The University of Kansas: Journals@KU
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The Impact of the Dobbs Decision on Access to Gender Diverse Care at a Midwest Academic Health Center
Get PDFIntroduction. The Dobbs decision returned the regulation of abortion to individual states. In the Midwest, several legislative efforts have included restrictions on both abortion and gender-affirming care. Clinics that provide abortion services sometimes offer gender-affirming care. Given this intersection, recent laws restricting abortion may have unintended consequences for access to gender-affirming care in the Midwest.
Methods. Authors of this retrospective study analyzed medical records of patients seen at a Midwestern health center. We included patients 18 or older who attended a new patient visit at either the gender diversity clinic (GDC) or the general gynecology (GYN) clinic between July 1, 2021 and June 30, 2023. We used generalized estimating equations to assess changes in wait times and distance traveled pre- vs. post-Dobbs. Differences in new patient volume were analyzed using Poisson regression.
Results. We reviewed 5,260 charts, 4,552 from the GYN clinic and 708 from the GDC. Following Dobbs, the GYN clinic experienced a 6% increase in new patients, while the GDC saw a 21% increase (p<0.001). The average wait time for a GYN appointment increased by two days, whereas the wait time for GDC appointments decreased by 21 days. The average distance traveled by new GYN patients decreased by 6.3 miles (p<0.001), while distance for GDC patients increased by 2.5 miles (p=0.738).
Conclusions. Patients continue to seek gender-affirming care in the post-Dobbs landscape. Despite an increase in patient volume, wait times for gender diversity appointments decreased, likely reflecting expanded appointment availability around the time of the Dobbs decision.
Assessing the Impact of Interpretation Experience and Training on Patient Satisfaction Levels at JayDoc Free Health Clinic –A QI Needs Assessment
Get PDFBridging Gaps in Rural Healthcare: Patient and Provider Readiness to Integrate Mobile Health and Artificial Intelligence Technologies into Remote Care
Get PDFExploring the Link Between Cerebral Perfusion during Sit-to-Stand and Cognitive Function in People After Stroke
Get PDFA Double Strike Against Tumor Resistance: IL-24 Enhances CAR-T Therapy by Disarming Cancer Stem Cells
Get PDFModeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course
No full textCaenorhabditis elegans is a widely used model organism in biomedical research due to its genetic tractability, short life cycle, and conservation of many developmental processes with humans. In this study, undergraduate students conducted nine independent experiments during a Developmental Biology course to model human phenotypes using C. elegans. Each group selected a human phenotype of interest, identified a gene associated with the phenotype, and then determined the orthologous or homologous gene in C. elegans. By obtaining mutants and designing phenotypic assays, students investigated the extent to which the worm models could recapitulate aspects of the human condition. This collective work highlights both the potential and limitations of C. elegans as a model for human phenotypic variation and disease and demonstrates the value of undergraduate inquiry as a catalyst for scientific engagement and research-based learning
A case of eculizumab-induced hemophagocytic lymphohistiocytosis (HLH) in a myasthenia gravis patient
Get PDFHemophagocytic lymphohistiocytosis (HLH) is an immune hyperactivation state that can occur in immunosuppressed patients and is associated with high mortality and worse prognosis. We present a case of 78-year-old patient on multiple immune suppressing medications, including eculizumab and azathioprine for myasthenia gravis, who presented to our hospital for evaluation of hyperbilirubinemia. She had extensive laboratory workup that was significant for anemia, thrombocytopenia, increased ferritin level, and hyponatremia. Additionally, she had increased CD25 and CXCL9 leading to the diagnosis of HLH. Investigations for triggering factors identified eculizumab after excluding multiple infectious and rheumatologic conditions. Unfortunately, the patient did not survive. We recommend evaluating for high ferritin as a reliable predictor for HLH for patients on myasthenia gravis on eculizumab
