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The effect of cognitive behavioral interventions applied to children with anxiety disorders on their anxiety level: A meta-analysis study
Get PDFBackground: Anxiety disorders are among the most prevalent mental health conditions in childhood, affecting an estimated 10 % to 20 % of children. Cognitive Behavioral Therapy (CBT) is the most commonly employed treatment for these disorders. This study utilizes a meta-analytic approach to evaluate the effectiveness of CBT interventions in reducing anxiety levels among children diagnosed with anxiety disorders. Methods: A comprehensive search was conducted in the PubMed, Science Direct, Scopus, and Web of Science databases to identify randomized controlled and quasi-experimental studies that investigated the impact of CBT on children's anxiety levels. Studies that met the inclusion criteria were selected for analysis. The methodological quality of the selected studies was assessed using the Critical Appraisal Checklists developed by the Joanna Briggs Institute (JBI). Meta-analytic procedures were performed using the Review Manager 5.4.1 software. Results: Twenty-nine studies published between 2015 and 2024 met the inclusion criteria and were included in the meta-analysis. The results indicate that CBT interventions are significantly effective in reducing anxiety levels in children with anxiety disorders (SMD: -1.51,95 % CI: -2.07, -0.95, Z = 5.28, p < 0.00001). Among the various types of CBT, cognitive behavioral play therapy emerged as the most effective in reducing anxiety (SMD: -2.41, 95 % CI: -2.95, -1.88, Z = 8.84, p < 0.00001). Additionally, follow-up assessments at 3, 6, and 12 months post-intervention demonstrated that CBT has a sustained effect in lowering children's anxiety levels over time. Conclusions: This meta-analysis offers a valuable update to the existing literature by reinforcing the efficacy of CBT interventions in treating anxiety disorders in children. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies
A Fluorometric Method for Diclofenac Determination in Liquid Formulations: Experimental and Computational Assessments
Get PDFDiclofenac (DCF) is an important non-steroidal anti-inflammatory drug frequently used to relieve rheumatic pain and acute injuries. Therefore, determination of DCF in real-life samples using an efficient and cost-effective indirect method is vital in pharmaceutical science. The proposed novel method is based on the formation of a solid Zn-BMHM complex (chemosensor BMHM; (E)-1-((((1H-benzo[d]imidazol-2-yl)methyl)imino)methyl)-5-methylphenol) via the displacement of zinc ions from the Zn-DCF complex in an ethanol medium. The method consists of rapid precipitation steps that prevent interference effects and a turn-on fluorescence effect by using a chemosensor. The increase in fluorescence intensity was linearly correlated with the concentration of Zn-DCF solution over the range of 5.0-50.0 mu M (R2: 0.999) with a LOD value of 1.64 mu M. The method was applied to liquid pharmaceutical formulations and obtained excellent recovery values (99.09%-103.9%). Geometry optimization, molecular orbitals, and NBO population analyses were performed using density functional theory to display the exchange reaction's characteristics between ligand DCF and chemosensor BMHM. Global reactivity parameters and local interaction sites on the DCF and BMHM were examined in detail in view of the analyzed reaction. Theoretical assessments supported the analysis of reaction selectivity towards the BMHM ligand.Dzce University Scientific Research Projects Unit [2019.05.03.947]This study was supported by the Duezce University Scientific Research Projects Unit (project number: 2019.05.03.947)
Effects of europinidin-o-methylated anthocyanidin on scopolamine-induced memory impairments by improving neurological expression: An integrated with insilico and ADMET properties by computational analysis
Get PDFThis research aimed to determine if europinidin-o-methylated anthocyanidin could protect rats from memory and learning impairments induced by scopolamine (SCOP). The experiment involved four groups of Wistar rats with normal control, SCOP-treated group, europinidin (10 mg/kg and 20 mg/kg p.o.) for 14-day. After that, assessments of movement, memory recall, and learning were conducted. Brain tissue was analyzed for various markers, namely choline acetyltransferase (ChAT), acetylcholine esterase (AChE), antioxidants, nitrites, antiinflammatory, and brain-derived neurotrophic factor (BDNF). SCOP significantly impaired memory and altered brain chemistry. Europinidin treatment, however, reversed these effects, improving neurobehavioral function, reducing oxidative stress and inflammation, and restoring AChE, ChAT, and BDNF levels. Docking studies further revealed europinidin's favourable interaction with ChAT, supporting its protective mechanism. Europinidin showed favorable affinity towards ChAT with docking scores of-8.77 kcal/mol. The study demonstrates europinidin effectiveness in mitigating SCOP-induced memory deficits among rats.King Saud University, Riyadh, Saudi Arabia [ORF-2025-939]The authors are thankful to the Ongoing Research Funding Program (ORF-2025-939), King Saud University, Riyadh, Saudi Arabia for financial support
Mâtürîdî Tefsirinde Makâsıdî Yorum, Yazar: Gülhan Maden (İstanbul: Ensar Yayınları, 2023), 320 sayfa, ISBN 978- 625-6506-20-6)
Get PDFMakâsıd Teorisi, erken dönemlerden itibaren “Makâsıdü’ş-Şerî’a” veya “Makâsıdü’ş-Teşrî” terimleriyle fıkıh ilminde ortaya çıkmıştır. Zamanla fıkıh disiplini içerisinde sistematik bir yapıya kavuşan bu teori, farklı âlimlerin katkıları ve yaklaşımlarıyla daha da gelişmiştir. Son yıllarda ise bu kavram, ‘Makâsıdî Tefsir’ adıyla tefsir ilmi içerisinde yeni bir yöntem olarak değerlendirilmiş ve bu alanda çeşitli çalışmalar yapılmıştır. Gülhan Maden’in Matürîdî Tefsirinde Makâsıdî Yorum adlı eseri, bu çabaların önemli bir ürünü olarak dikkat çekmektedir. Bu çalışma, makâsıd nazariyesinin ve makâsıdî tefsir yönteminin Matüridî’nin (ö. 333/944) Te’vîlâtü’l-Kur’ân adlı eserindeki temellerini tespit etmeyi hedeflemektedir. Eserde, hem makâsıd düşüncesinin oluşumunda Mâtürîdî’nin bir katkısının olup olmadığı hem de onun tefsirinin makasıdî yöntemi ne ölçüde yansıttığı detaylı bir şekilde incelenmiştir. Maden bu kitabında, Mâtüridî’nin tefsir metodolojisini sistematik bir şekilde analiz ederek, sağlıklı bir Kur’an anlayışının geliştirilmesine katkıda bulunmasının yanı sıra, İslâm dünyasının yaşadığı çok boyutlu krizlere çözüm sunabilecek metodolojik bir çerçeve oluşturmayı amaçlamaktadır. Bu yönüyle eser, klasik tefsir mirasımızın modern dönemin sorunlarına nasıl çözüm üretebileceğini göstermesi bakımından özgün bir değer taşımaktadır. Giriş ve dört bölümden oluşan eser, sonuç kısmında Te’vîlâtü’l-Kur’ân’ın makâsıdî tefsir kategorisinin ilk örneklerinden biri olduğunu ortaya koyan önemli tespitlerle tamamlanmaktadır. Maden’in bu çalışması, klasik tefsir geleneğinde makâsıd düşüncesinin izlerini sürmesi ve Mâtürîdî’nin bu alandaki özgün katkılarını ortaya koyması bakımından literatüre önemli bir katkı sağlamaktadır. Ayrıca, modern dönemde makâsıd teorisinin gelişimine ışık tutacak tarihsel bir perspektif sunması bakımından da değerli bir kaynak niteliği taşımaktadır
Reframing Plant Stress Tolerance in the Era of Climate Change
Get PDFCurrently every country is suffering from climate change and despite the ongoing efforts, there are still limited success stories for the improvement of plant abiotic stress resilience. The studies mainly focused on understanding the stress response and tolerance at the molecular level and utilizing it to another genotype with no tolerance. The strong interaction of plants with their environment is the main obstacle here, which prevents the outcomes of small-scale experiments to be repeated in the field. The inclusion of wild genotypes adapted to extreme environments in QTL studies and breeding efforts may stand as a promising approach for the improvement of abiotic stress tolerance. Agricultural practices including biostimulants, micronutrients and nanoparticles, genome editing, and engineering organelles can also lead to reduced yield loss. Understanding how stress memory is initiated and how to make it heritable even under favorable growth conditions is another approach that needs more investigation. The aim of this book chapter is to point out the fact that single efforts by themselves will not be enough for sustain-ability, and although there is still a gap between breeders, farmers, biodiversity scientists, agricultural engineers, molecular scientists, plant pathologists, and climate scientists, they should combine their knowledge to secure future generations. © 2025 Elsevier B.V., All rights reserved
Investigation of rs11568476 Polymorphism in the SLC13A2 Gene in Turkish Patients with Hypocitraturia and Calcium-Containing Kidney Stones
Get PDFBackground and Objectives: Hypocitraturia is a major risk factor for calcium-containing kidney stone disease. Citrate inhibits stone formation by binding calcium in the urine. The SLC13A2 gene encodes the sodium-dependent dicarboxylate cotransporter 1 (NaDC1), a membrane transport protein that facilitates citrate reabsorption in the proximal renal tubules. Variants in this gene, such as rs11568476 (V477M), have been shown to significantly impair transporter activity. This study aimed to investigate the presence of the rs11568476 polymorphism in SLC13A2 and its association with hypocitraturia in Turkish patients with calcium-containing kidney stones. To our knowledge, this is the first genetic study evaluating this polymorphism in a Turkish cohort. Materials and Methods: This prospective cross-sectional study included 90 patients diagnosed with calcium-containing kidney stones at D & uuml;zce University Faculty of Medicine, Department of Urology. Based on 24 h urinary citrate levels, patients were divided into two groups: normocitraturic (n = 38) and hypocitraturic (n = 52). Blood and 24 h urine samples were analyzed for biochemical parameters. The rs11568476 polymorphism in SLC13A2 was analyzed using Real-Time PCR. Results: There were no significant differences between the two groups in terms of age, gender, and most biochemical parameters. Serum uric acid levels were significantly higher in the hypocitraturic group (p = 0.002), whereas family history of stone disease was more prevalent in the normocitraturic group (p = 0.024). Genetic analysis revealed no polymorphism in the rs11568476 region; all patients exhibited the homozygous wild-type genotype (GG). Conclusions: No association was observed between the rs11568476 polymorphism and hypocitraturia in this cohort. The absence of the polymorphism suggests that this variant may be rare or absent in the Turkish population. These findings highlight the importance of investigating additional genetic and environmental contributors to hypocitraturia and nephrolithiasis through larger, multicenter studies
The Use of Synthesized Zinc Oxysulphide Nanoparticles in Phosphate Phosphorus Removal from Synthetic Wastewater and Statistical Analysis
Get PDFThis study investigated the phosphate phosphorus (PO4-P) removal potential of zinc oxysulfide (ZnOxSy) nanoparticles obtained by fifteen varying component ratios. The statistical meaning of the distinct synthesis compositions was evaluated by regression analysis based on the response of PO4-P removal efficiencies. The results indicated that ZnOxSy nanoparticles could remove PO4-P by 99.5% without optimization of the adsorption process (Initial PO4-P concentration: 15 mg/L, adsorbent dose: 1 g/L, pH: 4.31, contact time: 2 hr). However, the synthesis compositions of ZnOxSy nanoparticles strongly effect the PO4-P removal efficiency. The data could be interpreted by regression analysis with a high R2 of 89.61% and p value of 0.000. The main component that positively affect the PO4-P removal efficiency was hydrogen peroxide, whereas sodium sulfide component had a limited effect. © 2025 Elsevier B.V., All rights reserved
The effect of teaching based on reasoning and processing games on elementary school students' arithmetic processing skills
No full textBu araştırma, ilkokul 4. sınıf öğrencilerinin aritmetik işlem becerilerindeki eksiklikleri ele almak amacıyla tasarlanmıştır. PISA ve TIMSS gibi uluslararası değerlendirmelerin sonuçları, öğrencilerin dört işlem yeteneklerinde beklenen seviyeye ulaşamadıklarını gösterirken, geleneksel öğretim yöntemlerinin bu eksiklikleri gidermede yetersiz kaldığı ileri sürülmektedir. Dolayısıyla, özellikle somut materyallerle desteklenen ve öğrencileri aktif katılıma yönelten yenilikçi yaklaşımlara ihtiyaç duyulduğu düşünülmektedir. Bu bağlamda, akıl yürütme ve işlem oyunlarının, işlem becerilerini artırmada etkili bir yöntem olabileceği varsayımıyla bu araştırma planlanmıştır. Araştırma, deney ve kontrol gruplarından oluşan 108 ilkokul öğrencisi ile yarı-deneysel bir desen kullanılarak gerçekleştirilmiştir. Deney grubunda, matematik derslerinde akıl yürütme ve işlem oyunları kullanılırken, kontrol grubunda yürürlükteki ders kitabının içerikleri uygulanmıştır. Veri toplama sürecinde, aritmetik işlem başarı testi kullanılarak ön test ve son test ölçümleri yapılmıştır. Araştırma verileri tekrarlanmış ölçümler için ANOVA testi ile analiz edilmiştir. Araştırma bulguları, deney grubundaki öğrencilerin aritmetik işlem becerilerinde kontrol grubuna kıyasla anlamlı bir artış meydana geldiğini göstermektedir. Deney grubundaki değişimin %21,5'inin uygulama sürecinden kaynaklandığı belirlenmiştir. Araştırma bulguları, matematik öğretiminde akıl yürütme ve işlem oyunlarının daha yaygın kullanılması gerektiğini göstermektedir.This study was designed to address the deficiencies in arithmetic operations skills of 4th-grade primary school students. While the results of international assessments such as PISA and TIMSS show that students do not reach the expected level in four operations skills, it is argued that traditional teaching methods are insufficient to overcome these deficiencies. Therefore, there is a need for innovative approaches that are supported by concrete materials and encourage students to actively participate. In this context, this study was planned with the assumption that reasoning and operation games can be an effective method to improve operation skills. The study was conducted with 108 primary school students in experimental and control groups using a quasi-experimental design. In the experimental group, reasoning and operation games were used in mathematics lessons, while the content of the current textbook was applied in the control group. In the data collection process, pretest and posttest measurements were made using the arithmetic operations achievement test. The research data were analyzed with ANOVA test for repeated measures. The study's findings show a significant increase in the arithmetic operation skills of the students in the experimental group compared to the control group. It was determined that 21.5% of the change in the experimental group was due to the implementation process. Research findings suggest that reasoning and operations games should be used more widely in mathematics teaching
Prediction of Deep Drawing Ratio for DP800 Steel by Using Modified-Mohr-Coulomb Damage Criteria
Get PDFThe demand for low-cost production in vehicle manufacturing while complying with the safety and environmental regulations is an enormous challenge. To comply with these challenges, sheet metal forming industries now extensively use advanced high-strength steels (AHSSs) in their products. However, due to excellent strength levels of AHSSs, problems arising in their forming stage, such as large spring-back and fracture, hinder the manufacturing process. At this stage, implementing finite element analysis (FEA) in the design processes greatly improves manufacturing processes since it allows determining possible forming errors before the actual forming process. In this study, the formability of DP800 steel has been investigated by carrying out deep drawing experiments. For that, a series of circular sheet metals, whose diameters were incrementally increased, have been deep drawn to a cup shape to determine the limiting drawing ratio (LDR). Additionally, Modified Mohr-Coulomb damage model has been utilised to predict the LDR in FEA. It has been found that the LDR of DP800 is 2.13 and the implemented damage model can successfully predict the LDR within only 2.35% error
Green and simple microextraction method based on deep eutectic solvent-assisted smartphone digital imaging colorimetry (SDIC) for Rhodamine B analysis in food products
Get PDFThis study employed a deep eutectic solvent-based liquid-liquid microextraction method and smartphone digital image colorimetry to detect and quantify Rhodamine B in foods. The deep eutectic solvent, a green solvent, was prepared by mixing tetrabutylammonium bromide and octanol in a 1:2 ratio. It was observed that Rhodamine B dyestuff readily transitioned to the DES phase, eliminating the need for additional reagents. The impact of various parameters, including DES type, molar ratio, volume, solution pH, ultrasonic time, centrifugation time, and sample volume, on extraction efficiency was examined, and the most effective conditions were determined. Additionally, the diameter of the prepared colorimetric box and the distance between the detector and the sample were investigated, leading to the identification of optimal conditions. The developed method's limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.0054 mu g/mL and 0.018 mu g/mL, respectively, for the measurements taken using seven parallel blank solutions at 554 nm. The relative standard deviations intraday and interday were 1.29% and 2.03%, respectively. The calibration graph demonstrated good linearity, with a coefficient of determination of 0.9996. The developed method's intraday and interday relative standard deviation values were 2.03% and 1.29%, respectively. Rhodamine B was detected in food samples using the developed method, obtaining extraction recoveries ranging from 95.16 to 103.88%.Scientific and Techno-logical Research Council of Turkiye (TUBIdot;TAK)Duzce University Scientific Research Projects Fund [2025.05.03.1561]Open access funding provided by the Scientific and Techno-logical Research Council of Turkiye (TUB & Idot;TAK). This research was supported by the Duzce University Scientific Research Projects Fund (Project No.: 2025.05.03.1561) for contributing to the financial portion of the project