The University of Kansas: Journals@KU
Not a member yet
16504 research outputs found
Sort by
Whither Dendrelaphis in western India? A critique of recent papers by Vaishnav and Ghadi (2025) and Puranik et al. (2025)
Full text linkTreatise Online no. 185: Part R, Revised, Volume 1. Evolutionary history of decapod groups: Lobsters (Palaeopalaemonida, Polychelida, Achelata, Glypheidea, marine Astacidea)
No full text
Challenges in Translational Benign Prostatic Hyperplasia Research
Full text linkBenign Prostate Hyperplasia (BPH) is a common condition of aging that affects up to 80% of men in their lives. It requires medical and often surgical management. Despite its prevalence, molecular breakthroughs in the last 20 years have been lacking. In the following article, we outline the challenges and limitations within existing BPH research to frame the major issues for future researchers
Delineating the roles of HOXB13 X285K variant in prostate cancer
Full text linkHOXB13 X285K is a frameshift mutant due to the deletion of one nucleotide, c.853delT, within the HOXB13 stop codon, resulting in an extension of HOXB13 protein by 96 amino acids on the C terminus. It was found primarily in men of West African ancestry and associated with early-onset prostate cancer (PCa) and more advanced stage. Whether and how X285K contributes to PCa progression remains largely unknown. Here, we established isogenic 22Rv1 cell lines with heterozygous wildtype/X285K HOXB13, which recapitulates the genotypes of X285K in PCa patients. In addition, using the unique C-terminal region as an antigen, we developed an antibody that specifically recognizes the HOXB13 X285K protein. Lastly, we demonstrated that X285K retained the function of HOXB13 in suppressing target genes, such as FASN and PSA. In summary, our data suggest that the isogenic cell lines and the antibody generated in this study will be useful for a comprehensive investigation of X285K function in PCa
Nijmegen Breakage Syndrome Complicated by Colon Cancer with Liver Metastasis: A Case Report
No full textBackground Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder that increases the risk of malignant tumors. Colorectal cancer is one of the common malignant tumors, and its liver metastasis is a focal point and challenge in the treatment of colorectal cancer.
Case presentation A 24-year-old male was diagnosed with Nijmegen Breakage Syndrome Complicated by Colon Cancer with Liver Metastasis: A Case Report
Conclusions Early identification of Nijmegen Breakage Syndrome (NBS) is crucial for making correct diagnoses, conducting genetic counseling, and for cancer screening, risk reduction, and selection of anticancer treatments.
