The University of Kansas: Journals@KU
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Extracellular matrix in prostate cancer anti-androgen resistance
Get PDFExtracellular matrix (ECM) within the tumour microenvironment (TME) of prostate cancer has been extensively reported to be associated with the development of androgen-deprivation therapy (ADT) resistance in prostate cancer. Recent-year investigations have illustrated that the deposition of ECM proteins contribute to this resistance by regulating cell behaviours of cancer cells directly or indirectly through modulating immune cells within the TME, thereby protecting cancer cells from the tumour-suppressing effects of ADT. Here we review these findings, offering new perspectives on prostate cancer research and highlighting the potential of ECM proteins as novel clinical targets for predicting and treating ADT-resistance
Long-Read Sequencing Outperforms Short-Read Sequencing in Detecting Most Structural Variations
Get PDFStructural variations (SV) are common in the cancer genome and play critical roles in regulating tumorigenesis. In the past decades, many SVs have been detected through analyses of whole-genome sequencing (WGS) data generated mainly by Illumina paired-end short-read sequencing (SRS). Recent advances in long-read sequencing (LRS) techniques provide exciting opportunities for SV detection. However, a comprehensive analysis of the pros and cons of LRS and SRS in detecting SVs in a cancer genome is still lacking. Here, we performed WGS of the LNCaP prostate cancer cell line through LRS using the Oxford Nanopore Technology and called main SVs, which were compared to those derived from publicly available LNCaP SRS data. Strikingly, LRS is superior in detecting insertions of all sizes and deletions of <1000 bp long, whereas SRS is very useful in capturing long deletions, taking advantage of its paired-end reads. LRS identified more precise breakpoints of detected SVs. In addition, we found that SRS called many duplications and inversions, most of which were not confirmed by LRS, likely due to ambiguity in SRS read alignment to repetitive regions, leading to errors in SV calling. In conclusion, LRS outperformed SRS in detecting most SVs, except deletions longer than LRS read lengths. Our study highlights the advantages of LRS in resolving complex genomic rearrangements and underscores its potential for improving SV detection in cancer genomics
The Relative Risks of Heat-Related Illnesses Over the Past Ten Years in Adults Over 65 at an Academic Medical Center in Kansas City, Kansas
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A scoping review of factors within the higher education ecosystem influencing student-athlete mental health and wellbeing in North America: Insights and a model for mental health promotion
Get PDFThe purpose of this research was to synthesize peer-reviewed literature identifying factors in the organizational ecosystem that impact post-secondary student-athlete mental health in North America. We adopted a holistic definition of mental health considering outcomes related to both mental illness and multidimensional wellbeing (i.e., psychological, emotional, and social wellbeing). A structured scoping review method was used to search seven databases. Data from included studies (N = 57), were summarized according to the socioecological model of health and analyzed using thematic synthesis.
Post-secondary sport environments that promoted mental health and wellbeing supported student-athlete psychological need satisfaction and were characterized by: (1) growth-oriented motivational climates, (2) harmony between academic and athletic roles, (3) equity and inclusion, (4) social support, (5) positive relationships, (6) ethical leadership, and (7) health-promoting organizational operations. We propose a theoretically and empirically informed conceptual model illustrating features of post-secondary sport that interact to promote student-athlete mental health and wellbeing. These findings illustrate the need for multidimensional approaches to mental health promotion and further organizational research, particularly in Canada. This review highlights the mental health impacts of environmental demands and resources that can support effective institutional interventions to safeguard student-athlete mental health despite inherent stressors of competitive sport.
Determining the Epidemiology of Giardia Infections among High-Risk ZIP Codes in Sedgwick County, Kansas, 2017-2022
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The Other
No full textA fiction piece that deals with new motherhood, lactation concerns, and surreal visions