Revistas UPO (Universidad Pablo de Olivade)
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La villa romana El Altillo (Rus, Jaén)
Get PDFIn this article we present the first results of a research on the Roman villa of El Altillo (Rus). Starting from a specific find, we have developed the study of a large area by means of prospecting techniques, microprospecting, georadar and stratigraphic surveys, with the aim of defining a Roman site and assessing its potential for research, conservation and dissemination. The different methods used have made it possible to delimit specific areas of the site, such as the pars urbana, where the identification of a large room paved with mosaics stands out.En este artículo damos a conocer los primeros los resultados de un trabajo de investigación sobre la villa romana de El Altillo (Rus). Partiendo de un hallazgo puntual, se ha desarrollado el estudio de una extensa área mediante técnicas de prospección, microprospección, georradar y sondeos estratigráficos, encaminado a la definición de un sitio romano y valorar sus posibilidades de investigación, conservación y difusión. Las distintas metodologías aplicadas han permitido acotar áreas específicas del yacimiento, como la pars urbana, donde destaca la identificación de una gran sala pavimentada con mosaicos
Impacto del impuesto de renta en el costo promedio ponderado del capital en el sector agropecuario colombiano: 2018-2022
No full textThere is a belief that income tax raises the cost of capital. As it rises, it makes investment projects in the real sector unviable, decreases the value of companies, hinders access to sources of finance and hinders the financial management of firms. This research reviews the interaction between income tax, systematic risk and the cost of capital in the Colombian agricultural sector between 2018 and 2022. It explores how the tax burden influences investment decisions, through the cost of capital (WACC). The central hypothesis of tax experts suggests that income tax has a direct impact on the cost of capital: higher rates would imply a higher cost of capital and vice versa, in theory. Statistical analysis validates whether this relationship is true and concludes that it is not. What is important, and which affects the cost of capital through the perception of risk, is the lack of clear and effective tax policies that promote economic growth and the financial stability of companies. This study contributes to a better understanding of fiscal dynamics and their effect on the Colombian agricultural sector, offering a critical view of tax reforms and their impact on investment and financing decisions.Existe la creencia de que el impuesto de renta eleva el costo de capital. Al elevarse, se vuelven inviables los proyectos de inversión en el sector real, disminuye el valor de las compañías, dificulta el acceso a las fuentes de financiación y entorpece la gestión financiera de las empresas. En esta investigación se revisa la interacción entre el impuesto de renta, el riesgo sistemático y el costo de capital en el sector agropecuario colombiano entre los años 2018 y 2022. Se explora cómo la carga fiscal influye en las decisiones de inversión, a través del costo del capital (WACC). La hipótesis central de los expertos en tributación sugiere que el impuesto de renta impacta de manera directa en el costo de capital: tasas más altas implicarían un mayor costo de capital y viceversa, en teoría. A través de un análisis estadístico se valida si esta relación es cierta, llegando a la conclusión de que no es así. Lo que sí es importante, y que afecta al costo de capital a través de la percepción del riesgo, es la inexistencia de políticas tributarias claras, también efectivas, que promuevan el crecimiento económico y la estabilidad financiera de las empresas. Este estudio contribuye a comprender mejor las dinámicas fiscales y su efecto en el sector agropecuario colombiano, ofreciendo una visión crítica sobre las reformas tributarias y su impacto en las decisiones de inversión y financiación
Development of a semicontinuous system to evaluate the effects of K2 toxins on wine yeasts.
Get PDFSome yeast species can be infected by viral sequences from the Totiviridae family, which encode toxins (1). These toxins providea competitive advantage to the yeast carriers by inducing the death of sensitive cells (2). Additionally, "killer" yeasts must possess another auxiliary virus, called LA, responsible for providing the capsid and the replication functions for the killer virus. This study focuses on wine yeasts infected with the M2 killer virus, which encodes the K2 toxin, maintained by the auxiliary virus, L2.
The main objective of this work is to develop and assay a semicontinuous culture system that allows maintaining the culture in its exponential growth phase for as long as possible. This will enable the evaluation of competition between infected and non-carrier yeasts, as well as the effects of these toxins on wild wine yeasts. Since toxins are only active in a narrow range of pH the variation in the pH of the culture, caused by yeast metabolism, must be monitored and controlled using a pH -coupled peristaltic bomb that adds fresh medium to keep cells in proliferative state while keeping pH in the toxin active range.
To assess competitiveness between two yeast strains and observe the behavior and evolution in co-culture, strains must be genetically labeled to distinguish between them, to differentiate between yeasts that produce K2 and those that do not. Our last goal is to select yeast strains suitable for their use in wineries, so we have chosen to label the strains with spontaneous resistance mutations. This strategy allows the marked strain to be used in the food industry without restrictions. The spontaneous generation of mutants is carried out using different protocols, in which various toxins are employed, such as sulfometuron (3), copper sulfate (4), or 2-deoxyglucose (5).
In this poster we present preliminary results on the setup of the pH controlled bioreactor and the analysis of different strategies to isolate yeast spontaneous mutants
Study of the role of importin alpha Imp1 in the heat shock response.
Get PDFMotivation: Protein homeostasis or proteostasis is essential for cellular survival and tissue homeostasis. Cellular proteostasis is maintained by a tight balance between protein synthesis, folding and degradation. Various stress conditions, mutations, translation defects, etc. can disrupt this balance, leading to the accumulation of misfolded proteins prone to aggregation, a hallmark of several human diseases [1]. In this situation, cells activate the heat shock response (HSR), a transcriptional response driven by the universal transcription factor Hsf1, which upregulates molecular chaperones to counteract folding stress [2]. Among these chaperones, Hsp104 plays a key role in disaggregating misfolded proteins, promoting their refolding or degradation. However, the mechanisms regulating Hsp104 subcellular localization remain poorly understood. Previous results from the laboratory have shown that in the absence of Importin alpha Imp1, which functions in nucleocytoplasmic transport, the cellular distribution of the chaperone disaggregase Hsp104 is altered [3].
Methods: In this work, we used a combination of live-cell fluorescence microscopy and genetic analysis to characterize the role of Imp1 in the regulation of Hsp104 nucleocytoplasmic transport and its contribution to cellular proteostasis under folding stress conditions.
Results: Our results show that, in the absence of Imp1, nuclear levels of Hsp104-GFP are significantly reduced compared to wild-type cells and it is accumulated in nuclear foci or aggregates under non-stressed conditions. Upon heat stress, Hsp104 nuclear levels further decrease in imp1Δ cells, correlating with an impaired stress response and reduced cellular fitness. Currently we are testing whether Imp1 is required for the nuclear localization of other HSR chaperones as part of a general mechanism to maintain nuclear proteostasis in unperturbed conditions and upon folding stress.
Conclusions: Our findings demonstrate that Importin-α Imp1 is required to maintain cellular fitness upon folding stress through the regulation of Hsp104 nucleocytoplasmic transport
De Vera Cruz a Gran Poder:: Festejos en Camas por la llegada del Nazareno.
Get PDFThis paper analyzes the impact of the arrival of the Nazarene by Francisco Marco Díaz-Pintado in the town of Camas. The Vera Cruz Brotherhood, with origins dating back to the 16th century, underwent a change in its Christological devotion that would alter the future of the Corporation itself. The Valencian sculptor, known for his enthusiasm for participating in artistic contests, presented the statue of Jesus del Gran Poder at the Fine Arts Exhibition organized by the Ateneo of Seville in 1923. The exhibition took place between April 15 and May 20 of that year. The image of the Lord likely arrived in Camas in the early weeks of June, as its blessing was held on the morning of Sunday, June 17, 1923, in a festive atmosphere. According to the journalistic accounts of the time, the Nazarene sculpture was unique due to its technical and stylistic features. The classical style employed by Francisco Marco in its execution completely disappeared in the various interventions carried out on the statue throughout the 20th century.En el presente trabajo analizamos el impacto que tuvo la llegada del Nazareno de Francisco Marco Díaz-Pintado en la villa de Camas. La Cofradía de la Vera Cruz, con orígenes en el siglo XVI, sufrió un cambio de advocación cristífera que cambiaría el futuro de la propia Corporación. El escultor valenciano, tan aficionado a participar en certámenes artísticos, presentó la talla de Jesús del Gran Poder en la exposición de Bellas Artes, organizada por el Ateneo sevillano, en 1923. La muestra se llevó a cabo entre el 15 de abril y el 20 de mayo de ese mismo año. La imagen del Señor debió de llegar a Camas en las primeras semanas del mes de junio, ya que su bendición se llevó a cabo en la mañana del domingo 17 de junio de 1923, en un ambiente de fiesta. Según la crónica periodística de la época, la talla del Nazareno era única por sus características técnicas y estilísticas. El estilo clásico utilizado por Francisco Marco en su ejecución desapareció por completo en las distintas intervenciones realizadas a la talla a lo largo del siglo XX
Apenas un Río en el Océano. : La Expedición a Costa Firme del Teniente General Pablo Morillo en 1815. Un estudio orgánico de sus cuerpos y socio profesional de sus mandos.
Get PDFOn 17 February 1815, Lieutenant General Pablo Morillo's expedition to the Costa Firme left Cadiz. It was made up of 11,000 veteran soldiers from the Spanish Royal Army, grouped into eight regiments that had fought in the recently concluded War of Independence. These ‘Soldiers of the King’ came to the aid of the Royalist cause in America, shaken by the Wars of Emancipation that had been raging since 1810. This army of 1815 was very different from the army of 1808, which had been reorganised and its doctrine and training renewed thanks to the 6 years of (ultimately victorious) war against the 1st French Empire and its close collaboration with Arthur Wellesley's allied British army.
This research article deals with the organisation and military experience of its units and commanders, through the study of more than 350 service records of the chiefs, officers and subalterns who made up the expedition; unpublished documentation that has been deposited in the ‘Overseas’ section of the General Archive of Simancas.El 17 de febrero de 1815 partió de Cádiz la expedición a Costa Firme del Teniente General Pablo Morillo. Estaba integrada por unos 11.000 soldados veteranos del Ejército Real español, agrupados en ocho regimientos curtidos en la recién finalizada Guerra de la Independencia. Estos “Soldados del Rey” acudían en auxilio de la Causa Realista en América, sacudida por las Guerras de Emancipación abiertas desde 1810. Este Ejército de 1815 era muy distinto del de 1808, reorganizado y renovada su doctrina e instrucción gracias a los 6 años de guerra (al final victoriosos) contra el 1º Imperio francés y a su estrecha colaboración con el Ejército aliado británico de Arthur Wellesley.
Este artículo de investigación aborda la organización y experiencia militar de sus unidades y mandos, a través del estudio de más de 350 hojas de servicio de los jefes, oficiales y subalternos que integraron dicha expedición; documentación inédita que se halla depositada en la Sección “Ultramar” del Archivo General de Simancas
Desigualdades de género y sexualidad en la vida universitaria. Presencias y olvidos en las narrativas institucionales de una universidad del Conurbano Bonaerense (Argentina): Presence and Oversights in the Institutional Narratives of a University in the Buenos Aires Conurbation (Argentina)
No full textThe article studies the narratives of senior management staff at the National University of José C. Paz (UNPAZ) regarding the presence of the transgender population in this institution. These representations are examined in dialogue with the meanings constructed about the institution itself, its history, its relationship with the territory, and its student body. A qualitative approach is adopted, based on the analysis of in-depth interviews conducted in 2022 with senior management staff of UNPAZ. The findings are situated within the framework of a process of expanding sexual citizenship and the institutionalization of feminist demands in Argentine national universities. The findings highlight the paradoxical aspects inherent in the construction of sexual citizenship and modern identity politics, emphasizing the importance of incorporating an intersectional perspective in designing interventions from educational institutions to address social inequalities.En el artículo se estudian las narrativas del personal de distintas áreas de gestión institucional de la Universidad Nacional de José C. Paz (UNPAZ) sobre la presencia de población travesti y trans en esta institución. Dichas representaciones son analizadas en diálogo con los sentidos construidos sobre la institución misma, su historia, su relación con el territorio y su estudiantado. Se adopta un enfoque cualitativo basado en el análisis de entrevistas en profundidad realizadas en 2022 a personal de áreas de gestión institucional de la UNPAZ. Los hallazgos se sitúan en el marco de un proceso de ampliación de la ciudadanía sexual y de institucionalización de las demandas feministas en las universidades nacionales de Argentina. En las conclusiones se reflexiona sobre los aspectos paradójicos inherentes a la construcción de sujetos de derecho en la modernidad y las políticas de identidad, señalando la importancia de incorporar la perspectiva interseccional en el diseño de intervenciones desde las instituciones educativas para enfrentar las desigualdades sociales
Educar mediante arte y pedagogías queer: Propuesta de creación “Museo Queer”
Get PDFThis work is centred on the need to educate through queer pedagogies, in order to make visible and include the diversities of sex and gender in the current educational sphere and in society as a present reality. The innovative experience of the Queer Museum shows art as a tool for expression and self-knowledge that favours the educational process, giving voice to all those identities that inhabit the non-normative. The use of the focus group as a methodological technique allows us to observe and analyse the perceptions generated by this innovative experience in queer young people from different parts of the world.El presente trabajo está centrado en la necesidad de educar a través de pedagogías queer, a modo de visibilizar e incluir las diversidades de sexo y género en el plano educativo actual y en la sociedad como realidad presente. La experiencia innovadora del Museo Queer muestra el arte como herramienta eduartivista de expresión y autoconocimiento que favorece el proceso educativo, dando voz a todas aquellas identidades que habitan lo no normativo. El empleo del focus group como técnica metodológica permite observar y analizar las percepciones que genera dicha experiencia innovadora en jóvenes queer de diferentes partes del mundo
Condicionantes de ser agressor ou vítima na adolescência
No full textThe aim of the article is to investigate the thesis of a direct and indirect link between sex, gender, and aggressive and victim behavior from the perspective of bio–, social and psychological development. The meta-analysis of the previous study identifies risk factors and protective factors for becoming an aggressor or a victim and the role of sex and gender in that process. The work consists of two parts. The first part of the chapter is the review of the latest research in the field of aggression and adolescence focused on conditions of violence among youth. And the second part is the presentation of the latest research of the author. In the study, model were considered: bio, psycho and social factors such as sex, temperament; attachment; aggressiveness; family, teacher, and classmate support; resilience; and the previous victim or aggressor experiencesThe aim of the article is to investigate the thesis of a direct and indirect link between sex, gender, and aggressive and victim behavior from the perspective of bio–, social and psychological development. The meta-analysis of the previous study identifies risk factors and protective factors for becoming an aggressor or a victim and the role of sex and gender in that process. The work consists of two parts. The first part of the chapter is the review of the latest research in the field of aggression and adolescence focused on conditions of violence among youth. And the second part is the presentation of the latest research of the author. In the study, model were considered: bio, psycho and social factors such as sex, temperament; attachment; aggressiveness; family, teacher, and classmate support; resilience; and the previous victim or aggressor experiences.L'obiettivo dell'articolo è indagare la tesi di un legame diretto e indiretto tra sesso, genere e comportamento aggressivo e vittimistico dal punto di vista dello sviluppo biologico, sociale e psicologico. La meta-analisi dello studio precedente identifica i fattori di rischio e i fattori protettivi per diventare un aggressore o una vittima e il ruolo del sesso e del genere in questo processo. Il lavoro si compone di due parti. La prima parte del capitolo è una rassegna delle ultime ricerche nel campo dell'aggressività e dell'adolescenza, incentrate sulle condizioni di violenza tra i giovani. La seconda parte è la presentazione delle ultime ricerche dell'autore. Nello studio sono stati presi in considerazione fattori bio, psico e sociali come il sesso, il temperamento, l'attaccamento, l'aggressività, il supporto della famiglia, degli insegnanti e dei compagni, la resilienza e le precedenti esperienze di vittima o aggressore.O objetivo do artigo é investigar a tese de uma ligação direta e indireta entre sexo, género e comportamento agressivo e de vítima, na perspetiva do desenvolvimento biológico, social e psicológico. A meta-análise do estudo anterior identifica factores de risco e factores de proteção para se tornar agressor ou vítima e o papel do sexo e do género nesse processo. O trabalho é composto por duas partes. A primeira parte do capítulo consiste na revisão da investigação mais recente no domínio da agressão e da adolescência, centrada nas condições de violência entre os jovens. E a segunda parte é a apresentação da pesquisa mais recente do autor. No estudo, foram considerados os seguintes modelos: factores biológicos, psicológicos e sociais, tais como o sexo, o temperamento, a vinculação, a agressividade, o apoio da família, dos professores e dos colegas, a resiliência e as experiências anteriores da vítima ou do agressor
O interesse superior da criança face à violência mais grave: Apresentação de dois casos e da sua estratégia jurídica
No full textThis article describes two real cases brought into practice, where we can observe the social stigma and lack of awareness of the reality of violence against children that still persist in our legal system and our social reality. The gender perspective referred to by the Supreme Court in numerous judgments was conspicuous by its absence, since the judicial procedure involved an obvious secondary victimisation. As is so often the case, the victim will never receive the compensation imposed, so she will not even be compensated financially for the serious damage suffered during so many years. The victim remains a victim long after the crime ‘has been committed’. Prompt legal intervention, critical interpretation of evidence and comprehensive reparation must operate cohesively and thus effectively guarantee the best interests of the child and his or her protection from the most serious violence.En este artículo se describen dos casos reales traídos a la practica, en donde podemos observar el estigma social y la falta de conciencia sobre la realidad de las violencias hacia la infancia que todavía persisten en nuestro sistema jurídico y nuestra realidad social. La perspectiva de género a la que se refiere el Tribunal Supremo en numerosas sentencias, en estos dos casos, brilló por su ausencia, puesto que el procedimiento judicial supuso una evidente victimización secundaria y como es tan habitual, la víctima no recibirá nunca la indemnización impuesta, por lo que ni siquiera se la reparará económicamente del grave daño sufrido durante tantos. La víctima sigue siéndolo mucho después de que el delito “haya sido cometido”. La pronta intervención jurídica, la interpretación crítica de las pruebas y la reparación integral deben operar cohesivamente y así garantizar de manera efectiva el interés superior del menor y su protección ante las más graves violencias.Questo articolo descrive due casi concreti in cui possiamo osservare lo stigma sociale e la mancanza di consapevolezza della realtà della violenza contro i bambini che ancora persistono nel nostro sistema giuridico e nella nostra realtà sociale. La prospettiva di genere a cui la Corte Suprema ha fatto riferimento in numerose sentenze, in questi due casi è stata evidente per la sua assenza, dal momento che la procedura giudiziaria ha comportato un'evidente vittimizzazione secondaria e, come accade spesso, la vittima non riceverà mai il risarcimento imposto, quindi non sarà nemmeno risarcita economicamente per il grave danno subito per tanti anni. La vittima rimane tale anche molto tempo dopo che il reato “è stato commesso”. Un intervento legale tempestivo, un'interpretazione critica delle prove e un risarcimento completo devono operare in modo coeso e garantire così efficacemente l'interesse superiore del minore e la sua protezione dalle violenze più gravi.O presente artigo descreve dois casos reais levados à prática, onde podemos constatar o estigma social e o desconhecimento da realidade da violência contra crianças que ainda persistem no nosso sistema jurídico e na nossa realidade social. A perspetiva de género referida pelo Supremo Tribunal em inúmeros acórdãos, nestes dois casos, primou pela ausência, uma vez que o processo judicial envolveu uma evidente vitimização secundária e, como é tão comum, a vítima nunca receberá a indemnização imposta, pelo que nem sequer será compensada financeiramente pelos graves danos sofridos durante tantos anos. A vítima continua a ser vítima muito depois de o crime ter sido “cometido”. A pronta intervenção judicial, a interpretação crítica das provas e a reparação integral devem funcionar de forma coesa e assim garantir eficazmente o superior interesse da criança e a sua proteção contra a violência mais grave