27316 research outputs found
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Anadolu Haber, Sayı 291, 16-22 Ağustos 2004
No full textAnadolu Haber Gazetesi, Sayı 291, 16-22 Ağustos 200
Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3-diaryltriazene-substituted sulfathiazole derivatives
No full textISIK, MESUT/0000-0002-4677-8104; Gulcin, ilhami/0000-0001-5993-1668WOS: 000539602200001PubMed: 32529657In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their chemical structures were characterized by Fourier transform infrared,H-1-NMR (nuclear magnetic resonance),C-13-NMR, and high-resolution mass spectroscopy methods. These synthesized novel derivatives were found to be effective inhibitor molecules for alpha-glycosidase (alpha-GLY), human carbonic anhydrase (hCA), and acetylcholinesterase (AChE), withK(I)values in the range of 426.84 +/- 58.42-708.61 +/- 122.67 nM for alpha-GLY, 450.37 +/- 50.35-1,094.34 +/- 111.37 nM forhCA I, 504.37 +/- 57.22-1,205.36 +/- 195.47 nM forhCA II, and 68.28 +/- 10.26-193.74 +/- 19.75 nM for AChE. Among the synthesized novel compounds, several lead compounds were investigated against the tested metabolic enzymes. More specifically,ST11(4-[3-(perfluorophenyl)triaz-1-en-1-yl]-N-(thiazol-2-yl)benzenesulfonamide) showed a highly efficient inhibition profile againsthCA I,hCA II, and AChE, withK(I)values of 450.37 +/- 50.35, 504.37 +/- 57.22, and 68.28 +/- 10.26 nM, respectively. Due to its significant biological inhibitory potency, this derivative may be considered as an interesting lead compound against these enzymes.Research Fund of Anadolu UniversityAnadolu University [1610S681]Research Fund of Anadolu University, Grant/Award Number: 1610S68
Sharing experiences and interpretation of experiences: a phenomenological research on Instagram influencers
No full textSezerel, Hakan/0000-0003-1521-8638WOS: 000533776500001This research examines Instagram travel influencers' views on their experiences. Using a phenomenological approach, data were collected via semi-structured online interviews with 12 influencers, as well as reflective journals, and document review techniques. the data were analysed using thematic content analysis that define the experiences and perceptions of influencers. the findings were interpreted within the framework of three main themes and were presented with direct citations from participants' statements. the research suggests that being an influencer is a job that requires responsibility and competence. Influencers have a mediating role between the brands and the consumers. It was also found that the job difficulties experienced by the participants include workload, need for approval and impression management. the general means for collaborations between brands and influencers are paid partnership and barter collaborations. For collaborations to be successful, maintaining consistency between the brand image and the impression created by the influencer is vital
Development of emergent literacy skills of a child with hearing loss: a longitudinal case study
No full textWOS: 000524173000001This longitudinal case study aimed to investigate the development of emergent literacy skills of a child with hearing loss was carried out in a research and application centre which provides full-time day education using an auditory-oral approach for children with hearing loss. the study focuses on a child with profound hearing loss who started kindergarten education at the age of 52 months. the data was collected in the second and third grade of kindergarten and the first term of primary first grade. Results indicate that group and individual experiences, based on the Whole Language Approach, support the development of code-related and oral language skills and that the child benefited from intense and systematic application of drills in accordance with his individual needs
Anadolu Haber, Sayı 668, 22-28 Nisan 2013
No full textAnadolu Haber Gazetesi, Sayı 668, 22-28 Nisan 201