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Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review
Full text linkEndothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of therapy are being assessed in ongoing randomized controlled trials (RCTs) that focus on outpatients, hospitalized patients in medical wards, and patients critically ill with COVID-19. This paper provides a perspective of the ongoing or completed RCTs related to antithrombotic strategies used in COVID-19, the opportunities and challenges for the clinical trial enterprise, and areas of existing knowledge, as well as data gaps that may motivate the design of future RCTs. © 2021 American College of Cardiology Foundatio
Psychometric Properties of the Persian Version of the Teasing Questionnaire 23
Full text linkThe current study was a cross-sectional research and aimed to investigate the factor structure, internal consistency, and validities of the Persian version of the Teasing Questionnaire-Revised (TQ-R). Forward and backward translations of the TQ-R were performed; face and content validities were determined based on comments by a sample of psychology students and specialists. Using the cluster sampling method, 290 participants were recruited, and 201 valid data (Mage = 23.53, SD = 3.53, 64.2 men) were analyzed. The factor structure was assessed by confirmatory and exploratory factor analysis (EFA). The result of the confirmatory factor analysis(es) did not confirm the proposed three, four, and five-factor models. EFA revealed four factors with 23 items, explaining 52.03 of the total variance. The internal consistency of the Persian version of Teasing Questionnaire 23 was in the excellent range (α = 0.92), and its expected associations with external correlates (e.g., depression and anxiety) supported the measure�s convergent validity. The findings indicated that the Persian version of the TQ-R has sound psychometric properties and can be used as a valid and reliable tool in research and clinical outcomes. © Copyright © 2021 Ebrahimi, Elhami Athar, Hakim Shooshtari, Karsazi and Storch
A study on the factor structure, construct validity and reliability of the activities of daily living of iranian children (Adlic) scale
No full textBackground: The first and most basic area of occupational performance is the activities of daily living. These activities of life highly depend on the contextual and ecological (environmental) factors. Cultural values, parental expectations, social routines, and physical environment influence acquisition time of a child�s daily activities. At present, there is no comprehensive and adapted-culturally tool to evaluate the daily life activities of Iranian children aged 3-6 years. Objectives: This study aimed to investigate the factor structure, construct validity, and reliability of the Activities of Daily Living in Iranian Children (ADLIC) scale. Methods: The participants were 470 Iranian parents of children among the ages from 3 to 6. Exploratory factor analysis, internal consistency, and test-retest reliability were conducted for data analysis. Convergent validity was measured by correlation to the Pediatric Evaluation of Disability Inventory (PEDI). Results: The results indicated that ADLIC has excellent reliability due to internal consistency (Cronbach�s alpha 0.96). Furthermore, the temporal stability of ADLIC was supported using the Intra-class correlations coefficient, which ranged between 0.95 and 0.98. Convergent validity between the ADLIC and two subscales of PEDI, including self-care (0.88) and mobility (0.80), was good. The ADLIC scale showed a clear factor structure with five main components and ten factors based on the findings. Conclusions: ADLIC has excellent psychometric properties, including internal consistency and temporal stability, and can be used as a reliable and valid measure to assess the daily living activities of children aged 3-6 years. © 2021, Middle East Journal of Rehabilitation and Health Studies
Assessment of the association between body composition and risk of non-alcoholic fatty liver
Full text linkNon-alcoholic fatty liver disease (NAFLD) is defined as the condition of fat accumulation in the liver. This cross-sectional study aimed to investigate the relationship between body composition and fatty liver and determine of cut-off point for predicting NAFLD. Samples were selected from the nutrition clinic from 2016 to 2017 in Tehran, Iran. The liver steatosis was calculated using the CAP score through the FiroScan� and body composition was measured using the dual-energy X-ray absorptiometry scan method. A total of 2160 patients participated in this study, 745 (34.5) subjects had NAFLD. We found that fat-free tissue was inversely and fat tissue was directly correlated with the risk of NAFLD in almost all factors and the risk of developing NAFLD increases if the total fat exceeds 32.23 and 26.73 in women and men and abdominal fat exceeds 21.42 and 13.76 in women and men, respectively. Finally, we realized that the total fat percent had the highest AUC (0.932 for men and 0.917 for women) to predict the risk of NAFLD. Overall, the likelihood of NAFLD development rose significantly with increasing the amount of total fat and abdominal fat from the cut-off point level. Copyright: © 2021 Ariya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Evaluating the effect of hydro-alcoholic extract of Phoenix dactylifera L. spathe on streptozotocin-induced diabetic rats
No full textPhoenix dactylifera L. (Arecaceae) spathe has antioxidant and anti-inflammatory effects. Effects of hydro-alcoholic extract of Phoenix dactylifera spathe were examined in streptozotocin (STZ)-induced diabetic rats. Forty-nine male Wistar rats were randomly divided into seven groups; group 1 received normal saline solution daily, group 2 received STZ (50 mg/kg) on the first day, group 3 received STZ (50 mg/kg, ip) at the beginning of the study and metformin (150 mg/kg), daily for 30 days, groups 4�6 received STZ (50 mg/kg, ip) at the beginning of the study and were treated with Phoenix dactylifera spathe extract (PDSE; 50, 100, and 200 mg/kg, respectively) for 30 days, and group 7 received PDSE (200 mg/kg) for 30 days. Fasting blood sugar (FBS), insulin, weight change, adipokine leptin, tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), lipid profile, and oxidative stress biomarkers were assessed. Qualitative analyses of extracts revealed the presence of flavonoids, phenols, and alkaloids but the absence of steroids and saponins. PDSE significantly reduced serum level of FBS, triglyceride, low lipoprotein density, cholesterol, adipokine leptin, TNF-α, hsCRP, and malondialdehyde. PDSE significantly increased the serum levels of high lipoprotein density, insulin, total antioxidant capacity, reduced glutathione, as well as the body weight of diabetic rats. Our results showed that PDSE improves glycemic and lipidemic profile in STZ-induced diabetic rats. This suggests that PDSE may be a promising agent to mitigate diabetic symptoms in diabetic patients. © 2021, The Author(s), under exclusive licence to Springer-Verlag London Ltd. part of Springer Nature
Dermatochalasis Through Decades: A Histopathologic Study
No full textOBJECTIVES: Three prior studies (2008, 2011, 2018) histopathologically compared the eyelid specimens of patients with dermatochalasis (DC, undergoing blepharoplasty) with a control group and proposed that DC may begin with subclinical inflammation leading to elastolysis and lymphostasis. With growing number of younger patients consulting for blepharoplasty, the unanswered question is whether histopathologic changes of DC differ between the younger and the older. PATIENTS AND METHODS: In this prospective case series, 20 right upper eyelid skin of 20 nonsmoker, class 3 Fitzpatrik skin type women (30-68 years old) were histopathologically examined. Patients were divided into 2 age groups of 50 years or older and older than 50 years. Upper eyelid skin was preoperatively marked, intraoperatively removed, postoperatively divided into 3 sections: lateral (lateral limbus to lateral canthus), central (between medial and lateral limbi), and medial (medial limbus to medial canthus), and separately (totally 60 specimens) sent for histopathological examination. A masked pathologist recorded skin thickness in all specimens (60) as well as lymphatic vessels diameter and density, elastic fiber density, macrophage number, collagen intrafibril edema, and depth of collagen stromal bed in central sections (20 specimens). RESULTS: There were 10 patients at each age group. Histopathological measurements were not significantly different between the 2 age groups except mean lymphatic vessel diameter (P = 0.034) that was larger in the second group (>50 years). A significant positive correlation was also observed between the age and lymphatic vessel diameter (rs = 0.3, P = 0.009). CONCLUSIONS: Lymphangiectasia progresses significantly by age. Histopathological characteristics of DC are the same in the 2 age groups. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved
Correction to: Destructive Roles of Fibroblast-Like Synoviocytes in Chronic Inflammation and Joint Damage in Rheumatoid Arthritis (Inflammation, (2021), 44, 2, (466-479), 10.1007/s10753-020-01371-1)
Full text linkFollowing the publication of the original article, the corresponding author noticed that the second corresponding author has not been mentioned. The below statement must be added to the correspondence section: Jafar Karami; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. E-mail: [email protected]; [email protected] The original article has been corrected. © 2020, Springer Science+Business Media, LLC, part of Springer Nature
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Full text linkA systematic review and meta-analysis of human biomonitoring studies on exposure to environmental pollutants in Iran
Full text linkPopulation exposure to environmental contaminants can be precisely observed through human biomonitoring studies. The present study aimed to systematically review all the biomonitoring studies conducted in Iran on some selected carcinogen environmental pollutants. In this systematic review study, 11 carcinogen agents were selected including arsenic, cadmium, chromium, nickel, lindane, benzene, trichloroethylene (TCE), pentachlorophenol (PCP), radon-222, radium-224, � 226, � 228, and tobacco smoke. The Web of Science, PubMed, and Scopus databases were searched for peer-reviewed articles published in English. After several screening steps, data were extracted from the studies. Meta-analyses (a random-effect model using the DerSimonian-Laired method) were performed only for the biomarkers with more than three eligible articles, including cadmium in blood and breast milk, and arsenic in breast milk. Methodological quality of the studies was assessed using the Newcastle-Ottawa Quality Assessment Scale adapted for cross-sectional studies. Of the 610 articles found in the database search, 30 studies were eligible for qualitative review, and 13 were included in the meta-analysis (cadmium in blood (n = 3), cadmium in breast milk (n = 6), and arsenic in breast milk (n = 4)). The overall pooled average concentrations (95 CI) of cadmium in blood, cadmium in breast milk, and arsenic in breast milk were 0.11 (95 CI: 0.08, 0.14), 5.38 (95 CI: 3.60, 6.96), and 1.42 (95 CI: 1.02, 1.81) µg/L, respectively. These values were compared with the biomarker concentrations in other countries and health-based guideline values. This study showed that there is a need for comprehensive action plans to reduce the exposure of general population to these environmental contaminants. © 202
Digit ratio (2D:4D) a possible biomarker for cognitive style: A study on Iranian engineering and mathematics university students
No full textDigit ratio (2D:4D) is a biomarker for prenatal hormonal exposure. Some studies suggest that prenatal hormonal exposure might influence our cognitive styles characterized by systemizing and empathizing tendencies while other studies do not support these findings. By assessing 156 university students of engineering or mathematics (science, technology, engineering, and mathematics (STEM) (female: 63 and male 93) we concluded that digit ratio may support the hypothesis on sexual differences in cognitive styles. © 2020 Elsevier Lt