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The Implications of Genomics on the Nursing Care of Adults with Neuropsychiatric Conditions
No full textPurpose: Neuropsychiatric disorders contribute substantially to disease burden and quality of life across the lifespan and the globe. The purpose of this article is to review the state of the science regarding genomic contributions to selected common neuropsychiatric conditions and to examine the consequent immediate and future implications for nursing practice and research. Organizing Construct: Our work is guided by an ecological model that recognizes that common diseases are complex or multifactorial, meaning that multiple genomic and environmental factors contribute to their etiology. Methods: A review of the literature was conducted to determine the state of the science in relationship to the genomic contributions to selected neuropsychiatric disorders. Findings: Neuropsychiatric conditions are genomically heterogeneous, both within a single disorder and across groups of disorders. While recent genomic research yields clinically validated and useful information for a small subset of persons (e.g., predictive genetic testing for Huntington disease and early-onset Alzheimer disease), broad clinical application of genetic information is not yet available. In addition, the implications of genomics for the development and targeting of nonpharmacologic treatment strategies is largely unexplored. Conclusions: Further research is needed to expand knowledge beyond genomic risk for the presence of disease to knowledge about the genomic risk for symptoms, symptom burden, and tailored symptom management interventions. Clinical Relevance: Knowledge about the genomic influences on neuropsychiatric conditions suggests important implications for practicing nurses in the identification of persons at risk, provision of follow-up support, and in the administration of medications
Milestone 2013
Get PDFMilestone, the Hope College yearbook, is an annual publication of Hope College. The first yearbook was published in 1905 as a single edition and was titled The Hope College Annual. The yearbooks became an annual publication in 1916, which was also when it was titled Milestone.https://digitalcommons.hope.edu/milestone/1101/thumbnail.jp
The Anchor, Volume 127.03: September 18, 2013
Get PDFThe Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor\u27s history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular
Chris Smith Oral History
No full textChris Smith of the Chris-Craft Corporation remembers growing up in his family\u27s company. (2 minutes)https://digitalcommons.hope.edu/boat_builders/1089/thumbnail.jp
Lesions of the Intergeniculate Leaflet Lead to a Reorganization in Circadian Regulation and a Reversal in Masking Responses to Photic Stimuli in the Nile Grass Rat
Get PDFLight influences the daily patterning of behavior by entraining circadian rhythms and through its acute effects on activity levels (masking). Mechanisms of entrainment are quite similar across species, but masking can be very different. Specifically, in diurnal species, light generally increases locomotor activity (positive masking), and in nocturnal ones, it generally suppresses it (negative masking). The intergeniculate leaflet (IGL), a subdivision of the lateral geniculate complex, receives direct retinal input and is reciprocally connected with the primary circadian clock, the suprachiasmatic nucleus (SCN). Here, we evaluated the influence of the IGL on masking and the circadian system in a diurnal rodent, the Nile grass rat (Arvicanthis niloticus), by determining the effects of bilateral IGL lesions on general activity under different lighting conditions. To examine masking responses, light or dark pulses were delivered in the dark or light phase, respectively. Light pulses at Zeitgeber time (ZT) 14 increased activity in control animals but decreased it in animals with IGL lesions. Dark pulses had no effect on controls, but significantly increased activity in lesioned animals at ZT0. Lesions also significantly increased activity, primarily during the dark phase of a 12:12 light/dark cycle, and during the subjective night when animals were kept in constant conditions. Taken together, our results suggest that the IGL plays a vital role in the maintenance of both the species-typical masking responses to light, and the circadian contribution to diurnality in grass rats
The Practice of Creative Writing: A Guide for Students
No full textDesigned for all students in the introductory course, The Practice of Creative Writing has a simple message: you can do this, and it’s worthwhile to try. Heather Sellers, who writes in multiple genres herself, has developed an approach that focuses on the habits and strategies that produce good writing in any genre: Images; Energy; Tension; Pattern; Insight; and Revision. She teaches students how to focus, to generate lots of writing, and to get to the good stuff — the powerful imagery and the stories they really want to tell. She provides opportunities to be playful and to experiment at the same time she teaches students the importance of discipline and craft. This new edition gives students even more support and encouragement, with earlier attention to structure — because students struggle with this strategy — and with expanded coverage of revision and a wider range of genres they can use as generative tools
Hope College Abstracts: 12th Annual Celebration of Undergraduate Research and Creative Performance
Get PDFThe 12th Annual Celebration of Undergraduate Research and Creative Performance was held on April 12, 2013 in the Richard and Helen DeVos Fieldhouse at Hope College. It featured over 300 student-faculty collaborative research projects. This book of abstracts is a record reflective of those projects between the 2012-2013 academic year
Apathy Among Persons With Alzheimer Disease As Measured By The Neuropsychiatric Inventory And Apathy Inventory
No full textSynthesis, Cytotoxicity, And Structure-activity Insight Of Nh- And N-methyl-3,5-bis-(arylidenyl)-4-piperidones
No full textTwenty-one NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidone analogs of curcumin, 12 of which are novel, were synthesized and evaluated for their cytotoxicity against B16 (murine melanoma) and L1210 (murine lymphoma) cells grown in culture. These curcumin analogs are related to a known anticancer STAT3 inhibitor 3,5-bis-(4-fluorobenzyl)-4-piperidone (3). The compounds showed remarkable cytotoxicity, especially against B16 cells. The dimethoxy substituted analogs 4e and 4f and dihydroxy analog 4i emerged as the most active compounds with IC50 values in the range of 0.2-2.3 mu M. 4e, f, and i were about 10-times more cytotoxic against both cell lines than 3. Analysis of the results demonstrates that the position of the hydroxyl group is crucial for cytotoxicity. Amino-containing analogs are generally less active than their halogenated and oxygen-containing analogs, and N-substitution in the 4-piperidone moiety adds value to the cytotoxicity of the compounds