34575 research outputs found
Sort by
Synthesis and biological activities of 3-aminoimidazo[1,2-α]pyridine compounds
No full textDespite their importance in cancer treatment, anticancer compounds face significant challenges due to drug resistance and low specificity, creating an urgent need for the discovery of more effective alternative. Herein, we report the synthesis of eleven 3-aminoimidazole[1,2-α]pyridine compounds (9–19) employing the one-pot Groebke-Blackburn-Bienayme three-component reaction (GBB-3CR). The cytotoxicity of the synthesised compounds was evaluated against three cancer cell lines (MCF-7, HT-29, B16F10) and a normal cell (MEF). Considering effectiveness and safety, the results demonstrated that among the eleven synthesised compounds, only compounds 12 and 14 exhibited high inhibitory activity against cancer cell lines. Compound 12 with a nitro group at the C-2 position and a p-chlorophenyl group at C-3 position, showed the highest inhibitory activity against HT-29, with an IC50 of 4.15 ± 2.93 µM. Additionally, compound 14, with a tolyl moiety at the C-2 position and a p-chlorophenyl amine at C-3 position, can also be considered a promising bioactive product against B16F10, with an IC50 of 21.75 ± 0.81 µM. Further research on these compounds may yield more potent candidates for the development of new anticancer agents
Bricolentrepreneuring: A comparative phenomenological study of Ukrainian refugees’ entrepreneurial bricolage practices in the UK and Romania
No full textUncertainty, discrimination, and socioeconomic marginalisation in host countries lead many refugees to entrepreneurial bricolage. Understanding their bricolage practices is crucial to designing policies and programmes to support refugee entrepreneurship, yet little is known about how refugees enact bricolage practices where institutional support is lacking, resources are constrained and where they contend with war trauma due to displacement. In the first study of its kind, we use interpretive phenomenological analysis (IPA) and draw on the concept of ‘bricolage’ (Lévi-Strauss 1966; Baker and Nelson 2005) to investigate Ukrainian refugee practices in the UK and Romania. Our findings affirm the importance of understanding the contexts which shape these refugees’ practices. Importantly, they draw much-deserved attention to how war trauma that refugees carry with them influences their bricolentrepreneuring journeys. We state our theoretical contributions and explore implications for effective policy making to support ‘entrepreneurship at the margins’
Firm Complexity and Credit Ratings
No full textThis paper examines the effect of firm complexity on credit ratings. Using a sample of U.S. non-financial firms and the state-of-the-art measure of firm complexity, we document a significantly negative relation between firm complexity and credit ratings, suggesting that rating agencies assign significantly lower credit score to more complex firms. Our results remain robust to alternative specifications and various endogeneity checks. Moreover, we find that the negative effect on credit ratings becomes weaker in more transparent and better-governed firms. Finally, we show that the effect is more pronounced during periods of high policy uncertainty. Overall, our paper provides a better understanding of complex firms and underscores the importance of transparency that enhances creditworthiness and thus mitigates credit risk
Sunless Haven
No full textPresentation of 'Sunless Haven' (Dir. George Clark) at 38th European Media Art Festival, Osnabrück, Germany, April 2025. The film was awarded the EMAF prize
The Effective Language Teacher: A resource pack for pre-service and in-service language teachers
No full textThis resource pack has been developed as part of the British Council’s AELLCA (Advancing English Language Learning in Central Asia) project, an initiative aimed at enhancing English language education across the region. With a focus on practical, research-informed approaches, this collection of materials is designed to support educators in delivering high-quality English language instruction tailored to local needs.
The materials in this pack were developed based on a series of workshops held in Turkmenistan at Seyitnazar Seydi Turkmen State Pedagogical Institute, International University of Humanities and Development, and Magtymguly Turkmen State University. Feedback from participants in these workshops played a crucial role in shaping the content, ensuring its
relevance and applicability to the local teaching context.
In addition to supporting classroom practice, this resource pack serves as a Continuing Professional Development (CPD) tool, encouraging teachers to reflect on their teaching,
experiment with new methodologies, and engage in collaborative learning. By fostering a culture of continuous learning and adaptation, it aims to empower educators to enhance their teaching effectiveness and student engagement
Motion Sickness
No full textSummary
• Motion sickness is an inappropriate emetic response including related symptoms such as nausea, to an abnormal motion stimulus.
• Motion sickness arises from motion stimuli that fail to conform to the expected inter-relationships between signals from the components of the vestibular system or between vestibular signals and the associated visual expectations – the Sensory Conflict theory. Conflicting motion stimuli can occur in many forms of transport but are not a feature of terrestrial life on two feet.
• The so-called Toxin Detector hypothesis proposes that the brain has evolved to use the constancy of gravity and the visual stability of the external world as a reference against which to calibrate its function. Failure of calibration might be the result of an ingested neurotoxin for which vomiting would be an appropriate response having survival value.
• Motion sickness is a practical problem in aviation, particularly in trainee aircrew and for flight manoeuvres or flight in turbulent atmospheric conditions. It remains a significant problem in the weightless conditions of spaceflight. The introduction of visual technologies such a virtual reality and simulators can create additional problems from visually induced motion sickness.
• Continuing or repeated exposure to an initially nauseogenic motion stimulus leads to a gradual increase in tolerance and a diminution of symptoms. This adaptive effect is exploited in desensitisation therapy.
• Prophylactic drugs are not completely effective and have sedative side effects. Many conventional antiemetic drugs are ineffective against motion sickness
Wild Industry
No full textWILD INDUSTRY: How wind power is changing wild landscapes in the Scottish Highlands and the communities living there
Practice-based research examining how windfarms are changing wild landscapes in the Scotland Highlands, in particular how people are responding to these material changes; what it means at an individual level but also in relation to the world’s wider transition to net zero carbon emissions at a time of climate emergency.
Ultimately, we will produce moving image artworks; an essay film and a series of documentary portraits taking inspiration from the work of filmmaker and poet Margaret Tait (11 November 1918 – 16 April 1999), in particular her interest in how people exist in conversation with the landscape and the seasons
To begin research and development of off-grid display mechanisms for the project (solar web servers, wind powered and solar powered cinema etc
