JOS - UNSOED (Jurnal Online Soedirman - Universitas Jenderal Soedirman)
Not a member yet
6212 research outputs found
Sort by
Efek Penambatan Senyawa Demetoksikurkumin Dan Bisdemetoksikurkumin Terhadap Protein LSD1
Get PDFBeta-talasemia merupakan penyakit genetik pada sintesis hemoglobin di dalam sel darah merah yang ditandai dengan menurunnya produksi β-globin. Senyawa kurkumin diketahui dapat meningkatkan kadar HbF pada sel K562. Senyawa demetoksikurkumin dan bisdemetoksikurkumin diketahui memiliki stabilitas dan bioavaibilitas yang lebih baik dari kurkumin. Penelitian ini bertujuan untuk melihat interaksi senyawa demetoksikurkumin dan bisdemetoksikurkumin pada protein LSD1 secara in silico. Penelitian eksperimental yang dilakukan terbagi dalam dua tahap. Pertama, validasi metode yang meliputi pengunduhan struktur LSD1 (PDB ID: 6KGP), preparasi struktur protein dengan menghilangkan molekul air dan memisahkan molekul protein dan ligan natif, penambatan kembali dengan Ligan natif menggunakan AutoDock Vina dan penghitungan nilai RMSD. Kedua, penambatan molekuler senyawa demetoksikurkumin dan bisdemetoksikurkumin dengan protein LSD1 menggunakan koordinat hasil validasi yang valid dan visualisasi penambatan dengan menggunakan BIOVIA Discovery Studio 2020. Hasil validasi menunjukkan nilai RMSD yaitu 1,402 Å. Energi ikatan terendah untuk protein LSD1 yaitu -10,4 kkal/mol dan -10,2 kkal/mol untuk senyawa demetoksikurkumin dan bisdemetoksikurkumin. Residu asam amino pada LSD1 yang berperan pada pengikatan senyawa uji demetoksikurkumin yaitu Thr624; Val288 dan Arg316. Residu asam amino pada LSD1 yang berperan pada pengikatan senyawa uji demetoksikurkumin yaitu Thr624; Leu659; Val811; Arg316; Leu625; Tyr761 dan Trp751. Penelitian ini menunjukkan bahwa senyawa demetoksikurkumin menunjukkan hasil yang lebih baik dan interaksi yang lebih potensial pada protein LSD1 dibandingkan bisdemetoksikurkumi
THE EFFECT OF PURCHASE REGRET AND CUSTOMER DISSATISFACTION ON BRAND SWITCHING WITH CUSTOMER NEGATIVE ATTITUDE AS MEDIATING VARIABLE
Get PDFCompetition in the smartphone industry in Indonesia is getting tougher, with many brands offering innovative technology, competitive prices, and superior features. In this condition, the phenomenon of brand switching is an important concern for companies. This study aims to analyze the effect of purchase regret and customer dissatisfaction on brand switching decisions, with customer negative attitude as a mediating variable. This study uses a quantitative method with a survey approach to 130 respondents who have used Vivo smartphones and have switched to another brand. Data were collected through an online questionnaire using a Likert scale and analyzed with Structural Equation Modeling-Partial Least Square (SEM-PLS). The results showed that purchase regret and customer dissatisfaction have a positive effect on customer negative attitude. In addition, customer negative attitude has a positive influence on brand switching and is proven to mediate the relationship between purchase regret and brand switching, as well as between customer dissatisfaction and brand switching. These findings indicate that customers who feel disappointed or regretful after purchasing Vivo products tend to develop negative attitudes, which then encourage them to switch to other brands.
 
Pengaruh Ekspor terhadap Pertumbuhan Ekonomi di Negara Berkembang
Get PDFPertumbuhan ekspor memiliki peran yang penting dalam pertumbuhan ekonomi suatu negara terutama pada negara-negara berkembang. Akan tetapi, kebanyakan negara berkembang mengalami defisit neraca perdagangan yaitu lebih banyak impor dibandingkan dengan ekspor. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh ekspor terhadap pertumbuhan ekonomi pada negara-negara berkembang dan mencoba untuk menjawab permasalahan mengenai keadaan defisit neraca perdagangan tersebut. Penelitian ini menggunakan data panel yang diperoleh dari World Bank selama periode 1980-2023 dengan variabel kontrol berupa impor, inflasi, dan investasi asing langsung (FDI). Metode penelitian yang digunakan untuk mengetahui pengaruh antar variabel dengan menggunakan Uji ARDL (Autoregressive Distributed Lag). Pada penilitian ini ditemukan bahwa dalam jangka pendek pertumbuhan ekspor berpengaruh negatif terhadap pertumbuhan ekonomi sedangkan dalam jangka panjang pertumbuhan ekspor berpengaruh positif terhadap pertumbuhan ekonomi. Selain itu, tingkat inflasi juga berpengaruh negatif dan signifikan terhadap pertumbuhan ekonomi. Dengan demikian, kebijakan yang tepat dalam mendorong ekspor pada negara-negara berkembang dapat dilakukan melalui promosi ekspor dan kebijakan moneter dalam mengendalikan inflas
Pemanfaatan Limbah Serbuk Kaca sebagai Material Anti Bakar Pada Komposit Polimer Berpenguat Serat Ijuk
No full textEra industrialisasi saat ini menjadi persoalan serius tentang penanganan limbah hasil manufaktur dari sebuah produk. Saat ini sebagian besar industri pengecoran logam menggunakan pasir sebagai cetakan, salah satu jenis cetakan yang digunakan adalah cetakan pasir CO2 yang terdiri dari pasir silika yang berpengikat waterglass dan Gas CO2 dengan sifat yang hanya bisa dipakai beberapa kali sehingga penggunaanya terbatas dan cenderung menghasilkan limbah. Pasir silika disusun sebagain besar SiO2 yang memiliki ketahanan bakar yang baik, sehingga dapat digunakan sebagai material antibakar pada material komposit polimer berpenguat serat alam. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan limbah pasir CO2 0%, 5%, 10%, dan 15% pada matrik polyester terhadap karakteristik ketahanan bakar dan ketahanan bakar komposit serat ijuk Limbah pasir CO2 yang telah hancur dengan tingkat kehalusan 50 mesh dicampur dengan resin poliester sebagai matrik. Pengujian penelitian ini uji mekanik yang terdiri uji bending, dan uji bakar yang menghitung waktu awal pembakaran. Berdasarkan hasil uji mekanik dan uji bakar secara komulatif penambahan serbuk pasir CO2 dengan fraksi volume matrik-filler 5% merupakan varisai yang direkomendasikan untuk diterapkan. 
Smart City as a Form of Bureaucratic Transformation in Banyumas Regency
Get PDFThis study discusses the concept of smart city as a form of bureaucratic transformation in BanyumasRegency. In the digital era, the government is required to optimize public services through technologicalinnovation to improve the efficiency and quality of services to the community. Banyumas Regency, as oneof the regions that is developing the concept of smart city, is trying to carry out bureaucratic reform byadopting information and communication technology (ICT) to improve the efficiency, transparency, andaccountability of its government services. This study uses a qualitative method with a case studyapproach, where data is obtained through in-depth interviews, observations, and document analysisrelated to the implementation of smart city. The results of the study show that the implementation ofsmart city in Banyumas covers several sectors, including public services, infrastructure, and datamanagement. These findings also identify challenges in terms of infrastructure readiness, human resourcecompetency, and the need for community participation. The implementation of smart city in BanyumasRegency is expected to encourage the realization of a more responsive, transparent, and accountablebureaucracy, so that it can meet the needs of the community more effectively
Utilization of Social Capital in the Brown Sugar Industry to Maintain Business Continuity in Sukolilo Village, Wajak District, Malang Regency
Get PDFSukolilo Village is one of 378 villages in Malang Regency with various potentials, one of which is the brownsugar industry, a local identity of the local community's economy. However, the sustainability of this localindustry is threatened by modernization which has an impact on socio-cultural shifts by prioritizingproduction efficiency that abandons traditional values. As a result, local industries are faced with businesscompetition against large industries in terms of production resources, product competence, distributionand product prices on the market. The lack of regulations and policies from the government that supportpeople's businesses makes it difficult for local industries to develop. This study aims to identify the effortsand the challenges faced by the local community in maintaining their businesses. This research isimportant to provide recommendations to maximize the capabilities of industry players in increasing theresilience of local businesses. Social capital has an important role in maintaining the resilience of localindustries by transforming social resources into economic capital. The methodology used in this study is aqualitative approach with a descriptive method whose data collection is carried out through observationand interviews. The results of the study show that social capital in the form of networks, trust, and normsis a strong foundation in facing external challenges to maintain business continuity. Among them arehelping to mitigate financial risks and maintain business operations. The development of a morestructured and formal social capital can be the right strategic step in strengthening this industry
Localizing the Sustainable Development Goals (SDGs): The Resilience of ‘Posyandu Cadre’ in Promoting Stunting Reduction Program
Get PDFSince the Sustainable Development Goals (SDGs) were first adopted in New York in 2015, the Indonesiangovernment has taken a collaborative governance approach to achieving the SDGs targets. This means thatseveral institutions and different levels of government have been involved in the same SDG initiatives, suchas reducing the prevalence of stunting. While collaborative governance highlights the dominance of stateactors, this paper argues that regarding the stunting reduction, the backbone lies in the hands of Posyanducadres, a voluntary group of women who have effectively provided maternal and child health educationto the village women. These mothers, who work with expectant mothers, pregnant mothers, and motherswith children under 1000 days old, are the unsung heroes of the war against stunting. This research appliesthe localization of the SDGs framework to demonstrate how local actors also play essential roles inimplementing international norms and initiatives. This research uses the experience of Posyandu cadresin Banjar Seminai village, Siak Regency, as a case study of community resilience in reducing stunting
The Potential of MSMEs in Achieving the SDGs Towards Megatrend 2045
Get PDFMSMEs (Micro, Small, and Medium Enterprises) play a crucial role in Indonesia's economy, particularly in supporting economic growth at both the local and national levels. Indonesia is a country where MSMEs have experienced significant changes, and it is projected that in the next twenty years, major transformations will occur. This is evident from the estimate that by 2045, the global middle-income class will increase by 4.9 billion. This paper aims to analyze, and provide an evaluation of the economic potential of MSMEs that contribute to economic development on both a local and national scale. Additionally, these MSMEs support the achievement of the SDGs by helping to reduce poverty, create sustainable economic development, and improve the welfare of local communities. This study applies a qualitative method with a descriptive approach, and the data is analyzed using SWOT analysis techniques. Data were collected from various sources, including journals, books, papers, and other supporting data accessed through online platforms. The research results show that first, MSMEs support the local economy, create jobs, and help reduce poverty. Second, gender equality which is strengthened through education and training, supporting women's empowerment and SDGs 2045. This is expected to improve the quality of human resources to become more self-reliant. Lastly, collaboration between the government and the private sector strengthens the position of MSMEs in both national and international markets. Overall, these MSMEs have great potential with competitive and sustainable qualities, and they contribute to the achievement of SDGs and the Megatrend 2045
The Environmental Security and International Relations: The Case of Citarum River Water Pollution
Get PDFEnvironmental security as part of human security is a very significant global issue. Environment security became the concern of the Sustainable Development Goals (SDGs) achievement, namely securing the source of ground water which is an important problem in developing countries. This paper analyses the Citarum River, the longest river in West Java, Indonesia, which is heavily polluted due to various economic activities along the riverbanks. The process of industrialization, development and demands to meet the needs of life, as well as population growth have not succeeded in maintaining the river as a source of life. Economic interests and various political conflicts were unable to maintain environmental sustainability. The river pollution comes from factory waste operating along the river, without a process through the Wastewater Treatment Plant (WTP). The research would focus on the government securitization programs in Citarum River, by implementing four components of securitization namely referent objects, scope, mean, and actors. The analysis observed various government efforts and private sectors to restore the river. The research started in 2000, which is the beginning of “Citarum Harum” restoration until the end of the program in January 2025. The research found that securitisation efforts failed due to three issues; the corruption, collusion and nepotism (CCN) issues, lack of law enforcement, and weakness of bureaucracy and leadership. As a conclusion, various securitisation efforts need to be carried out more firmly and earnestly by providing adequate legal sanctions for the perpetrators of environmental damage.
Keywords: security, environment security, Citarum River, restoratio
Graf Identitas atas Grup Quaternion Tergeneralisasi
No full textIdentity graphs are graphs defined based on the relationship of group elements to identity elements. This study examines the relationship between the algebraic structure of the generalized quaternion group and the topological structure of the identity graph constructed from the group. Through a review of literature related to graph theory and group theory, this research identifies certain patterns in the identity graph of the generalized quaternion group. The results show that the identity graph formed has distinctive characteristics, such as a specific number of edges and cycles, as well as varying degrees of each vertex. Furthermore, this study proves that the identity graph on the generalized quaternion group is not eligible to be an Euler graph or a Hamiltonian graph. Moreover, based on the pattern formed, it can be identified that the identity graph on the group always forms a planar graph. The discussion is colosed with the identification of its girth and diameter