratio of girls has increased
W kręgu elit intelektualnych Galicji i Polski. Świat wartości Stanisława Tarnowskiego w świetle wspomnień pośmiertnych i mów pogrzebowych (1873–1917)
No full textThe aim of the article is to review the issues present in funeral speeches and posthumous reminiscences that constitute a significant aspect of Stanisław Tarnowski’s work. The basis for these considerations were works available in Digital Libraries Federation. The article focuses on the motifs of creating funeral speeches and posthumous reminiscences, factors shaping human life, politics, and modernization. Funeral speeches and posthumous reminiscences were an important source revealing Tarnowski’s political and philosophical views. They served as a source of his reflections and observations based on participation in many events of social, scientific, and political life.Celem artykułu jest dokonanie przeglądu problemów występujących w mowach pogrzebowych i wspomnieniach pośmiertnych stanowiących istotny nurt twórczości Stanisława Tarnowskiego. Podstawą niniejszych rozważań były utwory udostępnione w Federacji Bibliotek Cyfrowych. W artykule skoncentrowano się na motywach tworzenia mów pogrzebowych i wspomnień pośmiertnych, czynnikach kształtujących ludzkie życie, polityce i modernizacji. Mowy pogrzebowe i wspomnienia pośmiertne stanowiły ważne źródło ukazujące poglądy polityczne i filozoficzne Tarnowskiego. Były źródłem jego refleksji i obserwacji opartych na uczestnictwie w wielu wydarzeniach życia społecznego, naukowego, politycznego
English/French code-switching in later medieval charters
No full textThe spoken use of French in later medieval England cannot be recovered, except insofar as it may be inferred from surviving documents. The use in medieval Latin charters of the French definite article (FA) determining an English Noun (EN) is here taken to be a textually preserved remnant of spoken usage. Following earlier work by Ingham (2009), the FA + EN phenomenon is studied quantitatively, showing that the FA + EN construction occurs where it would accord with code-switching constraints observed in contemporary bilingual communities. Attention is paid in particular to the appearance or otherwise of the phenomenon in contexts featuring a possessive and an adjectival modifier of the Noun, where a clear structural contrast is obtained, as predicted on the assumption that spoken code-switching lay behind the establishment of the charter text. It is further shown that FA+EN is more frequent with a monosyllabic than a polysyllabic Noun, for which a prosodic explanation is proposed, in keeping with the hypothesis that the phenomenon was originally oral. This support for the existence of spoken bilingualism from the 13th century onwards in a professional environment fits the timeframe, furthermore, for the well-known expansion in the penetration of French loan words into English. Alternative explanations that have been proposed for the FA + EN phenomenon are considered but found to be inadequate
Simplified vs modified (reduced) ultrasound 6 joint score in assessing disease activity in rheumatoid arthritis patients
No full textAll subjects gave their informed consent for inclusion before they participated in the study. Approval of Ain Shams University Ethical Committee was obtained.Introduction and aim. With increasing ultrasound US assessment opportunities for tight rheumatoid arthritis (RA) management, more simplified accurate US-assessment is desired in clinical practice. Aim of the work is assessing modified vs simplified ultrasound 6-joint scores relevance in assessing rheumatoid arthritis disease activity.
Material and methods. Fifty-five RA patients were subjected to detailed history, clinical, and musculoskeletal examination with disease activity assessment by clinical disease activity index, simple disease activity index and disease activity score in 28 joints. Com plete blood count, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, anti-cyclic citrullinated peptide antibodies were done. Patients underwent US examination (gray-scale and power Doppler) for wrist, 2nd and 3rd metacarpophalangeal and knee joints bilaterally. Synovitis composite score was added. Two US indices were constructed: simplified S6 and modified M6 joint scores.
Results. Statistical significant positive correlations were high between S6/M6 score parameters (total, grey-scale (GS), power doppler (PD), Composite) and disease activity markers. Both M6 and S6 scores differentiated mild-moderate and moderate-severe disease activity patients. However, only S6 score differentiated remission from mild disease activity patients.
Conclusion. Ultrasound 6-joint scores (especially simplified S6) were rapid, easy and sensitive ultrasound tools assessing rheu matoid arthritis disease activity in clinical practice
Comparative study of pterygium excision with suture and sutureless conjunctival autograft
No full textWritten permissions were obtained from the Ethical Committee of Shri Shankaracharya Institute of Medical Sciences (SSIMS/EC/2022/21). The participants were informed about the purpose, method, and plan of the study by the researchers, and their informed consent were obtained.Introduction and aim. This is a prospective interventional study to compare corneal astigmatism before and after pterygium excision with conjunctival autograft, to determine the difference in mean corneal curvatures before and after pterygium excision, to evaluate the safety and efficacy of autologous blood technique, and sutured conjunctival autograft for primary pterygium.
Material and methods. Patients were divided into group A – pterygium excision+sutured conjunctival limbal autograft and group B – pterygium excision+autologous conjunctival limbal autograft under local anesthesia. The preoperative and post operative K1 and K2 values and BCVA were noted.
Results. There was statistically significant reduction in mean astigmatism at each post operative follow up in group A at 1 week (p=0.0249), 2 weeks (p=0.004), 1 month (p=0.0031) and at 3 months (p=0.0009) and similarly in group B post operative follow up at 1 week (p=0.0011), 2 weeks (p=0.0021), 1 month (p=0.0009) and at 3 months (p=0.0003).
Conclusion. Pterygium surgery decreases the cylindrical error and reverts corneal curvatures to normal, thus improving subjective visual acuity. Astigmatism produced by the pterygium is reduced after surgery We found autologous conjunctival autograft is superior than sutural conjunctival autograft. Pterygium causes astigmatism depending upon the size of pterygium it should be surgically removed to prevent obstruction in the vision