Dokkyo Medical University Repository / 獨協医科大学リポジトリ
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The Usefulness of Neoadjuvant Chemotherapy (S-1/Oxaliplatin) for Locally Advanced Mid-low Rectal Cancer
Get PDFBackground: Neoadjuvant chemotherapy (NAC), which excludes radiation therapy (RT), has been investigated with the aim of lowering the local recurrence rate and suppressing distant metastasis in patients with rectal cancer, as well as avoiding the adverse events (AEs) of RT.
Aim: To clarify the therapeutic results of NAC for patients with locally advanced mid-low rectal cancer.
Materials and methods: We reviewed the data of 33 patients with stage II or III mid-low rectal cancer who underwent primary tumor resection after NAC between April 2015 and April 2018. We retrospectively analyzed the short-term treatment results, including clinicopathological factors, AEs, and perioperative complications, as well as the long-term treatment results, including the 5-year recurrence-free survival rate (RFS).
Results: The median observation period was 61.5 months (range, 29.6-97.0 months). All patients underwent SOX (S-1 + oxaliplatin) therapy. The most common AEs were thrombocytopenia in five patients (15.1%) and neutropenia in two patients (6.1%). Pathological complete response was achieved in three patients (7.8%). Recurrence was observed in six patients (18.2%), and in each case was a local recurrence event. The 5-year RFS rate was 81.8%. Multivariate analysis using the COX proportional hazards model showed that preoperative lymph node metastasis positivity (p = 0.03) and lymphatic invasion positivity (p < 0.001) were independent prognostic factors.
Conclusion: SOX therapy as preoperative chemotherapy has few adverse events and a low postoperative complication rate, and can be performed relatively safely. Because there were many local recurrences, local control with chemotherapy alone may be insufficient.journal articl
Thoracoscopic Lung Resection for Pulmonary Intralobar Sequestration Associated with Scimitar Syndrome: A Case Report
Get PDFThe patient described here was a 19-year-old man with no relevant medical history. The patient was treated with antimicrobial agents for pneumonia, and his symptoms improved; however, a shadow persisted in radiographs of the right lower lung field. The patient was referred to our hospital for further examination and treatment. Enhanced computed tomography showed multiple cystic changes with well defined borders in the basement segment of the right lung. An abnormal artery was observed to originate from the celiac artery and returned to the inferior vena cava. We interpreted the symptoms of pulmonary sequestration with abnormal partial pulmonary venous return to be Scimitar syndrome. A surgical intervention was performed thoracoscopically. Scimitar syndrome is a very rare disease. It is important to pay attention to the preoperative cardiac functional assessment and intraoperative vascular treatment for associated pulmonary sequestration.journal articl
Impact of diabetes and glycated hemoglobin level on the clinical manifestations of Parkinson's disease
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Natural history of eosinophil-derived neurotoxin levels and the onset of allergic airway disease in preschool children
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Efficacy of an aerosol suction device Free-100M in removing aerosols produced by coughing to minimize COVID-19 infection
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Relationship between increased ba-PWV values and body composition in patients with type 2 diabetes mellitus
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