The University of Kansas: Journals@KU
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Characterizing Social Determinants of Health Among Prenatal Patients at a Student Run Free Clinic
Get PDFImplementation of the First Available Long-Acting HIV Medication (Cabotegravir/Rilpivirine) Into Routine Clinical Care
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Rural Primary Care: Examining Rural Provider Knowledge Regarding Accountable and Value-Based Care
Get PDFTargeting Streptococcus salivarius in Peri-Implantitis: Two Antimicrobial and Antibiofilm Peptides
Get PDFPeri-implantitis, a persistent complication associated with dental implants, is driven by complex, antibiotic-resistant oral biofilms. Antimicrobial Peptides (AMPs) may represent novel, safe, and effective therapies against Streptococcus salivarius, a key early colonizer in peri-implant biofilms. S. salivarius was isolated and identified by 16S sequencing from human saliva, followed by standardized growth and biofilm assays to establish a physiologically relevant testing model. RR12 is a novel peptide that was rationally designed, synthesized, and characterized for structural integrity for comparison against KR12, a natural LL-37 derivative known to be effective against bacteria. Both peptides demonstrated dose-dependent inhibition of S. salivarius biofilm formation, but KR12 consistently achieved superior antimicrobial and antibiofilm effects with lower cytotoxicity. These findings underscore the necessity of biological validation in peptide development and support the use of AMPs as promising alternatives to traditional antibiotics. AMP-based coatings and gels for dental implants could offer localized, resistance-proof infection control
Global climate change effect on Asian Mus musculus; Implication from last glacial maximum to the end of the 21st century
Get PDFGlobal climate change poses unprecedented challenges to biodiversity, prompting urgent investigations into its effects on various species. This study focuses on Mus musculus, a small rodent species and a crucial indicator of ecosystem health. Spanning from the last glacial maximum to the end of the 21st century, employed Species Distribution Models (SDMs) to assess the impacts of climate change on Mus musculus and its four subspecies across Asia (M. m musculus, M. m domesticus, M. m castaneus, and M. m bactrianus). The SDMs reveal nuanced responses among subspecies, with M. m. domesticus, M. m. musculus, and M. m. castaneus facing potential habitat contractions, while M. m. bactrianus shows habitat expansion. Variable importance analysis highlights the significance of temperature-related variables, indicating the growing impact of rising temperatures on distribution patterns. Findings underscore the ecological implications of these shifts, emphasizing the need for tailored conservation strategies. The robustness of models, as indicated by high Area Under the Curve (AUC) values, enhances confidence in the reliability of predictions. Despite data limitations, this study contributes valuable insights into the complex dynamics between climate change and Mus musculus populations, guiding future conservation efforts in the face of ongoing global environmental transformations.
 
Camp-Based Research in Neuromuscular Disorders: A Novel Framework for Natural History Data Collection
Get PDFNeuromuscular camps–dedicated retreats for individuals with conditions such as Duchenne Muscular Dystrophy and Charcot-Marie-Tooth disease–represent a profoundly underutilised resource for rare disease research. These camps provide unparalleled access to authentic, lived experiences that are rarely captured in clinical or support group settings. Within this environment, challenges surrounding mobility, personal care, socialisation, and energy budgeting are navigated organically, offering a holistic view of adaptation and resilience. Integrating prospective research methodologies, such as unobtrusive observational studies, wearable technology, and gamified assessments, into the camp setting could yield rich, real-world data without compromising the core purpose: joy, connection, and empowerment. This paper argues that neuromuscular camps, if approached ethically and collaboratively, can serve as natural history platforms, shaping future research and interventions while preserving the essential spirit of these transformative experiences. This paper proposes a hybrid model that integrates research methods such as wearable technology, narrative tools, and gamified assessments into camp life without compromising the primary ethos of joy and empowerment. Neuromuscular camps, if approached collaboratively and sensitively, can meaningfully reshape how we collect and interpret data in neuromuscular disease research
