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    Eco-Consciousness with a Queerful Face: Ana Luísa Amaral’s World(s)

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    The advocacy of Portuguese poet Ana Luísa Amaral (1956–2022) for both marginalized queer identities and more-than-human agency has been highlighted by several eminent scholars, with some approaches associating her poetry with eco-queer discourses. Less attention, however, has been allocated to just how hopeful this eco-consciousness may or may not be, in the sense of a queer environmental futurity. Within an uncertain landscape of positive ecological developments and retrograde steps — both in Portugal and globally — it is important to question critically the environmental strategies deployed in Amaral’s poetic collections, according to her own theoretical concept of ‘queerente’ [queerful]. Through this lens, the present article examines a selection of Amaral’s later poems (published between 2015 and 2021) in which one detects a playful, unstable semi-optimism surrounding human and more-than-human coexistence. As I shall argue, the poet evokes a world — or, alternatively, worlds — in flux, of queerful inter-species interaction. A forma como a poeta portuguesa Ana Luísa Amaral (1956–2022) defendeu tanto as identidades queer marginalizadas como as entidades maisque-humanas já foi salientada por várias críticas importantes, assim como outras que realçam a consciência eco-queer desta poesia. No entanto, tem-se prestado menos atenção à medida em que esta consciência pode ser interpretada como sendo esperançosa, no sentido de uma futuridade ambiental. Num contexto de avanços ecológicos positivos e passos retrógrados, tanto em Portugal como a nível global, torna-se necessário interrogar criticamente as estratégias ambientalistas utilizadas por Amaral, segundo o próprio conceito teórico da autora conhecido como ‘queerente’. Através desta ferramenta analítica, examinar-se-á um corpus de poemas amaralianos publicados entre 2015 e 2021, dentro dos quais se pode salientar um meio-otimismo lúdico e instável, no que diz respeito à convivência humana e mais-que-humana. Como se frisará, trata-se de um mundo — ou, melhor, de vários mundos — em fluxo, onde todas as espécies se interagem entre si de forma queerente

    Biosimilars in osteoporosis treatment: focus on denosumab

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    Osteoporosis is a significant public health issue due to its associated morbidity, mortality, and economic burden. Despite available effective treatments, a treatment gap persists, characterized by delayed diagnosis, undertreatment, and poor adherence. Biosimilars, such as biosimilars for denosumab, offer an opportunity to improve treatment accessibility and affordability for osteoporosis and cancer-related bone loss. This review explores the current treatment challenges in osteoporosis, the potential of denosumab biosimilars in improving access and outcomes, and the necessity of a multidisciplinary, patient-centered approach. The emergence of biosimilars for denosumab offers an opportunity to enhance accessibility and affordability of osteoporosis treatment, as biosimilars provide effective and economic versions of reference biologic therapies. A multidisciplinary approach is vital in managing osteoporosis, central to which is the patient, whose preferences, values, and lifestyle must guide the treatment plan. Healthcare providers play a crucial role in educating patients, promoting adherence to prescribed treatments, and involving patients in their own care to improve health outcomes

    Cost effectiveness of non-pharmacological interventions for fatigue in patients with long-term conditions: a systematic literature review

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    Introduction We aimed to assess the cost-effectiveness of non-pharmacological interventions for fatigue in patients with chronic conditions in the UK. Methods This systematic review of cost-effectiveness studies aligns with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 statement. Data sources: Electronic databases and citation searches. Inclusion criteria: Studies including adults with one or more long-term health condition, either physical or mental. Exclusion criteria: Studies associated with cancer, long-COVID, post-viral fatigue, medically unexplained conditions, developmental disorders and injuries. Assessment: A single reviewer completed a two-stage sifting process. Results Four studies met the inclusion criteria. They included patients with either multiple sclerosis or inflammatory rheumatic conditions, and assessed either cognitive behavioral therapy (CBT) or a personalized exercise programme (PEP). CBT was either dominated by usual care or had an incremental cost-effectiveness ratio (ICER) over £30,000. PEP dominated CBT, with the ICER for PEP versus usual care ranging from £13,159 to £35,424. Conclusions The economic literature on this topic is much more limited than the clinical effectiveness literature, both in terms of interventions and populations covered. Future research should focus on a de novo economic evaluation to identify interventions with a high potential to be cost-effective across multiple conditions. Registration PROSPERO (CRD42023440141

    Pub Psychic Nights: Spiritual and Social Transformation Beyond Institutional Boundaries

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    This article explores pub psychic nights in Britain. The audience of these events are predominantly working- class women who gather in local pubs and social clubs to participate in spirit communication led by a medium and/or psychic. Drawing on qualitative data from 16 interviews and four participant observations we examine the social and spiritual significance of these events for the audience, arguing that they have a profound impact in helping people deal with grief and loss, extending far beyond mere entertainment. We further argue that pub psychic nights create an opportunity to address existential questions and seek comfort outside of traditional religious institutions. We demonstrate how these nights blur the boundaries between the ordinary and the extraordinary and transform historically male-dominated pub spaces into local hubs of female- led spirituality. This research contributes to a deeper understanding of contemporary spiritual practices and their significance for marginalized communities

    Limited long-term cooling effects of Pangaean flood basalt weathering

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    The emplacement of large igneous provinces (LIPs) is known to be a driver of climate change in Earth’s past. However, the balance of climate warming through CO2 emission and cooling through weathering is poorly understood. To better understand the role of LIP emplacement on long-term climate change, here we utilize the SCION coupled climate-biogeochemical model which considers the impact of LIPs through degassing of CO2 and enhancement of local continental weathering rates. This approach results in better correspondence between the modelled output and proxy reconstructions of the period (especially for seawater Sr isotope composition) when compared to previous modelling studies. Of the seven LIPs during the breakup phase of Pangaea (approximately 300–150 Ma), only the Central Atlantic Magmatic Province (CAMP) drives noticeable long-term cooling in the model, a minor effect (between 1-2 °C) despite emplacement of a very large surface area in the humid tropics. Similarly, only the CAMP imparts a significant change in the long-term Sr isotope record whereas the other LIPs of this period do not. Due to limited areal extents, and emplacement outside tropical weathering zones, we conclude most LIPs have no significant global cooling effect on multimillion year timescales

    Sugarcane Extract (Polygain™) Supplementation Reduces Enteric Methane Emission in Dairy Calves

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    Polygain™ (PG), a polyphenolic extract from sugarcane, has recently been identified as a potential additive to reduce methane (CH4) emissions in livestock. This experiment examined the effects of PG on the enteric CH4 emission from Holstein Friesian weaned calves. Calves were allocated to annual pasture grazing and received supplementary pellets (200 g/calf/day; Barastoc calf-rearer cubes—Ridley Corporation). The experimental design followed was a completely randomized design (CRD), comprising 24 female calves (4–5 months old) allocated to two equal groups; control (standard pellets) vs. treatment (pellets formulated by adding PG to control pellets to deliver 10 g PG/calf/day). Experimental diets were fed for three months between August and November 2023, including a two-week adaptation period. Calves were weighed at the start and at the end of the study. A GreenFeed (C-Lock Pvt Ltd.) emission monitoring unit (GEM) was used to measure GHG emissions from the experimental calves in their groups in a 2-day rotational cycle. During a visit to the GEM, the calves were encouraged to enter an enclosed area or individual feeding stall where enteric CH4, CO2, O2, H2, and H2S measurements were taken. The results indicated a significant effect of PG supplementation on enteric methane emission in calves, with a lower production of CH4 in calves supplemented with PG (26.66 ± 2.06 g/day) as compared to the control group (35.28 ± 1.39 g/day, p < 0.001). The CO2/O2 ratio in the treatment (235 ± 14) and control groups (183 ± 9.6) differed significantly (p < 0.001). Overall, PG supplementation (10 g/calf/day) reduced their average methane emission per day and did not adversely affect the growth and development of experimental calves, confirming its useful anti-methanogenic potential

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