French-Ukrainian Journal of Chemistry
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Synthesis of Functionalized Methyl-Substituted Bicyclo[1.1.1]pentanes
Get PDFSynthesis of new functionalized methyl-substituted bicyclo[1.1.1]pentanes for medicinal chemistry is presented. All the products were obtained in multigram quantities with decent yields. The synthetic approaches reported are facile and scalable. We hope that this work will help process chemists at pharmaceutical companies with the preparation of bioactive bicyclo[1.1.1]pentanes suggested by medicinal chemists for clinical trials
Isoflavonoids Modified with Oxygen-containing Heterocycles with One Oxygen Atom
No full textThis review summarizes and systematizes the data available in the literature on the synthesis of 4H-chromen-4-ones modified at the 3-position with O-containing heterocycles with one oxygen atom. Classical and modern strategies for the synthesis of natural and synthetic 3-(O-containing)hetarylchromones, versatile synthons used in these syntheses and chemical modifications and transformations both on the chromone ring and heterocyclic rings of different sizes with one oxygen atom of the synthesized 3-hetarylchromones are discussed. Testing data for some types of biological activity including antitumor, antimicrobial, antiviral, hypolipidemic and cardial muscle activity of a number of 3-(O-containing)hetarylchromones and the products of their transformation are also given
Beckmann Fragmentation of Camphor-4-carboxylic and Camphor-4-acetic Acid Oximes
No full textA mild and efficient recyclization reaction of bornanone-4-carboxylic and bornanone-4-acetic acid oximes in aqueous hydrochloric acid has been developed. Beckmann fragmentation followed by hydrolysis provides a straightforward method for the preparation and isolation of functionalized [2.2.1] and [3.3.0] bicyclic lactones in nearly quantitative yields. These simple transformations offer the opportunity to obtain a wide range of more complex functionalized bicyclic terpenoids on a large-scale, starting from readily available camphor derivatives
Occurrence of Heavy Metals Concentration in Grown Food Crops (Manihot esculenta and Colocasia esculenta) around Disused Ogbete Coal Mine in Enugu Metropolis, South Eastern Nigeria
Get PDFThe major food crops frequently consumed by communities in southeastern Nigeria are Manihot esculenta (cassava) and Colocasia esculenta (cocoyam). The crops are sometimes grown in disused mining sites. The study was carried out in Ogbete disused coal mine area, GRA (government residential area) Enugu, in Enugu State, Nigeria. the study area is located between latitude 6̊ 27̍ N and 35.8704̎ N and longitude7̊ 32̍ E and 56.2164̎ E. This study was conducted to assess the occurrence and concentration of heavy metals in the soil and crop samples. The five heavy metals studied were (Cd, Cr, Zn, Ni and Pb). The samples included twenty-four crops of which eighteen were collected from three sampling locations. The study shows that food grown in the site could pose health risks. The study recommends the ongoing monitoring of heavy metal concentration in the study area
Absorption spectra of the dibenzofluorene derivative belonging to the KuQuinones family
Get PDFA detailed study of the UV-Vis spectra of the dibenzofluorene derivative belonging to the KuQuinones family was carried out in polar aprotic (CH3CN), polar protic (CH3OH), and slightly polar (CHCl3) solvents. The spectral properties of this compound underscore its similarity to other KuQuinones on the one hand, while on the other hand they confirm that it is not a planar but a three-dimensional (3D) structure with separated charges. The existence of keto–enol tautomerization and acid-base equilibrium under different pH conditions has also been investigated
Usage of Rice Husk for the Production of Low-Temperature Cement: Physico-Chemical and Technological Aspects
No full textThe aim of the work was to deepen scientific understanding of the physicochemical aspects of phase formation of silicate systems of the CaO-SiO2-Al2O3 type when using rice husk as a silica-containing component of technogenic origin.
The research methods included a complex of chemical, X-ray phase analyses, computer calculations and technological testing of materials. Based on the analysis of the results of calculations regarding compliance with the required values of the cement modulus characteristics, possible quantitative ratios of the carbonate component and rice husk were determined.
As a result of technological testing, the compositions of the initial binary mixture based on marl with a content of up to 28 wt. % rice husk were determined, which ensures the production of a mineral binder - an analogue of Roman cement with an increase in strength indicators by 1.5 times. According to the data of X-ray phase analysis, the peculiarities of physicochemical transformations during the firing of the compositions were established, which are associated with the increased reactivity of amorphous rice husk silica to phase formation with a change in the quantitative ratio of crystalline phases of calcium silicates, the development of C2AS and A3S2 phases distributed in the glass phase.
A conclusion was made about the possibility and feasibility of using rice husk to produce cement fired by low temperature for a comprehensive solution to the issues of chemical technology and resource saving
Investigating the Bioactive Compounds of Moringa and Garlic in the Treatment of Chronic Diseases: A Comprehensive Review
Get PDFHerbal remedies have been used for centuries to treat various ailments. Natural products, derived from plants, animals, and microorganisms, have been used for centuries as a source of medicinal compounds in traditional and modern herbal remedies. Understanding the chemical properties herbal remedies is crucial for their effective and safe application in managing chronic diseases. This review explores the chemical properties and mechanisms of two potent herbal remedies, Moringa oleifera and Garlic (Allium sativum L.) in managing chronic diseases such as diabetes, cardiovascular diseases, and autoimmune disorders. It emphasizes the need for a balanced approach combining herbal and conventional medicine, reducing healthcare costs and improving patient outcomes. The review includes 10 studies investigating the efficacy of herbal remedies in managing chronic diseases in Moringa and Ginger. The study revealed that Moringa oleifera, a valuable plant in traditional and modern medicine, has diverse therapeutic effects, making it beneficial for managing chronic diseases. Garlic, a powerful herbal remedy with bioactive compounds, is also considered a powerful natural treatment due to its antioxidant, anti-inflammatory, antimicrobial, antiemetic, and anticancer activities. The therapeutic potential of moringa and garlic in managing chronic diseases is underscored by their ability to alleviate symptoms and improve health outcomes through natural mechanisms. This review highlights the importance of integrating these herbal remedies into conventional medical practices to enhance disease management, promote overall well-being and develop effective treatments for chronic diseases and enhance their integration into modern medicine
Analysis of the complex of adaptive and compensatory changes in chronic inflammation of the reproductive system based on the evaluation of the features of the spectrum of cytochemical indicators of the activity of circulating and tissue leukocytes
Get PDFPhysiological processes occurring in the human body are reflected in cellular metabolism. One of the criteria for assessing the state of human health is the study of the features of the cytochemical indicators of the activity of circulating and tissue leukocytes, which react especially subtly to functional and pathological changes, reflecting multifactorial internal processes that affect the organism of the subject and provide important information about the reactivity of the organism and the severity of the course disease. The state of the cytochemical spectrum of these cells reflects reactive changes in the macroorganism, and makes it possible to determine the depth and direction of the pathological process. These studies at the cellular level can detect adaptive and compensatory changes in metabolism even when the cells do not change morphologically
Enantioselective Catalyzed Addition of Substituted Indens to Unsaturated Epoxides
No full textUnsaturated aromatic epoxides can be regioselectively opened by substituted indenes in the presence of catalytic amounts of (R)-1,1'-bi-2,2'-naphthotitanium diisopropoxide (1 mol%). The reaction proceeds and enables the synthesis of (1R,2R)-2-(5-bromo-1H-inden-3-yl)-2-phenyl-1-[(prop-2-yn-1-yl)oxy]propan-1-ol with moderate yield and high enantioselectivity (ee up to 97%)
Risk Factors for the Health of the Population of an Industrial City and Their Impact on Regional Features of Inflammatory Diseases
No full textThe medical and social significance of inflammatory diseases in Ukraine is growing every year, which is associated with the deterioration of the ecological situation and the decrease in the immune response under the influence of adverse environmental factors. Acute inflammatory processes are increasingly taking a protracted course, and inflammation, having arisen evolutionarily as an adaptive reaction aimed at the formation of an immune response, due to the inconsistency of its control mechanisms leads to the development of chronic inflammatory and autoimmune diseases, therefore, it is necessary to systematize knowledge about the mechanisms and specifics of the inflammatory reaction under the influence of factors of various nature, to present their similarities and differences