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Novel aspects of particle production in ultra-peripheral collisions
Get PDFOne of the hot topics in hadron physics is the study of the new exotic charmonium states and the determination of their internal structure. Another important topic is the study of the magnetic field produced in relativistic heavy-ion collisions and its effects on observables. In this note, we show that we can use ultra-peripheral collisions to address both topics.
We compute the cross section for the production of the D⁺D⁻ molecular bound state in photon-photon collisions and also the cross section for π⁰ production in the target induced by the magnetic field of the projectile. Both cross sections are sizeable, and their measurement would be very useful to elucidate the above-mentioned questions
UPC physics with ALICE in Run 3
Get PDFThe ALICE experiment has undergone a major detector upgrade for Run 3, expanding its detection capabilities for a wide variety of studies. The new continuous readout has significantly enhanced the physics potential for ultra-peripheral collision analyses. In this talk, we discussed some of the physics analyses that can be carried out in ultra-peripheral collisions using the Run 3 data and presented some of the first physics performance plots in both proton-proton and heavy-ion collisions
The Safety and Protective Effects of Intravitreal Injection of Human Adipose-Derived Mesenchymal Stem Cells in a Rat Model of Retinal Ischemia/Reperfusion Injury
Get PDFPurpose: The purpose of this study was to evaluate the safety and protective effects of intravitreal injection of human adipose-derived mesenchymal stem cells (ADMSCs) in a rat model of retinal ischemia/reperfusion (I/R) injury induced by anterior chamber perfusion.
Methods: Two weeks after induction of I/R injury, rats received a single intravitreal injection of human ADMSCs at doses of 2×10⁴ cells or 5×10⁴ cells suspended in 3 μL saline. Control rats received 3 μL saline or no injection. Retinal and optic nerve changes were assessed at two weeks after injection using immunofluorescence, hematoxylin and eosin staining, toluidine blue staining, and polymerase chain reaction to evaluate inflammation-related and neurotrophic factors.
Results: Intravitreal injection of human ADMSCs significantly reduced the number of apoptotic retinal ganglion cells after I/R injury, preserved the ganglion cell layer, and increased expression of neurotrophic factors such as brain-derived neurotrophic factor and insulin-like growth factor 1. The high-dose group (receiving 5×10⁴ cells) demonstrated superior neuroprotective effects compared to the low-dose group (receiving 2×10⁴ cells) as evidenced by less retinal ganglion cell apoptosis. In addition, histopathological analysis revealed localized tissue remodeling and increased microglial infiltration, particularly in the low-dose group.
Conclusion: The safety of intravitreal human adipose-derived mesenchymal stem cell transplantation requires further investigation, particularly with regard to potential proliferative responses and their long-term effects. In addition, the optimal dosage of adipose-derived mesenchymal stem cells needs to be explored to balance therapeutic efficacy and minimize adverse outcomes. which was associated with structural retinal damage. In addition, the high-dose group exhibited a potential risk of inflammation or maladaptive changes.
Impact of Nanopore Flow Cell Types on DNA Methylation Detection
Get PDFThird-generation sequencing technologies have revolutionized the study of epigenetic characteristics in human diseases, with Oxford Nanopore Technologies (ONT) at the forefront of long-read sequencing. ONT has made rapid improvements in flow cell designs, which greatly increased its sequencing accuracy but, at the same time, led to some projects utilizing different flow cell types, mainly R9 vs. R10, across samples. Whether and how the flow cell types affect genome-wide DNA methylation detection remains incompletely understood. Here, we used both flow cell types to analyze 6 human renal cell carcinoma (RCC) samples and compared the results. While there was a highly significant correlation between 5-methylcytosine (5mC) detected by R9 and R10 flow cells, we also observed substantial differences. R9 flow cells over-estimated 5mC levels at hypomethylated chromatin regions, mostly at promoters, while under-estimated 5mC at hypermethylated chromatin regions, enriched at intronic and intergenic regions. Such deviations in detection were likely caused by substantially lower sequencing accuracy of R9 flow cells, due to its mechanics, especially having problems sequencing homopolymeric DNA elements, such as CpG islands, leading to both higher false-positive and false-negative detections. Interestingly, such systematic errors were largely mitigated by batch-correction software, improving data comparability. In summary, our study reports superior performance of R10 flow cells, leading to much higher accuracy in base sequencing and DNA methylation detection
Treatise Online no. 191: Part R, Revised, Volume 1, Illustrated Glossary of the Decapoda
No full textIdentifying Barriers to Mental Health Care For Canadian Student-Athletes: A Narrative Approach
Get PDFCanadian student-athletes and American college athletes face unique stressors related to their sport and have demanding schedules. Although there is limited research specifically focused on the mental health of Canadian student-athletes participating in university sports, existing studies indicate that Canadian student-athletes report increased levels of psychological distress and are more susceptible to mental health issues compared to the general student population. Despite this, many do not seek or receive the treatment they need. This study aimed to identify the barriers to mental health care for Canadian student-athletes competing in Canada. Using a narrative approach, participants identified barriers to mental health treatment, including cultural stigma and voluntary isolation, in addition to a lack of availability of mental health services and the suffering of Canadian student-athletes
Extended mate accompaniment and a novel context for female body-bridging in Pygmy Rattlesnakes, Sistrurus miliarius (Linnaeus 1766)
Get PDFA case of cannibalism in the Indian Spectacled Cobra (Naja naja) from Nagpur, Maharashtra, India
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