Jacobs Institute of Women's Health
George Washington University: Health Sciences Research Commons (HSRC)Not a member yet
51297 research outputs found
Sort by
Comparing antihypertensive strategies in hypertensive emergencies with heart failure
No full textBACKGROUND: 6.2 million Americans live with heart failure (HF) and are at risk for hospitalization due to hypertensive emergencies. Optimal treatment strategy for acute hypertensive heart failure remains unclear. Our study investigates what treatment modality is most effective in achieving guideline-directed blood pressure control. METHODS: This was a retrospective cohort study of hypertensive emergency with HF exacerbation from 2019 to 2021. The primary outcome was length of time for a 25 % decrease in systolic BP or BP of \u3c160/110 mmHg. Patients were categorized into 4 groups: only oral medications, IV bolus, continuous IV infusion (CIVI), or both CIVI and IV bolus. RESULTS: A total of 120 admissions were analyzed after applying exclusion criteria to a total of 1041 reviewed. Groups were well balanced and similar in characteristics. There were no significant differences in achieving the target BP among groups (ANOVA p = 0.662). CIVI had a nonsignificant trend towards achieving target BP fastest, however, IV bolus administration resulted in significantly fewer days in ICU compared to CIVI without a significant change in total hospital length of stay. Acute kidney injury was the most common complication, occuring in 31 (25.83 %) patients without differences across groups (p = 0.825). CONCLUSIONS: Acute hypertensive heart failure was managed adequately with any treatment modality. Use of IV bolus therapy in these patients was associated with shorter ICU length of stay. Our results add to growing evidence that hypertensive emergencies may be less clinically significant than previously thought
Dual-energy subtraction radiography (DESR): a systematic review and meta-analysis of pulmonary nodule detection
No full textPURPOSE: This study examined the literature to compare the accuracy, sensitivity, and specificity of dual-energy subtraction radiography (DESR) with conventional radiography (CR) in the detection of pulmonary nodules. To our knowledge, no meta-analysis has been conducted to compare DESR with CR. MATERIAL AND METHODS: The authors searched Pubmed using the terms Dual-energy subtraction radiography, and Dual-Energy Chest Radiography. Only studies comparing the detection of pulmonary nodules between DESR and CR were included. Studies utilizing artificial intelligence were excluded. The primary study outcomes analyzed were the mean difference of receiver operating characteristic area under the curve (ROC AUC), mean difference of sensitivity, and mean difference of specificity. RESULTS: Twenty-three studies between 1994 and 2022 were included. Of these twenty-three, eighteen reported ROC AUC statistics. The difference between DESR ROC AUC (mean = 0.7702, SD = 0.1361) and CR ROC AUC (mean = 0.7106, SD = 0.1183) was 0.0597 (P\u3c0.001). Sensitivity data was reported for thirteen of the twenty-three selected studies. The difference between DESR sensitivity (mean = 0.5753, SD = 0.1546) and CR sensitivity (mean = 0.4391, SD = 0.1007) was 0.136 (P\u3c0.001). Specificity data were reported for ten of the twenty-three selected studies. The difference between DESR specificity (mean = 0.753, SD = 0.1575) and CR specificity (mean = 0.764, SD = 0.1168) was -0.011 (P=0.767). This was not statistically significant. CONCLUSIONS: DESR showed superior sensitivity and ROC AUC values compared with CR in detecting pulmonary nodules. There was no difference in specificity
Mechanisms and treatment of pulmonary arterial hypertension
No full textSubstantial progress has been made in the management of pulmonary arterial hypertension (PAH) in the past 25 years, but the disease remains life-limiting. Established therapies for PAH are mostly limited to symptomatic relief by correcting the imbalance of vasoactive factors. The tyrosine kinase inhibitor imatinib, the first predominantly non-vasodilatory drug to be tested in patients with PAH, improved exercise capacity and pulmonary haemodynamics compared with placebo but at the expense of adverse events such as subdural haematoma. Given that administration by inhalation might reduce the risk of systemic adverse effects, inhaled formulations of tyrosine kinase inhibitors are currently in clinical development. Other novel therapeutic approaches for PAH include suppression of activin receptor type IIA signalling with sotatercept, which has shown substantial efficacy in clinical trials and was approved for use in the USA in 2024, but the long-term safety of the drug remains unclear. Future advances in the management of PAH will focus on right ventricular function and involve deep phenotyping and the development of a personalized medicine approach. In this Review, we summarize the mechanisms underlying PAH, provide an overview of available PAH therapies and their limitations, describe the development of newer, predominantly non-vasodilatory drugs that are currently being tested in phase II or III clinical trials, and discuss future directions for PAH research
Genetic counselors\u27 professional identity in North America: A scoping review
No full textProfessional identity (PI) comprises attributes, beliefs, values, motives, and experiences by which people define themselves in a professional role and evolves through socialization with others in the workplace. While there have been several studies exploring the expanding roles of genetic counselors, few have specifically addressed PI. This scoping review aimed to describe the contexts in which PI has been discussed or examined in the genetic counseling literature. Articles were searched using PubMed, Scopus, and CINAHL with a priori terms including and related to PI. Articles based in the United States or Canada and of all study designs, commentaries, and speeches were included. Date of publication was not restricted. Using social identity theory (SIT) to formulate a definition of PI, multiple reviewers applied inclusion and exclusion criteria to all titles, abstracts, and full-text articles with conflicts addressed through consensus among all reviewers. A total of 5523 titles and/or abstracts were screened, and 467 full-text articles were evaluated and categorized as (1) focusing on PI specifically, (2) containing elements of PI although focused on another topic, or (3) not related to PI. Eighty-seven (87) articles were reviewed during the extraction phase. Ultimately, 41 articles were deemed to meet the agreed upon characteristics of PI. While empirical studies of PI among genetic counselors were limited, PI is being addressed in research focused on related areas, including professional development and diversity, equity, and inclusion, as well as in personal accounts, addresses, and commentaries. Sentiments regarding PI voiced by genetic counselors align with those reported among other health professionals. Given the lack of diversity in the field and rapidly expanding opportunities for genetic counselors, there is risk of some members of the profession feeling excluded, which in turn could negatively impact the collective identity of the profession and translate into impacts on patient care. Additional research regarding the PI of genetic counselors is needed
Intrinsic Factors and Psychological Safety Among Nursing Students During Simulation-Based Learning-A Correlational Design
No full textINTRODUCTION: Well-designed simulation-based learning (SBL) experiences enhance students\u27 self-confidence, self-efficacy, clinical judgment, and psychomotor skill development. An emerging concept in SBL research is psychological safety. There is currently no research on factors influencing psychological safety specifically related to the SBL environment, nor is there any literature found to determine whether intrinsic student characteristic, such as self-compassion and resilience, contributes to SBL learning outcomes. The aim of this study is to determine whether there is a relationship between nursing students\u27 intrinsic characteristics (self-compassion, resilience, and anxiety sensitivity) and their psychological safety. METHODS: Bivariate correlation was used to examine associations among sociodemographic variables and outcome variables. Multiple regression was used to determine the predictive nature of the sociodemographic variables. Assumptions for variables in multiple regression models were tested (normal distribution, heteroscedasticity, multicollinearity). All data were analyzed in SPSS, Version 28. The P value of significance was set at 0.05 for all analyses. RESULTS: Most of the 118 participants were non-Hispanic (89%), White (65%), and females (95%). Results of the demographic bivariate analysis revealed no significant differences among this diverse group or semester in the curriculum for psychological safety. The multiple regression found self-compassion (β = 29, P = 0.004), anxiety sensitivity (β = -0.16, P = 0.049), and resilience (β = 0.26, P = 0.004) predict psychological safety. CONCLUSIONS: The importance of creating a psychologically safe learning environment has been recognized as essential to best practices. Our findings suggest that an understanding of student characteristics that impact their perception of psychological safety will allow educators to develop strategies to better support learners in the simulation environment
Recurrent vaginal squamous cell carcinoma mimicking peri-rectal abscess: The role of endoscopic ultrasound
No full textRecurrence of vaginal squamous cell carcinoma (SCC) involving the rectum is extremely rare and usually results from direct spread of the primary tumor. Such cases often present with pelvic metastases and can mimic infectious or inflammatory conditions, complicating diagnosis and delaying treatment. While computed tomography scans are commonly used for diagnosis, they may be misleading. Endoscopic ultrasound (EUS) is crucial for accurately assessing rectal and perirectal lesions. We present the case of a 60-year-old female with a history of vaginal SCC who presented with refractory constipation. Initial imaging suggested a perirectal abscess, but a definitive evaluation with EUS revealed rectal wall thickening and a lesion involving the submucosa. Biopsy confirmed high-grade squamous intraepithelial neoplasia consistent with recurrent vaginal SCC. This case highlights the critical role of EUS in diagnosing recurrent pelvic malignancies with rectal involvement
The role of autoantibodies in post-chikungunya viral arthritis disease severity
No full textPost-chikungunya viral arthritis may persist for months to years after infection and is characterized by relapsing and remitting symptoms. This study investigates the relationship between autoantibodies and chikungunya arthritis severity, providing insights into arthritis pathogenesis. We assessed arthritis measures in a cohort of serologically confirmed chikungunya cases from Colombia between 2019 and 2021 (n = 144). We measured arthritis disease severity, flare intensity, pain, and disability, then plasma antibody levels of rheumatoid factor IgM, anti-cyclic citrullinated peptide (CCP), anti-citrullinated α-enolase peptide 1 (CEP-1), anti-nuclear antibody (ANA), anti-citrullinated vimentin (Sa), and immunoglobulins produced in response to chikungunya, Zika and Mayaro. Finally, we examined the correlation between the arthritis measures with the titers of antibodies hypothesized to play a potential role in arthritis pathogenesis. Cases were characterized by moderate disease severity (Disease Activity Score-28 mean, 3.66 ± 1.23) in current arthritis flare with moderate intensity (Flare Score, 25.42 ± 12.38), moderate pain (61.47 ± 27.23 on visual analog scale 0-100), and some disability (Health Assessment Questionnaire 0.77 ± 0.58). After Bonferroni adjustment, there were no statistically significant correlations between the levels of antibodies and arthritis measures. Weak correlations between rheumatoid factor IgM with arthritis severity and pain (P \u3c 0.01) and anti-CEP1 with disability (P \u3c 0.05) were observed when unadjusted for multiple comparisons. The data suggest that autoantibodies, such as RF, anti-CCP, and anti-CEP-1, do not correlate with post-chikungunya arthritis disease severity, thus unlikely to significantly contribute to pathogenesis. Exposure to other arboviral infections was not related to worse post-chikungunya arthritis. This suggests that other pathways for arthritis disease pathogenesis should be examined.IMPORTANCEThis cohort study describes the correlation between levels of autoantibodies, viral antibodies, and arthritis outcomes, suggesting that autoantibodies known to play an important role in other autoimmune diseases do not correlate with chikungunya arthritis relapse disease severity and are unlikely to contribute significantly to arthritis pathogenesis. This suggests that other pathways for arthritis disease pathogenesis should be examined to identify diagnostic and prognostic markers of alphaviral arthritis
Health, Housing, and Justice: Two-Year Implementation Evaluation of a Health System\u27s Multi-State Medical-Legal Partnership to Address Housing Instability
No full textOBJECTIVE: To assess reach and identify facilitators of and barriers to the implementation of housing-focused medical-legal partnerships (MLPs) within a large healthcare system. STUDY SETTING AND DESIGN: In 2021, Kaiser Permanente (KP) launched the Health, Housing, and Justice (HHJ) Initiative to embed MLPs within five medical centers across four states. KP invested in the capacity of five publicly funded legal aid providers to collaborate with healthcare teams and focus on housing stability. This paper summarizes findings from a mixed-methods implementation evaluation conducted from 2021 to 2023 on staff and system capacity, operational facilitators and barriers, and lessons learned. DATA SOURCES AND ANALYTIC SAMPLE: Data sources included key informant interviews with healthcare and legal staff, surveys of social workers and care navigators, and administrative data on 857 legal referrals made by medical staff in 2022-2023 for housing-related legal support. PRINCIPAL FINDINGS: Implementation characteristics and the rate of referrals varied across each of the six sites engaged in the multisite MLP. Attorneys reported that the MLP enabled access to legal resources for clients who typically would not have access. Most cases (82%) were addressed with fewer than 5 h of attorney time. Key implementation facilitators included clinical champions in the partnering medical team, staff training with a focus on knowledge of housing-related legal issues and MLP referral criteria, and existing social screening processes. Key implementation barriers were associated with information sharing, orienting legal partners to a complex medical system, and mismatches in service delivery areas between KP and the legal aid organizations. CONCLUSIONS: Embedding MLPs upstream in healthcare systems can enable access to legal resources for underserved clients. Attention to key implementation factors can support the spread of MLPs within other large healthcare systems