The University of Kansas: Journals@KU
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Observations of amplexus in Mountain Yellow-legged Frogs (Rana muscosa) in the San Jacinto Mountains
Get PDFTherapeutic targeting of Aurora Kinase A in advanced prostate cancer
Get PDFProstate cancer (PCa) progresses from an androgen-dependent state to a castration-resistant form (CRPC) following androgen deprivation therapy (ADT), driven by adaptations that restore androgen receptor (AR) signaling. A subset of CRPC tumors evolves into neuroendocrine prostate cancer (NEPC), marked by AR independence, neuroendocrine marker expression, and poor prognosis. NEPC development is associated with genetic and epigenetic alterations, including loss of tumor suppressors (TP53, RB1) and activation of lineage plasticity pathways. Aurora kinase A (AURKA), a serine/threonine kinase regulating mitosis, is frequently overexpressed in NEPC and CRPC, promoting tumor aggressiveness. Recent studies highlight CXCR7\u27s role in driving enzalutamide-resistant CRPC by activating AURKA through β-arrestin recruitment. Targeting AURKA with inhibitors like alisertib shows potential but is hindered by toxicity and patient variability, emphasizing the need for biomarkers to stratify responders.
AURKA inhibition is synthetically lethal with RB1 or TP53 loss and may exploit vulnerabilities in tumors with homologous recombination defects, linking AURKA activity to resistance against DNA-damaging therapies, including PARP inhibitors, AR pathway inhibitors, and chemotherapy. Further investigation into AURKA alterations in CRPC/NEPC and their correlation with therapeutic outcomes may refine treatment strategies. Targeting AURKA holds promise for overcoming resistance and improving outcomes in aggressive, treatment-refractory PCa subtypes
Assessing the use of Canadian Literature in teaching at Simon Fraser University
Get PDFFor over a decade, members of Canada’s creative industries have claimed that Canadian post-secondary institutions are copying and using content without adequately compensating creators; these campaigns have primarily focused on fiction authors. This study aims to address these claims by determining how much Canadian creative literature is actually being used in a representative Canadian university. We analyzed reading materials provided to students as library reserves, textbooks, and course packs for the periods 2010-2012 and 2018-2022 and found that across both periods approximately 1.3% of courses assigned Canadian creative works as readings. An analysis of only the Fall semesters across these periods found that approximately 0.7% of all works – that is, copied excerpts and uncopied (purchased) works – assigned via library reserves, textbooks, and course packs were Canadian creative works. The number of assigned readings that included copied Canadian creative works (generally consisting only of course packs, not textbooks and likely not library reserves) would comprise much less than 0.7%. Therefore, this research suggests that the use and specifically copying of Canadian creative content in Canadian universities is not substantial enough to result in significant potential remuneration for the copying of an author’s work
Subclavicular and Suprascapular Placement of Response Neurostimulator Generator: Two Unique Cases
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