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Intraoperative MRI Utilization by Moving Patients to the Magnet: Results From a Prospective Series of Brain Tumor Operations
No full textUse of e-cigarettes, traditional combustible cigarettes, and high sensitivity C-reactive protein: The Cross Cohort Collaboration
No full textBiliary Breach: A Rare Case of a Biliary Pleural Fistula Without a History of Trauma
No full textBiliary pleural fistulas (BPFs) are pathologic connections between the biliary tree and pleural cavity, allowing for abnormal flow of bile into the pleural space. This finding is rare and typically results from surgical procedures, such as chest tube placement, or trauma. We present the case of an 84-year-old male who initially presented with respiratory and gastrointestinal symptoms. Non-contrast CT of the chest, abdomen, and pelvis demonstrated a large right-sided empyema, which appeared to be continuous with a fluid-containing structure in the gallbladder fossa. Subsequent diagnostic workup revealed a biliary pleural fistula, which was ultimately treated with robotic cholecystectomy and fistula takedown. BPFs are rare entities; however, clinicians should consider them in the differential diagnoses of patients who present with both gastrointestinal and respiratory symptoms
The role of upfront radiation therapy for brain metastases in the era of CNS-active systemic therapies: a narrative review of clinical trial design and lessons learned
No full textTrifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma: A Phase II Study
No full textBackground: Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel combination of trifluridine/tipiracil with oxaliplatin as induction chemotherapy (IC) followed by CRT.
Methods: We enrolled patients with potentially resectable localized EGAC (T3, T4aN0, or node-positive disease) in this open-label, single-arm, multicenter, Phase II trial between January 2020 and October 2022. Patients received three cycles of IC with trifluridine/tipiracil and oxaliplatin and then underwent concurrent CRT with weekly carboplatin and paclitaxel followed by surgery. The primary objective was to evaluate the pCR rate. The secondary objectives were to evaluate 2-year progression-free survival (PFS), 2-year overall survival (OS), and toxicities. Circulating tumor DNA (ctDNA) was measured at prespecified intervals to assess its correlation with clinical outcomes.
Results: Of the 22 enrolled patients, 19 (86.4%) were male and 20 (90.9%) were Caucasian. The median age was 61 years, and 12 (54.5%) had their primary disease at the gastroesophageal junction. Twenty (90.9%) patients had T3 disease, and 15 (68.2%) had node-positive disease. Only two patients had pCRs, and an additional five had near pCRs. Since we could not meet our predefined pCR rate at the interim analysis, the study was closed. After a median follow-up of 15.8 months, 2-year OS and PFS were 43% and 41%, respectively. ctDNA clearance was associated with a significantly higher OS rate (p = 0.012) and PFS rate (p = 0.008). Nausea (59.1%) and fatigue (59.1%) were common treatment-related adverse events (AEs); nine (40.9%) patients had Grade 3 or higher AEs.
Conclusion: IC with trifluridine/tipiracil and oxaliplatin followed by CRT did not improve pCR rate in resectable EGAC compared to pCR from previous reports with CRT alone. We found a correlation between ctDNA clearance and improved survival, which merits further investigation
Racial and Ethnic Disparities in Healthcare Costs for Lung Cancer Patients: A Comprehensive Analysis
No full texthttps://scholarlycommons.baptisthealth.net/bhsf-academic-week-2025/1169/thumbnail.jp
Leveling Up Clinical Competence in an Inpatient Oncology Unit: Utilizing Competitive Gaming through Nursing Olympics to Master Clinical Skills
No full texthttps://scholarlycommons.baptisthealth.net/bhsf-academic-week-2025/1075/thumbnail.jp
Association between Endothelial Activation and Stress Index (EASIX) Score and Mortality among Critically Ill Heart Failure Patients
No full texthttps://scholarlycommons.baptisthealth.net/bhsf-academic-week-2025/1118/thumbnail.jp