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The Role of Tumor-Associated Macrophages in the Link Between Endometriosis and Ovarian Cancer: Implications for Early Detection and Treatment
Get PDFEndometriosis is a condition in which endometrial-like cells grow outside the uterus, causing lower abdominal and other types of pain from chronic inflammation, infertility, and increased risk of ovarian cancer, a cancer in which most cases are diagnosed at later stages, when the overall 5-year survival rate is only 47%. One possible explanation for this increased risk is that women with endometriosis have immune system abnormalities, including chronic inflammation and immune dysregulation, which impair the body\u27s ability to clear abnormal cells. These immune changes may contribute to disease persistence and an increased risk of ovarian cancer. Increasing evidence suggests that immune cells, including tumor-associated macrophages (TAMs) play pivotal roles in the etiology and progression of these conditions. TAMs lie at the interface of the chronic immune suppression, tissue remodeling, and inflammation for both diseases. TAMs help aid in the growth of abnormal endometriotic tissue and immune evasion that could prevent the growth and spread of ovarian cancer. Understanding how TAMs and other immune cells interact in these diseases is key to developing new treatments that can improve the immune environment and benefit patients. This review highlights the potential of TAMs in the involvement in the transition of endometriosis to ovarian cancer and future research will focus on determining the association of endometriosis with TAMs in ovarian tumors.https://scholarworks.merrimack.edu/rcac_2025_posters/1164/thumbnail.jp
When Online Gambling was Legalized, Did We As a Society Think about the Long Term Consequences?
Get PDFLegalized online gambling has increased the amount of problematic gamblers, due to companies such as DraftKings and FanDuel advertising their product, and the governments in US and Canada having a liberation point of view when it comes to people’s free will to gamble. This paper covers the rise of sports betting since its legalization, and how it impacts various demographics of people in order to understand the limits of sports betting and to not be persuaded to gamble irresponsibly by outside influences
Culvert inspection framework using hybrid XGBoost and risk-based prioritization: Utah case study
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We need Olivia Benson: College student and employee perspectives on norms and beliefs about sexual violence
No full textHigher education community engagement pivots supported through a virtual community of practice
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Universal School Meal Policies and Perceived Stigma: Quantitative Evidence From Eight US States
No full textBackground
Universal school meals (USMs) policies, which provide free meals to all students regardless of income, have the potential to improve child nutrition and reduce stigma. Quantitative evidence on the association between USM and stigma is limited. Methods
Leveraging a natural policy variation in state‐level USM implementation, we surveyed 1066 middle and high school students from eight US states (four with USM, four without) during the 2022–2023 school year. Stigma was measured as self‐reported embarrassment about eating school lunch. We used generalized estimating equations to examine the associations between USM, embarrassment, and lunch participation. Results
Overall about one in nine students (11.5%) across all surveyed states reported embarrassment, which was associated with 11% less frequent (aRR = 0.89, 95% CI: 0.83–0.97). School lunch participation overall, especially among those from low‐income families. While USM was associated with lower odds of embarrassment among students from low‐income families, higher‐income students in USM states were more likely to feel embarrassed. Implications
Addressing stigma requires pairing USM with strategies to enhance meal quality, cultural relevance, and inclusive messaging. Conclusions
USM can alleviate stigma for lower‐income students yet may increase embarrassment among higher‐income peers, highlighting the need for comprehensive approaches benefiting all socioeconomic groups
