Dokkyo Medical University Repository / 獨協医科大学リポジトリ
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Predictive Factors of Patients with Chronic Phase Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitor
Get PDFBackground: Chronic Myeloid Leukemia (CML) is a hematological malignancy caused by an abnormality of the Philadelphia chromosome. Along with the development of CML treatment, the discovery of tyrosine kinase inhibitors (TKI) paved the way for CML patient and lead to longer survival rate. It is very important to know whether the treatment response is successful or not as well as the predictive factors that can improve the therapeutic response of CML patients treated with TKI.
Methods: This study is an observational cohort study conducted for 12 months long and involving 40 CML patients treated with TKI, both hematological and molecular therapy response were evaluated in this study. We analyzed some predictive factors such as relationship between early clinical and laboratory symptoms before the treatment by TKI and treatment response and the relationship between Eutos, Sokal and Hasford scores and treatment response.
Results: A total of 40 chronic phase CML patients, consist of 25 men (62.5%) and 15 women (37.5%) with mean age of 37 years. Most common clinical manifestation was weight loss (100%), followed by splenomegaly in 39 people (97.5%). Complete Hematologic Response (CHR) after 3 months of TKI therapy was achieved by 15 patients (37.5%). The number of patients who achieved 6-months CHR increased to 19 patients (47.5%). Among 37 samples who performed quantitative examination on fusion of the breakpoint cluster region (BCR) gene on chromosome 22 gene in band q11 and Abelson murine leukemia (ABL1) gene on chromosome 9 band q34 (BCR-ABL), 20 patients (54%) achieved major molecular response (MMR), and the remaining 17 (45.9%) had not yet achieved MMR. We found significant relationship between basophils and quantitative BCR-ABL levels (p < 0.01). We didn't find any relationships between these three scores (Eutos, Sokal and Hasford) with treatment response, both hematological and molecular treatment response.
Conclusions: The prevalence of CHR at 3 months was 37.5% meanwhile prevalence of MMR after 12 months was 54%. We found that basophil percent at 3 months after treatment is predictive factor and significantly associated with quantitative BCR-ABL levels (p < 0.05).journal articl
Evaluation of Autonomously Functioning Thyroid Nodule by 3-dimensional99mTc-pertechnetate Thyroid SPECT/CT Imaging
Get PDFTwo-dimensional 99mTcO4- scintigraphy using a gamma camera is widely used as a simple test method that can simultaneously evaluate the morphology and function of the thyroid gland. However, some thyroid diseases require three-dimensional (3D-) morphological evaluation and evaluation of local accumulation. In this study, we used SPECT/CT to verify the quantitative evaluation of autonomously functioning thyroid nodule (AFTN) cases and the measurement of 99mTcO4- uptake rate. In the diagnosis of AFTN, 3D-morphological and functional information was obtained by using 99mTcO4- SPECT/CT. Furthermore, it was clarified that the intake rate obtained by 99mTcO4- SPECT/CT had the same quantitativeness as the conventional method.journal articl
Remimazolam: a randomised controlled study of its suitability for insertion of a supraglottic airway
Get PDF獨協医科大学博士（医学）令和5年度doctoral thesi
Usefulness of an automatic cuff pressure controller （SmartCuff） in inhibiting gasleakage around the cuff after tracheal intubation: a randomized controlled study
Get PDF獨協医科大学博士（医学）令和5年度doctoral thesi
Relationship between details in fiberoptic endoscopic evaluation of swallowing dysfunction and clinical outcomes
Get PDF獨協医科大学博士（医学）令和5年度doctoral thesi
Hemodynamic predictors of negative false lumen remodeling after frozen elephant trunk for acute aortic dissection
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New surgical indication criterion combining ultrasonography and cytology findings for thyroid nodules
Get PDF獨協医科大学博士（医学）令和5年度doctoral thesi
Long-term efficacy of dupilumab for eosinophilic chronic rhinosinusitis
Get PDF獨協医科大学博士（医学）令和5年度doctoral thesi
Ovariectomy-induced dry skin increases IL-31-induced scratching behavior in mice
Get PDF獨協医科大学博士（医学）令和5年度doctoral thesi
Pollinosis
Get PDF花粉症は，花粉を抗原とする季節性アレルギー性鼻炎であり，日本においてはスギ花粉症が最も多く，2016年の東京都におけるスギ花粉症の有病率は 48.8％と推測され，その有病率は今後さらなる上昇が予想される．スギ花粉症に対する治療は，薬物療法が中心となっているが，薬物療法は症状は改善するものの治癒に至る治療法ではないため，長期の臨床効果が期待される舌下免疫療法も広く行われつつある．また，免疫療法におけるアナフィラキシーショックに代表される副作用を軽減するペプチド療法も現在開発されている．スギ花粉抗原である Cry j 1 と Cry j 2 のヒト T細胞エピトープを連結した 7 linked dominant T cell epitopes を発現させたスギ花粉米の経口摂取による症状の緩和が報告されていることからも，今後スギ花粉症の治療の選択肢が増える可能性がある．スギ花粉症患者を層別化することにより，最適な治療方法の選択がバイオマーカーから可能となることが期待される．Pollinosis is a seasonal allergic rhinitis caused by pollen antigens. In Japan, Japanese cedar pollinosis is the most common type of pollinosis, with an estimated prevalence of 48.8% in Tokyo in 2016. This prevalence is expected to increase further in the future. The main treatment for Japanese cedar pollinosis is medical therapy, which improves symptoms but does not cure the disease. Therefore, sublingual immunotherapy, which is expected to have long-term clinical effects, is becoming more widely used. In addition, peptide immunotherapy is currently being developed to reduce the side effects of immunotherapy, such as anaphylactic shock. For Japanese cedar pollinosis, immunotherapy using oral intake of transgenic rice containing 7 linked dominant T cell epitopes, which are human T cell epitopes of Japanese cedar pollen antigens, has been reported. This may increase treatment options for Japanese cedar pollinosis in the future. By stratifying Japanese cedar pollinosis patients, it is hoped that the selection of optimal treatment methods will be possible based on biomarkers.journal articl