OJS UNPATTI Publication Center (Universitas Pattimura)
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Evaluation of the Antimicrobial Efficacy of Hibiscus sabdariffa L. Antiperspirant Preparations Against Staphylococcus epidermidis
No full textCommercial antiperspirant products commonly incorporate synthetic compounds, several of which have raised concerns due to their potential carcinogenicity. Moreover, the inclusion of natural antibacterial agents in these formulations remains limited. Hibiscus sabdariffa L. (Rosella), a plant rich in bioactive secondary metabolites, offers a promising natural alternative. This study aimed to evaluate the antibacterial efficacy of rosella-based antiperspirant formulations, particularly against Staphylococcus epidermidis, a key contributor to body odor. Three formulations (F1, F2, and F3) were developed and assessed based on several parameters: pH, organoleptic properties, homogeneity, spreadability, adhesiveness, and antibacterial activity against Staphylococcus epidermidis. The results demonstrated that the antiperspirant preparations complied with standard evaluation criteria. Furthermore, the antibacterial assay outcomes yielded statistically significant differences (p < 0.05) in the mean diameter of the inhibition zones, indicating that H. sabdariffa L. exhibited measurable antibacterial activity against S. epidermidis. These findings support the potential application of Rosella extract in developing natural and efficacious anti-perspirant products
Synthesis of Asymmetric Curcumin Analogue (2,6)-2-(3-bromo-4-methoxybenzylidine)-6-(3,4-dimethoxybenzylidine)cyclohexanone with a Base Catalyst
No full textCurcumin analogs are phenolic secondary metabolites that are more stable than curcumin because they do not contain active methylene groups. Generally, these compounds have a symmetric structure, while asymmetric curcumin analogs with higher frequency and potency are rarely synthesized. This study aimed to synthesize asymmetric curcumin analogs from 2-(3,4-dimethoxybenzylidene)cyclohexanone and bromoanisaldehyde. The synthesis was conducted using the Claisen-Schmidt condensation method with a base catalyst in ethanol at 25 °C for 12 hours. The intermediate compound available in the laboratory was characterized using GC-MS, showing a molecular ion (M⁺) at m/z 246. Meanwhile, bromoanisaldehyde was characterized by GC-MS and FT-IR, yielding a molecular ion at m/z 215 and a C–Br stretching vibration peak at 812 cm⁻¹. The study yielded a yellow solid weighing 0.13 g (yield percentage: 2.93%) with a melting point of 143-147 °C. UV-Vis, FT-IR, and HR-MS analysis confirmed the successful synthesis and characterization of the asymmetric curcumin analog, as evidenced by the molecular ion (M⁺) at m/z 443.06274 in the HR-MS spectrum. However, further analysis, such as ¹H-NMR and ¹³C-NMR, is needed to confirm the structure of the compound. Furthermore, research related to bioactivity testing is crucial for obtaining more stable and effective drug candidates
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF BERBASIS ISPRING SUITE 9 UNTUK MENINGKATKAN KEMAMPUAN PEMBELAJARAN MATEMATIKA DI SEKOLAH DASAR
No full textPenelitian ini bertujuan untuk mengembangkan media pembelajaran berbasis iSpring Suite 9 untuk materi keliling segitiga di kelas V SD Alhilaal Namsina, Kabupaten Buru, guna meningkatkan motivasi belajar matematika siswa. Pengembangan menggunakan model ADDIE (Analysis, Design, Development, Implementation, Evaluation). Pada tahap analisis, ditemukan bahwa pembelajaran sebelumnya hanya menggunakan buku teks dan ceramah tanpa media interaktif. Pada tahap perancangan, media interaktif iSpring Suite 9 dibuat dan divalidasi oleh ahli. Hasil penelitian menunjukkan bahwa media ini dinilai sangat layak dan efektif. Ahli materi memberikan skor 83% dan ahli media 87%, keduanya dalam kategori sangat layak. Evaluasi dari pendidik menunjukkan peningkatan dari 84% pada uji coba pertama menjadi 94% pada uji coba kedua. Respon peserta didik juga sangat positif, dengan peningkatan skor dari uji coba pertama ke kedua dalam aspek kualitas isi (86% ke 94%), kualitas media (86% ke 96%), tampilan media (92% ke 94%), perasaan terhadap penggunaan media (82% ke 96%), rasa ingin tahu (84% ke 98%), dan motivasi (86% ke 98%). Media ini dinyatakan valid, layak, dan efektif dalam memotivasi serta mendukung pembelajaran matematika
The Influence of the Extemporaneous Method on the Public Speaking Ability
No full textThis study investigates the effectiveness of the extemporaneous speaking method on the public speaking abilities of ninth-grade students at SMP LKMD Tawiri, Teluk Ambon District. Using a mixed-methods descriptive quantitative design, the research involved 23 ninth-grade students as participants. Data collection employed questionnaires using the Guttman Scale and performance assessments using structured rubrics with nine evaluation criteria. The study utilized the Product Moment Correlation formula to analyze the relationship between the extemporaneous method implementation and students' public speaking competencies. Results revealed a significant improvement in students' public speaking abilities, with mean scores increasing from 70 (traditional methods) to 78 (extemporaneous method). The correlation coefficient of 1.09 indicated a very strong positive relationship, leading to the acceptance of the alternative hypothesis (Ha) that the extemporaneous method significantly influences public speaking proficiency. The findings suggest that structured extemporaneous speaking instruction can effectively enhance students' oral communication skills in Indonesian secondary education contexts
Peningkatan Hasil Belajar Menggunakan Metode Kooperatif Jigsaw untuk Materi Sistem Pertidaksamaan Linear Dua Variabel pada Kelas X-1 SMA Budi Utama
Get PDFRendahnya hasil belajar matematika masih menjadi permasalahan yang dijumpai melalui asesmen formatif. Penelitian yang dilakukan merupakan penelitian tindakan kelas (PTK) yang bertujuan untuk meningkatkan hasil belajar kelas X-1 SMA Budi Utama Yogyakarta dengan mengimplementasikan metode pembelajaran kooperatif tipe jigsaw menggunakan model Hopkins pada topik sistem pertidaksamaan linear dua variabel (SPtLDV). Penelitian dilakukan dalam dua siklus pembelajaran yang melibatkan 20 peserta didik. Setiap akhir siklus dilaksanakan asesmen untuk mengukur hasil belajar. Teknik mengumpulkan data menggunakan pengamatan dan tes. Data dianalisis secara deskriptif komparatif. Hasil menyatakan peningkatan, pada siklus I nilai rerata kelas 60.75 (60% tuntas) dan pada siklus II nilai rerata kelas 93.75 (100% tuntas). Standar deviasi menurun dari 28.43 menjadi 8.2 yang menunjukkan hasil yang lebih merata. Dengan demikian, penggunaan model pembelajaran kooperatif tipe jigsaw mampu meningkatkan hasil belajar di kelas X-1 SMA Budi Utama Yogyakarta pada topik SPtLDV
Survei Kemampuan Guru Menerapkan Pendekatan Saintifik dalam Pembelajaran Senam Ketangkasan di SMA Negeri 5 Buru
Get PDFThe application of the scientific approach in Physical Education, Sports, and Health (PJOK) plays a crucial role in enhancing the quality of the teaching and learning process. This study aims to examine the extent to which PJOK teachers implement the scientific approach in classroom instruction, particularly in the subject of gymnastics skills. This is a descriptive study using a qualitative approach. Data were collected through observation, interviews, documentation, and triangulation, and analyzed using qualitative methods. The research subjects were PJOK teachers at SMA Negeri 5 Buru, located in Sawa Village, Lilialy District, selected through purposive and snowball sampling techniques, based on their roles and competencies. The findings indicate that teachers generally apply the scientific approach adequately in the learning process. However, its implementation is not yet optimal, mainly due to the lack of active student participation during classroom activities. These results suggest that the success of the scientific approach depends not only on the teacher’s competence but also on the students’ engagement in the learning process
Comparison of LASSO, Ridge, and Elastic Net Regularization with Balanced Bagging Classifier
Get PDFPredicting Drug-Induced Autoimmunity (DIA) is crucial in pharmaceutical safety assessment, as early identification of compounds with autoimmune risk can prevent adverse drug reactions and improve patient outcomes. Classification analysis often faces challenges when the number of predictor variables exceeds the number of observations or when high correlations among predictors lead to multicollinearity and overfitting. Regularization methods, such as Ridge Regression, Least Absolute Shrinkage and Selection Operator (LASSO), and Elastic-Net, help stabilize parameter estimation and improve model interpretability. This study focuses on building a binary classification model to predict the risk of DIA using 196 molecular descriptors derived from chemical compound structures. To address class imbalance in the response variable, the Balanced Bagging Classifier (BBC) is combined with regularized logistic regression models. Elastic Net + BBC outperforms other models with the highest accuracy (0.825), followed closely by LASSO + BBC and Ridge + BBC (both 0.816). This integration not only improves classification accuracy but also enhances generalization and the reliable detection of minority class instances, supporting the early identification of autoimmune risks in drug discovery
The Implementation of the Game Based Learning Model to Improve Student Learning Outcomes in Grade V at Inpres Rotnama Elementary School
Get PDFThis study aims to analyze the implementation of the Game-Based Learning (GBL) model in improving the learning outcomes of fifth-grade students at SD Inpres Rotnama, Mdona Hyera District, Southwest Maluku Regency. This research employs the Classroom Action Research (CAR) method with 14 students (12 males and 2 females) as subjects. Data were collected through pre-test and post-test in Cycle I and Cycle II. The results of Cycle I showed an increase in the average score from 48.28 to 61.78, but it had not yet reached the Minimum Mastery Criterion (65). In Cycle II, the average score significantly increased to 78.21, indicating the successful implementation of GBL in improving student learning outcomes. Thus, the GBL model is effective in enhancing students' understanding and can be applied as an innovative learning method in elementary schools
Penetapan Harga Pokok Produksi Dalammenentukan Harga Jual dengan Menggunakan Metode Variable Costing (Studi pada Usaha Pabrik Roti Ainayah Kota Ambon)
Get PDFThe determination of the cost of goods manufactured (COGM) is crucial in setting a competitive selling price and ensuring business sustainability. Ainayah Bread Factory in Ambon has faced challenges in accurately calculating COGM due to its reliance on simple methods. This study aims to analyze the application of the variable costing method in calculating COGM and determining the selling price. A descriptive qualitative approach was applied using interviews, observations, and documentation. The findings reveal that the total monthly production cost is Rp205,540,280 with a production capacity of 180,000 breads, resulting in a unit cost of Rp1,141.89. With a selling price of Rp1,300 per unit, the profit margin reached Rp158.11 or 13.84% of revenue. These results confirm that variable costing provides more accurate cost information and supports sound pricing decisions. The condition highlights the enterprise’s potential for growth, efficiency improvement, and long-term competitiveness. The study implies the importance of cost accounting education for SMEs and recommends training on basic financial reporting to strengthen business sustainability
Analisis Motivasi Belajar Mahasiswa Penerima Beasiswa KIP-Kuliah Pada Mahasiswa Program Studi Pendidikan Ekonomi
Get PDFLearning motivation is a key determinant of students’ academic success, including those receiving the KIP-Kuliah scholarship. Despite being selected based on merit, some students show academic instability across semesters. This study aims to analyze the learning motivation of KIP-Kuliah recipients in the 2020–2021 cohort of the Economic Education Study Program. A descriptive qualitative approach was employed, with data collected through unstructured interviews and documentation from four purposively selected students. The main findings reveal that while most students demonstrate an intrinsic desire to succeed, inconsistent academic behavior persists, such as tardiness, lack of discipline, and inadequate learning environments. Both internal and external factors significantly influence fluctuations in GPA. It is thus crucial for institutions to foster a supportive academic ecosystem by providing adequate learning facilities and recognizing positive behaviors. Academic mentoring programs focusing on sustained motivation development are also recommended as part of a long-term strategy