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Location selection methodology for data center with renewable energy integration
Full text linkWith the development of technology, dependence on the Internet has increased the demand for data centers. However, selecting optimal locations for data centers remains a critical challenge due to the need for energy efficiency and environmental sustainability. This study addresses this research gap by proposing a novel decision-making framework that integrates renewable energy considerations into the data center site selection process. The main objective is to identify the most suitable locations for data centers by evaluating multiple criteria. Expert-based evaluations are collected and processed using the Picture-Fuzzy SWARA (PiF-SWARA) method to determine the relative importance of criteria, providing a robust weighting mechanism. The Picture-Fuzzy VIKOR (PiF-VIKOR) method is then applied to rank six potential data center locations in Türkiye. This study is the first to combine PiF-SWARA and PiF-VIKOR in the context of renewable energy-integrated data center siting, offering a novel and comprehensive decision-making approach. Findings indicate that locations with high solar and wind energy potential, coupled with strong infrastructure accessibility, offer the most viable solutions. As the first study to integrate the PiF-SWARA and PiF-VIKOR methods for data center site selection, this research contributes to developing sustainable infrastructure and offers a replicable framework for future studies. © 2025 Elsevier Lt
Development of interpretable intelligent frameworks for estimating river water turbidity
Full text linkTurbidity (TU) is one of the paramount water quality indicators in rivers and streams. Therefore, knowledge of water TU plays a fundamental role in optimal managing and monitoring river water quality. This study aimed at developing four intelligent schemes including three boosting methods i.e. Categorical Boosting (CatBoost), Light Gradient-Boosting Machine (LightGBM), eXtreme Gradient Boosting (XGBoost), and a deep learning method named Convolutional Neural Networks (CNN). To evaluate the performance of proposed models, two gauging river stations situated in United States (i.e. USGS 14206950 and USGS 14211720) were selected as a case study. 70% and 30% of whole data were utilized as the training and validation datasets when developing the models, respectively. It is worthwhile to note that the development of boosting models and their performance companions with a deep learning model, as well as addressing the impacts of input features on the models' outputs using SHapley Additive exPlanations (SHAP) are the novel aspects of this study, which have been rarely considered in preceding studies for river water TU estimation. Based on the achieved results during the validation period, the CatBoost and XGBoost models were found to be generally best models for an accurate estimation of river water TU in the studied sites. During the validation period, the best-performing models were XGBoost (R = 0.951, NSE = 0.903, RMSE = 3.552 FNU, MAE = 1.816 FNU) at USGS 14206950, and CatBoost (R = 0.961, NSE = 0.920, RMSE = 2.502 FNU, MAE = 1.219 FNU) at USGS 14211720 both established using full-input estimators. An interpretability assessment of the developed models was finally conducted taking into account the SHAP. Analysis of the SHAP graphs in a global level during the validation phase illustrated that river discharge was the most important input variable affecting the output results of the best-performing implemented models
Determination of the In Vitro Cytotoxic Activities of Several Coumarin Derivatives on Neuroblastoma Cell Lines With In Silico Inhibitory Effects on CDK9, VEGFR2 and EGFR Proteins and ADME Studies
No full textDue to their stable nature and medical applicability properties, coumarin derivatives have fascinated medicinal chemists in the
discovery of novel therapeutics. In this study, the cytotoxic/anticancer properties of some newly synthesized coumarin derivatives were aimed at designing, synthesizing, and examining cultured human neuroblastoma cells. Moreover, molecular
docking studies were carried out to determine the potential mechanism. In addition, ADMET properties were evaluated to
examine the drug‐likeness of newly designed coumarin derivatives. To detect the cytotoxic action of compounds, 3‐(4,5‐
dimethylthiazol‐2‐yl)‐2,5 2,5‐diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release assays were carried
out. In addition, Hoechst 33258 staining was used to detect abnormal nuclear structures. In silico, the estimates for all
compounds (3a‐3c) used in the study revealed that they possessed desirable physicochemical properties for bioavailability. The
results of our study showed that all tested compounds exhibited remarkable cytotoxic effects on human neuroblastoma cell lines
(p < 0.05). Additionally, among the compounds tested, 3a and 3c showed selective effects on neuroblastoma cells effectively at
all tested concentrations. However, it was found that the selective feature of 3b, unlike the others, was concentration‐
dependent. Our findings clearly showed that novel coumarin derivatives exerted potent and selective anticancer effects. Results
of molecular docking studies were in parallel with in vitro studies. Unlike the majority of hybrid coumarin derivatives reported
in anticancer research, the present study introduces minimalist, heteroatom‐free coumarins bearing bulky aliphatic substituents. These compounds demonstrated selective cytotoxicity against SH‐SY5Y neuroblastoma cells and a favorable multi‐target
binding profile, highlighting a distinct hydrophobic volume‐based SAR. As a result, the obtained data exhibited that all used
molecules may be good multitarget drug alternatives for the treatment of neuroblastoma
The contributions of children's libraries in disadvantaged areas to critical thinking skills
Full text linkCritical thinking emerges as a crucial skill that can bring meaning to the lives of children, particularly those facing challenging living conditions. This qualitative study aims to examine the critical thinking tendencies of 30 children (15 girls and 15 boys) aged 7 to 10 from disadvantaged areas who experienced the 2023 Kahramanmaras, earthquake and regularly attended a children's library in Gaziantep, Turkey. The participants were selected using a purposive sampling method and participated consistently in workshops offered by the library. Data were collected through written interview forms designed to evaluate the children's critical thinking skills and assess the impact of the library programs. These data were analyzed using content analysis to gain a deeper understanding of the children's thought processes and the influence of library programs on these processes. The findings revealed that the library environment and workshop activities significantly enhanced the children's critical thinking skills. Through group discussions and interactions with diverse information sources in the library, children developed key components of critical thinking, including the ability to evaluate different perspectives, analyze information, and think independently. This study highlights the pivotal role of children's libraries in supporting critical thinking skills, particularly among children in disadvantaged areas. Based on the study's findings, it is recommended to diversify and expand workshop programs in children's libraries that target critical thinking skills. Additionally, implementing community-based educational programs in collaboration with local communities could further strengthen children's critical thinking abilities, equipping them to become more capable individuals in the future
Spastik serebral palsili çocuklarda hippoterapi similatörünün alt ekstremite selektif motor kontrolü, denge ve gövde kontrolüne etkisinin incelenmesi
Full text linkBu çalışmanın amacı Serebral Palsi (SP)'li çocuklarda konvansiyonel fizyoterapiye ek olarak uygulanan hippoterapi simülatörünün alt ekstremite selektif motor kontrolü, denge ve gövde kontrolüne etkisini incelemektir. SP'li bireyler hippoterapi simülatörü (HS) (n=13) ve kontrol grubu (KG) (n=13) olarak randomizasyon yöntemiyle iki gruba ayrıldı. HS grubuna 20 dakika konvansiyonel fizyoterapi ve 20 dakika hippoterapi simülatörü eğitimi, kontrol grubuna ise 40 dakika konvansiyonel fizyoterapi eğitimi 8 hafta süresince, haftada 2 kez uygulandı. SP'li bireylerin spastisite değerlendirmesi için Modifiye Asworth Skalası (MAS), selektif motor kontrol değerlendirmesi için Alt Ekstremite Selektif Motor Kontrol Skalası (AESKS), denge değerlendirmesi için Pediatrik Berg Denge Skalası (PBDS), gövde kontrolü değerlendirmesi için Gövde Kontrol Ölçüm Skalası (GKÖS) kullanıldı. Bireylerin başlangıç AESKS dominant taraf değerlerine göre grupların benzer oldukları bulundu (p=0,111), non-dominant tarafta ise kontrol grubunun yüksek olduğu görüldü (p=0,013). Tedavi sonrası HS grubunun dominant ve non-dominant taraf AESKS değerlerinde artış gözlendi (p<0,05). Tedavi sonrası KG'da dominant ve non-dominant taraf AESKS değerlerinde değişim gözlenmedi (p>0,05). Tedavi sonrası gruplar arası dominant ve non-dominant taraf AESKS değerleri benzer bulundu (p>0,05). Bireylerin başlangıç spastisite şiddetleri gastrocnemius dominant taraf değerleri gruplarda benzerdi (p=0,055). Diğer başlangıç spastisite şiddetleri farklılık gösterdi (p<0,05). Her iki grupta müdahale sonrası spastisite şiddetinde değişim gözlenmedi (p>0,05). Bireylerin başlangıç denge değerlerinde kontrol grubunun değerlerinin yüksek olduğu bulundu (p=0,013). Her iki grupta müdahale sonrası denge skorlarında anlamlı artış bulundu (p<0,05). Tedavi sonrası gruplar arası denge değerleri benzer bulundu (p=0,521). Bireylerin başlangıç gövde kontrolü toplam değerlerine göre grupların benzer olduğu görüldü (p=0,054). HS grubunda GKÖS tüm alt parametreleri ve toplam puanda artış gözlendi (p<0,05). KG' de GKÖS statik oturma alt parametresi dışında diğer parametrelerde anlamlı bir gelişim bulunmadı (p>0,05). Tedavi sonrası gruplar arası GKÖS toplam değerleri benzer bulundu (p=0,605). Bu bulgular, SP'li çocuklarda HS'nin alt ekstremite selektif motor kontrol, denge ve gövde kontrolünü geliştirmede konvansiyonel fizyoterapiye ek olarak uygulanmasının faydalı olacağını belirtmektedir.The aim of this study was to investigate the effect of hippotherapy simulator applied in addition to conventional physiotherapy on lower extremity selective motor control, balance and trunk control in children with Cerebral Palsy (CP). Individuals with CP were randomized into two groups as hippotherapy simulator (HS) (n=13) and control group (CG) (n=13). The HS group received 20 minutes of conventional physiotherapy and 20 minutes of hippotherapy simulator training and the control group received 40 minutes of conventional physiotherapy training twice a week for 8 weeks. Modified Asworth Scale (MAS) was used for spasticity assessment, Lower Extremity Selective Motor Control Scale (LEMSC) for selective motor control assessment, Pediatric Berg Balance Scale (PBDS) for balance assessment, and Trunk Control Measurement Scale (TCMS) for trunk control assessment. According to the baseline AESCS dominant side values of the individuals, the groups were similar (p=0.111), whereas the control group was higher on the non-dominant side (p=0.013). After treatment, an increase was observed in the dominant and non-dominant side AESCS values of the HS group (p<0.05). No change was observed in the dominant and non-dominant side AESCS values in the CG after treatment (p>0.05). Dominant and non-dominant side AESCS values were similar between groups after treatment (p>0.05). The baseline spasticity severities of the gastrocnemius dominant side values were similar in the groups (p=0.055). Other baseline spasticity severities differed (p<0.05). No change in spasticity severity was observed in both groups after the intervention (p>0.05). In the initial balance values of the individuals, the values of the control group were found to be higher (p=0.013). There was a significant increase in balance scores after intervention in both groups (p<0.05). Balance values between groups were similar after treatment (p=0,521). According to the baseline trunk control total values of the individuals, the groups were similar (p=0,054). In the HS group, an increase was observed in all sub-parameters and total score (p<0.05). In the CG group, no significant improvement was found in the other parameters except for the static sitting sub-parameter (p>0.05). After the treatment, the total values of the SCSS were similar between the groups (p=0.605). These findings suggest that HS may be useful in addition to conventional physiotherapy to improve lower extremity selective motor control, balance and trunk control in children with CP
Identıfyıng Crıtıcal Barrıers To Cırcular Constructıon Adoptıon From A Cross-Country Perspectıve
Full text linkCircular construction (CC) is a transformative approach in the construction industry, emphasizing the integration of circular economy (CE) principles to overcome sustainability barriers, reduce waste, and optimize resource efficiency. This innovative methodology prioritizes material design, deconstruction, and reuse while fostering collaboration to drive systemic change. However, CC adoption faces significant challenges across countries, which has limited global understanding and implementation. These disparities highlight the need for targeted research to address barriers specific to various national contexts. Transitioning to CC offers an opportunity to decouple construction activities from resource depletion and environmental degradation. Yet, the limited research on CC adoption, particularly regarding its impact on project performance, underscores the urgency of identifying hindering factors. Therefore, this study aims to systematically identify, classify, and prioritize critical barriers through a systematic literature review (SLR). Barriers will be categorized based on their occurrence in countries with differing development levels, enabling cross-country insights and comparisons. The findings will illuminate the most critical obstacles to CC adoption and propose key indicators and strategies to address them. This research seeks to facilitate CC adoption globally by offering actionable insights, contributing to enhanced construction management practices, and sustainable development. © 2025 ISEC Press
Transformative impacts of technological developments on architectural education: A holistic scientometric analysis
No full textPurpose: This study aims to outline the transformative impacts of technological developments (TD) on architectural education (AE). The focus is on studying the dynamics of convergence and erosion, aiming to understand the impact of current digital transformations such as the COVID-19 pandemic, sustainability considerations and technology integration on AE. Design/methodology/approach: A scientometric analysis and bibliometric search were performed to understand the current knowledge in the field. The Web of Science (WoS) was selected for its comprehensive collection of significant research articles and integrated analytical tools for generating representative data. The study involved an extensive bibliometric analysis of 131 journal articles on TD in AE from 2000 to 2023. Subsequently, the VOSviewer software was employed to illuminate the transformative impacts of technological advancements on AE. Robust methodologies, including citation analysis and co-citation networks, unravel quantitative dimensions such as publication trends, influential authors, prolific journals, geographic distribution and prevalent themes or technological domains within the discourse. Findings: The findings reveal significant evolution in AE due to TD, with notable shifts influenced by factors such as the COVID-19 pandemic, sustainability concerns and the integration of modern technologies. Key findings include the increasing adoption of online platforms and technologies like Building Information Modeling (BIM), the crucial role of design thinking methodologies and the recognition of innovative modules such as architectural photogrammetry and augmented reality (AR) applications. Furthermore, keyword clusters were classified into six groups: “AE pedagogy and curriculum development,” “Development of architectural design process and studio,” “Educational approaches and digitalization in architectural design,” “Transition to online AE,” “Development/emergence of photogrammetry at architectural education” and “use of AR.” Originality/value: Although several studies have addressed TD in AE from various perspectives and methods, they have yet to investigate the subject using scientometric analysis from a holistic perspective. A holistic exploration of TD in AE still needs to be improved in the existing literature. In contrast to previous investigations, this study is the first to leverage the quantitative analytical capabilities of VOSviewer. The originality lies in uncovering quantitative dimensions such as publication trends, influential authors and prevalent themes, providing a comprehensive understanding of the nuanced dimensions of this evolving intersection. © 2025, Emerald Publishing Limited
The effect of a stress ball on pain and anxiety during sharp debridement in patients with diabetic foot ulcers: A randomized controlled, single-blind study
Full text linkObjective: The aim of this study was to investigate the effect of using a stress ball during sharp debridement on the pain and anxiety in patients with diabetic foot ulcers. Methods: This study with a randomized, controlled and single-blind design was conducted at a single-center on patients diagnosed with diabetic foot ulcers who were being treated at the endocrinology and metabolic diseases clinic of a university hospital. Patients in the intervention group started using a stress ball before the debridement procedure and continued to use it until the procedure ended. No intervention was made to the patients in the control group. Data were collected by using the Descriptive Information Form, Diabetic Foot Meggit-Wagner Classification, Visual Analogue Scale (VAS), and State Anxiety Inventory (STAI). Results: The study was completed with a total of 76 patients, 38 each in the intervention and control groups. The use of stress balls led to a reduction in anxiety and pain symptoms in the intervention group. The anxiety score of the patients in the intervention group was also found to be statistically significantly lower than those in the control group after the procedure (p = 0.008; η2 = 0,091). The VAS scores of the patients in the intervention group were found to be statistically significantly lower than those in the control group both during (p < 0.001; η2 = 0.348) and after (p < 0.001; η2 = 0.438) the procedure. Conclusions: The use of a stress ball was found to be an effective method of reducing the level of pain and anxiety that occurs during the sharp debridement procedure. Stress ball application is a practical, easy, and cost-effective non-pharmacological method. Clinical trial number: The study was recorded in the ClinicalTrials.gov website with the number NCT06316115. © 2025 The Author
Determination of paclobutrazol using square wave voltammetry based on a molecularly imprinted polymer and boron-doped copper oxide/graphene nanocomposite
No full textIn the present study, a novel voltammetric sensor based on a boron-doped copper oxide/graphene (B-CuO-Gr) nanocomposite and molecularly imprinted polymer (MIP) was developed for the detection of paclobutrazol (PAC) in apple and orange juice samples. The B-CuO-Gr nanocomposite was prepared using sol-gel and calcination methods. After modifying glassy carbon electrodes with the B-CuO-Gr nanocomposite, PAC-imprinted electrodes were prepared in the presence of 100.0 mM pyrrole (Py) monomer and 25.0 mM PAC using cyclic voltammetry (CV). After elucidating the surface properties of the prepared B-CuO-Gr nanocomposite and PAC-imprinted electrodes using various characterization techniques, the PAC-imprinted sensor was successfully applied to apple and orange juice samples, demonstrating high recovery. A linear range of 1.0 x 10-9 to 1.0 x 10-8 M PAC (R2 = 0.9983) and a detection limit (LOD) of 3.30 x 10-10 M were observed, along with high selectivity, stability, and reproducibility for the MIP/B-CuO-Gr/GCE sensor
Reliability and validity of Turkish translation of the questionnaire of physiotherapeutic specific exercises of scoliosis (qpsse): A brief report
No full textThis study aimed to evaluated the reliability and validity of the Turkish adaptation of the Questionnaire of Physiotherapeutic Specific Exercises of Scoliosis (QPSSE). Fifty-one individuals who had been performing scoliosis-specific exercises (PSSEs) for at least two months completed the QPSSE. Validity was analyzed by correlating the QPSSE with the Scoliosis Research Society-22 (SRS-22) questionnaire and the Scoliosis Japanese Questionnaire-27 (SJ-27). The intraclass correlation coefficients (ICC) were used to estimate test-retest reliability. The QPSSE demonstrated excellent internal consistency (Cronbach’s alpha coefficients were.90 and.93) and test-retest reliability (ICC =.92, 95% confidence interval [.86–.95]). The QPSSE also demonstrated strong construct validity with the SRS-22 (r = −.57) and SJ-27 (r = −.66) total scores. The Turkish QPSSE is a valid and reliable questionnaire for evaluating the physical functioning, self-image, PSSEs, psychosocial functioning, cognitive functioning, compliance, motivation, and pain-related physiotherapeutic specific exercises of scoliosis in idiopathic scoliosis. © The Author(s) 2025