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Effectiveness of explanatory documents ascertaining patients’ wishes regarding organ and tissue donation: A randomized controlled trial
Get PDFSince many patients die without considering organ/tissue donation （OTD）, it is crucial to ascertain their end-of-life wishes in advance. Therefore, the present study aimed to evaluate the effectiveness of using explanatory documents （OTD） in helping physicians ascertain and record patients’ wishes in their medical charts. This study was a randomized controlled trial conducted in Japan. Explanatory documents with and without OTD descriptions were used. The primary outcome was to identify whether physicians recorded patient’s OTD wishes in their medical charts. More specifically, 30 physicians were included in the analysis, 27 of whom had no OTD experience. Of the 16 physicians who used documents with OTD information, 11 （40.7％; p＜0.001） created records. On the contrary, none of the 11 physicians who used documents without OTD information created any records. Among physicians with no OTD experience, those who used explanatory documents that included OTD information were found to record patients’ OTD wishes in their medical charts significantly more frequently. Conclusively, when physicians lacking OTD experience used documents with OTD information, they were more likely to ascertain patients’ wishes regarding OTD than when using documents without such information. Our findings demonstrate that the use of explanatory documents with OTD information could standardize the contents and timing of ascertaining patients’ OTD wishes. Our results could therefore contribute to the establishment of a healthcare system that respects all patients’ wishes during end-of-life care.departmental bulletin pape
Validating the minimally invasive balloon removal technique in fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia using high-intensity focused ultrasound
Get PDFThe current methods of removing the tracheal occlusion balloon in fetal endoscopic tracheal occlusion （FETO） for congenital diaphragmatic hernia （CDH） are significantly invasive for both the mother and the fetus. This study explores the validity of a novel approach combining high-intensity focused ultrasound （HIFU） and limonene emulsion to achieve noninvasive balloon removal after FETO. A FETO balloon model using natural rubber injected with 0.3ml limonene emulsion was subjected to HIFU irradiation at five output voltages （240, 200, 160, 120, and 80Vpp） across 25 experiments. Using a high-speed camera, the model was observed for balloon rupture or shrinkage. Higher HIFU output power frequently led to rupture patterns. Further regression analysis revealed that higher output power tended to reduce the rupture time; however, it was statistically nonsignificant （p＝0.1361）. Cavitation and emulsion collapse observed using the high-speed camera confirmed that the rupture mechanism was attributable to the interaction between limonene and latex and the physical effects of HIFU. Limonene emulsion with latex subjected to HIFU can be used as a noninvasive method for balloon removal after FETO. Further research is warranted to clinically validate these results and identify the optimal HIFU output power for adequate balloon collapse.departmental bulletin pape
Potent efficacy of 3-amino-4-hydroxy benzoic acid, a small molecule having anti-fibrotic activity, in a mouse model of non-alcoholic steatohepatitis
Get PDF昭和大学博士(薬学)2023年度doctoral thesi
Association between oral health status and functional independence measure on admission in convalescent hospitalized patients
Get PDF昭和大学博士(歯学)2023年度doctoral thesi
Collagen induction of immune cells in the mammary glands during pregnancy
Get PDF昭和大学博士(歯学)2023年度doctoral thesi
