16789 research outputs found
Sort by
Multistep Synthesis of Boron-Nitrogen-Carbon Polymer
No full textThis study investigates the synthesis of boron-nitrogen complexes (BNC) as a potential alternative to plastics contributing to ocean pollution. Benzenetetramine and boron trichloride were combined and refluxed, yielding 315mg of a black solid with a 97.8% yield. The product’s degradation was analyzed using buffers of varying pH values (4, 5, 7, 9, and 10) using UV-Vis spectroscopy. The results indicated abnormal degradation patterns at pH 5, 7, and 10, with rapid degradation at pH 4 and steady degradation at pH 9. Given that ocean pH is around 8, BNC polymers may present a promising alternative to conventional plastics. Future research is warranted to further explore the degradation properties at neutral pH
Cognitive Copilot: Artificial Intelligence and the Academic Moral Quandary
No full textOver the last five years, Artificial Intelligence (AI) has been increasingly ubiquitous in ways that impact the higher education experience. Eastern Washington University, a medium-sized regional comprehensive, located in the inland Pacific Northwest, is no exception. This study examines how students are using AI in their daily and academic lives. Most students report knowing of and using AI, and note that professors provide both positive and negative messages. Students express their own ambivalence about current AI usage and apprehension for future implications. Using interviews and surveys, we explore how students are using - and want to use - AI
Determination of Optimal Assay Conditions for a Lethal ITPA Mutant
No full textInosine triphosphate pyrophosphatase (ITPA) is an important enzyme in humans that breaks down inosine triphosphate (ITP) nucleotides into inosine monophosphate (IMP) and pyrophosphate, preventing excess amounts of ITP from forming. However, some ITPA mutants are unable to function properly, leading to various medical conditions and diseases caused by increased levels of ITP. One severe mutant, labeled R178C, modifies an arginine residue into cysteine at the 178th amino acid position. The R178C protein has reduced stability, but is able to bind to the substrate. However, it catalyzes the reaction at a much slower rate. This then leads to a fatal encephalopathy in newborns. It is imperative that R178C be studied to help create treatment options for this condition. To better study the R178C protein, magnesium chloride and pH assays of the protein were performed alongside wild type ITPA. The data was measured using high performance liquid chromatography. Assays showed that significant levels of magnesium are necessary for the function of both R178C and wild type ITPA. The pH optima of wild type ITPA was found to be 8.5 while R178C had the highest activity at a lower pH. This information will be used to make a standardized procedure for the development of a chemical screening assay for the discovery of molecules that stabilize R178C
\u3ci\u3eOf Withering and Chlorosis\u3c/i\u3e, \u3ci\u3eKitty\u3c/i\u3e, and \u3ci\u3eCat\u3c/i\u3e
No full textOf Withering and Chlorosis is a watercolor painting that focuses on the juxtaposition of assertion and suppression. The crawling vines are highlighting the epitome of perfection that we as a society tend to set on others, and this is all while the figure is obscured by said vines as they block their ears, eyes, and mouth from speaking.
Kitty and Cat are both dry point prints that were made onto pressed pennies. Despite how pennies are the least valued currency in the United States, this made them an ideal medium and their own challenge due to how small they were to work on. The subject matter of cats was chosen as a parallel to the technique of dry point and of cats lives, which are both fleeting in nature
\u3ci\u3eThe Reality of Time\u3c/i\u3e
No full text“The Reality of Time” is an electronic music composition created and inspired by my grandfather\u27s reel-to-reel tapes, which were recorded while serving in the Vietnam War, and sent to my grandmother in lieu of letters. These tapes, representing artifacts of oral history, hold a special meaning in our modern world, as they are a unique lens to the past when everyone was not surrounded by today\u27s technology, which allows you to communicate instantaneously. This composition tries to encapsulate the long-distance relationships that many families had to endure during times of war, as well as showcasing the unseen feelings of a person currently enduring these circumstances
\u3ci\u3eEchoes over Big Bear\u3c/i\u3e
No full textEchoes over Big Bear is a watercolor, ink and prismacolor work inspired by eagles Jackie and Shadow, who have lived together in Big Bear Valley since 2018. They’ve laid over 14 eggs together, with only 5 having hatched. This piece explores the concepts of loss, mourning, and looking towards the future. My purpose is to invite the viewer to think about the relationship between the eagle and its chick and how we can relate them to our experiences with loss.
The colors that were chosen were inspired by cultural symbols of mourning as well as by the paintings made during and after World War 1. Muted tones of yellow, green and brown were chosen, creating smog-like clouds around the main eagle subject to draw attention to them. The chick below them is a bright golden color, rather than the white downy feathers that they normally are to represent hope for the future
Can Neurodynamic Therapy Work Alongside Functional Rehab for Chronic Ankle Instability in College Athletes
No full textA 22-year-old male college basketball athlete presented with a history of multiple lateral ankle sprains bilaterally with a diagnosis of chronic ankle instability (CAI). The athlete had neurological symptoms specifically in his left ankle only, and when paired with the history of CAI led to muscular weakness and proprioception challenges. Typical functional rehabilitation was used bilaterally, however neurodynamic therapy was used on the left ankle to address these deficits. These therapies are emerging in prevalence and target neurological symptoms by using a nerve flossing technique that helps move the nerve through tension and gliding through the body through light movements in the body aimed at moving the tissue around the surrounding tissue. This has been shown to reduce nerve irritation and pain while improving nerve function. A single leg hop and the star excursion balance test were used and show improvements bilaterally, but no observable differences between the affected and unaffected limb were noted. Using the FAOS scale the patient saw continuous improvement, as well as expressing that he felt his affected leg had grown as strong as his unaffected leg. While clinical outcomes were inconclusive for benefits, patient outcomes showed beneficial to the athlete. The outcomes of this case suggest that using neurodynamic therapy to address a patient\u27s level of strength and neuromuscular activation while improving the patient perception of recovery with chronic ankle instability could be a useful tool for clinicians
Influences of Multiple Myeloma on Osteoclastogenesis
No full textMultiple myeloma is a cancer of antibody secreting B lymphocytes, also known as plasma cells. While both malignant and non-malignant plasma cells are home to the bone marrow, myeloma is often accompanied by osteodegenerative disease which is characterized by an imbalance of bone resorption and formation in favor of the former. Bone disease in multiple myeloma is driven by dysregulated signaling of myeloma cells and the increased abundance of these cells in the bone marrow. Osteoclasts are bone resorbing cells – formed from the fusion of macrophages – whose activity are putatively enhanced by the presence of multiple myeloma cells. Herein, using in vitro models, we investigate the influences of multiple myeloma on the differentiation of osteoclasts at 1) various temporal stages of osteoclastogenesis, 2) the spatial requirements of these effects, and 3) the underpinnings biological mechanisms at play. The results of this work will further elucidate the underlying biology of bone disease in multiple myeloma and will inform potential precision medicine strategies to ameliorate this disease sequelae