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Relationship between aerobic fitness and adipose tissue insulin resistance
No full textObjective: Aerobic fitness is associated with greater skeletal muscle insulin sensitivity with regards to glucose uptake. Whether fitness is associated with an improvement in the insulin36 regulation of adipose tissue lipolysis is unknown.
Methods: We collated adipose insulin sensitivity, body composition and fitness data from six of our previously published and two of our unpublished studies. ADIPO- IRpalmitate data was available for 340 volunteers and the insulin concentration resulting in a 50% suppression of palmitate rate of appearance (FFApalmitate IC50) measured using the insulin clamp technique was available for 108 volunteers. Pearson correlation and multiple linear regression analysis were performed to assess the relationship between the independent variables of aerobic fitness (VO2 peak, mL•kg FFM-1•min-1), age, sex, BMI, visceral adipose tissue (VAT), body fat, percent body fat and the dependent variables ADIPO-IRpalmitate and FFApalmitate IC50.
Results: Factors that were univariately correlated (ppalmitate and FFApalmitate IC50 were BMI, percent body fat, body fat and VAT. Fitness correlated negatively with ADIPO- IRpalmitate and FFApalmitate IC50. Stepwise regression analysis showed that fitness independently predicted ADIPO- IRpalmitate and FFApalmitate IC50 after adjusting for the other significant factors.
Conclusions: These findings suggest that aerobic fitness may promote metabolic health through positive effects on adipose tissue
Connection, 1994 October 26
No full textSinai Samaritan Medical Center, Milwaukee, WI: Internal publication for staff and volunteers. This issue summarizes the year\u27s accomplishments.https://institutionalrepository.aah.org/alldocuments/2233/thumbnail.jp
Tirzepatide and cardiovascular outcomes: A narrative review of mechanisms, efficacy and implications for heart failure management
No full textBackground: Tirzepatide, a dual GIP/GLP-1 receptor agonist, offers a novel cardiometabolic strategy beyond glycemic control with important implications for heart failure care. By producing potent, sustained weight reduction and favourable changes in lipids, blood pressure, systemic inflammation and endothelial biology, tirzepatide targets central pathophysiologic drivers of obesity-related HFpEF.
Methods: We conducted this review to synthesise current evidence on the mechanisms, clinical efficacy and therapeutic implications of tirzepatide for heart failure management, with emphasis on obesity-related HFpEF, cardiorenal effects and safety considerations. Randomised clinical programmes and the SUMMIT outcomes trial have demonstrated symptomatic and functional improvements, reverse cardiac remodelling on imaging, reduced circulating markers of myocardial stress and fewer worsening heart-failure events versus placebo, alongside signals of renal stabilisation.
Results: The tolerability profile aligns with the GLP-1 class, with gastrointestinal events predominating and a low risk of clinically important hypoglycemia; biliary events may be more likely at higher doses, while pancreatitis risk has not been clearly elevated. Data in HFrEF remain limited and caution is advised given prior mixed results with incretin therapies and theoretical concerns about rapid weight loss in advanced systolic failure.
Conclusion: This review integrates mechanistic insights and contemporary trial evidence to clarify how dual incretin agonism may modify the trajectory of obesity-driven heart failure, to inform multidisciplinary clinical decision making, and to highlight key unanswered questions and research priorities needed to define tirzepatide\u27s full role in heart failure management
Can Mesh Be Safely Placed In Multi-Recurrent Right Inguinal Hernia Repair Requiring An Appendectomy
No full textSodium channel inhibitors in clinical development for pain management: A focused review
No full textChronic and neuropathic pain remain significant clinical challenges owing to limited efficacy and safety concerns associated with conventional analgesics, including opioids and NSAIDs. Voltage-gated sodium channels, particularly Nav1.7 and Nav1.8, have emerged as promising non-opioid targets for pain modulation, given their selective expression in peripheral nociceptors and critical roles in pain signal transmission. Recent advances in structural biology and pharmacology have enabled the development of highly selective inhibitors targeting these channels. This review explores sodium channel inhibitors currently in clinical development, with a focus on suzetrigine (VX-548), the first US Food and Drug Administration (FDA)-approved Nav1.8 inhibitor for acute pain, as well as other investigational agents such as ralfinamide, OLP-1002, LTGO-33 and HBW-004285. Despite setbacks in early candidates owing to selectivity and tolerability issues, ongoing trials demonstrate renewed optimism for a new class of analgesics that may overcome the limitations of traditional pain therapies. We discuss key pharmacological challenges observed in earlier trials including functional redundancy, species differences, and on-target side effects, and outline how emerging strategies, such as structural biology-guided design, combination therapies, and precision medicine, are paving the way for safer, more effective, nonaddictive pain treatments
Inside Aurora Sinai Medical Center, 2002 January
No full textAurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.https://institutionalrepository.aah.org/alldocuments/2237/thumbnail.jp
Inside Aurora Sinai Medical Center, 2003 April
No full textAurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.https://institutionalrepository.aah.org/alldocuments/2250/thumbnail.jp
Inside Aurora Sinai Medical Center, 2004 March
No full textAurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events. This issue introduces the Planetree plan for Aurora hospitals.https://institutionalrepository.aah.org/alldocuments/2259/thumbnail.jp
Come on down, utilizing gamification learning techniques to improve nurse-sensitive outcomes
No full textThe Ultimate Nursing-Sensitive Indicator Showdown project aimed to enhance nursing and unlicensed personnel\u27s knowledge and improve nursing-sensitive indicator outcomes through gamified education. The initiative focused on preventing hospital-acquired conditions. Utilizing Keller\u27s ARCS (attention, relevance, confidence, and satisfaction) model, the project employed interactive games to engage participants, resulting in improved clinical practice and patient outcomes. The pilot showed positive results, supporting the expansion of this innovative educational approach sitewide