The University of Kansas: Journals@KU
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Double Wide Toad Rite
No full textThis story concerns the frayed connection between three former friends and their desire to recapture the magic of a disturbing ritual they had accidentally discovered years before.
Safety Evaluation of Albumin-Bound Paclitaxel in Patients with Non-Small Cell Lung Cancer Based on CHPS：A single institution retrospective study
No full textUnraveling the Role of N6-Methyladenosine in Prostate Cancer: Implications for Prognosis and Tumor Aggression
Full text linkThe epitranscriptomic modification N6-methyladenosine (m6A) has emerged as a central regulator of RNA metabolism, influencing diverse physiological and pathological processes. As the most abundant RNA modification in eukaryotic cells, m6A dynamically modulates gene expression by regulating RNA processing, stability, and translation. Dysregulation of m6A has been implicated in key oncogenic processes, including tumor initiation, progression, metastasis, therapy resistance, and interactions within the tumor microenvironment. Despite these advances, the role of m6A in prostate cancer remains poorly understood, highlighting the need for further investigation. In a recent study, Xu et al. utilized refined m6A meRIP-seq to profile 162 primary prostate cancer patient samples, unveiling novel insights into the epitranscriptomic landscape of this malignancy. These findings not only enhance our understanding of m6A regulation in cancer biology but also underscore its potential to inform diagnostic, prognostic, and therapeutic strategies for prostate cancer
A Review of Sipuleucel-T in Combination with Other Therapies for Metastatic Castration-Resistant Prostate Cancer
Full text linkRecent research has expanded the therapeutic landscape for sipuleucel-T by introducing several combination treatments. These include innovative hormone therapies (enzalutamide and abiraterone), immunomodulatory agents (including IL-15, IL-7, atezolizumab, ipilimumab, and indoximod), DNA vaccines, and radiopharmaceuticals, many of which have demonstrated enhanced clinical outcomes and received approval from the U.S. Food and Drug Administration (FDA). These combination therapies present novel opportunities to enhance patient survival and quality of life. Sipuleucel-T, a significant autologous cell immunotherapy, was approved by the FDA in 2010 for the treatment of patients with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Integration of sipuleucel-T with other therapeutic modalities holds promise for advancing mCRPC treatment. Nevertheless, the optimal sequencing and combination strategies for sipuleucel-T with other therapies remain under investigation, with numerous clinical trials currently exploring new treatment paradigms. Incorporation of these therapies, particularly to develop more effective and personalized treatment strategies, necessitates additional research. Future studies should aim to ascertain the optimal timing and sequencing of treatments and to identify biomarkers that can predict treatment responses, thereby enhancing outcomes for patients with mCRPC. This review underscores potential strategies for the integration of sipuleucel-T with other therapies and examines their therapeutic potential in mCRPC
Malinche, Malinches, de Juliana Faesler: história/histórias da mulher/mulheres no cenário mexicano do século XXI
No full textLa Malinche is one of the most controversial characters in Mexican history and, therefore, one of those who has provoked the most interesting reflections from the scholarly field and from the literary and theatrical creation. Malinche, Malinches, by Juliana Faesler, is a dramatic piece premiered in 2010 that is part of a previous tradition of interpreting the character from a gender perspective. The play offers a peculiar approach to the historical figure and also an inquiry into the condition of women in contemporary Mexico. The historical Malinche (only accessible through the writing of others) is reconstructed throughout the play in a complex way, while many other women\u27s voices of the most varied conditions inhabit the scene in a dialogue that allows to question the hegemonic patriarchal discourse.La Malinche es uno de los personajes más controvertidos de la historia mexicana y, por ello, también uno de los que ha provocado reflexiones de mayor interés desde el ámbito académico y desde la creación literaria y teatral. Estrenada en 2010, Malinche, Malinches, de Juliana Faesler, es una pieza dramática que se inscribe en toda una tradición previa de interpretación del personaje desde una perspectiva de género y que, en este sentido, ofrece a un tiempo un peculiar acercamiento a la figura histórica y una indagación en torno a la condición de la mujer en el México actual. La Malinche histórica (solo accesible a través de la escritura de otros) se reconstruye a lo largo de la obra de forma compleja, al tiempo que van habitando la escena otras muchas voces de mujeres de las más variadas condiciones en un diálogo que permite a su vez cuestionar el discurso patriarcal hegemónico.La Malinche é um dos personagens mais polêmicos da história mexicana e, portanto, também um dos que tem provocado reflexões de maior interesse no meio acadêmico e na criação literária e teatral. Malinche, Malinches, de Juliana Faesler, é uma peça dramática lançada em 2010 que faz parte de uma tradição anterior de interpretação da personagem a partir de uma perspectiva de gênero. A peça oferece uma abordagem peculiar à figura histórica e também uma investigação sobre a condição das mulheres no México de hoje. A Malinche histórica (acessível apenas através da escrita alheia) é reconstruída ao longo da peça de forma complexa, enquanto muitas outras vozes de mulheres das mais variadas condições habitam a cena num diálogo que permite por sua vez questionar o discurso patriarcal hegemônico
Diagnostic and treatment challenges in MRI-negative myelitis associated with MOG antibody: A case report and literature review.
Full text linkBackground:
MRI negative cases of anti-MOG-seropositive longitudinally extensive transverse myelitis (LETM), optic neuritis and encephalitis have been reported in the literature. Negative MRI can lead to diagnostic uncertainties and treatment delay.
Objectives: We report a case of a patient with LETM with negative spinal MRI who tested positive for serum MOG antibody and showed continuous improvement with immunotherapy.
Conclusion: Negative spinal cord MRI in patients with clinical presentation of LETM or transverse myelitis should not preclude investigation of MOG Antibody associated disease and initiation of early empirical immunotherapy. 
When Facioscapulohumeral dystrophy Meets Myasthenia gravis: Case Report and Literature Review
Full text linkSimultaneous occurrences of rare disorders are significant diagnostic and management challenges. In this case report, we describe the initial clinical presentation, diagnosis, and management of a 66-year-old man with a history of concurrent facioscapulohumeral dystrophy (FSHD) and myasthenia gravis (MG). He presented at age 54 with longstanding symptoms of facial, scapular, and limb weakness which had previously diagnosed at age 23 as limb girdle muscular dystrophy. He also exhibited new symptoms of ptosis, diplopia, and bulbar muscle weakness. Genetic testing and acetylcholine receptor autoantibody testing confirmed the diagnoses of both FSHD and MG. This report discusses the diagnostic obstacles, findings before and after treatment, and reviews previously reported cases of concurrent FSHD and MG. We emphasize the need for clinicians to remain vigilant for the development of symptoms from another rare disease in patients already diagnosed with one, avoiding premature attribution of new symptoms to the baseline condition