Dokkyo Medical University Repository / 獨協医科大学リポジトリ
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Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis
Get PDFObjective: To determine whether tumor necrosis factor (TNF) blockade improves small airway obstruction in rheumatoid arthritis (RA) patients without apparent respiratory symptoms.
Methods: Pulmonary function tests were performed before and one year after TNF blockade therapy in 29 RA patients without apparent respiratory symptoms. As a control, pulmonary function was examined at a one-year interval in 27 RA patients with conventional disease-modifying antirheumatic drugs (DMARDs) alone. Small airway obstruction was diagnosed when one of maximal mid-expiratory flow rate (MMEF), forced expiratory flow at 50% (FEF50) or 75% (FEF75) of the vital capacity was decreased to less than 60%, 55%, or 45% of predicted values, respectively.
Results: Small airway obstruction was found in 62.5% of RA patients. No differences were found in age, sex, disease duration, or disease activities. TNF inhibitors dramatically reduced disease activities. However, TNF inhibitors failed to improve small airway obstructions but worsened them.
Conclusions: TNF blockade fails to improve small airway obstruction, suggesting that TNF-independent pathways play important roles in the development of small airway obstruction in RA.journal articl
A Case of Giant Lipoma of the Transverse Colon with Intussusception Treated Successfully by Laparoscopic Surgery
Get PDFLipoma of the transverse colon with intussusception is a rare disease. We report our experience of a case of lipoma of the transverse colon with intussusception that was successfully treated by laparoscopic surgery. The case was an 81-year-old woman who consulted a local clinic with a chief complaint of abdominal pain. The patient was referred to our department because abdominal CT scan revealed intussusception of the transverse colon. A fist-sized abdominal mass was found along with corresponding tenderness in her left upper abdominal area to the periumbilical area. The patient was diagnosed with intussusception caused by transverse colon tumor and was planned to undergo surgery. Intussusception associated with tumor was observed in the middle of the transverse colon. However, since the mobility in the abdominal cavity was favorable, partial resection of the transverse colon was performed through small laparotomy. The resection specimen showed a semi pedunculated submucosal tumor 9 × 6 cm in size. Histopathologically, the patient was diagnosed with adipose tumor outgrown with mature adipocytes in varied sizes.journal articl
Substantia Nigra Hyperechogenicity in Parkinson's Disease and Related Disorders: A Follow-up Study
Get PDFBackground: Previous studies have shown that the hyperechogenic area of the substantia nigra (SN) does not change over the disease course in patients with Parkinson's disease (PD). However, longitudinal changes in SN echogenicity in patients with atypical parkinsonian syndrome (APS) remain unclear. We evaluated the change in SN hyperechogenic area over time in patients with PD and those with APS, including multiple system atrophy (MSA) and progressive supranuclear palsy (PSP).
Methods: A total of 22 patients with parkinsonism (14 PD, aged 71.0 ± 8.3 years; 8 APS (6 PSP and 2 MSA), aged 69.9 ± 9.6 years) who underwent transcranial sonography twice (≥6 months apart) were included in this study. Patients with insufficient temporal bone windows were excluded.
Results: The mean interval between examinations was 24.7 ± 15.3 months. No differences were detected in the hyperechogenic SN area between the first and second examinations (all patients, 0.17 ± 0.09 cm2 vs. 0.17 ± 0.08 cm2, p = 0.67; PD, 0.20 ± 0.08 cm2 vs. 0.20 ± 0.08 cm2, p = 0.45; APS, 0.11 ± 0.06 cm2 vs. 0.12 ± 0.06 cm2, p = 0.37, respectively). In both groups, there were no correlations between the hyperechogenic SN area and disease duration or severity.
Conclusion: The hyperechogenic SN area did not change over the disease course in PD or APS patients.journal articl
Possible involvement of type 2 cytokines in alloknesis in mouse models of menopause and dry skin
Get PDF獨協医科大学博士（医学）令和3年度doctoral thesi
Low-intensity resistance training with moderate blood flow restriction appears safe and increases skeletal muscle strength and size in cardiovascular surgery patients: A pilot study.
Get PDF獨協医科大学博士（医学）令和3年度doctoral thesi
Predictors of Clopidogrel hyper-responsiveness in neuro-interventional procedures
Get PDF獨協医科大学博士（医学）令和3年度doctoral thesi
