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Leveraging ChatGPT in pharmacovigilance event extraction : an empirical study
Get PDFWith the advent of large language models (LLMs), there has been growing interest in exploring their potential for medical applications. This research aims to investigate the ability of LLMs, specifically ChatGPT, in the context of pharmacovigilance event extraction, of which the main goal is to identify and extract adverse events or potential therapeutic events from textual medical sources. We conduct extensive experiments to assess the performance of ChatGPT in the pharmacovigilance event extraction task, employing various prompts and demonstration selection strategies. The findings demonstrate that while ChatGPT demonstrates reasonable performance with appropriate demonstration selection strategies, it still falls short compared to fully fine-tuned small models. Additionally, we explore the potential of leveraging ChatGPT for data augmentation. However, our investigation reveals that the inclusion of synthesized data into fine-tuning may lead to a decrease in performance, possibly attributed to noise in the ChatGPT-generated labels. To mitigate this, we explore different filtering strategies and find that, with the proper approach, more stable performance can be achieved, although constant improvement remains elusive
Can terrorism ever be morally justified?
Get PDFThis paper provides a framework to make moral sense of terrorism. The framework consists in a test, referred to as the MODAL test, which is an acronym standing for five tests or principles for determining the moral defensibility or indefensibility of terrorism. The five principles concern the motives for terrorism, its objectives, destructiveness, availability of alternatives, and likelihood of success. This approach makes it conceivable but highly unlikely in practice that a terrorist act is morally justified. The MODAL test does not claim to be an exhaustive framework for analysing the moral legitimacy or illegitimacy of terrorism but rather a practical analytical tool aimed at securing a reliable grasp of the tricky question of the relation between morality and terrorism
Deeply Christian and serving the common good? A survey of Anglican cathedral provision for schools
Get PDFThe Church of England’s vision for education is generous and seeks to allow the riches of Christian life to overflow throughout schools. The vision is captured by the strapline ‘Deeply Christian, serving the common good’. The present study assesses the contribution made to service this vision by the 43 Anglican cathedrals within England and the Isle of Man. Drawing on a careful analysis of information presented by the websites of these cathedrals, the study concluded that all 43 Anglican cathedrals dedicated considerable space on their websites to a regular programme of teaching and learning provision across the age range from early years foundation stage to sixth-form, relevant to a range of curriculum areas, and giving attention to pupils’ personal development and well-being
Constraining the reflective properties of WASP-178 b using CHEOPS photometry
No full textContext. Multiwavelength photometry of the secondary eclipses of extrasolar planets is able to disentangle the reflected and thermally emitted light radiated from the planetary dayside. Based on this, we can measure the planetary geometric albedo Ag, which is an indicator of the presence of clouds in the atmosphere, and the recirculation efficiency ϵ, which quantifies the energy transport within the atmosphere.
Aims. We measure Ag and ϵ for the planet WASP-178 b, a highly irradiated giant planet with an estimated equilibrium temperature of 2450 K.
Methods. We analyzed archival spectra and the light curves collected by CHEOPS and TESS to characterize the host WASP-178, refine the ephemeris of the system, and measure the eclipse depth in the passbands of the two telescopes.
Results. We measured a marginally significant eclipse depth of 70 ± 40 ppm in the TESS passband, and a statistically significant depth of 70 ± 20 ppm in the CHEOPS passband.
Conclusions. Combining the eclipse-depth measurement in the CHEOPS (λeff = 6300 Å) and TESS (λeff = 8000 Å) passbands, we constrained the dayside brightness temperature of WASP-178 b in the 2250–2800 K interval. The geometric albedo 0.10.7 makes WASP-178 b an interesting laboratory for testing the current heat-recirculation model
Direct imaging of magnetohydrodynamic wave mode conversion near a 3D null point on the sun
Get PDFMutual conversion of various kinds of magnetohydrodynamic (MHD) waves can have profound impacts on wave propagation, energy transfer, and heating of the solar chromosphere and corona. Mode conversion occurs when an MHD wave travels through a region where the Alfvén and sound speeds are equal (e.g., a 3D magnetic null point). Here we report the direct extreme ultraviolet (EUV) imaging of mode conversion from a fast-mode to a slow-mode MHD wave near a 3D null point using Solar Dynamics Observatory/Atmospheric Imaging Assembly (SDO/AIA) observations. An incident fast EUV wavefront associated with an adjacent eruptive flare propagates laterally through a neighboring pseudostreamer. Shortly after the passage of the fast EUV wave through the null point, a slow-mode wave appears near the null that propagates upward along the open structures and simultaneously downward along the separatrix encompassing the fan loops of the pseudostreamer base. These observations suggest the existence of mode conversion near 3D nulls in the solar corona, as predicted by theory and MHD simulations. Moreover, we observe decaying transverse oscillations in both the open and closed structures of the pseudostreamer, along with quasiperiodic type III radio bursts indicative of repetitive episodes of electron acceleration
Conversational technology and reactions to withheld information
Get PDFPeople frequently face decisions that require making inferences about withheld information. The advent of large language models coupled with conversational technology, e.g., Alexa, Siri, Cortana, and the Google Assistant, is changing the mode in which people make these inferences. We demonstrate that conversational modes of information provision, relative to traditional digital media, result in more critical responses to withheld information, including: (1) a reduction in evaluations of a product or service for which information is withheld and (2) an increased likelihood of recalling that information was withheld. These effects are robust across multiple conversational modes: a recorded phone conversation, an unfolding chat conversation, and a conversation script. We provide further evidence that these effects hold for conversations with the Google Assistant, a prominent conversational technology. The experimental results point to participants’ intuitions about why the information was withheld as the driver of the effect
Data analytics for project delivery : unlocking the potential of an emerging field
Get PDFPurpose:
In recent years, there has been a growing interest in the potential of data analytics to enhance project delivery. Yet many argue that its application in projects is still lagging behind other disciplines. This paper aims to provide a review of the current use of data analytics in project delivery encompassing both academic research and practice to accelerate current understanding and use this to formulate questions and goals for future research.
Design/methodology/approach:
We propose to achieve the research aim through the creation of a systematic review of the status of data analytics in project delivery. Fusing the methodology of integrative literature review with a recently established practice to include both white and grey literature amounts to an approach tailored to the state of the domain. It serves to delineate a research agenda informed by current developments in both academic research and industrial practice.
Findings:
The literature review reveals a dearth of work in both academic research and practice relating to data analytics in project delivery and characterises this situation as having “more gap than knowledge.” Some work does exist in the application of machine learning to predicting project delivery though this is restricted to disparate, single context studies that do not reach extendible findings on algorithm selection or key predictive characteristics. Grey literature addresses the potential benefits of data analytics in project delivery but in a manner reliant on “thought-experiments” and devoid of empirical examples.
Originality/value:
Based on the review we articulate a research agenda to create knowledge fundamental to the effective use of data analytics in project delivery. This is structured around the functional framework devised by this investigation and highlights both organisational and data analytic challenges. Specifically, we express this structure in the form of an “onion-skin” model for conceptual structuring of data analytics in projects. We conclude with a discussion about if and how today’s project studies research community can respond to the totality of these challenges. This paper provides a blueprint for a bridge connecting data analytics and project management
The politics of STEMM collaboration between Australia and China : national security, geopolitics, and academic freedom
Get PDFSince the 1990s, there has been a proliferation in science, technology, engineering, maths, and medical (STEMM) collaboration between Australian and Chinese universities and academics, which has produced divisions over the scientific, economic, human rights, and national security implications. Drawing on interviews with 22 academic researchers and the works of public commentators, I devise a typology of perceptions on STEMM collaboration: Pragmatic, Cosmopolitan, CCP-critic, and Leftist. Pragmatic and Cosmopolitan perceptions, which promote deep China engagement, are the most influential over the Australian government and university leadership strategy due to the economic and scientific opportunities that China presents, but CCP-critics, who highlight the national security and human rights risks involved, have growing influence over how the government and universities perceive and manage the relationship. The interviews also reveal that academic freedom means the freedom to pursue research without external influence. Shaped by individual experiences and assumptions regarding China, academics differ over what academic freedom should protect to maximise the benefits of STEMM collaboration while minimising risks. Overall, my findings suggest that geopolitical competition and perceptions of the risks and opportunities of China engagement shape STEMM collaboration and the freedom of academics
Research priorities for randomised controlled trials in chronic migraine preventive medication : a stakeholder consensus workshop [version 1; peer review: awaiting peer review]
Get PDFBackground
Chronic migraine is a disabling condition that can substantially impact on quality of life. People with chronic migraine have headaches on at least 15 days of every month. Preventative medications aiming to reduce number of days with migraine are available, but high-quality randomised evidence is lacking for many drugs, and it is unclear which medications should be prioritised for research. There is also no existing evidence about patient and clinicians’ priorities for research.
Methods
We undertook a consensus workshop with patient and healthcare professional stakeholders, using nominal group technique, to understand these stakeholders’ priorities for future randomised controlled trials. We reached a consensus on a set of research recommendations for the field.
Results
Eight people with chronic migraine and eleven healthcare professionals took part in an online workshop. Comparisons of calcitonin gene-related peptide monoclonal antibodies (CGRP MAbs) and OnabotulinumtoxinA (BTA) were a top priority for our group. Candesartan and Flunarizine were the top drugs the group wanted to compare against placebo.
Conclusions
These research recommendations should guide researchers in the field, and funders when prioritising commissioned research and assessing funding applications. Particular areas to explore further are Candesartan or Flunarizine versus placebo, and comparing and combining CGRP MAbs with other medications